Polyunsaturated fatty acid regulation of gene transcription: A mechanism to improve energy balance and insulin resistance

British Journal of Nutrition

Volumn 83, Issue SUPPL. 1, 2000, Pages

  Clarke, Steven D ^a  

^a UNIVERSITY OF TEXAS AT AUSTIN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; INSULIN; OMEGA 3 FATTY ACID; OMEGA 6 FATTY ACID; POLYUNSATURATED FATTY ACID;

CONFERENCE PAPER; DOWN REGULATION; ENERGY BALANCE; FAT INTAKE; FATTY ACID OXIDATION; FATTY ACID SYNTHESIS; GENETIC TRANSCRIPTION; GLUCOSE METABOLISM; HUMAN; INSULIN RESISTANCE; LIPID STORAGE; NONHUMAN; OBESITY;

EUKARYOTA;

EID: 0034032555     PISSN: 00071145     EISSN: None     Source Type: Journal    
DOI: 10.1017/s0007114500000969     Document Type: Conference Paper

References (72)

1. Allmann DW & Gibson DW (1969) Fatty acid synthesis during early linoleic acid deficiency in the mouse. Journal of Lipid Research 6, 51-62.
2. Anderson JW, Herman RH & Zakim D (1973) Effect of high glucose and high sucrose diets on glucose tolerance of normal men. American Journal of Clinical Nutrition 26, 600-606.
3. Baillie RA, Takada R, Nakamura M & Clarke SD (1999) Coordinate induction of peroxisomal acyl-CoA oxidase and UCP-3 by dietary fish oil: a mechanism for decreased body fat deposition. Prostaglandins, Leukotrienes and Essential Fatty Acids 60, 351-356.
4. Baur LA, O'Connor J, Pan DA, Kritketos A & Storlien LH (1998) The fatty acid composition of skeletal muscle membrane phospholipid: its relationship with the type of feeding and plasma glucose levels in young children. Diabetes 47, 106-112.
5. Boden G & Chen XH (1995) Effects of fat on glucose uptake and utilization in patients with non-insulin-dependent diabetes. Journal of Clinical Investigation 96, 1261-1268.
6. Boss O, Muzzin P. & Giacobino JP (1998) The uncoupling proteins, a review. European Journal of Endocrinology 139, 1-9.
7. Brown MS & Goldstein JL (1999) A proteolytic pathway that controls the cholesterol content of membranes, cells, and blood. Proceedings of the National Academy of Sciences, USA 96, 1041-11048.
8. Brun RP, Kim JB, Hu E, Altiok S & Spiegelman BM (1996) Adipocyte differentiation: a transcriptional regulatory cascade. Current Opinion in Cell Biology 8, 826-832.
9. Cho HP, Nakamura MT & Clarke SD (1999) Cloning, expression, and nutritional regulation of the mammalian Δ-6 desaturase. Journal of Biological Chemistry 274, 471-477.
10. Clarke SD (1999) Polyunsaturated fatty acids as fuel partitioners: a transcriptional mechanism. Chemistry and Physics of Lipids 101, 141 (abstr.).
11. Clarke SD & Jump DB (1993) Regulation of hepatic gene expression by dietary fats: a unique role for polyunsaturated fatty acids. In Nutrition and Gene Expression, pp. 227-245 [CD Berdanier & JL Hargrove, editors]. Boca Raton, FL: CRC Press.
12. Clarke SD, Armstrong MK and Jump DB (1990) Dietary polyunsaturated fats uniquely suppress rat liver fatty acid synthase and S14 mRNA content. Journal of Nutrition 120, 225-232.
13. Clarke SD, Baillie R, Jump DB & Nakamura MT (1997) Fatty acid regulation of gene expression: its role in fuel partitioning and insulin resistance. Annals of the New York Academy of Sciences 827, 178-187.
14. Clarke, SD, Thuillier P, Baillie RA & Sha X (1999) Peroxisome proliferator-activated receptors: a family of lipid-activated transcription factors. American Journal of Clinical Nutrition 70, 566-577.
15. Costet P, Legendre C, More J, Edgar A, Galtier P & Pineau T (1998) Peroxisome proliferator-activated receptor a-isoform deficiency leads to progressive dyslipidemia with sexually dimorphic obesity and steatosis. Journal of Biological Chemistry 273, 29577-29585.
16. Couet C, Delarue J, Fitz P, Antonine JM & Lamisse F (1997) Effect of dietary fish oil on body fat mass and basal fat oxidation in healthy adults. International Journal of Obesity 21, 637-643.
17. Da Silva AL, De Marcucci OL & Kuhnle ZR (1993) Dietary polyunsaturated fats suppress the high-sucrose induced increase of rat liver pyruvate dehydrogenase levels. Biochimica Biophysica Acta 1169, 126-134.
18. DuBois RN, Gupta R, Brockman J, Reddy BS, Krakow SL & Lazar MA (1998) The nuclear eicosanoid receptor, PPARγ, is aberrantly expressed in colonie cancers. Carcinogenesis 19, 49-53.
19. Field CJ, Ryan EA, Thomson ABR & Clandinin MT (1990) Diet fat composition alters membrane phospholipid composition, insulin binding and glucose metabolism in adipocytes from control and diabetic animals. Journal of Biological Chemistry 265, 11143-11150.
20. Fleury C, Neverova M, Collins S, Raimbault S, Champigny O, Levi-Meyrueis C, Bouillaud F, Seldin MF, Surwit RS, Ricquirer D & Warden CH (1997) Uncoupling protein-2: a novel gene linked to obesity and hyperinsulinemia. Nature Genetics 15, 269-272.
21. Foellmi-Adams LA, Wyse BM, Herron D, Nedergarrd J Kletzien RF (1996) Induction of uncoupling protein in brown adipose tissue. Synergy between norepinephrine and pioglitazone, an insulin-sensitizing agent. Biochemical Pharmacology 52, 693-701.
22. Kliewer SA, Sundseth SS, Jones SA, Brown PJ, Wisely GB, Koble CS, Devachand P, Wahli W, Willson TM, Lenhard J & Lehmann JM (1997) Fatty acids and eicosanoids regulate gene expression through direct interactions with peroxisome proliferator-activated receptors α and γ. Proceedings of the National Academy of Sciences, USA 94, 4318-4323.
23. Forman BM, Tontonoz P, Chen J, Brun RP, Spiegelman BM & Evans RM (1995) 15-deoxy-D-12,14-prostaglandin J2 is a ligand for the adipocyte determination factor PPARγ. Cell 83, 803-812.
24. Gasperikova D, Klimes I, Kolter T, Bohov P, Maassen A, Eckel J, Clandinin MT & Sebova E ( 1997) Glucose transport and insulin signaling in rat muscle and adipose tissue: effect of lipid availability. Proceedings of the New York Academy of Sciences 827, 144-157.
25. Hertz R, Magenheim J, Berman I & Bar-Tana J (1998) Fatty acid-CoA esters are ligands of hepatic nuclear factor-4α. Nature 392, 512-516.
26. Hill JO, Peters JC, Lin D, Yakubu F, Greene H & Swife L (1993) Lipid accumulation and body fat distribution is influenced by type of dietary fat fed to rats. International Journal of Obesity 17, 223-236.
27. Issemann I & Green S (1990) Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators. Nature 347, 645-650.
28. Jaburek M, Varecha M, Gimeno RE, Dembski M, Jezek P, Zhang M, Burn P, Tartaglia LA & Garlid KD (1999) Transport function and regulation of mitochondrial uncoupling proteins 2 and 3. Journal of Biological Chemistry 274, 26003-26007.
29. Jump DB & Clarke SD (1999) Regulation of gene expression by dietary fat. Annual Review of Nutrition 19, 63-90.
30. Jump D, Clarke SD, Thelen A & Liimatta M (1994) Coordinate regulation of glycolytic and lipogenic gene expression by polyunsaturated fatty acids. Journal of Lipid Research 35, 1076-1084.
31. Kahn B & Pedersen O (1993) Suppression of GLUT 4 expression skeletal muscle of rats that are obese from high fat feeding but not from high carbohydrate feeding or genetic obesity. Endocrinology 132, 13-22.
32. Kahn SH & Sorof S (1994) Liver fatty acid-binding protein: specific mediator of the mitogenesis induced by two classes of carcinogenic peroxisome proliferators. Proceedings of the National Academy of Sciences, USA 91, 848-852.
33. Katsurada A, Iritani N, Fukuda H, Noguchi T & Tanaka T (1990) Influence of nutrients and hormones on transcriptional and post-transcriptional regulation of acetyl-CoA carboxylase in rat liver. European Journal of Biochemistry 190, 435-441.
34. Kawashima Y, Musoh K & Kozuka H (1990) Peroxisome proliferators enhance linoleic acid metabolism in rat liver. Journal of Biological Chemistry 265, 9170-9175.
35. Kletzien RF, Foellmi LA, Harris PKW, Wyse BM & Clarke SD (1992) Adipocyte fatty acids binding protein (aFABP): regulation of gene expression in vivo and in vitro by an insulin-sensitizing agent. Molecular Pharmacology 42, 558-562.
36. Kliewer SA, Sundseth SS, Jones SA, Brown PJ, Wisely GB, Koble CS, Devachand P, Wahli W, Willson TM, Lenhard J & Lehmann JM (1997) Fatty acids and eicosanoids regulate gene expression through direct interactions with peroxisome proliferator-activated receptors. Proceedings of the National Academy of Sciences, USA 94, 4318-4323.
37. Kolterman OG, Greenfield GM, Reaven GM, Saekow M & Olefsky JM (1979) Effect of a high carbohydrate diet on insulin binding to adipocytes and on insulin action in vivo in man. Diabetes 28, 731-736.
38. Kondrup J & Lazarow PB (1985) Flux of palmitate through the peroxisomal and mitochondrial beta-oxidation systems in isolated rat hepatocytes. Biochimica Biophysica Acta 835, 147-153.
39. Liimatta M, Towle HC, Clarke SD & Jump DB (1994) Dietary polyunsaturated fatty acids interfere with the insulin/glucose activation of L-type pyruvate kinase gene transcription. Molecular Endocrinology 8, 1147-1153.
40. Malasanos, TH & Stacpoole PW (1991) Biological effects of n-3 fatty acids in diabetes mellitus. Diabetes Care 14, 1160-1179.
41. Martin G, Schoonjans K, Lefebvre AM, Staels B & Auwerx J (1997) Coordinate regulation of the expression of the fatty acid transport protein and acyl-CoA synthetase genes by PPARα and PPARγ activators. Journal of Biological Chemistry 272, 28210-28217.
42. Mascaro C, Acosta E, Ortiz JA, Marrero PF, Hegardt FG & Haro D (1998) Control of human muscle-type carnitine palmitoyltransferase I gene transcription by peroxisome proliferator-activated receptor. Journal of Biological Chemistry 273, 8560-8563.
43. Mater MK, Pan D, Bergen WG & Jump DB (1998) Arachidonic acid inhibits lipogenic gene expression in 3T3-L adipocytes through a prostanoid pathway. Journal of Lipid Research 39, 1327-1334.
44. Matsui H, Okumura K, Kawakami K, Hibino M, Toki Y & Ito T (1997) Improved insulin sensitivity by bezafibrate in rats. Relationship to fatty acid composition of skeletal muscle triglycerides. Diabetes 46, 348-353.
45. Nestel PJ, Connor WE, Reardon MF, Connors S, Wong S & Boston R. (1984) Suppression by diets rich in fish oil of very low density lipoprotein production in man. Journal of Clinical Investigation 74, 82-89.
46. Nolan JJ, Ludvik B, Beerdsen P, Joyce M & Olefsky J (1994) Improvement in glucose tolerance and insulin resistance in obese subjects treated with troglitazone. New England Journal of Medicine 331, 1188-1193.
47. Olefsky JM & Saekow M (1978) The effects of dietary carbohydrate content on insulin binding and glucose metabolism by isolated rat adipocytes. Endocrinology 103, 2252-2263.
48. Podolin DA, Gayles EC, Wei Y, Thresher JS & Pagliassotti MJ (1998) Menhaden oil prevents but does not reverse sucrose-induced insulin resistance in rats. Proceedings of the National Academy of Sciences, USA 96, 11041-11048.
49. Power GW & Newsholme EA (1997) Dietary fatty acids influence the activity and metabolic control of mitochondrial carnitine palmitoyltransferase I in rat heart and skeletal muscle. Journal of Nutrition 127, 2142-2150.
50. Prentki M & Corkey BE (1996) Are the β-cell signaling molecules malonyl-CoA and cytosolic long-chain acyl-CoA implicated in multiple tissue defects of obesity and NIDDM? Diabetes 45, 273-283.
51. Reddy JK & Mannaerts GP (1994) Peroxisomal lipid metabolism. Annual Review of Nutrition 14, 343-370.
52. Rodriguez JC, Gil-Gomez B, Hegradt FG & Haro D (1994) Peroxisome proliferator-activated receptor mediates induction of the mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase gene by fatty acids. Journal of Biological Chemistry 269, 1867-1872.
53. Saha AK, Kurowski TG & Ruderman NB (1995) A malonyl-CoA fuel sensing mechanism in muscle: effects of insulin glucose, and denervation. American Journal of Physiology 269, E383-E289.
54. Saloranta C, Koivisto V, Widen E, Falholt K, DeFronzo RA, Harkonen M & Groop L (1993) Contribution of muscle and liver to glucose-fatty acid cycle in humans. American Journal of Physiology 264, E599-E605.
55. Schrauwen P, Walder K & Ravussin E (1999) Human uncoupling proteins and obesity. Obesity Research 7, 97-105.
56. Shimomura I, Shimano H, Korn BS, Bashmakov Y & Horton JD (1998) Nuclear sterol regulatory element-binding proteins activate genes responsible for the entire program of unsaturated fatty acid biosynthesis in transgenic mouse liver. Journal of Biological Chemistry 273, 35299-35306.
57. Solanes G, Vidal-Puig A, Grujic D, Flier JS & Lowell BB (1997) The human uncoupling protein-3 gene. Journal of Biological Chemistry 272, 25433-25436.
58. Staels B, Schoonjans K, Fruchart JC & Auwerx J (1998) The effects of fibrates and thiazolidinediones on plasma triglyceride metabolism are mediated by distinct peroxisome proliferator activated receptors (PPARs) Biochimie 79, 95-99.
59. Storlien LH, Kraegen WE, Chisholm DJ, Ford GL, Bruce DG & Pascoe WE (1987) Fish oil prevents insulin resistance induced by high fat feeding in rats. Science 237, 885-888.
60. Storlien LH, Jenkins AB, Chisholm DJ, Pascoe WS, Khouri S & Kraegen EW (1991) Influence of dietary fat composition on development of insulin resistance: relationship to muscle tri-glyceride and n-3 fatty acids in muscle phospholipids. Diabetes 40, 280-289.
61. Takada R, Saitoh M & Mori T (1994) Dietary gamma-linolenic acid enriched oil reduces body fat content and induces liver enzyme activities relating to fatty acid beta-oxidation in rats. Journal of Nutrition 124, 469-479.
62. Thomassen MS, Christiansen EN & Norum KR (1982) Characterization of the stimulatory effect of high fat diets on peroxisomal β-oxidation in rat liver. Biochemical Journal 206, 195-202.
63. Tontonoz P, Nagy L, Alvarez JGA, Thomazy VA & Evans RM (1998) PPARγ promotes monocyte/macrophage differentiation and uptake of oxidized LDL. Cell 93, 241-252.
64. Van Epps-Fung M, Williford J, Wells A & Hardy RW (1997) Fatty acid induced insulin resistance in adipocytes. Endocrinology 138, 4338-4345.
65. Varanasi U, Chu R, Huang Q, Castellon R, Yeldani AV & Reddy JK (1996) Identification of a peroxisome proliferator-responsive element upstream of the human peroxisomal fatty acyl coenzyme A oxidase gene. Journal of Biological Chemistry 271, 2147-2155.
66. Vidal-Puig A, Solanes G, Grujic D, Flier FS & Lowell BB (1997) UCP3: an uncoupling protein homologue expressed preferentially and abundantly in skeletal muscle and brown adipose tissue. Biochemical and Biophysical Research Communications 235, 79-82.
67. Weigle DS, Sefridge LE, Schwartz MW, Seeley RJ, Cummings DE, Havel PJ, Kuijper JL & Beltrandel-Rio H (1999) Elevated free fatty acids induce uncoupling protein 3 expression in muscle. Diabetes 47, 298-302.
68. Wilson MD, Salati LM, Blake WL & Clarke SD (1990) The potency of polyunsaturated and saturated fats as short term inhibitors of hepatic lipogenesis. Journal of Nutrition 120, 544-552.
69. Wong SH, Nestel PJ, Trimble RP, Storere GB, Illman RJ & Topping DL. (1984) The adaptive effects of dietary fish and safflower oil on lipid and lipoprotein metabolism in perfused rat liver. Biochimica Biophysica Acta 792, 103-109.
70. Worgall TS, Sturley SL, Seo T, Osborne TF & Deckelman RJ (1998) Polyunsaturated fatty acids decrease expression of promoters with sterol regulatory elements by decreasing levels of mature sterol regulatory element binding protein. Journal of Biological Chemistry 273, 25537-25540.
71. Xu J, Nakamura T, Cho HP & Clarke SD (1999) Sterol regulatory element binding protein-1 expression is suppressed by dietary polyunsaturated fatty acids. Journal of Biological Chemistry 274, 23577-23588.
72. Zierath JR, Houseknecht KL, Gnudi L & Kahn BB (1997) High-fat feeding impairs insulin-stimulated GLUT4 recruitment via an early insulin signaling defect. Diabetes 46, 215-223.