Intracellular lipid-binding proteins and their genes

Annual Review of Nutrition

Volumn 17, Issue , 1997, Pages 277-303

  Bernlohr, David A ^a,b   Simpson, Melanie A ^a   Hertzel, Ann Vogel ^a   Banaszak, Leonard J ^b  

^a UNIVERSITY OF MINNESOTA   (United States)

^b UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

Author keywords

Carrier proteins; Dietary fat; Fatty acids; Gene expression; Peroxisome proliferator activated receptors

Indexed keywords

PEROXISOME PROLIFERATOR;

BINDING AFFINITY; ENHANCER REGION; GENE EXPRESSION; GENE EXPRESSION REGULATION; HYDROPHOBICITY; LIPID BINDING; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; REVIEW; X RAY CRYSTALLOGRAPHY;

AMINO ACID SEQUENCE; ANIMALS; CARRIER PROTEINS; CONSERVED SEQUENCE; FATTY ACID-BINDING PROTEINS; GENE EXPRESSION; HUMANS; MOLECULAR SEQUENCE DATA; MYELIN P2 PROTEIN; NEOPLASM PROTEINS; TUMOR SUPPRESSOR PROTEINS;

EID: 0030837971     PISSN: 01999885     EISSN: None     Source Type: Book Series    
DOI: 10.1146/annurev.nutr.17.1.277     Document Type: Review

References (137)

1. Baier LJ, Bogardus C, Sacchettini JC. 1996. A polymorphism in the human intestinal fatty acid binding protein alters fatty acid transport across Caco-2 cells. J. Biol. Chem. 271:10892-96
2. Baier LJ, Sacchettini JC, Knowler WC, Eads J, Paolisso G, et al. 1995. An amino acid substitution in the human intestinal fatty acid binding protein is associated with increased fatty acid binding, increased fat oxidation and insulin resistance. J. Clin. Invest. 95:1281-87
3. Banasazk L, Winter N, Xu Z, Bernlohr DA, Cowan S, Jones TA. 1994. Lipid-binding proteins: a family of fatty acid and retinoid transport proteins. Adv. Prot. Chem. 45:89-151
4. Bass NM. 1988. The cellular fatty acid binding proteins: aspects of structure, regulation, and function. Intl. Rev. Cytol. 111:143-84
5. Bass NM. 1990. Fatty acid-binding protein expression in the liver: its regulation and relationship to the zonation of fatty acid metabolism. Mol. Cell. Biochem. 98:167-76
6. Bass NM, Manning JA, Ockner RK. 1985. Turnover and short-term regulation of fatty acid binding protein in liver. J. Biol. Chem. 260:9603-7
7. Bass NM, Manning JA, Ockner RK, Gordon JI, Seetharam S, Alpers DH. 1985. Regulation of the biosynthesis of two distinct fatty acid-binding proteins in rat liver and intestine. Influences of sex difference and of clofibrate. J. Biol. Chem. 260:1432-36
8. c.) from the human blood fluke Schistosoma japonicum. Gene 148:321-51
9. Benning MM, Smith AF, Wells MA, Holden HM. 1992. Crystallization, structure determination and least-squares refinement to 1.75 Å resolution of the fatty-acid-binding protein isolated from Manduca sexta. J. Mol. Biol. 228:208-19
10. 422 protein, a putative lipid carrier, in mouse adipocytes. Biochem. Biophys. Res. Commun. 132:850-55
11. Birkenmeier EH, Gwynn B, Howard S, Jerry J, Gordon JI, et al. 1989. Tissuespecific expression, developmental regulation, and genetic mapping of the gene encoding CCAAT/enhancer binding protein. Genes Dev. 3:1146-56
12. Birkenmeier EH, Rowe LB, Crossman MW, Gordon JI. 1994. Ileal lipidbinding protein (Illbp) gene maps to mouse chromosome 11. Mamm. Gen. 5:805-6
13. Cannon JR, Eacho PI. 1991. Interaction of LY171883 and other peroxisome proliferators with fatty-acid-binding protein isolated from rat liver. Biochem. J. 280:387-91
14. Carey JO, Neufer PD, Farrar RP, Veerkamp JH, Dohm GL. 1994. Transcriptional regulation of muscle fatty acid-binding protein. Biochem. J. 298: 613-7
15. Chen JD, Evans RM. 1995. A transcriptional co-repressor that interacts with nuclear hormone receptors. Nature 377:454-57
16. Christy RJ, Yang VW, Ntambi JM, Geiman DE, Landschulz WH, et al. 1989. Differentiation-induced gene expression in 3T3-L1 preadipocytes: CCAAT/enhancer binding protein interacts with and activates the promoters of two adipocyte-specific genes. Genes Dev. 3:1323-35
17. Cistola DP, Kim K, Rogl H, Frieden C. 1996. Fatty acid interactions with a helix-less variant of intestinal fatty acid-binding protein. Biochemistry 35:7559-65
18. 13C NMR study. J. Biol. Chem. 264:2700-10
19. Clarke SD, Armstrong MK. 1989. Cellular lipid binding proteins: expression, function, and nutritional regulation. FASEB J. 3:2480-87
20. Cohn SM, Simon TC, Roth KA, Birkenmeier EH, Gordon JI. 1992. Use of transgenic mice to map cis-acting elements in the intestinal fatty acid binding protein gene (Fabpi) that control its cell lineage-specific and regional patterns of expression along the duodenal-colonic and crypt-villus axes of the gut epithelium. J. Cell Biol 119:27-44
21. Cook JS, Lucas JJ, Sibley E, Bolanowski MA, Christy RJ, et al. 1988. Expression of the differentiation-induced gene for fatty acid-binding protein is activated by glucocorticoid and cAMP. Proc. Natl. Acad. Sci. USA 85:2949-53
22. Cowan SW, Newcomer ME, Jones TA. 1993. Crystallographic studies on a family of cellular lipophilic transport proteins. Refinement of P2 myelin protein and the structure determination and refinement of cellular retinol-binding protein in complex with all-trans-retinol. J. Mol. Biol. 230:1225-46
23. Crossman MW, Hauft SM, Gordon JI. 1994. The mouse ileal lipid-binding protein gene: a model for studying axial patterning during gut morphogenesis. J. Cell Biol. 126:1547-64
24. 4 pathway to inflammation control. Nature 384:39-43
25. Distel RJ, Robinson GS, Spiegelman BM. 1992. Fatty acid regulation of gene expression. Transcriptional and posttranscriptional mechanisms. J. Biol. Chem. 267:5937-41
26. Dreyer C, Krey G, Keller H, Givel F, Helftenbein G, Wahli W. 1992. Control of the peroxisomal beta-oxidation pathway by a novel family of nuclear hormone receptors. Cell 68:879-87
27. Feng L, Hatten ME, Heintz N. 1994. Brain lipid-binding protein (BLBP): a novel signaling system in the developing mammalian CNS. Neuron 12:895-908
28. Forman BM, Tontonoz P, Chen J, Brun RP, Spiegelman BM, Evans RM. 1995. 15-Deoxy-delta 12, 14-prostaglandin J2 is a ligand for the adipocyte determination factor PPAR gamma. Cell 83:803-12
29. Fujita M, Fujii H, Kanda T, Sato E, Hatakeyama K, Ono T. 1995. Molecular cloning, expression, and characterization of a human intestinal 15-kDa protein. Eur. J. Biochem. 233:406-13
30. Godbout R. 1993. Identification and characterization of transcripts present at elevated levels in the undifferentiated chick retina. Exp. Eye Res. 561:95-106
31. Gong YZ, Everett ET, Schwartz DA, Norris JS, Wilson FA. 1994. Molecular cloning, tissue distribution, and expression of a 14-kDa bile acid-binding protein from rat ileal cytosol. Proc. Natl. Acad. Sci. USA 91:4741-45
32. Graves RA, Tontonoz P, Ross SR, Spiegelman BM. 1991. Identification of a potent adipocyte-specific enhancer: involvement of an NF-1-like factor. Genes Dev. 5:428-37
33. Graves RA, Tontonoz P, Spiegelman BM. 1992. Analysis of a tissuespecific enhancer: ARF6 regulates adipogenic gene expression. Mol. Cell. Biol. 12:1202-8
34. Green RP, Cohn SM, Sacchettini JC, Jackson KE, Gordon JI. 1992. The mouse intestinal fatty acid binding protein gene: nucleotide sequence, pattern of developmental and regional expression, and proposed structure of its protein product. DNA Cell. Biol. 11:31-41
35. Harris PK, Kletzien RF. 1994. Localization of a pioglitazone response element in the adipocyte fatty acid-binding protein gene. Mol. Pharmacol. 45:439-45
36. Hauft SM, Sweetser DA, Rotwein PS, Lajara R, Hoppe PC, et al. 1989. A transgenic mouse model that is useful for analyzing cellular and geographic differentiation of the intestine during fetal development. J Biol. Chem. 264:8419-29
37. Hayasaka K, Himoro M, Takada G, Takahashi E, Minoshima S, Shimizu N. 1993. Structure and localization of the gene encoding human peripheral myelin protein 2 (PMP2). Genomics 18:244-48
38. Herr FM, Aronson J, Storch J. 1996. Role of portal region lysine residues in electrostatic interactions between heart fatty acid binding protein and phospholipid membranes. Biochemistry 35: 1296-1303
39. Herr FM, Matarese V, Bernlohr DA, Storch J. 1995. Surface lysine residues modulate the collisional transfer of fatty acid from adipocyte fatty acid binding protein to membranes. Biochemistry 34:11840-45
40. Heuckeroth RO, Birkenmeier EH, Levin MS, Gordon JI. 1987. Analysis of the tissue-specific expression, developmental regulation, and linkage relationships of a rodent gene encoding heart fatty acid binding protein. J. Biol. Chem. 262:9709-17
41. Horlein AJ, Naar AM, Heinzel T, Torchia J, Gloss B, et al. 1995. Ligandindependent repression by the thyroid hormone receptor mediated by a nuclear receptor co-repressor. Nature 377:397-404
42. Hotamisligil GS, Budavari A, Murray D, Spiegelman BM. 1994. Reduced tyrosine kinase activity of the insulin receptor in obesity-diabetes. Central role of tumor necrosis factor-alpha. J. Clin. Invest. 94:1543-49
43. Hotamisligil GS, Johnson RS, Distel RJ, Ellis R, Papaioannou VE, Spiegelman BM. 1996. Uncoupling of obesity from insulin resistance through a targeted mutation in aP2, the adipocyte fatty acid binding protein. Science 274:1377-79
44. Hsu K-T, Storch J. 1996. Fatty acid transfer from liver and intestinal fatty acid-binding proteins to membranes occurs by different mechanisms. J Biol. Chem. 271:13317-23
45. Hubbell T, Behnke WD, Woodford JK, Schroeder F. 1994. Recombinant liver fatty acid binding protein interacts with fatty acyl-coenzyme A. Biochemistry 33:3327-34
46. Hunt CR, Ro JH, Dobson DE, Min HY, Spiegelman BM. 1986. Adipocyte P2 gene: developmental expression and homology of 5′-flanking sequences among fat cell-specific genes. Proc. Natl. Acad. Sci. USA 83:3786-90
47. Issemann I, Green S. 1990. Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators. Nature 347:645-50
48. Issemann I, Prince R, Tugwood J, Green S. 1992. A role for fatty acids and liver fatty acid binding protein in peroxisome proliferation? Biochem. Soc. Trans. 20: 824-27
49. Jakoby MG, Miller KR, Toner JJ, Bauman A, Cheng L, et al. 1993. Ligandprotein electrostatic interactions govern the specificity of retinol- and fatty acid-binding proteins. Biochemistry 32:872-78
50. Jamison RS, Newcomer ME, Ong DE. 1994. Cellular retinoid-binding proteins: Limited proteolysis reveals a conformational change upon ligand binding. Biochemistry 33:2873-79
51. Jaworski C, Wistow G. 1996. LP2, a differentiation-associated lipid-binding protein expressed in bovine lens. Biochem. J. 320:49-54
52. Johnson PF. 1993. Identification of C/EBP basic region residues involved in DNA sequence recognition and halfsite spacing preference. Mol. Cell. Biol. 13:6919-30
53. Kaikaus RM, Bass NM, Ockner RK. 1990. Functions of fatty acid binding proteins. Experientia 46:617-30
54. Kaikaus RM, Chan WK, Ortiz de Montellano PR, Bass NM. 1993. Mechanisms of regulation of liver fatty acid-binding protein. Mol. Cell. Biochem. 123:93-100
55. Kanda T, Odani S, Tomoi M, Matsubara Y, Ono T. 1991. Primary structure of a 15-kDa protein from rat intestinal epithelium: sequence similarity to fatty acid-binding proteins. Eur. J. Biochem. 197:759-68
56. Kane CD, Bernlohr DA. 1996. A simple assay for intracellular lipid-binding proteins using displacement of 1-anilinonaphthalene 8-sulfonic acid. Anal. Biochem. 233:197-204
57. Kane CD, Ribarik Coe N, Vanlandingham B, Krieg P, Bernlohr DA. 1996. Expression, purification, and ligandbinding analysis of recombinant keratinocyte lipid-binding protein (MAL-1), an intracellular lipid-binding protein found overexpressed in neoplastic skin cells. Biochemistry 35:2894-900
58. Kim K, Cistola DP, Frieden C. 1996. Intestinal fatty acid-binding protein: the structure and stability of a helix-less variant. Biochemistry 35:7553-58
59. Kliewer SA, Forman BM, Blumberg B, Ong ES, Borgmeyer U, et al. 1994. Differential expression and activation of a family of murine peroxisome proliferator-activated receptors. Proc. Natl. Acad. Sci. USA 91:7355-59
60. Kliewer SA, Lenhard JM, Willson TM, Patel I, Morris DC, Lehmann JM. 1995. A prostaglandin J2 metabolite binds peroxisome proliferator-activated receptor gamma and promotes adipocyte differentiation. Cell 83:813-19
61. Kliewer SA, Umesono K, Noonan DJ, Heyman RA, Evans RM. 1992. Convergence of 9-cis retinoic acid and peroxisome proliferator signalling pathways through heterodimer formation of their receptors. Nature 358:771-74
62. Krieg P, Feil S, Furstenberger G, Bowden GT. 1993. Tumor-specific overexpression of a novel keratinocyte lipid-binding protein. Identification and characterization of a cloned sequence activated during multistage carcinogenesis in mouse skin. J. Biol. Chem. 268: 17362-69
63. Kurian E, Kirk WR, Prendergast FG. 1996. Affinity of fatty acid for rRat intestinal fatty acid binding protein: further examination. Biochemistry 35: 3865-74
64. Kurtz A, Zimmer A, Schnutgen F, Bruning G, Spener F, Muller T. 1994. The expression pattern of a novel gene encoding brain-fatty acid binding protein correlates with neuronal and glial cell development. Development 120:2637-49
65. LaLonde JM, Bernlohr DA, Banaszak LJ. 1994. X-ray crystallographic structures of adipocyte lipid-binding protein complexed with palmitate and hexadecanesulfonic acid. Properties of cavity binding sites. Biochemistry 33:4885-95
66. LaLonde JM, Levenson MA, Roe JJ, Bernlohr DA, Banaszak LJ. 1994. Adipocyte lipid-binding protein complexed with arachidonic acid. Titration calorimetry and x-ray crystallographic studies. J. Biol. Chem. 269:25339-47
67. Landschulz WH, Johnson PF, Adashi EY, Graves BJ, McKnight SL. 1989. Isolation of a recombinant copy of the gene encoding C/EBP. Genes Dev. 2:786-800
68. Lehmann JM, Moore LB, Smith-Oliver TA, Wilkison WO, Willson TM, Kliewer SA 1995. An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor gamma (PPAR gamma). J. Biol. Chem. 270:12953-56
69. Lemberger T, Saladin R, Vazquez M, Assimacopoulos F, Staels B, et al. 1996. Expression of the peroxisome proliferator-activated receptor alpha gene is stimulated by stress and follows a diurnal rhythm. J. Biol. Chem. 271:1764-69
70. Lemberger T, Staels B, Saladin R, Desvergne B, Auwerx J, Wahli W. 1994. Regulation of the peroxisome proliferator-activated receptor alpha gene by glucocorticoids. J Biol. Chem. 269: 24527-30
71. Li E, Norris AW. 1996. Structure/function of cytoplasmic vitamin A-binding proteins. Annu. Rev. Nutr. 16: 205-34
72. MacDougald OA, Cornelius P, Liu R, Lane MD. 1995. Insulin regulates transcription of the CCAAT/enhancer binding protein (C/EBP) alpha, beta, and delta genes in fully-differentiated 3T3-L1 adipocytes. J. Biol. Chem. 270:647-54
73. Madsen P, Rasmussen HH, Leffers H, Honore B, Celis JE. 1992. Molecular cloning and expression of a novel keratinocyte protein psoriasis-associated fatty acid-binding protein (PA-FABP) that is highly upregulated in psoriatic skin and that shares similarity to fatty acid-binding proteins. J. Invest. Dermatol. 99:299-305
74. Medzihradszky KF, Gibson BW, Kaur S, Yu ZH, Medzihradszky D, et al. 1992. The primary structure of fatty-acid-binding protein from nurse shark liver. Structural and evolutionary relationship to the mammalian fatty-acid-binding protein family. Eur. J. Biochem. 203:327-39
75. Miller KR, Cistola DP. 1993. Titration calorimetry as a binding assay for lipidbinding proteins. Mol. Cell. Biochem. 123:29-37
76. Miyata KS, McCaw SE, Patel HV, Rachubinski RA, Capone JP. 1996. The orphan nuclear hormone receptor LXR alpha interacts with the peroxisome proliferator-activated receptor and inhibits peroxisome proliferator signaling. J. Biol Chem. 271:9189-92
77. Moser D, Tendler M, Griffiths G, Klinkert MQ. 1991. A 14-kDa Schistosoma mansoni polypeptide is homologous to a gene family of fatty acid binding proteins. J Biol. Chem. 266:8447-54
78. Myers-Payne SC, Hubbell T, Pu LX, Schnutgen F, Borchers T, et al. 1996. Isolation and characterization of two fatty acid binding proteins from mouse brain. J. Neurochem. 66:1648-56
79. Narayanan V, Barbosa E, Reed R, Tennekoon G. 1988. Characterization of a cloned cDNA encoding rabbit myelin P2 protein. J Biol. Chem. 263:8332-37
80. Narayanan V, Kaestner KH, Tennekoon GI. 1991. Structure of the mouse myelin P2 protein gene. J. Neurochem. 57:75-80
81. Nerlov C, Ziff EB. 1994. Three levels of functional interaction determine the activity of CCAAT/enhancer binding protein-alpha on the serum albumin promoter. Genes Dev. 8:350-62
82. Ockner RK, Lysenko N, Manning JA, Monroe SE, Burnett DA. 1980. Sex steroid modulation of fatty acid utilization and fatty acid binding protein concentration in rat liver. J. Clin. Invest. 65:1013-23
83. Ockner RK, Manning JA, Poppenhausen RB, Ho WK. 1972. A binding protein for fatty acids in cytosol of intestinal mucosa, liver, myocardium, and other tissues. Science 177:56-58
84. Oelkers P, Dawson PA. 1995. Cloning and chromosomal localization of the human ileal lipid-binding protein. Biochim. Biophys. Acta 1257:199-202
85. Oko R, Morales CR. 1994. A novel testicular protein, with sequence similarities to a family of lipid binding proteins, is a major component of the rat sperm perinuclear theca. Dev. Biol. 166:235-45
86. Palmer CN, Hsu MH, Griffin HJ, Johnson EF. 1995. Novel sequence determinants in peroxisome proliferator signaling. J. Biol. Chem. 270:16114-21
87. Paulussen RJ, Geelen MJ, Beynen AC, Veerkamp JH. 1989. Immunochemical quantitation of fatty-acid-binding proteins. I. Tissue and intracellular distribution, postnatal development and influence of physiological conditions on rat heart and liver FABP. Biochim. Biophys. Acta 1001:201-9
88. Peeters RA, Veerkamp JH, Geurts van Kessel A, Kanda T, Ono T. 1991. Cloning of the cDNA encoding human skeletal-muscle fatty-acid-binding protein, its peptide sequence and chromosomal localization. Biochem. J. 276:203-7
89. Phillips M, Djian P, Green H. 1986. The nucleotide sequence of three genes participating in the adipose differentiation of 3T3 cells. J. Biol. Chem. 261:10821-27
90. Deleted in proof
91. Rauscher FJ 3d, Sambucetti LC, Curran T, Distel RJ, Spiegelman BM. 1988. Common DNA binding site for Fos protein complexes and transcription factor AP-1. Cell 52:471-80
92. Raza H, Pongubala JR, Sorof S. 1989. Specific high affinity binding of lipoxygenase metabolites of arachidonic acid by liver fatty acid binding protein. Biochem. Biophys. Res. Commun. 161:448-55
93. Richieri GV, Ogata RT, Kleinfeld AM. 1994. Equilibrium constants for the binding of fatty acids with fatty acid-binding proteins from adipocyte, intestine, heart, and liver measured with the fluorescent probe ADIFAB. J. Biol. Chem. 269:23918-30
94. Richieri GV, Ogata RT, Kleinfeld AM. 1996. Kinetics of fatty acid interactions with fatty acid binding proteins from adipocyte, heart, and intestine. J Biol. Chem. 271:11291-300
95. Rodriguez-Perez J, Rodriguez-Medina JR, Garcia-Blanco MA, Hillyer GV. 1992. Fasciola hepatica: molecular cloning, nucleotide sequence, and expression of a gene encoding a polypeptide homologous to a Schistosoma mansoni fatty acid-binding protein. Exp. Parasitol. 74:400-7
96. Ross SR, Graves RA, Greenstein A, Platt KA, Shyu HL, et al. 1990. A fat-specific enhancer is the primary determinant of gene expression for adipocyte P2 in vivo. Proc. Natl. Acad. Sci. USA 87:9590-94
97. Rottman JN, Gordon JI. 1993. Comparison of the patterns of expression of rat intestinal fatty acid binding protein/human growth hormone fusion genes in cultured intestinal epithelial cell lines and in the gut epithelium of transgenic mice. J. Biol. Chem. 268:11994-2002
98. Sacchettini JC, Gordon JI, Banaszak LJ. 1989. Refined apoprotein structure of rat intestinal fatty acid binding protein produced in Escherichia coli. Proc. Natl. Acad. Sci. USA 86:7736-40
99. Sachettini JC, Hauft SM, Van Camp SL, Cistola DP, Gordon JI. 1990. Developmental and structural studies of an intracellular lipid binding protein expressed in the ileal epithelium. J. Biol. Chem. 265:19199-207
100. Sacchettini JC, Scapin G, Gopaul D, Gordon JI. 1992. Refinement of the Structure of Escherichia coli-derived rat intestinal fatty acid binding protein with bound oleate to 1.75-Å resolution. Correlation with the structures of the apoprotein and the protein with bound palmitate. J Biol. Chem. 267:23534-45
101. Scapin G, Gordon JI, Sacchettini JC. 1992. Refinement of the structure of recombinant rat intestinal fatty acid-binding apoprotein at 1.2-Å resolution. J. Biol. Chem. 267:4253-69
102. Scapin G, Spadon P, Mammi M, Zanotti G, Monaco HL. 1990. Crystal structure of chicken liver basic fatty acid-binding protein at 2.7-Å resolution. Molec. Cell. Biochem. 98:95-99
103. Schleicher CH, Cordoba OL, Santome JA, Dell'Angelica EC. 1995. Molecular evolution of the multigene family of intracellular lipid-binding proteins. Biochem. Molec. Biol. Int. 36:1117-25
104. Deleted in proof
105. Schoonjans K, Staels B, Auwerx J. 1996. The peroxisome proliferator activated receptors (PPARs) and their effects on lipid metabolism and adipocyte differentiation. Biochim. Biophys. Acta-Lipids Lipid Metab. 1302:93-109
106. Sha RS, Kane CD, Xu Z, Banaszak LJ, Bernlohr DA. 1993. Modulation of ligand binding affinity of the adipocyte lipid-binding protein by selective mutation: analysis in vitro and in situ. J. Biol. Chem. 268:7885-92
107. Siegenthaler G, Hotz R, ChatellardGruaz D, Didierjean L, Hellman U, Saurat JH. 1994. Purification and characterization of the human epidermal fatty acid-binding protein: localization during epidermal cell differentiation in vivo and in vitro. Biochem. J. 302:363-71
108. Simon TC, Roth KA, Gordon JI. 1993. Use of transgenic mice to map cis-acting elements in the liver fatty acid-binding protein gene (Fabpl) that regulate its cell lineage-specific, differentiationdependent, and spatial patterns of expression in the gut epithelium and in the liver acinus. J Biol. Chem. 268:18345-58
109. Smith AF, Tsuchida K, Hanneman E, Suzuki TC, Wells MA. 1992. Isolation, characterization, and cDNA sequence of two fatty acid-binding proteins from the midgut of Manduca sexta larvae. J. Biol. Chem. 267:380-84
110. Sorof S. 1994. Modulation of mitogenesis by liver fatty acid binding protein. Cancer Metastasis Rev. 13:317-36
111. Steineger HH, Sorensen HN, Tugwood JD, Skrede S, Spydevold O, Gautvik KM. 1994. Dexamethasone and insulin demonstrate marked and opposite regulation of the steady-state mRNA level of the peroxisomal proliferator-activated receptor (PPAR) in hepatic cells. Hormonal modulation of fatty-acid-induced transcription. Eur. J. Biochem. 225:967-74
112. Storch J. 1993. Diversity of fatty acidbinding protein structure and function: studies with fluorescent ligands. Mol. Cell. Biochem. 123:45-53
113. Sweetser DA, Birkenmeier EH, Hoppe PC, McKeel DW, Gordon JI. 1988. Mechanisms underlying generation of gradients in gene expression within the intestine: an analysis using transgenic mice containing fatty acid binding protein-human growth hormone fusion genes. Genes Dev. 2:1318-32
114. Sweetser DA, Birkenmeier EH, Klisak U, Zollman S, Sparkes RS, et al. 1987. The human and rodent intestinal fatty acid binding protein genes. A comparative analysis of their structure, expression, and linkage relationships. J Biol. Chem. 262:16060-71
115. Sweetser DA, Hauft SM, Hoppe PC, Birkenmeier EH, Gordon JI. 1988. Transgenic mice containing intestinal fatty acid-binding protein-human growth hormone fusion genes exhibit correct regional and cell-specific expression of the reporter gene in their small intestine. Proc. Natl. Acad. Sci. USA 85:9611-15
116. Sweetser DA, Lowe JB, Gordon JI. 1986. The nucleotide sequence of the rat liver fatty acid-binding protein gene. Evidence that exon 1 encodes an oligopeptide domain shared by a family of proteins which bind hydrophobic ligands. J. Biol. Chem. 261:5553-61
117. Tataranni PA, Baier LJ, Paolisso G, Howard BV, Ravussin E. 1996. Role of lipids in development of noninsulindependent diabetes mellitus: lessons learned from Pima Indians. Lipids 31: S267-70
118. Thumser AEA, Voysey J, Wilton DC. 1996. Mutations of recombinant rat liver fatty acid-binding protein at residues 102 and 122 alter its structural integrity and affinity for physiological ligands. Biochem. J. 314:943-49
119. Tontonoz P, Hu E, Graves RA, Budavari AI, Spiegelman BM. 1994. mPPAR gamma 2: tissue-specific regulator of an adipocyte enhancer. Genes Dev. 8:1224-34
120. Treuner M, Kozak CA, Gallahan D, Grosse R, Muller T. 1994. Cloning and characterization of the mouse gene encoding mammary-derived growth inhibitor/ heart-fatty acid-binding protein. Gene 147:237-42
121. Tweedie S, Edwards Y. 1989. cDNA sequence for mouse heart fatty acid binding protein, H-FABP. Nucleic Acids Res. 17:4374
122. Umek RM, Friedman AD, McKnight SL. 1991. CCAAT-enhancer binding protein: a component of a differentiation switch. Science 251:288-92
123. Veerkamp JH, Maatman RGHJ. 1995. Cytoplasmic fatty acid-binding proteins: their structure and genes. Prog. Lipid Res. 34:17-52
124. Vidal-Puig A, Jimenez-Linan M, Lowell BB, Hamann A, Hu E, et al 1996. Regulation of PPAR gamma gene expression by nutrition and obesity in rodents. J. Clin. Invest. 97:2553-61
125. 125I]iodo-4-azido-N-hexadecylsalicylamide. Evidence for a role of fatty acid binding proteins in lipid uptake. J. Biol. Chem. 265:11417-20
126. Wedel A, Ziegler-Heitbrock HW. 1995. The C/EBP family of transcription factors, Immunobiology 193:171-85
127. Wen Y, Li GW, Chen P, Wong E, Bekhor I. 1995. Lens epithelial cell mRNA. II. Expression of a mRNA encoding a lipidbinding protein in rat lens epithelial cells. Gene 158:269-74
128. Williams SC, Cantwell CA, Johnson PF. 1991. A family of C/EBP-related proteins capable of forming covalently linked leucine zipper dimers in vitro. Genes Dev. 5:1553-67
129. Wilson R, Ainscough R, Anderson K, Baynes C, Berks M, et al. 1996. 2. 2 Mb of contiguous nucleotide sequence from chromosome III of C. elegans. Nature 368:32-38
130. Winter NS, Bratt JM, Banaszak LJ. 1993. Crystal structures of holo and apo-cellular retinol-binding protein II. J. Mol. Biol. 230:1247-59
131. Wu ZD, Bucher NLR, Farmer SR. 1996. Induction of peroxisome proliferatoractivated receptor gamma during the conversion of 3T3 fibroblasts into adipocytes is mediated by C/EBP-beta, C/EBP-delta, and glucocorticoids. Mol. Cell. Biol. 16:4128-36
132. Xu Z, Bernlohr DA, Banaszak LJ. 1992. Crystal structure of recombinant murine adipocyte lipid-binding protein. Biochemistry 31:3484-92
133. Xu Z, Bernlohr DA, Banaszak LJ. 1993. The adipocyte lipid-binding protein at 1.6-Å. Crystal structures of the apoprotein and with bound saturated and unsaturated fatty acids. J. Biol. Chem. 268:7874-84
134. Young ACM, Scapin G, Kromminga A, Patel SB, Veerkamp JH, Sacchettini JC. 1994. Structural studies on human muscle fatty acid binding protein at 1.4 Å resolution: binding interactions with three C18 fatty acids. Structure 2:523-34
135. Zanotti G, Scapin G, Spadon P, Veerkamp JH, Sacchettini JC. 1992. Three-dimensional structure of recombinant human muscle fatty acid-binding protein. J. Biol. Chem. 267:18541-50
136. Zschiesche W, Kleine AH, Spitzer E, Veerkamp JH, Glatz JF. 1995. Histochemical localization of heart-type fattyacid binding protein in human and murine tissues. Histochem. Cell Biol. 103:147-56
137. Zhu Y, Alvares K, Huang Q, Rao MS, Reddy JK. 1993. Cloning of a new member of the peroxisome proliferatoractivated receptor gene family from mouse liver. J. Biol. Chem. 268:26817-20