Adenovirus E1A activates cyclin A gene transcription in the absence of growth factors through interaction with p 107

Journal of Virology

Volumn 70, Issue 4, 1996, Pages 2637-2642

  Zerfass, Karin ^a   Spitkovsky, Dimitry ^a   Schulze, Almut ^a   Joswig, Silvia ^a   Henglein, Berthold ^b   Jansen Dürr, Pidder ^a  

^a GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^b CNRS   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN A; GROWTH FACTOR; VIRUS PROTEIN;

ARTICLE; CONTROLLED STUDY; FIBROBLAST; GENE ACTIVATION; GENE EXPRESSION REGULATION; HUMAN; HUMAN ADENOVIRUS 5; HUMAN CELL; NORMAL HUMAN; PRIORITY JOURNAL; PROMOTER REGION; VIRUS CELL TRANSFORMATION;

3T3 CELLS; ADENOVIRUSES, HUMAN; ANIMALS; BINDING SITES; CELL LINE; CYCLINS; GENE EXPRESSION REGULATION, VIRAL; HUMANS; MICE; NUCLEAR PROTEINS; PROMOTER REGIONS (GENETICS); RETINOBLASTOMA-LIKE PROTEIN P107; RNA, MESSENGER; TRANS-ACTIVATION (GENETICS);

EID: 0029872246     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/jvi.70.4.2637-2642.1996     Document Type: Article

References (44)

1. Banks, L., C. Edmonds, and K. Vousden. 1990. Ability of the HPV16 E7 protein to bind RB and induce DNA synthesis is not sufficient for efficient transforming activity in NIH3T3 cells. Oncogene 5:1383-1389.
2. Beijersbergen, R. L., L. Carlee, R. M. Kerkhoven, and R. Bernards. 1995. Regulation of the retinoblastoma protein-related p107 by G(1) cyclin complexes Genes Dev. 9:1340-1353.
3. Berk, A. J. 1986. Adenovirus promoters and E1A transactivation. Annu. Rev. Genet. 20:45-79.
4. Braithwaite, A. W., B. F. Cheetham, P. Li, C. R. Parish, L. K. Waldron-Stevens, and A. J. D. Bellet. 1983. Adenovirus-induced alterations of the cell growth cycle: a requirement for expression of E1A but not of E1B. J. Virol. 45:192-199.
5. Chen, C., and H. Okayama. 1987. High-efficiency transformation of mammalian cells by plasmid DNA Mol. Cell. Biol. 7:2745-2752
6. Claudio, P. P., C. M. Howard, A. Baldi, A. Deluca, Y. Fu, G. Condorelli, Y. Sun, N. Colburn, B. Calabretta, and A. Giordano. 1994. p130/pRb2 has growth suppressive properties similar to yet distinctive from those of retinoblastoma family members pRb and p107. Cancer Res. 54:5556-5560.
7. Cobrinik, D., P. Whyte, D. S. Peeper, T. Jacks, and R. A. Weinberg. 1993. Cell cycle-specific association of E2F with the p130 E1A-binding protein. Genes Dev 7:2392-2404.
8. Corbeil, H. B., and P. E. Branton. 1994. Functional importance of complex formation between the retinoblastoma tumor suppressor family and adenovirus E1A proteins as determined by mutational analysis of E1A conserved region 2. J. Virol. 68:6697-6709.
9. Desdouets, C., G. Matesic, C. A. Molina, N. S. Foulkes, P. Sassonecorsi, C. Brechot, and J. Sobczakthepot. 1995. Cell cycle regulation of cyclin A gene expression by the cyclic AMP-responsive transcription factors CREB and CREM. Mol. Cell. Biol. 15:3301-3309.
10. de Wet, J. R., K. V. Wood, M. DeLuca, D. R. Helinski, and S. Subramani. 1987. Firefly luciferase gene, structure and expression in mammalian cells. Mol. Cell. Biol 7:725-737
11. Dyson, N., P. Guida, K. MÜnger, and E. Harlow. 1992. Homologous sequences in adenovirus E1A and human papillomavirus E7 proteins mediate interactions with the same set of cellular proteins. J. Virol. 66:6893-6902.
12. Eckner, R., M. Ewen, D. Newsome, M. Gerdes, J. DeCaprio, J. Bentley, J. B. Lawrence, and D. Livingston. 1994. Molecular cloning and functional analysis of the adenovirus E1A-associated 300-kD protein (p300) reveals a protein with the properties of a transcriptional adaptor. Genes Dev. 8:869-884.
13. Girard, F., U. Strausfeld, A. Fernandez, and N. Lamb. 1991. Cyclin A is required for the onset of DNA replication in mammalian fibroblasts Cell 67:1169-1179.
14. Graham, F. L. 1984. Transformation by and oncogenicity of human adenoviruses, p. 339-398. In H Ginsberg (ed.), The adenoviruses. Plenum Publishing Group, New York.
15. Helin, K., E. Harlow, and A. Fattaey. 1993. Inhibition of E2F-1 transactivation by direct binding of the retinoblastoma protein Mol. Cell. Biol 13: 6501-6508.
16. Henglein, B., X. Chenivesse, J. Wang, D. Eick, and C. Brechot. 1994. Structure and cell cycle regulated transcription of the human cyclin A gene. Proc. Natl. Acad. Sci. USA 91:5490-5494.
17. Hiebert, S. W., S. P. Chellappan, J. M. Horowitz, and J. R. Nevins. 1992. The interaction of RB with E2F coincides with an inhibition of the transcriptional activity of E2F. Genes Dev. 6:177-185.
18. Houweling, A., P. J. van den Elsen, and A. J. van der Eb. 1980 Partial transformation of primary rat cells by the leftmost 4.5% fragment of adenovirus 5 DNA. Virology 105:537-550.
19. Ikeda, M.-A., and J. R. Nevins. 1993. Identification of distinct roles for separate E1A domains in disruption of E2F complexes Mol. Cell. Biol. 13:7029-7035.
20. Jansen-Dürr, P., A. Meichle, P. Steiner, M. Pagano, K. Finke, J. Botz, J. Wessbecher, G. Draetta, and M. Eilers. 1993. Differential modulation of cyclin gene expression by MYC. Proc. Natl. Acad. Sci. USA 90:2547-2552.
21. Kraus, V. B., J. A. Inostroza, K. Yeung, D. Reinberg, and J. R. Nevins. 1994. Interaction of the Dr1 inhibitory factor with the TA TA binding protein is disrupted by adenovirus E1A. Proc. Natl Acad. Sci. USA 91:6279-6282.
22. La Thangue, N. B. 1994. Drtf1/E2F - an expanding family of heterodimeric transcription factors implicated in cell-cycle control. Trends Biochem Sci. 19:108-114.
23. Lee, W. S., C. C. Kai, G. O. Bryant, X. Lin, and A. J. Berk. 1991. Adenovirus E1A activation domain binds the basic repeat in the TATA box transcription factor. Cell 67:365-376.
24. Moran, E., and M. B. Mathews. 1987. Multiple functional domains in the adenovirus E1A gene. Cell 48:177-178.
25. 24a.Moro, A., et al. Unpublished data.
26. Nevins, J. R. 1993. Transcriptional activation by the adenovirus E1A proteins. Semin. Virol 4:25-31.
27. Pagano, M., G. Draetta, and P. Jansen-Dürr. 1992. Association of cdk2 kinase with the transcription factor E2F during S phase. Science 255:1144-1147
28. Pagano, M., R. Pepperkok, F. Verde, W. Ansorge, and G. Draetta. 1992. Cyclin A is required at two points in the human cell cycle. EMBO J. 11:961-971.
29. Rao, L., M. Debbas, P. Sabbatini, D. Hockenbery, S. Korsmeyer, and E. White. 1992. The adenovirus E1A proteins induce apoptosis. which is inhibited by the E1B 19-kDa and Bcl-2 proteins. Proc. Natl. Acad. Sci USA 89:7742-7746.
30. Ruley, H. E. 1983. Adenovirus early region 1A enables viral and cellular transforming genes to transform primary cells in culture. Nature (London) 304:602-606.
31. Schulze, A., K. Zerfass, D. Spitkovsky, J. Berges, S. Middendorp, P. Jansen-Durr, and B. Henglein. 1995. Cell cycle regulation of cyclin A gene transcription is mediated by a variant E2F binding site. Proc. Natl Acad Sci. USA 92:11264-11268.
32. Spindler, K. R., C. Y. Eng, and A. J. Berk. 1985. An adenovirus early region 1A protein is required for maximal viral DNA replication in growth-arrested human cells. J. Virol. 53:742-750.
33. 31a.Spitkovsky, D., and M. Crescenzi. Unpublished data.
34. Spitkovsky, D., P. Steiner, J. Lukas, E. Lees, M. Pagano, A. Schulze, S. Joswig, D. Picard, M. Tommasino, M. Eilers, and P. Jansen-Dürr. 1994. Modulation of cyclin gene expression by adenovirus E1A in a cell line with E1A-dependent conditional proliferation. J. Virol. 68:2206-2214.
35. Stabel, S., P. Argos, and L. Philipson. 1985. The release of growth arrest by microinjection of adenovirus E1A DNA. EMBO J. 4:2329-2336.
36. Vairo, G., D. M. Livingston, and D. Ginsberg. 1995. Functional interaction between E2F-4 and p130: evidence for distinct mechanisms underlying growth suppression by different retinoblastoma protein family members. Genes Dev. 9:869-881.
37. Wang, H.-G., H. Y. Rikitake, M. Corrigan Carter, P. Yaciuk, S. E. Abraham, B. Zerler, and E. Moran. 1993 Identification of specific adenovirus E1A N-terminal residues critical to the binding of cellular proteins and to the control of cell growth. J. Virol. 67:476-488.
38. Weinberg, R. A. 1995. The retinoblastoma protein and cell cycle control Cell 81:323-330.
39. Whyte, P., N. W. Williamson, and E. Harlow. 1989 Cellular targets for transformation by the adenovirus E1A proteins. Cell 56:67-75.
40. Zamanian, M., and N. B. LaThangue. 1993. Transcriptional repression by the Rb-related protein-p107 Mol Biol. Cell 4:389-396.
41. 38a.Zerfass, K. Unpublished data.
42. Zerfass, K., L. Levy, C. Cremonesi, F. Ciccolini, P. Jansen-Dürr, L. Crawford, R. Ralston, and M. Tommasino. 1995. Cell cycle dependent disruption of E2F/p107 complexes by human papillomavirus type 16 E7 J. Gen. Virol. 76:1815-1820.
43. Zerfass, K., A. Schulze, D. Spitkovsky, V. Friedman, B. Henglein, and P. Jansen-Dürr. 1995 Sequential activation of cyclin E and cyclin A gene expression by human papillomavirus type 16 E7 through sequences necessary for transformation. J. Virol. 69:6389-6399.
44. Zhu, L., S. Vandenheuvel, K. Helin, A. Fattaey, M. Ewen, D. Livingston, N. Dyson, and E. Harlow. 1993. Inhibition of cell proliferation by p107, a relative of the retinoblastoma protein. Genes Dev. 7:1111-1125.