The Drosophila trio plays an essential role in patterning of axons by regulating their directional extension

Neuron

Volumn 26, Issue 1, 2000, Pages 119-131

  Awasaki, Takeshi ^a,b,d   Saito, Mai ^a,b   Sone, Masaki ^a   Suzuki, Emiko ^b,c   Sakai, Ryoko ^a,b   Ito, Kei ^b,d   Hama, Chihiro ^a,b  

^a NATIONAL INSTITUTE OF NEUROSCIENCE   (Japan)

^b JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^c UNIVERSITY OF TOKYO   (Japan)

^d NATIONAL INSTITUTE FOR BASIC BIOLOGY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

GUANOSINE TRIPHOSPHATASE; RHO FACTOR;

ARTICLE; BRAIN REGION; CENTRAL NERVOUS SYSTEM; DROSOPHILA; EMBRYO; ENZYME ACTIVATION; GENE LOCATION; GENE MUTATION; NERVE FIBER GROWTH; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; SEQUENCE HOMOLOGY;

EID: 0033695698     PISSN: 08966273     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0896-6273(00)81143-5     Document Type: Article

References (38)

1. The Rho GTPase and a putative RhoGEF mediate a signaling pathway for the cell shape changes in Drosophila gastrulation
2. The guanine nucleotide exchange factor Trio mediates axonal development in the Drosophila embryo
3. Axon guidance to and from choice points
4. Tripartite mushroom body architecture revealed by antigenic markers
5. P-element insertion alleles of essential genes on the third chromosome of Drosophila melanogaster: Correlation of physical and cytogenetic maps in chromosomal region 86E-87F
6. The multidomain protein Trio binds the LAR transmembrane tyrosine phosphatase, contains a protein kinase domain, and has separate rac-specific and rho-specific guanine nucleotide exchange factor domains
7. Axon guidance: GTPases help axons reach their targets
8. Drosophila photoreceptor axon guidance and targeting requires the dreadlocks SH2/SH3 adapter protein
9. Pattern formation in the limbs of Drosophila: Bric a brac is expressed in both a gradient and a wave-like pattern and is required for specification and proper segmentation of the tarsus
10. Mutagenesis
11. Rho GTPases and the actin cytoskeleton
12. A Drosophila homolog of the Rac- and Cdc42-activated serine/threonine kinase PAK is a potential focal adhesion and focal complex protein that colocalizes with dynamic actin structures
13. Pak functions downstream of Dock to regulate photoreceptor axon guidance in Drosophila
14. Molecular dissection of the Rho-associated protein kinase (p160ROCK) -regulated neurite remodeling in neuroblastoma N1E-115 cells
15. Hikaru genki, a CNS-specific gene identified by abnormal locomotion in Drosophila, encodes a novel type of protein
16. Hikaru genki protein is secreted into synaptic clefts from an early stage of synapse formation in Drosophila
17. The organization of extrinsic neurons and their implications in the functional roles of the mushroom bodies in Drosophila melanogaster Meigen
18. Rho family GTPases and neuronal growth cone remodeling: Relationship between increased complexity induced by Cdc42Hs, Rac1, and acetylcholine and collapse induced by RhoA and lysophosphatidic acid
19. Mosaic analysis with a repressible neurotechnique cell marker for studies of gene function in neuronal morphogenesis
20. Development of the Drosophila mushroom bodies: Sequential generation of three distinct types of neurons from a neuroblast
21. Essential roles of Drosophila RhoA in the regulation of neuroblast proliferation and dendritic but not axonal morphogenesis
22. Dosage-sensitive, reciprocal genetic interactions between the Abl tyrosine kinase and the putative GEF trio reveal trio's role in axon pathfinding
23. Distinct morphogenetic functions of similar small GTPases: Drosophila Drac1 is involved in axonal outgrowth and myoblast fusion
24. Differential effects of the Rac GTPase on Purkinje cell axons and dendritic trunks and spines
25. Synaptic organization of columnar elements in the lamina of the wild type in Drosophila melanogaster
26. Trio combines with Dock to regulate Pak activity during photoreceptor axon pathfinding in Drosophila
27. Regulation and function of the Rho subfamily of small GTPases
28. Still life, a protein in synaptic terminals of Drosophila homologous to GDP-GTP exchangers
29. UNC-73 activates the Rac GTPase and is required for cell and growth cone migration in C.elegans
30. A non-radioactive in situ hybridization method for the localization of specific RNAs in Drosophila embryos reveals translational control of the segmentation gene hunchback
31. The molecular biology of axon guidance
32. A LIM-homeodomain combinatorial code for motor-neuron pathway selection
33. Rho GTPases and signaling networks
34. The guanine nucleotide exchange factor Tiam1 affects neuronal morphology; opposing roles for the small GTPases Rac and Rho
35. Adhesion and signaling in axonal fasciculation
36. Genes that control neuromuscular specificity in Drosophila
37. Dbl family proteins
38. Role of a new Rho family member in cell migration and axon guidance in C. elegans