Protein synthesis is required for caspase activation and induction of apoptosis by bisphosphonate drugs

Molecular Pharmacology

Volumn 54, Issue 4, 1998, Pages 631-638

  Coxon, Fraser P ^a,b,c   Benford, Helena L ^a   Russell, R Graham G ^b   Rogers, Michael J ^a  

^a UNIVERSITY OF ABERDEEN   (United Kingdom)

^b UNIVERSITY OF SHEFFIELD   (United Kingdom)

^c UNIVERSITY OF ABERDEEN   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ALENDRONIC ACID; BISPHOSPHONIC ACID DERIVATIVE; COMPACTIN; CYCLOHEXIMIDE; DNA FRAGMENT; PAMIDRONIC ACID; SERINE PROTEINASE; STATIN; STAUROSPORINE;

ANIMAL CELL; APOPTOSIS; ARTICLE; DRUG CYTOTOXICITY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INDUCTION; MACROPHAGE; MOUSE; NONHUMAN; OSTEOCLAST; OSTEOLYSIS; PRIORITY JOURNAL; PROTEIN SYNTHESIS; PROTEIN SYNTHESIS INHIBITION;

ALENDRONATE; ANIMALS; APOPTOSIS; CARBON RADIOISOTOPES; CASPASE 3; CASPASES; CELL LINE; CYCLOHEXIMIDE; DIPHOSPHONATES; ENZYME ACTIVATION; ENZYME INHIBITORS; LOVASTATIN; MACROPHAGES; MEVALONIC ACID; MICE; PROTEIN BIOSYNTHESIS; PROTEIN SYNTHESIS INHIBITORS;

EID: 0031785895     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (40)

1. Aparicio A, Gardner A, Tu Y, Savage A, Berenson J, and Lichtenstein A (1998) In vitro cytoreductive effects on multiple myeloma cells induced by bisphosphonates. Leukaemia 12:220-229.
2. Borner MM, Myers CE, Sartor O, Sei Y, Toko T, Trepel JB, and Schneider E (1995) Drug-induced apoptosis is not necessarily dependent on macromolecular synthesis or proliferation in the p53-negative human prostate cancer cell line PC-3. Cancer Res 55:2122-2128.
3. Chestnut MH, Rogers MJ, Watts DJ, Xiong X, Russell RGG, Ebetino FH, Grosik TL, Finch JL, Amburgey JS, and Ibbotson KJ (1995) Cellular uptake of bisphosphonates: localisation using fluorescently-labelled alendronate. Bone 17:599.
4. Cohen GM (1997) Caspases: the executioners of apoptosis. Biochem J 326:1-16.
5. Cohen JJ and Duke RC (1984) Glucocorticoid activation of a calcium-dependent endonuclease in thymocyte nuclei leads to cell death. J Immunol 132:38-42.
6. Cortez D, Stoica G, Pierce JH, and Pendergast AM (1996) The BCR-ABL tyrosine kinase inhibits apoptosis by activating a Ras-dependent signaling pathway. Oncogene 13:2589-2594.
7. L. J Biol Chem 271:17601-17604.
8. Fenton RG, Kung H-F, Longo DL, and Smith MR (1992) Regulation of intracellular actin polymerization by prenylated cellular proteins. J Cell Biol 117:347-356.
9. Fernandes-Alnemri T, Litwack G, and Alnemri ES (1994) Caspase-3: a novel human apoptotic protein with homology to Caenorhabditis elegans cell death protein ced-3 and mammalian interleukin-1β-converting enzyme. J Biol Chem 269:30761-30764.
10. Fleisch H (1988) Bisphosphonates: a new class of drugs in disease of bone and calcium metabolism, in Handbook of Experimental Pharmacology (Baker PF, ed), pp 441-466, Springer-Verlag, Berlin.
11. Fleisch H (1991) Bisphosphonates: pharmacology and use in the treatment of tumour-induced hypercalcaemic and metastatic bone disease. Drugs 42:919-942.
12. Frith JC, Mönkkönen J, Blackburn GM, Russell RGG, and Rogers MJ (1997) Clodronate and liposome-encapsulated clodronate are metabolized to a toxic ATP analog, adenosine 5'-(β,γ-dichloromethylene) triphosphate, by mammalian cells in vitro. J Bone Miner Res 12:1358-1367.
13. Hale AJ, Smith CA, Sutherland LC, Stoneman VEA, Longthorne VL, Culhane AC, and Williams GT (1996) Apoptosis: molecular regulation of cell death. Eur J Biochem 236:1-26.
14. Hughes DE, Wright KR, Uy HL, Sasaki A, Yoneda T, Roodman GD, Mundy GR, and Boyce BF (1995) Bisphosphonates promote apoptosis in murine osteoclasts in vitro and in vivo. J Bone Miner Res 10:1478-1487.
15. Inayat-Hussain SH, Couet C, Cohen GM, and Cain K (1997) Processing/activation of CPP32-like proteases is involved in transforming growth factor β1-induced apoptosis in rat hepatocytes. Hepatology 25:1516-1526.
16. Kanis JA, O'Rourke N, and McCloskey EV (1994) Consequences of neoplasia induced bone resorption and the use of clodronate. Int J Oncol 5:713-731.
17. Koch G, Benz C, Scmidt G, Olenik C, and Aktories K (1997) Role of Rho protein in lovastatin-induced breakdown of actin cytoskeleton. J Pharmacol Exp Ther 283:901-909.
18. Lazebnik YA, Takahashi A, Poirier GG, Kaufman SH, and Earnshaw WC (1995) Characterization of the execution phase of apoptosis using extracts from condemned-phase cells. J Cell Sci S19:41-49.
19. Lerner EC, Qian Y, Blaskovich MA, Fossum RA, Vogt A, Sun J, Cox AD, Der CJ, Hamilton AD, and Sebti SM (1995) Ras CAAX peptidomimetic FTI-277 selectively blocks oncogenic Ras signalling by inducing cytoplasmic accumulation of inactive Ras-Raf complexes. J Biol Chem 270:26802-26806.
20. Liberman UA, Weiss SR, Broll J, Minne HW, Quan H, Bell NH, Rodriquez-Portales J, Downs RW, Dequeker J, Favus M, Seeman E, Recker RR, Capizzi T, Santora AC, Lombardi A, Shah RV, Hirsch LJ, and Karpf DB (1995) Effect of oral alendronate on bone mineral density and the incidence of fractures in postmenopausal osteoporosis. N Engl J Med 333:1437-1443.
21. Luckman SP, Coxon FP, Ebetino FH, Russell RGG, and Rogers MJ (1998a) Heterocycle-containing bisphosphonates cause apoptosis and inhibit bone resorption by preventing protein prenylation: evidence from structure-activity relationships in J774 macrophages. J Bone Miner Res, in press.
22. Luckman SP, Hughes DE, Coxon FP, Russell RGG, and Rogers MJ (1998b) Nitrogen-containing bisphosphonates inhibit the mevalonate pathway and prevent post-translational prenylation of GTP-binding proteins, including Ras. J Bone Miner Res 13:581-589.
23. Marcelli M, Cunningham GR, Haidacher SJ, Padayatty SJ, Sturgis L, Kagan C, and Denner L (1998) Caspase-7 is activated during lovastatin-induced apoptosis of the prostate cancer cell line LNCaP. Cancer Res 58:76-83.
24. Medina V, Edmonds B, Young GP, James R, Appleton S, and Zalewski PD (1997) Induction of caspase-3 protease activity and apoptosis by butyrate and trichostatin A (inhibitors of histone deacetylase): dependence on protein synthesis and synergy with a mitochondrial/cytochrome c-dependent pathway. Cancer Res 57:3697-3707.
25. Moorman JP, Bobak DA, and Hahn CS (1996) Inactivation of the small GTP binding protein Rho induces multinucleate cell formation and apoptosis in Murine T lymphoma EL4. J Immunol 156:4146-4153.
26. Nicholson DW, Ali A, Thornberry NA, Vaillancourt JP, Dig CK, Gallant M, Gareau Y, Griffin PR, Labelle M, Lazebnik YA, Munday NA, Raju SM, Smulson ME, Yanin NA, Yu VL, and Miller DK (1995) Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis. Nature 376:37-43.
27. Padayatty SJ, Marcelli M, Shao TC, and Cunningham GR (1997) Lovastatin-induced apoptosis in prostate stromal cells. J Clin Endocrinol Metab 82:1434-1439.
28. Perez-Sala D, Collado-Escobar D, and Mollinedo F (1995) Intracellular alkalinization suppresses lovastatin-induced apoptosis in HL-60 cells through the inactivation of a pH-dependent endonuclease. J Biol Chem 11:6235-6242.
29. Perez-Sala D and Mollinedo F (1994) Inhibition of isoprenoid biosynthesis induces apoptosis in human promyelocytic HL-60 cells. Biochem Biophys Res Commun 199:1209-1215.
30. Repko EM and Maltese WA (1989) Post-translational isoprenylation of cellular proteins is altered in response to mevalonate availability. J Biol Chem 264:9945-9952.
31. Rodan GA and Fleisch HA (1996) Bisphosphonates: mechanisms of action. J Clin Invest 97: 2692-2696.
32. Rogers MJ, Chilton KM, Coxon FP, Lawry J, Smith MO, Suri S, and Russell RGG (1996) Bisphosphonates induce apoptosis in mouse macrophage-like cells by a nitric oxide-independent mechanism. J Bone Miner Res 11:1482-1491.
33. Rogers MJ, Xiong X, Ji X, Mönkkönen J, Russell RGG, Williamson MP, Ebetino FH, and Watts DJ (1997) Inhibition of growth of Dictyostelium discoideum amoebae by bisphosphonate drugs is dependent on cellular uptake. Pharm Res 14:625-630.
34. Selander KS, Mönkkönen J, Karhukorpi E-K, Härkönen P, Hannuniemi R, and Väänänen HK (1996) Characteristics of clodronate-induced apoptosis in osteoclasts and macrophages. Mol Pharmacol 50:1127-1138.
35. Shinoda H, Adamek G, Felix R, Fleisch H, Schenk R, and Hagan P (1983) Structure-activity relationships of various bisphosphonates. Calcif Tissue Int 35:87-99.
36. Shipman C, Rogers MJ, Russell RGG, Apperley J, and Croucher PI (1997) Bisphosphonates induce apoptosis in human myeloma cell lines: a novel antitumour activity. Br J Haematol 98:665-672.
37. Trauth BC, Klas C, Peters AMJ, Matzku S, Moller P, Falk W, Debatin K-M, and Krammer PH (1989) Monoclonal-antibody-mediated tumor regression by induction of apoptosis. Science 245:301-305.
38. Weil M, Jacobson MD, Coles HSR, Davies TJ, Gardner RL, Raff KD, and Raff MC (1996) Constitutive expression of the machinery for programmed cell death. J Cell Biol 133:1053-1059.
39. Wyllie AH (1980) Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation. Nature (Lond) 284:555-556.
40. Wyllie AH, Morris RG, Smith AL, and Dunlop D (1984) Chromatin cleavage in apoptosis: association with condensed chromatin morphology and dependence on macromolecular synthesis. J Pathol 142:67-72.