Clodronate and liposome-encapsulated clodronate are metabolized to a toxic ATP analog, adenosine 5'-(β,γ-dichloromethylene) triphosphate, by mammalian cells in vitro

Journal of Bone and Mineral Research

Volumn 12, Issue 9, 1997, Pages 1358-1367

  Frith, Julie C ^a   Mönkkönen, Jukka ^b   Blackburn, G Michael ^c   Russell, R Graham G ^a   Rogers, Michael J ^a,d  

^a UNIVERSITY OF SHEFFIELD   (United Kingdom)

^b UNIVERSITY OF EASTERN FINLAND   (Finland)

^c UNIVERSITY OF SHEFFIELD   (United Kingdom)

^d UNIVERSITY OF ABERDEEN   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE DERIVATIVE; ALENDRONIC ACID; BETA,GAMMA DICHLOROMETHYLENEADENOSINE TRIPHOSPHATE; BETA,GAMMA METHYLENEADENOSINE TRIPHOSPHATE; BISPHOSPHONIC ACID DERIVATIVE; CLODRONIC ACID; LIPOSOME; MEDRONIC ACID; UNCLASSIFIED DRUG;

ANIMAL CELL; APOPTOSIS; ARTHRITIS; ARTICLE; BONE METASTASIS; CELL DEATH; CONTROLLED STUDY; DRUG FORMULATION; DRUG METABOLISM; DRUG POTENCY; HUMAN; HUMAN CELL; HYPERCALCEMIA; INFLAMMATION; MACROPHAGE; NONHUMAN; OSTEOCLAST; OSTEOLYSIS; PAGET BONE DISEASE;

ADENOSINE TRIPHOSPHATE; ALENDRONATE; ANALGESICS, NON-NARCOTIC; APOPTOSIS; CELL SURVIVAL; CELLS, CULTURED; CLODRONIC ACID; DIPHOSPHONATES; HUMANS; LIPOSOMES; MICROSCOPY, FLUORESCENCE;

EID: 1842405434     PISSN: 08840431     EISSN: None     Source Type: Journal    
DOI: 10.1359/jbmr.1997.12.9.1358     Document Type: Article

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