Postprandial lipemic response is modified by the polymorphism at codon 54 of the fatty acid-binding protein 2 gene

Arteriosclerosis, Thrombosis, and Vascular Biology

Volumn 18, Issue 10, 1998, Pages 1606-1610

  Ågren, Jyrki J ^a   Valve, Raisa ^a   Vidgren, Helvi ^a   Laakso, Markku ^a   Uusitupa, Matti ^a  

^a UNIVERSITY OF EASTERN FINLAND   (Finland)

Author keywords

Fatty acid binding protein; Insulin; Postprandial lipemia; Triglycerides

Indexed keywords

CHOLESTEROL; CHYLOMICRON; FATTY ACID BINDING PROTEIN; GLUCOSE; INSULIN; TRIACYLGLYCEROL; VERY LOW DENSITY LIPOPROTEIN;

ADULT; AGED; AREA UNDER THE CURVE; ARTICLE; BODY MASS; CHOLESTEROL BLOOD LEVEL; CLINICAL ARTICLE; CODON; CONTROLLED STUDY; FEMALE; GENETIC POLYMORPHISM; GLUCOSE BLOOD LEVEL; HUMAN; HYPERLIPIDEMIA; INSULIN BLOOD LEVEL; LIPID METABOLISM; MALE; POSTPRANDIAL STATE; PRIORITY JOURNAL; TRIACYLGLYCEROL BLOOD LEVEL;

EID: 0031709728     PISSN: 10795642     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.ATV.18.10.1606     Document Type: Article

References (21)

1. Sweetser DA, Heuckeroth RO, Gordon JI. The metabolic significance of mammalian fatty-acid-binding proteins: abundant proteins in search of a function. Annu Rev Nutr. 1987;7:337-359.
2. Lowe JB, Sacchettini JC, Laposata M, McQuillam JJ, Gordon JI. Expression of rat intestinal fatty acid-binding protein in Escherichia coli. J Biol Chem. 1987;262:5931-5937.
3. Baier LJ, Sacchettini JC, Knowler WC, Eads J, Paolisso G, Tataranni PA, Hisayoshi M, Bennett PH, Bogardus C, Prochazka M. An amino acid substitution in the human intestinal fatty acid binding protein is associated with increased fatty acid binding, increased fat oxidation, and insulin resistance. J Clin Invest. 1995;95:1281-1287.
4. Roche HM, Gibney MJ. Postprandial triacylglycerolaemia: nutritional implications. Prog Lipid Res. 1995;34:249-266.
5. Schrezenmeier J, Keppler I, Fenselau S, Weber P, Biesalski HK, Probst R, Laue C, Zuchhold HD, Prellwitz W, Beyer J. The phenomenon of a high triglyceride response to an oral lipid load in healthy subjects and its link to the metabolic syndrome. Ann NY Acad Sci. 1993;683:302-314.
6. Jeppesen J, Holleebeck CB, Zhou M-Y, Coulston AM, Jones C, Chen Y-DI, Reaven GM. Relation between insulin resistance, hyperinsulinemia, postheparin plasma lipoprotein lipase activity, and postprandial lipemia. Arterioscler Thromb Vasc Biol. 1995;15:320-324.
7. Sipiläinen R, Uusitupa M, Heikkinen S, Rissanen A, Laakso M. Variants in the human intestinal fatty acid binding protein 2 gene in obese subjects. J Clin Endocrinol Metab. 1997;82:2629-2632.
8. Vidgren HM, Sipiläinen RH, Heikkinen S, Laakso M, Uusitupa MIJ. Threonine allele in codon 54 of the fatty acid binding protein 2 gene does not modify the fatty acid composition of serum lipids in obese subjects. Eur J Clin Invest. 1997;27:405-408.
9. Uusitupa MIJ, Karhunen L, Rissanen A, Franssila-Kallunki A, Niskanen L, Kervinen K, Kesäniemi YA. Apolipoprotein E phenotype modifies metabolic and hemodynamic abnormalities related to central obesity in women. Am J Clin Nutr. 1996;64:131-136.
10. Uusitupa MIJ, Niskanen LK, Siitonen O, Voutilainen E, Pyörää K. Ten-year cardiovascular mortality in relation to risk factors and abnormalities in lipoprotein composition in type 2 (non-insulin dependent) diabetic and non-diabetic subjects. Diabetologia. 1993;36:1175-1184.
11. Vauhkonen I, Niskanen L, Ryynänen M, Voutilainen R, Partanen J, Töyry J, Mercuri M, Rauramaa R, Uusitupa M. Divergent association of apolipoprotein E polymorphism with cardiovascular disease in patients with NIDDM and control subjects. Diabet Med. 1997;14:748-756.
12. Rastas M, Seppänen R, Knuts L-R, Karvetti R-L, Varo P. Nutrient composition of foods [in Finnish]. 3rd ed. Helsinki, Finland: Social Insurance Institution; 1990.
13. Baier LJ, Bogardus C, Sacchettini JC. A polymorphism in the human intestinal fatty acid binding protein alters fatty acid transport across Caco-2 cells. J Biol Chem. 1996;271:10892-10896.
14. Pihlajamäki J, Rissanen J, Heikkinen S, Karjalainen L, Laakso M. Codon 54 polymorphism of the human intestinal fatty acid binding protein 2 gene is associated with dyslipidemias but not with insulin resistance in patients with familial combined hyperlipidemia. Arterioscler Thromb Vasc Biol. 1997;17:1039-1044.
15. Felber JP, Haesler E, Jéquier E. Metabolic origin of insulin resistance in obesity with and without type 2 (non-insulin-dependent) diabetes mellitus. Diabetologia. 1993;36:1221-1229.
16. Eckel RH, Yost TJ, Jensen DR. Alterations in lipoprotein lipase in insulin resistance. Int J Obesity. 1995;19(suppl)1:16-21.
17. Humphreys P, McCarthy M, Tuomilehto J, Tuomilehto-Wolf E, Stratton I, Morgan R, Rees A, Owens D, Stengard J, Nissinen A, Hitman G, Turner RC, O'Rahilly. Chromosome 4q locus associated with insulin resistance in Pima Indians: studies in three European NIDDM populations. Diabetes. 1994;43:800-804.
18. Kashyap ML, Barnhart RL, Srivastava LS, Perisutti G, Allen C, Hogg E, Glueck CJ, Jackson RL. Alimentary lipemia: plasma high-density lipoproteins and apolipoproteins CII and CIII in healthy subjects. Am J Clin Nutr. 1983;37:233-243.
19. Cohn JS, McNamara JR, Cohn SD, Ordovas JM, Schaefer EJ. Post-prandial plasma lipoprotein changes in human subjects of different ages. J Lipid Res. 1988;29:469-479.
20. Zilversmit DB. Atherosclerosis: a postprandial phenomenon. Circulation. 1979;60:473-485.
21. Steiner G. Triglyceride-rich lipoproteins and atherosclerosis, from fast to feast. Ann Med. 1993;25:431-435.