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Volumn 17, Issue 15, 1998, Pages 4328-4339

PAK promotes morphological changes by acting upstream of Rac

Author keywords

Guanine nucleotide exchange factor; Lamellipodia formation; Neurite outgrowth; PAK; Rac

Indexed keywords

CELL CYCLE PROTEIN; GUANOSINE TRIPHOSPHATASE; PHOSPHOTRANSFERASE; PROTEIN P21; PROTEIN SERINE THREONINE KINASE;

EID: 0032479975     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/17.15.4328     Document Type: Article
Times cited : (177)

References (43)
  • 1
    • 0029099132 scopus 로고
    • GTPase-activating protein activity of n (α1)-chimerin and effects of lipids
    • Ahmed, S., Kozma, R., Hall, C. and Lim, L. (1995) GTPase-activating protein activity of n (α1)-chimerin and effects of lipids. Methods Enzymol., 256B, 114-124.
    • (1995) Methods Enzymol. , vol.256 B , pp. 114-124
    • Ahmed, S.1    Kozma, R.2    Hall, C.3    Lim, L.4
  • 2
    • 0029937918 scopus 로고    scopus 로고
    • Src, Ras and Rac mediate the migratory response elicited by NGF and PMA in PC12 cells
    • Altun-Gulekin, Z.F. and Wagner, J.A. (1996) Src, Ras and Rac mediate the migratory response elicited by NGF and PMA in PC12 cells. J. Neurosci. Res., 44, 308-327.
    • (1996) J. Neurosci. Res. , vol.44 , pp. 308-327
    • Altun-Gulekin, Z.F.1    Wagner, J.A.2
  • 3
    • 0027931640 scopus 로고
    • Membrane targeting of the nucleotide exchange factor Sos is sufficient for activating the Ras signalling pathway
    • Aronheim, A., Engelberg, D., Li, N., AlAlawi, N., Schlessinger, J. and Karin, M. (1994) Membrane targeting of the nucleotide exchange factor Sos is sufficient for activating the Ras signalling pathway. Cell, 78, 949-961.
    • (1994) Cell , vol.78 , pp. 949-961
    • Aronheim, A.1    Engelberg, D.2    Li, N.3    Alalawi, N.4    Schlessinger, J.5    Karin, M.6
  • 4
    • 0028875683 scopus 로고
    • Cdc42 and PAK-mediated signalling leads to Jun kinase and p38 mitogen-activated protein kinase activation
    • Bagrodia, S., Dérijard, B., Davis, R.J. and Cerione, R.A. (1995) Cdc42 and PAK-mediated signalling leads to Jun kinase and p38 mitogen-activated protein kinase activation. J. Biol. Chem., 270, 27995-27998.
    • (1995) J. Biol. Chem. , vol.270 , pp. 27995-27998
    • Bagrodia, S.1    Dérijard, B.2    Davis, R.J.3    Cerione, R.A.4
  • 6
    • 0025823448 scopus 로고
    • ERKs: A family of protein-serine/threonine kinases that are activated and tyrosine phosphorylated in response to insulin and NGF
    • Boulton, T.G. et al. (1991) ERKs: a family of protein-serine/threonine kinases that are activated and tyrosine phosphorylated in response to insulin and NGF. Cell, 65, 663-675.
    • (1991) Cell , vol.65 , pp. 663-675
    • Boulton, T.G.1
  • 7
    • 0030134625 scopus 로고    scopus 로고
    • Human Ste20 homologue hPAK1 links GTPases to the JNK MAP kinase pathway
    • Brown, J.L., Sowers, L., Baer, M., Trejo, J., Coughlin, S. and Chant, J. (1996) Human Ste20 homologue hPAK1 links GTPases to the JNK MAP kinase pathway. Curr. Biol., 6, 598-605.
    • (1996) Curr. Biol. , vol.6 , pp. 598-605
    • Brown, J.L.1    Sowers, L.2    Baer, M.3    Trejo, J.4    Coughlin, S.5    Chant, J.6
  • 8
    • 0028786020 scopus 로고
    • A conserved binding motif defines numerous candidate target proteins for both Cdc42 and Rac GTPases
    • Burbelo, P.D., Drechsel, D. and Hall, A. (1995) A conserved binding motif defines numerous candidate target proteins for both Cdc42 and Rac GTPases. J. Biol. Chem., 270, 29071-29074.
    • (1995) J. Biol. Chem. , vol.270 , pp. 29071-29074
    • Burbelo, P.D.1    Drechsel, D.2    Hall, A.3
  • 9
    • 0029055812 scopus 로고
    • The small GTP-binding proteins Rac1 and Cdc42 regulate the activity of the JNK/SAPK signalling pathway
    • Coso, O.A., Chiariello, M., Yu, J.-C., Teramoto, H., Crespo, P., Xu, N., Miki, T. and Gutkind, S.J. (1995) The small GTP-binding proteins Rac1 and Cdc42 regulate the activity of the JNK/SAPK signalling pathway. Cell, 81, 1137-1146.
    • (1995) Cell , vol.81 , pp. 1137-1146
    • Coso, O.A.1    Chiariello, M.2    Yu, J.-C.3    Teramoto, H.4    Crespo, P.5    Xu, N.6    Miki, T.7    Gutkind, S.J.8
  • 10
    • 0032472918 scopus 로고    scopus 로고
    • Membrane targeting of p21-activated kinase1 (PAK1) induces neurite outgrowth from PC12 cells
    • Daniels, R.H., Hall, P.S. and Bokoch, G.M. (1998) Membrane targeting of p21-activated kinase1 (PAK1) induces neurite outgrowth from PC12 cells. EMBO J., 17, 754-764.
    • (1998) EMBO J. , vol.17 , pp. 754-764
    • Daniels, R.H.1    Hall, P.S.2    Bokoch, G.M.3
  • 11
    • 0029830139 scopus 로고    scopus 로고
    • The adaptor protein Nck links tyrosine kinases with the serine-threonine kinase Pakl
    • Galisteo, M.L., Chernoff, J., Su, Y.-C., Skolnik, E.Y. and Schlessinger, J. (1996) The adaptor protein Nck links tyrosine kinases with the serine-threonine kinase Pakl. J. Biol. Chem., 271, 20997-21000.
    • (1996) J. Biol. Chem. , vol.271 , pp. 20997-21000
    • Galisteo, M.L.1    Chernoff, J.2    Su, Y.-C.3    Skolnik, E.Y.4    Schlessinger, J.5
  • 12
    • 0030929149 scopus 로고    scopus 로고
    • Identification of a novel, putative Rho-specific GDP/GTP exchange factor and a RhoA-binding protein: Control of neuronal morphology
    • Gebbink, M.F.B.G., Kranenburg, O., Pol and, M., vanHorck, F.P.G., Houssa, B. and Moolenar, W.H. (1997) Identification of a novel, putative Rho-specific GDP/GTP exchange factor and a RhoA-binding protein: control of neuronal morphology. J. Cell Biol., 137, 1603-1613.
    • (1997) J. Cell Biol. , vol.137 , pp. 1603-1613
    • Gebbink, M.F.B.G.1    Kranenburg, O.2    Pol And, M.3    VanHorck, F.P.G.4    Houssa, B.5    Moolenar, W.H.6
  • 13
    • 0029802561 scopus 로고    scopus 로고
    • RAC regulation of actin polymerization by a pathway distinct from Jun kinase
    • Joneson, T. McDonough, M., Bar-Sagi, D. and Van Aelst, L. (1996) RAC regulation of actin polymerization by a pathway distinct from Jun kinase. Science, 274, 1374-1376.
    • (1996) Science , vol.274 , pp. 1374-1376
    • Joneson, T.1    McDonough, M.2    Bar-Sagi, D.3    Van Aelst, L.4
  • 14
    • 0028115022 scopus 로고
    • Neurotrophin signal transduction by the Trk receptor
    • Kaplan, D.R. and Stephens, R.M. (1994) Neurotrophin signal transduction by the Trk receptor. J. Neurobiol., 25, 1404-1417.
    • (1994) J. Neurobiol. , vol.25 , pp. 1404-1417
    • Kaplan, D.R.1    Stephens, R.M.2
  • 15
    • 0028800305 scopus 로고
    • Activation of Rac1. RhoA and mitogen-activated protein kinases is required for Ras transformation
    • Khosravi-Far, R., Solski, P.A., Clark, G.J., Kinch, M.S. and Der, C.J. (1995) Activation of Rac1. RhoA and mitogen-activated protein kinases is required for Ras transformation. Mol. Cell. Biol., 15, 6443-6543.
    • (1995) Mol. Cell. Biol. , vol.15 , pp. 6443-6543
    • Khosravi-Far, R.1    Solski, P.A.2    Clark, G.J.3    Kinch, M.S.4    Der, C.J.5
  • 16
    • 0028986034 scopus 로고
    • The ras-related protein Cdc42Hs and bradykinin promote formation of peripheral actin microspikes and filopodia in Swiss 3T3 fibroblasts
    • Kozma, R., Ahmed, S., Best, A. and Lim, L. (1995) The ras-related protein Cdc42Hs and bradykinin promote formation of peripheral actin microspikes and filopodia in Swiss 3T3 fibroblasts. Mol. Cell. Biol., 15, 1942-1952.
    • (1995) Mol. Cell. Biol. , vol.15 , pp. 1942-1952
    • Kozma, R.1    Ahmed, S.2    Best, A.3    Lim, L.4
  • 17
    • 0031027205 scopus 로고    scopus 로고
    • Rho family GTPases and neuronal growth cone remodelling: Relationship between increased complexity induced by Cdc42Hs, Rac1 and acetylcholine and collapse induced by RhoA and lysophosphatidic acid
    • Kozma, R., Sarner, S., Ahmed, S. and Lim, L. (1997) Rho family GTPases and neuronal growth cone remodelling: relationship between increased complexity induced by Cdc42Hs, Rac1 and acetylcholine and collapse induced by RhoA and lysophosphatidic acid. Mol. Cell. Biol., 17, 1201-1211.
    • (1997) Mol. Cell. Biol. , vol.17 , pp. 1201-1211
    • Kozma, R.1    Sarner, S.2    Ahmed, S.3    Lim, L.4
  • 19
    • 0000562849 scopus 로고    scopus 로고
    • Regulation of actin cytoskeleton by Rho-family GTPases and their associated proteins
    • Lim, L., Hall, C. and Monfries, C. (1996a) Regulation of actin cytoskeleton by Rho-family GTPases and their associated proteins. Semin. Cell Dev. Biol., 7, 699-706.
    • (1996) Semin. Cell Dev. Biol. , vol.7 , pp. 699-706
    • Lim, L.1    Hall, C.2    Monfries, C.3
  • 20
    • 0029805324 scopus 로고    scopus 로고
    • Regulation of phosphorylation pathways. The p21-Ras-related Rho subfamily and its role in phosphorylation signalling pathways
    • Lim, L., Manser, E., Leung, T. and Hall, C. (1996b) Regulation of phosphorylation pathways. The p21-Ras-related Rho subfamily and its role in phosphorylation signalling pathways. Eur. J. Biochem., 242, 171-185.
    • (1996) Eur. J. Biochem. , vol.242 , pp. 171-185
    • Lim, L.1    Manser, E.2    Leung, T.3    Hall, C.4
  • 21
    • 0031065475 scopus 로고    scopus 로고
    • Rho family small GTP-binding proteins in growth cone signalling
    • Luo, L., Jan, L.Y. and Jan, Y.-N. (1997) Rho family small GTP-binding proteins in growth cone signalling. Curr. Opin. Neurobiol., 7, 81-86.
    • (1997) Curr. Opin. Neurobiol. , vol.7 , pp. 81-86
    • Luo, L.1    Jan, L.Y.2    Jan, Y.-N.3
  • 22
    • 0028078824 scopus 로고
    • A brain serine/threonine protein kinase activated by Cdc42 and Rac1
    • Manser, E., Leung, T., Salihuddin, H., Zhao, Z.-S. and Lim, L. (1994) A brain serine/threonine protein kinase activated by Cdc42 and Rac1. Nature, 367, 40-46.
    • (1994) Nature , vol.367 , pp. 40-46
    • Manser, E.1    Leung, T.2    Salihuddin, H.3    Zhao, Z.-S.4    Lim, L.5
  • 23
    • 0028862297 scopus 로고
    • Molecular cloning of a new member of the p21-Cdc42/Rac-activated kinase (PAK) family
    • Manser, E., Chong, C., Zhao, Z.-S., Leung, T., Michael, G., Hall, C. and Lim, L. (1995) Molecular cloning of a new member of the p21-Cdc42/Rac-activated kinase (PAK) family. J. Biol. Chem., 270, 25070-25078.
    • (1995) J. Biol. Chem. , vol.270 , pp. 25070-25078
    • Manser, E.1    Chong, C.2    Zhao, Z.-S.3    Leung, T.4    Michael, G.5    Hall, C.6    Lim, L.7
  • 24
    • 0031036626 scopus 로고    scopus 로고
    • Expression of constitutively active α-PAK reveals effects of the kinase on actin and focal complexes
    • Manser, E., Huang, H.-Y., Loo, T.-H., Chen, X.-Q. Leung, T. and Lim, L. (1997) Expression of constitutively active α-PAK reveals effects of the kinase on actin and focal complexes. Mol. Cell. Biol., 17, 1129-1143.
    • (1997) Mol. Cell. Biol. , vol.17 , pp. 1129-1143
    • Manser, E.1    Huang, H.-Y.2    Loo, T.-H.3    Chen, X.-Q.4    Leung, T.5    Lim, L.6
  • 26
    • 0027212082 scopus 로고
    • How receptors turn Ras on
    • McCormick, F. (1993) How receptors turn Ras on. Nature, 363, 15-16.
    • (1993) Nature , vol.363 , pp. 15-16
    • McCormick, F.1
  • 27
    • 0029070887 scopus 로고
    • Selective activation of the JNK signalling cascade and c-Jun transcriptional activity by the small GTPases Rac and Cdc42Hs
    • Minden, A., Lin, A., Claret, F.-X., Abo, A. and Karin, M. (1995) Selective activation of the JNK signalling cascade and c-Jun transcriptional activity by the small GTPases Rac and Cdc42Hs. Cell, 81, 1147-1157.
    • (1995) Cell , vol.81 , pp. 1147-1157
    • Minden, A.1    Lin, A.2    Claret, F.-X.3    Abo, A.4    Karin, M.5
  • 28
    • 0028961293 scopus 로고
    • Rho, Rac and Cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibres, lamellipodia and filopodia
    • Nobes, C.D. and Hall, A. (1995) Rho, Rac and Cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibres, lamellipodia and filopodia. Cell, 81, 53-62.
    • (1995) Cell , vol.81 , pp. 53-62
    • Nobes, C.D.1    Hall, A.2
  • 29
    • 0028293929 scopus 로고
    • Neuronal differentiation signals are controlled by nerve growth factor receptor/Trk binding sites for SHC and PLCγ
    • Obermeier, A., Bradshaw, R.A., Seedorf, K., Choidas, A., Schlessinger, J. and Ullrich, A. (1994) Neuronal differentiation signals are controlled by nerve growth factor receptor/Trk binding sites for SHC and PLCγ-EMBO J., 13, 1585-1590.
    • (1994) EMBO J. , vol.13 , pp. 1585-1590
    • Obermeier, A.1    Bradshaw, R.A.2    Seedorf, K.3    Choidas, A.4    Schlessinger, J.5    Ullrich, A.6
  • 31
    • 0027236954 scopus 로고
    • Production of high-titer helper-free retroviruses by transient transfection
    • Pear, W.S., Nolan, G.P, Scott, M.L. and Baltimore, D. (1993) Production of high-titer helper-free retroviruses by transient transfection. Proc. Natl Acad. Sci. USA, 90, 8392-8396.
    • (1993) Proc. Natl Acad. Sci. USA , vol.90 , pp. 8392-8396
    • Pear, W.S.1    Nolan, G.P.2    Scott, M.L.3    Baltimore, D.4
  • 32
    • 0028903247 scopus 로고
    • An essential role for Rac in Ras transformation
    • Qui, R.-G., Chen, J., Kirn, D., McCormick, F. and Symons, M. (1995) An essential role for Rac in Ras transformation. Nature, 374, 457-459.
    • (1995) Nature , vol.374 , pp. 457-459
    • Qui, R.-G.1    Chen, J.2    Kirn, D.3    McCormick, F.4    Symons, M.5
  • 33
    • 0026654125 scopus 로고
    • The small GTP-binding protein Rac regulates growth factor-induced membrane ruffling
    • Ridley, A.J., Paterson, H.E. Johnston, C.L., Diekmann, D. and Hall, A. (1992) The small GTP-binding protein Rac regulates growth factor-induced membrane ruffling. Cell, 70, 401-410.
    • (1992) Cell , vol.70 , pp. 401-410
    • Ridley, A.J.1    Paterson, H.E.2    Johnston, C.L.3    Diekmann, D.4    Hall, A.5
  • 34
    • 0031127255 scopus 로고    scopus 로고
    • Emerging from the Pak: The p21-activated protein kinase family
    • Sells, M.A. and Chernoff, J. (1997) Emerging from the Pak: the p21-activated protein kinase family. Trends Cell Biol., 7, 162-167.
    • (1997) Trends Cell Biol. , vol.7 , pp. 162-167
    • Sells, M.A.1    Chernoff, J.2
  • 35
  • 36
    • 0028863477 scopus 로고
    • Making the connection: Cytoskeletal rearrangements during growth cone guidance
    • Tanaka, E. and Sabry, J. (1995) Making the connection: cytoskeletal rearrangements during growth cone guidance. Cell, 83, 171-176.
    • (1995) Cell , vol.83 , pp. 171-176
    • Tanaka, E.1    Sabry, J.2
  • 37
    • 0030811528 scopus 로고    scopus 로고
    • Kinase-deficient Pak1 mutants inhibit Ras transformation of Rat-1 fibroblasts
    • Tang, Y., Chen, Z., Ambrose, D., Liu, J., Gibbs, J.B., Chernoff, J. and Field, J. (1997) Kinase-deficient Pak1 mutants inhibit Ras transformation of Rat-1 fibroblasts. Mol. Cell. Biol., 17, 4454-4464.
    • (1997) Mol. Cell. Biol. , vol.17 , pp. 4454-4464
    • Tang, Y.1    Chen, Z.2    Ambrose, D.3    Liu, J.4    Gibbs, J.B.5    Chernoff, J.6    Field, J.7
  • 38
    • 0031042493 scopus 로고    scopus 로고
    • Rho, Rac and Cdc42 GTPases regulate the organization of the actin cytoskeleton
    • Tapon, N. and Hall, A. (1997) Rho, Rac and Cdc42 GTPases regulate the organization of the actin cytoskeleton. Curr. Opin. Cell Biol., 9, 86-92.
    • (1997) Curr. Opin. Cell Biol. , vol.9 , pp. 86-92
    • Tapon, N.1    Hall, A.2
  • 39
    • 0029911520 scopus 로고    scopus 로고
    • The small GTP-binding protein Rho activates c-Jun N-terminal kinases/stress-activated protein kinases in human kidney 293T cells. Evidence for a Pak1-independent signalling pathway
    • Teramoto, H., Crespo, P., Coso, O.A., Igishi, T. Xu, N. and Gutkind, S.J. (1996) The small GTP-binding protein Rho activates c-Jun N-terminal kinases/stress-activated protein kinases in human kidney 293T cells. Evidence for a Pak1-independent signalling pathway. J. Biol. Chem., 271, 25731-25734.
    • (1996) J. Biol. Chem. , vol.271 , pp. 25731-25734
    • Teramoto, H.1    Crespo, P.2    Coso, O.A.3    Igishi, T.4    Xu, N.5    Gutkind, S.J.6
  • 40
    • 0030968580 scopus 로고    scopus 로고
    • Rho GTPases and signaling networks
    • Van Aelst, L. and D'Souza-Schorey, C.D. (1997) Rho GTPases and signaling networks. Genes Dev., 11, 2295-2322.
    • (1997) Genes Dev. , vol.11 , pp. 2295-2322
    • Van Aelst, L.1    D'Souza-Schorey, C.D.2
  • 41
    • 0029757748 scopus 로고    scopus 로고
    • Identification of a novel Rac1-interacting protein involved in membrane ruffling
    • Van Aelst, L., Joneson, T. and Bar-Sagi, D. (1996) Identification of a novel Rac1-interacting protein involved in membrane ruffling. EMBO J., 15, 3778-3786.
    • (1996) EMBO J. , vol.15 , pp. 3778-3786
    • Van Aelst, L.1    Joneson, T.2    Bar-Sagi, D.3
  • 42
    • 0031026132 scopus 로고    scopus 로고
    • Rac regulation of transformation, gene expression and actin organization by multiple, PAK-independent pathways
    • Westwick, J.K., Lambert, Q.T., Clark, G.J., Symons, M., Van Aelst, L., Pestell, R.G. and Der, C.J. (1997) Rac regulation of transformation, gene expression and actin organization by multiple, PAK-independent pathways. Mol. Cell. Biol., 17, 1324-1335.
    • (1997) Mol. Cell. Biol. , vol.17 , pp. 1324-1335
    • Westwick, J.K.1    Lambert, Q.T.2    Clark, G.J.3    Symons, M.4    Van Aelst, L.5    Pestell, R.G.6    Der, C.J.7
  • 43
    • 0028880006 scopus 로고
    • Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis
    • Xia, Z., Dickens, M., Raingeaud, J., Davis, R.J. and Greenberg, M.E. (1995) Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis. Science, 270, 1326-1331.
    • (1995) Science , vol.270 , pp. 1326-1331
    • Xia, Z.1    Dickens, M.2    Raingeaud, J.3    Davis, R.J.4    Greenberg, M.E.5


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