Human protein tyrosine phosphatase-σ: Alternative splicing and inhibition by bisphosphonates

Journal of Bone and Mineral Research

Volumn 11, Issue 4, 1996, Pages 535-543

  Endo, Naoto ^a,b   Rutledge, Su Jane ^a   Opas, Evan E ^a   Vogel, Robert ^a   Rodan, Gideon A ^a   Schmidt, Azriel ^a,b  

^a NIIGATA UNIVERSITY   (Japan)

^b MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BISPHOSPHONIC ACID DERIVATIVE; PROTEIN TYROSINE PHOSPHATASE;

ALTERNATIVE RNA SPLICING; ANIMAL CELL; ARTICLE; BRAIN; CHROMOSOMAL LOCALIZATION; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME INHIBITION; HUMAN; HUMAN CELL; MOLECULAR CLONING; NONHUMAN; OSTEOBLAST; POLYMERASE CHAIN REACTION; RAT; RNA HYBRIDIZATION;

EID: 0029873660     PISSN: 08840431     EISSN: None     Source Type: Journal    
DOI: 10.1002/jbmr.5650110415     Document Type: Article

References (46)

1. Hunter T 1989 Protein-tyrosine phosphatases: The other side of the coin. Cell 58:1013-1016.
2. Tonks NK, Charbonneau H 1989 Protein tyrosine dephosphorylation and signaltransduction. Trends Biochem Sci 14:497-500.
3. Alexander DR, Cantrell, DA 1989 Kinases and phosphatases in T-cell activation. Immunol Today 10:200-205.
4. Fischer EH, Charbonneau H, Tonks NK 1991 Protein tyrosine phosphatases: A diverse family of intracellular and transmembrane enzymes. Science 253:401-406.
5. Ullrich A, Schlessinger J 1990 Signal transduction by receptors with tyrosine kinase activity. Cell 61:203-212.
6. Gautier J, Solomon MJ, Booher RN, Bazan JF, Kirschner NW 1991 cdc25 is a specific tyrosine phosphatase that directly activates p34cdc2. Cell 67:197-211.
7. Zheng XM, Wang Y, Pallen CJ 1992 Cell transformation and activation of pp60c-src by overexpression of a protein tyrosine phosphatase. Nature 359:336-339.
8. Cooper JA, Howell B 1993 The how and why of Src regulation. Cell 73:1051-1054.
9. Canalis E, Pash J, Gabbitas B, Rydziel S, Varghese S 1993 Growth factors regulate the synthesis of insulin-like growth factor-I in bone cell cultures. Endocrinology 133:33-38.
10. Corboz VA, Cecchini MG, Felix R, Fleisch H, van der Pluijm G, Lowik CW 1992 Effect of macrophage colony stimulating factor on in vitro osteoclast generation and bone resorption Endocrinology 130:437-442.
11. Soriano P, Montgomery C, Geske R, Bradley A 1991 Targeted disruption of the c-src proto-oncogene leads to osteopetrosis in mice. Cell 64:693-702.
12. Lau KH, Tanimoto H, Baylink DJ 1988 Vanadate stimulates bone cell proliferation and bone collagen synthesis in vitro. Endocrinology 123:2858-2866.
13. Krieger NS, Tashjian AHD Jr 1983 Inhibition of stimulated bone resorption by vanadate. Endocrinology 113:324-328.
14. Fleisch H 1987 Bisphosphonates - history and experimental basis. Bone 8:S23-S28.
15. Sato M, Grasser W, Endo N, Akins R, Simmons H, Thompson DD, Golub E, Rodan GA 1991 Bisphosphonate action. Alendronate localization in rat bone and effects on osteoclast ultrastructure. J Clin Invest 88:2095-2105.
16. Rodan GA 1994 Emerging therapies in osteoporosis. Ann Rep Medic Chem 29:275-285.
17. Gatti D, Zamberlan N, Braga V, Dorizzi, R, Adami S, Rossini M 1994 Long-term effects of a treatment course with oral alendronate of postmenopausal osteoporosis. J Bone Miner Res 9:1833-1837.
18. Rodan GA, Balena R 1993 Bisphosphonates in the treatment of metabolic bone diseases. Ann Med 25:373-378.
19. Schmidt, A., Rutledge, S.J., Endo, N., Opas, E.E., Tanaka, H., Wesolowski, G., Leu, C-T., Huang, Z., Ramachandran, C., Rodan, S.B., and Rodan, G.A. Protein tyrosine phosphatase activity regulates osteoclast formation and function: inhibition by alendronate. Proc. Natl. Acad. Sci., in press.
20. Yan H, Grossman A, Wang H, D'Eustachio P, Mossie K, Musacchio JM, Silvennoinen O, Schlessinger J 1993 A novel receptor tyrosine phosphatase-sigma that is highly expressed in the nervous system J Biol Chem 268:24880-24886.
21. Walton KM, Martell KJ, Kwak SP, Dixton JE, Largent BL1993 A novel receptor-type protein tyrosine phosphatase is expressed during neurogenesis in the olfactory neuroepithelium Neuron 11:387-400.
22. Rodan SB, Imai Y, Thiede MA, Wesolowski G, Thompson D, Bar-Shavit Z, Shull S, Mann K, Rodan GA 1987 Characterization of a human osteosarcoma cell line (Saos-2) with osteoblastic properties. Cancer Res 47:4961-4966.
23. Chomczynski P, Sacchi N 1987 Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem 162:156-159.
24. Nemeth GG, Heydemann A., Bolander ME 1989 Isolation and analysis of ribonucleic acids from skeletal tissues. Anal Biochem 183:301-304.
25. Desmarais S, Govindarajan A, Ramachandran C, Zamboni R, Huang Z 1995 Continuous spectrophotometric and fluorometric assays for protein tyrosine phosphatases using substituted aryl phosphates. FASEB J 9:A1347.
26. Krueger NX, Streuli M, Saito H 1990 Structural diversity and evolution of human receptor-like protein tyrosine phosphatases. EMBO J 9:3241-3252.
27. Kaplan R, Morse B, Huebner K, Croce C, Howk R, Ravera M, Ricca G, Jaye M, Schlessinger J 1990 Cloning of three human tyrosine phosphatases reveals a multigene family of receptorlinked protein-tyrosine-phosphatases expressed in brain. Proc Natl Acad Sci USA 87:7000-7004.
28. Matthews RJ, Cahir ED, Thomas ML 1990 Identification of an additional member of the protein-tyrosine-phosphatase family: evidence for alternative splicing in the tyrosine phosphatase domain. Proc Natl Acad Sci USA 87:4444-4448.
29. Sap J, D'Eustachio P, Givol D, Schlessinger J 1990 Cloning and expression of a widely expressed receptor tyrosine phosphatase. Proc Natl Acad Sci USA 87:6112-6116.
30. Gu M, York JD, Wasawsky I, Majerus PW 1991 Identification, cloning, and expression of a cytosolic megakaryocyte proteintyrosine-phosphatase with sequence homology to cytoskeletal protein 4.1. Proc Nati Acad Sci USA 88:5867-5871.
31. Streuli M, Krueger NX, Hall LR, Schlossman SF, Saito H 1988 A new member of the immunoglobulin superfamily that has a cytoplasmic region homology to the leukocyte common antigen. J Exp Med 168:1523-1530.
32. Murray BA, Hemperly JJ, Gallin WJ, MacGregor JS, Edelman GM, Cunningham BA 1984 Isolation of cDNA clones for the chicken neural cell adhesion molecule (N-CAM). Proc Natl Acad Sci USA 81:5584-5588.
33. Owen GC, Edelman GM, Cunningham BA 1987 Organization of the neural cell adhesion molecule (N-CAM) gene: Alternative exon usage as the basis for different membrane-associated domains. Proc Natl Acad Sci USA 84:294-298.
34. Staunton DE, Marlin SD, Stratowa C, Dustin ML, Springer TA 1988 Primary structure of ICAM-1 demonstrates interaction between members of the immunoglobulin and integrin supergene families. Cell 52:925-933.
35. Sap J, Jiang YP, Friedlander D, Grumet M, Schlessinger J 1994 Receptor tyrosine phosphatase R-PTP-kappa mediates homophilic binding. Mol Cell Biol 14:1-9.
36. Brady-Kalnay SM, Flint AJ, Tonks NK 1993 Homophilic binding of PTP mu, a receptor-type protein tyrosine phosphatase, can mediate cell-cell aggregation. J Cell Biol 122:961-972.
37. Murray BA, Owens GC, Prediger EA, Crossin KL, Cunningham BA, Edelman GM 1986 Cell surface modulation of the neural cell adhesion molecule resulting from alternative mRNA splicing in a tissue-specific developmental sequence. J Cell Biol 103:1431-1439.
38. O'Grady P, Krueger NX, Streuli M, Saito H 1994 Genomic organization of the human LAR protein tyrosine phosphatase gene and alternative splicing in the extracellular fibronectin type-III domains. J Biol Chem 269:25193-25199.
39. Rothstein DM, Saito H, Streuli M, Schlossman SF, Morimoto C 1992 The alternative splicing of the CD45 tyrosuie phosphatase is controlled by negative regulatory trans-acting splicing factors. J Biol Chem 267:7139-7147.
40. Pulido R, Krueger NX, Serra-Pages C, Saito H, Stereuli M 1995 Molecular characterization of the human transmembrane protein-tyrosine phosphatase delta. Evidence for tissue-specific expression of alternative human transmembrane protein-tyrosine phosphatase delta isoforms. J Biol Chem 270:6722-6728.
41. Bellosta P, Costa M, Lin DA, Basilico C 1995 The receptor tyrosine kinase ARK mediates cell aggregation by homophilic binding. Mol Cell Biol 15:614-625.
42. Stitt TN, Conn G, Gore M, Lai C, Bruno J, Radziejewski C, Mattsson K 1995 The anticoagulation factor Protein-S and its relative, Gas6, are ligands for the TYRO 3/AXL family of receptor tyrosine kinases. Cell 80:661-670.
43. Varnum BC, Young C, Elliott G, Garcia A, Bartley TD, Fridell YW, Hunt RW 1995 AXL receptor tyrosine kinase stimulated by the vitamin-k-dependent protein encoded by growth-arrestspecific gene-6. Nature 373:623-626.
44. Canalis E, Pash J, Varghese S 1993 Skeletal growth factors. Crit Rev 3:155-166.
45. Valkema R, Vismans FJ, Papapoulos SE, Pauwels EK, Bijvoet OL 1989 Maintained improvement in calcium balance and bone mineral content in patients with osteoporosis treated with the bisphosphonate APD. Bone and Miner 5:183-192.
46. Sahni M, Guenther HL, Fleisch H, Collin P, Martin TJ 1993 Bisphosphonates act on rat bone resorption through the mediation of osteoblasts. J Clin Invest 91:2004-2011.