Rho family GTPases as key regulators for neuronal network formation

Journal of Biochemistry

Volumn 132, Issue 2, 2002, Pages 157-166

  Negishi, Manabu ^a   Katoh, Hironori ^a  

^a KYOTO UNIVERSITY   (Japan)

Author keywords

G protein; Neuron; Neuronal network; Rho

Indexed keywords

GUANOSINE TRIPHOSPHATASE; RHO FACTOR; NERVE GROWTH FACTOR; RHO GUANINE NUCLEOTIDE BINDING PROTEIN;

CELL FUNCTION; CELL MATURATION; CELL MIGRATION; CELL POLARITY; CYTOSKELETON; DENDRITE; ENDOTHELIUM CELL; ENZYME ANALYSIS; FIBROBLAST; GENE EXPRESSION; GROWTH CONE; HUMAN; MENTAL DEFICIENCY; NERVE CELL NETWORK; NERVE FIBER GROWTH; PROTEIN FAMILY; REVIEW; SIGNAL TRANSDUCTION; SYNAPSE; X CHROMOSOME LINKAGE; ANIMAL; CELL LINE; CELL MOTION; CELL SIZE; CLASSIFICATION; CYTOLOGY; GENETICS; METABOLISM; NERVE CELL; NEUROLOGIC DISEASE; PHYLOGENY; PHYSIOLOGY;

ANIMALS; CELL LINE; CELL MOVEMENT; CELL SIZE; HUMANS; NERVE GROWTH FACTORS; NERVE NET; NERVOUS SYSTEM DISEASES; NEURONS; PHYLOGENY; RHO GTP-BINDING PROTEINS; SIGNAL TRANSDUCTION;

EID: 0036684178     PISSN: 0021924X     EISSN: None     Source Type: Journal    
DOI: 10.1093/oxfordjournals.jbchem.a003205     Document Type: Review

References (93)

1. The small GTPase Rho: Cellular functions and signal transduction
2. Rho GTPases and the actin cytoskeleton
3. The Rho small G protein family-Rho GDI system as a temporal and spatial determinant for cytoskeletal control
4. Inhibition of lysophosphatidate- and thrombin-induced neurite retraction and neuronal cell rounding by ADP ribosylation of the small GTP-binding protein Rho
5. Prostaglandin E receptor EP3 subtype induces neurite retraction via small GTPase Rho
6. Sphingosine-1-phosphate rapidly induces Rho-dependent neurite retraction: Action through a specific cell surface receptor
7. Effectors for the Rho GTPases
8. p160 RhoA-binding kinase ROKα induces neurite retraction
9. Molecular dissection of the Rho-associated protein kinase (p160ROCK)-regulated neurite remodeling in neuroblastoma N1E-115 cells
10. Rho-Rho-kinase pathway in smooth muscle contraction and cytoskeletal reorganization of non-muscle cells
11. Myosin II activation promotes neurite retraction during the action of Rho and Rho-kinase
12. Signaling from Rho to the actin cytoskeleton through protein kinases ROCK and LIM-kinase
13. Motor proteins regulate force interactions between microtubules and microfilaments in the axon
14. mDia mediates Rho-regulated formation and orientation of stable microtubules
15. RhoA-binding kinase α translocation is facilitated by the collapse of the vimentin intermediate filament network
16. Constitutively active Gα12, Gα13, and Gαq induce Rho-dependent neurite retraction through different signaling pathways
17. Activation of RhoA by lysophosphatidic acid and Gα12/13 subunits in neuronal cells: Induction of neurite retraction
18. Differential involvement of Gα12 and Gα13 in receptor-mediated stress fiber formation
19. Signal transduction pathway regulating prostaglandin EP3 receptor-induced neurite retraction: Requirement for two different tyrosine kinases
20. Direct stimulation of the guanine nucleotide exchange activity of p115 RhoGEF by Gα13
21. A novel PDZ domain containing guanine nucleotide exchange factor links heterotrimeric G proteins to Rho
22. Functions of a Rho-specific guanine nucleotide exchange factor in neurite retraction
23. Signal transduction underlying growth cone guidance by diffusible factors
24. Rac1 mediates collapsing-1-induced growth cone collapse
25. Myelin and collapsing-1 induce motor neuron growth cone collapse through different pathways-inhibition of collapse by opposing mutants of Rac1
26. Sema3A-induced growth-cone collapse is mediated by Rac1 amino acids 17-32
27. Semaphorin-mediated axonal guidance via Rho-related G proteins
28. The semaphorin 3A receptor may directly regulate the activity of small GTPases
29. The semaphorin receptor plexin-B1 specifically interacts with active Rac in a ligand-dependent manner
30. Plexin-B semaphoring receptors interact directly with active Rac and regulate the actin cytoskeleton by activating Rho
31. Plexin B mediates axon guidance in Drosophila by simultaneously inhibiting active Rac and enhancing RhoA signaling
32. Ephrin-A5 induces collapse of growth cones by activating Rho and Rho kinase
33. EphA receptors regulate growth cone dynamics through the novel guanine nucleotide exchange factor ephexin
34. Signal transduction in neuronal migration: Roles of GTPase activating proteins and the small GTPase Cdc42 in the Slit-Robo pathway
35. Growth cone collapse through coincident loss of actin bundles and leading edge actin depolymerization
36. Phosphorylation of cofilin by LIM-kinase is necessary for semaphoring 3A-induced growth cone collapse
37. Specificity of receptor tyrosine kinase signaling: Transient versus sustained extracellular signal-regulated kinase activation
38. The myotonic dystrophy kinase-related Cdc42-binding kinase is involved in the regulation of neurite outgrowth in PC12 cells
39. Differential responses to nerve growth factor and epidermal growth factor in neurite outgrowth of PC12 cells are determined by Rac1 activation systems
40. Rac is required for growth cone function but not neurite assembly
41. Different roles for RhoA during neurite initiation, elongation, and regeneration in PC12 cells
42. Rho family GTPases and neuronal growth cone remodeling: Relationship between increased complexity induced by Cdc42Hs, Rac1, and acetylcholine and collapse induced by RhoA and lysophosphatidic acid
43. RhoA inhibits the nerve growth factor-induced Rac1 activation through Rho-associated kinase-dependent pathway
44. Neurotrophin binding to the p75 receptor modulates Rho activity and axonal outgrowth
45. A critical role for a Rho-associated kinase, p160ROCK, in determining axon outgrowth in mammalian CNS neurons
46. p190 RhoGAP is the principal src substrate in brain and regulates axon outgrowth, guidance and fasciculation
47. Regulating axon branch stability: The role of p190 RhoGAP in repressing a retraction signaling pathway
48. Small GTPase RhoG is a key regulator for neurite outgrowth in PC12 cells
49. Kinectin is a key effector of RhoG microtubule-dependent cellular activity
50. The human Rho-GEF Trio and its target GTPase RhoG are involved in the NGF pathway, leading to neurite outgrowth
51. The Drosophila Trio plays an essential role in patterning of axons by regulating their directional extension
52. Trio combines with Dock to regulate Pak activity during photoreceptor axon pathfinding in Drosophila
53. The guanine nucleotide exchange factor Tiam1 affects neuronal morphology; opposing roles for the small GTPases Rac and Rho
54. Characterization of STEF, a guanine nucleotide exchange factor for Rac1, required for neurite growth
55. Membrane targeting of p21-activated kinase 1 (PAK1) induces neurite outgrowth from PC12 cells
56. PAK promotes morphological changes by acting upstream of Rac
57. PAK5, a new brain-specific kinase, promotes neurite outgrowth in N1E-115 cells
58. The myotonic dystrophy kinase-related Cdc42-binding kinase is involved in the regulation of neurite outgrowth in PC12 cells
59. Essential role of neural Wiskott-Aldrich syndrome protein in neurite extension in PC12 cells and rat hippocampal primary culture cells
60. Cc42Hs facilitates cytoskeletal reorganization and neurite outgrowth by localizing the 48-kD insulin receptor substrate to filamentous actin
61. Evidence for the involvement of Tiam1 in axon formation
62. The role of local actin instability in axon formation
63. CRMP-2 induces axons in cultured hippocampal neurons
64. Phosphorylation of collapsing response mediator protein-2 by Rho-kinase
65. The role of notch and Rho GTPase signaling in the control of dendritic development
66. Regulation of dendritic growth and remodeling by Rho, Rac, and Cdc42
67. Overexpression of a neural-specific Rho family GTPase, cRac1B, selectively induces enhanced neuritogenesis and neurite branching in primary neurons
68. Essential roles of Drosophila RhoA in the regulation of neuroblast proliferation and dendritic but not axonal morphogenesis
69. Rho GTPases regulate distinct aspects of dendritic arbor growth in Xenopus central neurons in vivo
70. The neuronal architecture of Xenopus retinal ganglion cells is sculpted by Rho-family GTPases in vivo
71. Small GTPases Rac and Rho in the maintenance of dendritic spines and branches in hippocampal pyramidal neurons
72. Dendritic spines: Structure, dynamics and regulation
73. Differential effects of the Rac GTPase on Purkinje cell axons and dendritic trunks and spines
74. The neuronal Rho-GEF Kalirin-7 interacts with PDZ domain-containing proteins and regulates dendritic morphogenesis
75. Synaptic development is controlled in the periactive zones of Drosophila synapses
76. Regulation of dendritic spine morphology by the Rho family of small GTPases: Antagonistic roles of Rac and Rho
77. The small GTP-binding protein TC10 promotes nerve elongation in neuronal cells, and its expression is induced during nerve regeneration in rats
78. Distinct cellular effects and interactions of the Rho-family GTPase TC10
79. A new member of the Rho family, Rnd1, promotes disassembly of actin filament structures and cell adhesion
80. Rnd1, a novel Rho family GTPase, induces the formation of neuritic processes in PC12 cells
81. Involvement of the small GTPases XrhoA and XRnd1 in cell adhesion and head formation in early Xenopus development
82. The semaphorin 3A receptor may directly regulate the activity of small GTPases
83. Antagonistic effects of Rnd1 and RhoD GTPases regulate receptor activity in semaphorin 3A-induced cytoskeletal collapse
84. Socius is a novel Rnd GTPase-interacting protein involved in disassembly of actin stress fibers
85. RhoN, a novel small GTP-binding protein expressed predominantly in neurons and hepatic stellate cells
86. Rho proteins and the cellular mechanisms of mental retardation
87. Oligophrenin-1 encodes a rhoGAP protein involved in X-linked mental retardation
88. RAK3 mutation in nonsyndromic X-linked mental retardation
89. Mutations in ARHGEF6, encoding a guanine nucleotide exchange factor for Rho GTPases, in patients with X-linked mental retardation
90. Isolation and characterization of the facio-genital dysplasia (Aarskog-Scott syndrom) gene: A putative Rho/Rac guanine nucleotide exchange factor
91. A highly conserved protein family interacting with the fragile X mental retardation protein (FMRP) and displaying selective interactions with FMRP-related proteins FXR1P and FXR2P
92. Cofilin phosphorylation by LIM-kinase 1 and its role in Rac-mediated actin reorganization