Caspase Inhibitors Attenuate 1-Methyl-4-Phenylpyridinium Toxicity in Primary Cultures of Mesencephalic Dopaminergic Neurons

Journal of Neuroscience

Volumn 22, Issue 7, 2002, Pages 2637-2649

  Bilsland, James ^a   Roy, Sophie ^b   Xanthoudakis, Steve ^b   Nicholson, Donald W ^b   Han, Yongxin ^b   Grimm, Erich ^b   Hefti, Franz ^a   Harper, Sarah J ^a  

^a NEUROSCIENCE RESEARCH CENTRE   (United Kingdom)

^b MERCK FROSST CENTRE FOR THERAPEUTIC RESEARCH   (Canada)

Author keywords

Apoptosis; Caspase; Dopaminergic neurons; MPP+; Neuroprotection; Parkinson's disease

Indexed keywords

1 METHYL 4 PHENYLPYRIDINIUM; BENZYLOXYCARBONYLASPARTYLGLUTAMYLVALYLASPARTYL FLUOROMETHYL KETONE; BENZYLOXYCARBONYLLEUCYLGLUTAMYLHISTIDYLASPARTYL FLUOROMETHYL KETONE; BENZYLOXYCARBONYLTYROSYLVALYLALANYLASPARTYL CHLOROMETHYL KETONE; BENZYLOXYCARBONYLVALYLALANYLASPARTYL FLUOROMETHYL KETONE; CASPASE 2; CASPASE 3; CASPASE 9; CASPASE INHIBITOR; UNCLASSIFIED DRUG; BENZYLOXYCARBONYLVALYL ALANYL ASPARTYL FLUOROMETHYL KETONE; BENZYLOXYCARBONYLVALYL-ALANYL-ASPARTYL FLUOROMETHYL KETONE; CASP3 PROTEIN, RAT; CASPASE; DOPAMINE; ENZYME INHIBITOR; NEUROPROTECTIVE AGENT; PEPTIDE CHLOROMETHYL KETONE; TYROSINE 3 MONOOXYGENASE;

ANIMAL CELL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL COUNT; CELL SURVIVAL; CHROMATIN; CONTROLLED STUDY; DOPAMINERGIC NERVE CELL; DRUG ACTIVITY; DRUG SCREENING; DRUG SELECTIVITY; ENZYME INHIBITION; MESENCEPHALON; MOLECULAR MECHANICS; NERVE CELL CULTURE; NERVE FUNCTION; NERVE REGENERATION; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; PARKINSON DISEASE; POLYMERIZATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SPECTRUM; ANIMAL; BIOSYNTHESIS; CELL CULTURE; CYTOLOGY; DOSE RESPONSE; DRUG ANTAGONISM; DRUG EFFECT; METABOLISM; NERVE CELL; NEURITE; PRENATAL DEVELOPMENT; SPRAGUE DAWLEY RAT; ULTRASTRUCTURE;

1-METHYL-4-PHENYLPYRIDINIUM; AMINO ACID CHLOROMETHYL KETONES; ANIMALS; CASPASE 3; CASPASES; CELL SURVIVAL; CELLS, CULTURED; DOPAMINE; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; MESENCEPHALON; NEURITES; NEURONS; NEUROPROTECTIVE AGENTS; PARKINSON DISEASE; RATS; RATS, SPRAGUE-DAWLEY; TYROSINE 3-MONOOXYGENASE;

EID: 0036549215     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.22-07-02637.2002     Document Type: Article

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