Fatty acids enter cells by simple diffusion

Proceedings of the Society for Experimental Biology and Medicine

Volumn 212, Issue 1, 1996, Pages 5-14

  Zakim, David ^a  

^a WEILL CORNELL MEDICAL COLLEGE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FATTY ACID; MYRISTIC ACID; OLEIC ACID; PALMITIC ACID; STEARIC ACID;

BILAYER MEMBRANE; CELL MEMBRANE POTENTIAL; CELL MEMBRANE TRANSPORT; ESCHERICHIA COLI; FATTY ACID TRANSPORT; LIPID SOLUBILITY; MEMBRANE STRUCTURE; NONHUMAN; PROTEIN LIPID INTERACTION; REVIEW; TRANSPORT KINETICS;

EID: 0029877955     PISSN: 00379727     EISSN: None     Source Type: Journal    
DOI: 10.3181/00379727-212-43986     Document Type: Review

References (53)

1. Spector AA, Steinberg D, Tanaka A. Uptake of free fatty acids by Ehrlich ascites tumor cells. J Biol Chem 240:1032-1041, 1965.
2. De Grella RF, Light RJ. Uptake and metabolism of fatty acids by dispersed adult rat heart myocytes. II. Inhibition by albumin and fatty acid homologues, and the effect of temperature and metabolic reagents. J Biol Chem 255:9731-9738, 1980.
3. Spooner PJR, Gantz DL, Hamilton JA, Small DM. The distribution of oleic acid between chylomicron-like emulsions, phospholipid bilayers, and serum albumin. J Biol Chem 265:12650-12657, 1990.
4. Noy N, Zakim D. Fatty acids bound to unilamellar lipid vesicles as substrates for microsomal acyl-CoA ligase. Biochemistry 24:3521-35225, 1985.
5. Noy N, Zakim D. Substrate specificity of fatty-acyl-CoA ligase in liver microsomes. Biochem Biophys Acta 833:239-244, 1985.
6. Noy N, Donnelly TM, Zakim D. Physical-chemical model for the entry of water-insoluble compounds into cells. Studies of fatty acid uptake by the liver. Biochemistry 25:2013-2021, 1986.
7. Jain M, van Echteld CJA, Ramirez F, deGeir J, deHaas GH, vanDeenen LLM. Association of lysophosphatidylcholine with fatty acids in aqueous phase to form bilayers. Nature 284:486-487, 1980.
8. Van Dyke RW. Mechanisms of digestion and absorption of food. In: Sleisenger MH, Fordtran JS, Eds. Gastrointestinal Disease (4th ed). Philadelphia: W. B. Saunders, pp1062-1088, 1989.
9. Lieb WR, Stein WD. Biological membranes behave as nonporous polymeric sheets with respect to the diffusion of non-electrolytes. Nature 224:240-243, 1969.
10. Dill KA. The mechanism of retention in reversed-phase liquid chromatography. J Phys Chem 91:1980-1988, 1987.
11. Dill KA. Chain molecules at high densities at interfaces. Annu Rev Phys Chem 39:425-461, 1988.
12. Small DM, Cabral DJ, Cistola DP, Parkes JS, Hamilton JA. The ionization behavior of fatty acids and bile acids in micelles and membranes. Hepatology 4:77s-79s, 1984.
13. King MD, Marsh D. Translational diffusion of lipid monomers determined by spin label electron spin resonance. Biochim Biophys Acta 863:341-344, 1986.
14. Vaz WLC, Goodsaid-Zalduondo F, Jacobson K. Lateral diffusion of lipids and proteins in bilayer membranes. FEBS Lett 174:199-207, 1984.
15. Merkle H, Subczynski WK, Kusumi A. Dynamic fluorescence quenching studies on lipid mobilities in phosphatidylcholine-cholesterol membranes. Biochim Biophys Acta 897:238-248, 1987.
16. Daniels C, Noy N, Zakim D. Rates of hydration of fatty acids bound to unilamellar vesicles of phosphatidylcholine or to albumin. Biochemistry 24:3286-3292, 1985.
17. Weisiger R, Gollan J, Ockner R. Receptor for albumin on the liver surface may mediate uptake of fatty acids and other albumin-bound ligands. Science 211:1048-1050, 1981.
18. Weisiger RA. Dissociation from albumin: A potentially rate-limiting step in the clearance of substances by the liver. Proc Natl Acad Sci USA 82:1563-1567, 1985.
19. Cooper RB, Noy N, Zakim D. Mechanism for binding of fatty acids to hepatocyte plasma membranes. J Lipid Res 30:1719-1726, 1989.
20. Noy N, Donnelly TM, Cooper RB, Zakim D. The physical chemical basis for sex-related differences in uptake of fatty acids by the liver. Biochim Biophys Acta 1003:125-130, 1989.
21. Noy N, Zakim D. Physical chemical basis for the uptake of organic compounds by cells. In: Tavolini N, Berk PD, Eds. Hepatic Transport and Bile Secretion: Physiology and Pathophysiology. New York: Raven, pp313-335, 1993.
22. Cooper RB, Noy N, Zakim D. A physical-chemical model for cellular uptake of fatty acids: Prediction of intracellular pool sizes. Biochemistry 26:5890-5896, 1987.
23. Hamilton JA, Cistola DP. Transfer of oleic acid between albumin and phospholipid vesicles. Proc Natl Acad Sci USA 83:82-86, 1986.
24. Op den Kamp JAF. Lipid asymmetry in membranes. Annu Rev Biochem 48:47-71, 1979.
25. Van Zoelan EJJ, DeKruijff B, Van Deenen LLM. Protein mediated transbilayer movement of lysophosphalidylcholine in glycophorin containing vesicles. Biochim Biophys Acta 508:97-108, 1978.
26. Gerritsen WJ, Henricks PAJ, DeKuijff B, Van Deenen LLM. The transbilayer movement of phosphatidylcholine in vesicles reconstituted with intrinsic proteins from the human erythrocyte membrane. Biochim Biophys Acta 600:607-619, 1980.
27. Storch J, Kleinfeld AM. Transfer of long-chain fluorescent free fatty acids between unilamellar vesicles. Biochemistry 25:1717-1726, 1986.
28. Kleinfeld AM, Storch J. Transfer of fluorescent fatty acids between small and large unilamellar vesicles. Biochemistry 32:2053-2061, 1993.
29. Kleinfeld AM. Comments. Mol Cell Biophys 6:361-383, 1990.
30. Stremmel W. Translocation of fatty acids across the basolateral rat liver plasma membrane is driven by an active potential-sensitive sodium-dependent transport system. Jrnl Biol Chem 262:6284-6289, 1987.
31. Stremmel W, Strohmeyer G, Berk PD. Hepatocellular uptake of oleate is energy dependent, sodium linked, and inhibited by an antibody to hepatocyte plasma membrane fatty acid binding protein. Proc Natl Acad Sci USA 83:3584-3588, 1986.
32. Abumrad NA, Perkins RC, Park JH, Park CR. Mechanism of long chain fatty acid permeation in the isolated adipocyte. J Biol Chem 256:9183-9191, 1981.
33. Stremmel W, Strohmeyer G, Borchard F, Kochwa S, Berk PD. Isolation and partial characterization of a fatty acid binding protein in rat liver plasma membranes. Proc Natl Acad Sci USA 82:4-8, 1985.
34. Berk PD, Potter BJ, Stremmel W. Role of plasma membrane ligand binding proteins in the hepatocellular uptake of albumin-bound organic anions. Hepatology 7:165-176, 1987.
35. Williams JA, Withrow CD, Woodbury DM. Effects of ouabain and diphenylhydantoin on transmembrane potentials, intracellular electrolytes, and cell pH of rat muscle and liver in vivo. J Physiol (Lond) 212:101-115, 1971.
36. Diede HE, Rodilla-Sala E, Gunawan J, Manns M, Stremmel W. Identification and characterization of a monoclonal antibody to the membrane fatty acid binding protein. Biochim Biophys Acta 1125:13-20, 1992.
37. Freeman FE, Bennet W. Studies on the uptake of fatty acids by Escherichia coli. Arch Biochem Biophys 159:434-443, 1973.
38. Nunn WD. A molecular view of fatty acid catabolism in Escherichia coli. Microbiol Rev 50:179-192, 1986.
39. Maloy SR, Ginsburgh CL, Simons RW, Nunn WD. Transport of long and medium chain fatty acids by Escherichia coli. J Biol Chem 256:3735-3742, 1981.
40. Broring K, Haest CWM, Deuticke B. Translocation of oleic acid across the erythrocyte membrane. Evidence for a fast process. Biochim Biophys Acta 986:321-331, 1989.
41. Doody MC, Pownall HJ, Kao YJ, Smith LC. Mechanism and kinetics of transfer of a fluorescent fatty acid between single-walled phosphatidylcholine vesicles. Biochemistry 19:108-116, 1980.
42. Rennie AR, Tabor D. Hydrostatic pressure and long chain organic molecule diffusion through a polymer matrix. Nature 286:372-373, 1980.
43. Almgren M, Sivarup S. Fluorescence stopped-flow study of the interactions of alkylpyridinium salts and pyrene substituted fatty acids with lecithin vesicles. Chem Phys Lipids 31:22-31, 1982.
44. Galla H-J, Theilen U, Hartmann W. Transversal mobility in bilayer membrane vesicles: use of pyrene lecithin as optical probe. Chem Phys Lipids 23:239-251, 1979.
45. Hamilton JA, Cistola DP. Transfer of oleic acid between albumin and phospholipid veiscles. Proc Natl Acad Sci USA 83:82-86, 1986.
46. Bramhall J. Permeation of amphiphilic solutes across lipid bilayer. In: Kabara JJ, Ed. The Pharmacological Effect of Lipids. Champaign, IL: American Oil Chem. Soc., pp43-50, 1985.
47. Gutnecht J. Proton conductance caused by long-chain fatty acids in phospholipid bilayer membranes. J Membr Biol 106:83-93, 1988.
48. Jain MK, Jahagirdar DV, Van Linde M, Rolfofsen B, Eibl H. Solute-induced acceleration of transbilayer movement and its implications on models of blood-brain barrier. Biochim Biophys Acta 818:356-364, 1985.
49. Jordan PC, Stark G. Kinetics of transport of hydrophobic ions through lipid membranes inducing diffusion polarization in the aqueous phase. Biophys Chem 10:273-287, 1979.
50. Kamp F, Zakim D, Zhang F, Noy N, Hamilton JA. Fatty acid flip-flop in phospholipid bilayers is extremely fast. Biochemistry 34:11928-11937, 1995.
51. Kamp F, Hamilton JA. Movement of fatty acids, fatty acid analogues, and bile acids across phospholipid bilayers. Biochemistry 32:11074-11087, 1993.
52. Storch J. Mechanism for binding of fatty acids to hepatocyte plasma membranes: Different interpretation. Hepatology 12:1447-1449, 1990.
53. Reichen J, Blitzer BL, Berk PD. Binding of unconjugated and conjugated sulfobromothalein to rat liver plasma membrane fractions in vitro. Biochim Biophys Acta 640:298-312, 1986.