The human Rho-GEF Trio and its target GTPase RhoG are involved in the NGF pathway, leading to neurite outgrowth

Current Biology

Volumn 12, Issue 4, 2002, Pages 307-312

  Estrach, Soline ^a   Schmidt, Susanne ^a   Diriong, Sylvie ^a   Penna, Aubin ^a   Blangy, Anne ^a   Fort, Philippe ^a   Debant, Anne ^a  

^a Centre National de la Recherche Scientifique   (France)

Author keywords

[No Author keywords available]

Indexed keywords

GUANINE NUCLEOTIDE EXCHANGE FACTOR; GUANOSINE TRIPHOSPHATASE; NERVE GROWTH FACTOR; PROTEIN CDC42; RAC PROTEIN; RHO GUANINE NUCLEOTIDE BINDING PROTEIN; RHOG PROTEIN, HUMAN; RHOG PROTEIN, RAT;

ANIMAL; ARTICLE; CELL DIFFERENTIATION; CELL SIZE; CELL STRAIN; DRUG EFFECT; GENETICS; GROWTH CONE; HUMAN; METABOLISM; MICROSCOPY; MUTATION; NEURITE; PSEUDOPODIUM; RAT;

ANIMALS; CDC42 GTP-BINDING PROTEIN; CELL DIFFERENTIATION; CELL SIZE; GROWTH CONES; GTP PHOSPHOHYDROLASES; GUANINE NUCLEOTIDE EXCHANGE FACTORS; HUMANS; MICROSCOPY, VIDEO; MUTATION; NERVE GROWTH FACTOR; NEURITES; PC12 CELLS; PSEUDOPODIA; RAC GTP-BINDING PROTEINS; RATS; RHO GTP-BINDING PROTEINS;

EID: 0037133037     PISSN: 09609822     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-9822(02)00658-9     Document Type: Article

References (19)

1. Rho GTPases and the actin cytoskeleton
2. Rho family GTPases and neuronal growth cone remodelling: Relationship between increased complexity induced by Cdc42Hs, Rac1, and acetylcholine and collapse induced by RhoA and lysophosphatidic acid
3. Inhibition of lysophosphatidate-and thrombin-induced neurite retraction and neuronal cell rounding by ADP ribosylation of the small GTP-binding protein Rho
4. Small GTPase RhoG is a key regulator for neurite outgrowth in PC12 cells
5. Axon guidance: GTPases help axons reach their targets
6. The DH protein family, exchange factors for Rho-like GTPases
7. The multidomain protein Trio binds the LAR transmembrane tyrosine phosphatase, contains a protein kinase domain, and has separate rac-specific and rhospecific guanine nucleotide exchange factor domains
8. The two guanine nucleotide exchange factor domains of Trio link the Rac1 and the RhoA pathways in vivo
9. TrioGEF1 controls Rac- and Cdc42-dependent cell structures through the direct activation of rhoG
10. Trio combines with dock to regulate Pak activity during photoreceptor axon pathfinding in Drosophila
11. The Drosophila trio plays an essential role in patterning of axons by regulating their directional extension
12. The guanine nucleotide exchange factor trio mediates axonal development in the Drosophila embryo
13. Dosage-sensitive, reciprocal genetic interactions between the Abl tyrosine kinase and the putative GEF trio reveal trio's role in axon pathfinding
14. UNC-73 activates the Rac GTPase and is required for cell and growth cone migrations in C. elegans
15. Pak functions downstream of Dock to regulate photoreceptor axon guidance in Drosophila
16. Kinectin is a key effector of RhoG microtubule-dependent cellular activity
17. Essential roles of Drosophila RhoA in the regulation of neuro-blast proliferation and dendritic but not axonal morphogenesis
18. RhoG GTPase controls a pathway that independently activates Rac1 and Cdc42Hs
19. Improved methods for preserving macromolecular structures and visualizing them by fluorescence and scanning electron microscopy