Sema3A-induced growth-cone collapse is mediated by Rac1 amino acids 17-32

Current Biology

Volumn 9, Issue 18, 1999, Pages 991-998

  Västrik, Imre ^a,d   Eickholt, Britta J ^a   Walsh, Frank S ^b   Ridley, Anne ^c   Doherty, Patrick ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

^b GLAXOSMITHKLINE   (United Kingdom)

^c UNIVERSITY COLLEGE LONDON   (United Kingdom)

^d IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 0033598204     PISSN: 09609822     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-9822(99)80447-3     Document Type: Article

References (30)

1. Goodman CS: Mechanisms and molecules that control growth cone guidance. Annu Rev Neurosci 1996, 19:341-377.
2. Gallo G, Letourneau PC: Axon guidance: GTPases help axons reach their targets. Curr Biol 1998, 8:R80-R82.
3. Mackay DJG, Nobes CD, HAll A: The Rho's progress: A potential role during neuritogenesis for the Rho family of GTPases. Trends Neurosci 1995, 18:496-501.
4. Aspenström P: Effectors for the Rho GTPases. Curr Opin Cell Biol 1999, 11:95-102.
5. Mackay DJ, HAll A: Rho GTPases. J Biol Chem 1998, 273:20685-20688.
6. Van AeLst L, D'Souza-Schorey C: Rho GTPases and signaling networks. Genes Dev 1997, 11:2295-2322.
7. Burbelo PD, Drechsel D, Hall A: A conserved binding motif defines numerous candidate target proteins for both Cdc42 and Rac GTPases. J Biol Chem 1995, 270:29071-29074.
8. Tapon N, Hall A: Rho, Rac and Cdc42 GTPases regulate the organization of the actin cytoskeleton. Curr Opin Cell Biol 1997, 9:86-92.
9. Lamarche N, Tapon N, Stowers L, Burbelo PD, Aspenström P, Bridges T, et al.: Rac and Cdc42 induce actin polymerization and G1 cell cycle progression independently of p65PAK and the JNK/SAPK MAP kinase cascade. Cell 1996, 87:519-529.
10. White MA, Nicolette C, Minden A, Polverino A, Van Aelst L, Karin M, et al.: Multiple Ras functions can contribute to mammalian cell transformation. Cell 1995, 80:533-541.
11. Prochiantz A: Getting hydrophilic compounds into cells: Lessons from homeopeptides. Curr Opin Neurobiol 1996, 6:629-634.
12. Luo Y, Raible D, Raper JA: Collapsin: A protein in brain that induces the collapse and paralysis of neuronal growth cones. Cell 1993, 75:217-227.
13. Kolodkin AL, Levengood DV, Rowe EG, Tai YT, Giger RJ, Ginty DD: Neuropilin is a semaphorin III receptor. Cell 1997, 90:753-762.
14. He Z, Tessier-Lavigne M: Neuropilin is a receptor for the axonal chemorepellent semaphorin III. Cell 1997, 90:739-751.
15. Jin Z, Strittmatter SM: Rac1 mediates collapsin-1-induced growth cone collapse. J Neurosci 1997, 17:6256-6263.
16. Kuhn TB, Brown MD, Wilcox CL, Raper JA, Bamburg JR: Myelin and collapsin-1 induce motor neuron growth cone collapse through different pathways: Inhibition of collapse by opposing mutants of rac1. J Neurosci 1999, 19:1965-1975.
17. Eickholt BJ, Morrow R, Walsh FS, Doherty P: Structural features of collapsin required for biological activity and distribution of binding sites in the developing chick. Mol Cell Neurosci 1997, 9:358-371.
18. Whitehead IP, Campbell S, Rossman KL, Der CJ: Dbl family proteins. Biochim Biophys Acta 1997, 1332:F1-F23.
19. Miki H, Sasaki T, Takai Y, Takenawa T: Induction of filopodium formation by a WASP-related actin-depolymerizing protein N-WASP. Nature 1998, 391:93-96.
20. Rojas M, Yao S, Lin YZ: Controlling epidermal growth factor (EGF)-stimulated Ras activation in intact cells by a cell-permeable peptide mimicking phosphorylated EGF receptor. J Biol Chem 1996, 271:27456-27461.
21. Williams EJ, Dunican DJ, Green PJ, Howell FV, Derossi D, Walsh FS, et al.: Selective inhibition of growth factor-stimulated mitogenesis by a cell-permeable Grb2-binding peptide. J Biol Chem 1997, 272:22349-22354.
22. Giorgetti-Peraldi S, Ottinger E, Wolf G, Ye B, Burke TR Jr, Shoelson SE: Cellular effects of phosphotyrosine-binding domain inhibitors on insulin receptor signaling and trafficking. Mol Cell Biol 1997, 17:1180-1188.
23. Cussac D, Vidal M, Leprince C, Liu WQ, Cornille F, Tiraboschi G, et al.: A Sos-derived peptidimer blocks the Ras signaling pathway by binding both Grb2 SH3 domains and displays antiproliferative activity. FASEB J 1999, 13:31-38.
24. Warne PH, Viciana PR, Downward J: Direct interaction of Ras and the amino-terminal region of Raf-1 in vitro. Nature 1993, 364:352-355.
25. Abdul-Manan N, Aghazadeh B, Liu GA, MAjumdar A, Ourfelli O, Siminovitch KA, et al.: Structure of Cdc42 in complex with the GTPase-binding domain of the 'Wiskott-Aldrich syndrome' protein. Nature 1999, 399:379-383.
26. Mott HR, Owen D, Nietlispach D, Lowe PN, Manser E, Lim L, et al.: Structure of the small G protein Cdc42 bound to the GTPase-binding domain of ACK. Nature 1999, 399:384-388.
27. Cicchetti P, Ridley AJ, Zheng Y, Cerione RA, Baltimore D: 3BP-1, an SH3 domain binding protein, has GAP activity for Rac and inhibits growth factor induced membrane ruffling in fibroblasts. Embo J 1995, 14:3127-3135.
28. Bagrodia S, Taylor SJ, Creasy CL, Chernoff J, Cerione RA: Identification of a mouse p21Cdc42/Rac activated kinase. J Biol Chem 1995, 270:22731-22737.
29. Hill CS, Wynne J, Treisman R: The Rho family GTPases RhoA, Rac1, and CDC42Hs regulate transcriptional activation by SRF. Cell 1995, 81:1159-1170.
30. Hirshberg M, Stockley RW, Dodson G, Webb MR: The crystal structure of human rac1, a member of the rho-family complexed with a GTP analogue. Nat Struct Biol 1997, 4:147-152.