PAK5, a new brain-specific kinase, promotes neurite outgrowth in N1E-115 cells

Molecular and Cellular Biology

Volumn 22, Issue 2, 2002, Pages 567-577

  Dan, C ^a   Nath, N ^a   Liberto, M ^a   Minden, A ^a  

^a Och Spine at New York Presbyterian Hospitals   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

P21 ACTIVATED KINASE 4; PROTEIN CDC42; PROTEIN SERINE THREONINE KINASE; PROTEIN SERINE THREONINE KINASE PAK5; RAC PROTEIN; RHO GUANINE NUCLEOTIDE BINDING PROTEIN; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN; STRESS ACTIVATED PROTEIN KINASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BRAIN; CELL MATURATION; CONTROLLED STUDY; DROSOPHILA; ENZYME ACTIVATION; ENZYME ACTIVITY; GENE EXPRESSION; GENE MUTATION; HUMAN; MAMMAL; MOUSE; NERVE FIBER GROWTH; NEUROBLASTOMA CELL; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FAMILY; PROTEIN TARGETING; SEQUENCE HOMOLOGY; SIGNAL TRANSDUCTION; TISSUE SPECIFICITY;

AMINO ACID SEQUENCE; ANIMALS; BASE SEQUENCE; BRAIN; CDC42 GTP-BINDING PROTEIN; CELL LINE; CLONING, MOLECULAR; DNA, COMPLEMENTARY; ENZYME ACTIVATION; HUMANS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MITOGEN-ACTIVATED PROTEIN KINASES; MOLECULAR SEQUENCE DATA; MUTATION; NEURITES; NEURONS; PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES; RAC GTP-BINDING PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID;

ANIMALIA; BASIDIOMYCOTA; MAMMALIA;

EID: 0036135015     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.22.2.567-577.2002     Document Type: Article

References (55)

1. PAK4, a novel effector for Cdc42Hs, is implicated in the reorganization of the actin cytoskeleton and in the formation of filopodia
2. Cdc42 and PAK-mediated signaling leads to Jun kinase and p38 mitogen-activated protein kinase activation
3. Fast actions of neurotrophic factors
4. Human Ste2O homologue hPAK1 links GTPases to the JNK MAP kinase pathway
5. Cdc42 stimulates neurite outgrowth and formation of growth cone filopodia and lamellipodia
6. The small GTP-binding proteins Rac1 and Cdc42 regulate the activity of the JNK/SAPK signaling pathway
7. p21-activated protein kinase: A crucial component of morphological signaling?
8. Membrane targeting of p21-activated kinase 1 (PAK1) induces neurite outgrowth from PC12 cell
9. JNK1: A protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain
10. Cytokinesis arrest and redistribution of actin-cytoskeleton regulatory components in cells expressing the Rho GTPase CDC42Hs
11. Identification of a novel, putative Rho-specific GDP/GTP exchange factor and a RhoA-binding protein: Control of neuronal morphology
12. Pak functions downstream of dock to regulate photoreceptor axon guidance in Drosophila
13. RAC regulation of actin polymerization and proliferation by a pathway distinct from Jun kinase
14. Drosophila Rac1 controls motor axon guidance
15. Strong and prolonged induction of c-jun and c-fos proto-oncogenes by photodynamic therapy
16. Micro-injection of activated phosphatidylinositol-3-kinase induces process outgrowth in rat PC12 cells through the Rac-JNK signal transduction pathway
17. The p21Rac/Cdc42-activated kinases (PAKs)
18. The Ras-related protein Cdc42Hs and bradykinin promote formation of peripheral actin microspikes and filopodia in Swiss 3T3 fibroblasts
19. Rho family GTPases and neuronal growth cone remodelling: Relationship between increased complexity induced by Cdc42Hs, Rac1, and acetylcholine and collapse induced by RhoA and lysophosphatidic acid
20. The Jnk1 and Jnk2 protein kinases are required for regional specific apoptosis during early brain development
21. 1 cell cycle progression independently of p65PAK and the JNK/SAPK MAP kinase cascade
22. Rac is required for growth cone function but not neurite assembly
23. Differential regulation of c-Jun by ERK and JNK during PC12 cell differentiation
24. Rho GTPases in neuronal morphogenesis
25. Distinct morphogenetic functions of similar small GTPases: Drosophila Drac1 is involved in axonal outgrowth and myoblast fusion
26. Expression of constitutively active alpha-PAK reveals effects of the kinase on actin and focal complexes
27. A novel serine kinase activated by rac1/CDC42Hs-dependent autophosphorylation is related to PAK65 and STE20
28. A protein related to p21-activated kinase (PAK) that is involved in neurogenesis in the Drosophila adult central nervous system
29. Regulation and function of the JNK subgroup of MAP kinases
30. Selective activation of the JNK signaling cascade and c-Jun transcriptional activity by the small GTPases Rac and Cdc42Hs
31. Differential activation of ERK and JNK mitogen-activated protein kinases by Raf-1 and MEKK
32. c-Jun N-terminal phosphorylation correlates with activation of the JNK subgroup but not the ERK subgroup of mitogen-activated protein kinases
33. Growth cone guidance: First steps towards a deeper understanding
34. Trio combines with dock to regulate Pak activity during photoreceptor axon pathfinding in Drosophila
35. Rho, rac, and cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia
36. Activated PAK4 regulates cell adhesion and anchorage-independent growth
37. Rhotekin, a new putative target for Rho bearing homology to a serine/threonine kinase, PKN, and rhophilin in the rho-binding domain
38. The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors
39. The small GTP-binding protein rac regulates growth factor-induced membrane ruffling
40. Rac downregulates Rho activity: Reciprocal balance between both GTPases determines cellular morphology and migratory behavior
41. Phosphatidylinositol 3-kinase, Cdc42, and Rac1 Act downstream of Ras in integrin-dependent neurite outgrowth in N1E-115 neuroblastoma cells
42. Apoptosis and the nervous system
43. Purification of recombinant Rho/Rac/G25K from Escherichia coli
44. Emerging from the Pak: The p21-activated protein kinase family
45. Human p21-activated kinase (Pak1) regulates actin organization in mammalian cells
46. Netrin-1 is required for commissural axon guidance in the developing vertebrate nervous system
47. LIM-kinase 1
48. UNC-73 activates the Rac GTPase and is required for cell and growth cone migrations in C. elegans
49. Structural framework for the protein kinase family
50. Lysophosphatidic acid-induced neurite retraction in PC12 cells: Neurite-protective effects of cyclic AMP signaling
51. 2+ signaling and Rho
52. The guanine nucleotide exchange factor Tiam1 affects neuronal morphology: Opposing roles for the small GTPases Rac and Rho
53. Androgen receptor specifically interacts with a novel p21-activated kinase, PAK6
54. Rho family GTPases regulate p38 mitogen-activated protein kinase through the downstream mediator Pak1
55. Role of a new Rho family member in cell migration and axon guidance in C. elegans