Synergistic effects of caspase inhibitors and MK-801 in brain injury after transient focal cerebral ischaemia in mice

British Journal of Pharmacology

Volumn 124, Issue 4, 1998, Pages 756-762

  Ma, Jianya ^a   Endres, Matthias ^a   Moskowitz, Michael A ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

Apoptosis; Focal cerebral ischaemia; ICE family caspases; MK 801; NMDA receptor

Indexed keywords

DIZOCILPINE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN INJURY; BRAIN ISCHEMIA; DRUG POTENTIATION; INTRAPERITONEAL DRUG ADMINISTRATION; MALE; MOUSE; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; CYSTEINE PROTEINASE INHIBITORS; DIZOCILPINE MALEATE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SYNERGISM; EXCITATORY AMINO ACID ANTAGONISTS; ISCHEMIC ATTACK, TRANSIENT; MALE; MICE; RECEPTORS, N-METHYL-D-ASPARTATE; TIME FACTORS;

EID: 0031806280     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0701871     Document Type: Article

References (48)

1. ALBERS, G.W., ATKINSON, R.P., KELLEY, R.E. & ROSENBAUM, D.M. (1995). Safety, tolerability, and pharmacokinetics of the N-methyl-D-aspartate antagonist dextrophan in patients with acute stroke. Stroke, 26, 254-258.
2. ALNEMRI, E.S., LIVINGSTON, D.J., NICHOLSON, D.W., SALVESEN, G., THORNBERRY, N.A., WONG, W.W. & YUAN, J. (1996). Human ICE/CED-3 protease nomenclature. Cell, 87, 171.
3. AYATA, C., AYATA, G., HARA, H., MATTHEWS, R.T., BEAL, M.F., FERRANTE, R.J., ENDRES, M., KIM, A., CHRISTIE, R., WAEBER, C., HUANG, P.L., HYMAN, B.T. & MOSKOWITZ, M.A. (1997). Mechanisms of reduced striatal NMDA excitotoxicity in type I nitric oxide synthase knock-out mice. J Neurosci., 17, 6908-6917.
4. BEDERSON, J.B., PITTS, L.H., TSUJI, M., NISHIMURA, M.C., DAVIS, R.L. & BARTKOWSKI, H.M. (1986). Rat middle cerebral artery occlusion: evaluation of the model and development of a quantification of experimental cerebral infarction in rats. Stroke, 17, 472-476.
5. BONFOCO, E., KRAINC, D., ANKARCRONA, M., NICOTERA, P. & LIPTON, S.A. (1995). Apoptosis and necrosis: two distinct events induced, respectively, by mild and intense insults with N-methyl-D-aspartate or nitric oxide/superoxide in cortical cell cultures. Proc. Natl. Acad. Sci. U.S.A., 92, 7162-7166.
6. BUCHAN, A.M., LI, H. & PULSINELLI, W.A. (1991). The N-methyl-D-aspartate antagonist, MK-801, fails to protect against neuronal damage caused by transient, severe forebrain ischemia in adult rats. J. Neurosci., 11, 1049-1056.
7. BUCHAN, A.M., SLIVKA, A. & XUE, D. (1992). The effect of the NMDA receptor antagonist MK-801 on cerebral blood flow and infarct volume in experimental focal stroke. Brain Res., 574, 171-177.
8. CHARRIAUT-MARLANGUE, C., MARGAILL, I., REPRESA, A., POPOVICI, T., PLOTKINE, M. & BEN-ARI, Y. (1996). Apoptosis and necrosis after reversible focal ischemia: an in situ DNA fragmentation analysis. J. Cereb. Blood Flow Metab., 16, 186-194.
9. CHOI, D.W. (1992). Excitotoxic cell death. J. Neurobiol., 23, 1261-1267.
10. CHOI, D.W. (1996). Ischemia-induced neuronal apoptosis. Curr. Opin. Neurobiol., 6, 667-672.
11. DEUTSCH, S.I., MASTROPAOLO, J., SCHWARTZ, B.L., ROSSE, R.B. & MORIHISA, J.M. (1989). A "glutamatergic hypothesis" of schizophrenia: rationale for pharmacotherapy with glycine. Clin. Neuropharmacol., 12, 1-13.
12. DEZSI, L., GREENBERG, J.H., HAMAR, J., SLADKY, J., KARP, A. & REIVICH, M. (1992). Acute improvement in histological outcome by MK-801 following focal cerebral ischemia and reperfusion in the cat independent of blood flow changes. J. Cereb. Blood Flow Metab., 12, 390-399.
13. DIRNAGL, U., TANABE, J. & PULSINELLI, W. (1990). Pre- and post-treatment with MK-801 but not pretreatment alone reduces neocortical damage after focal cerebral ischemia in the rat. Brain Res., 527, 62-68.
14. DU, C., HU, R., CSERNANSKY, C.A., HSU, C.Y. & CHOI, D.W. (1996a). Very delayed infarction after mild focal cerebral ischemia: A role for apoptosis? J. Cereb. Blood Flow Metab., 16, 195-201.
15. DU, C., HU, R., CSERNANSKY, C.A., LIU, X.Z., HSU, C.Y. & CHOI, D.W. (1996b). Additive neuroprotective effects of dextrophan and cycloheximide in rats subjected to transient focal cerebral ischemia. Brain Res., 718, 233-236.
16. ELLIS, R.E., YUAN, J. & HORVITZ, H.R. (1991). Mechanisms and functions of cell death. Ann. Rev. Cell Biol., 7, 663-698.
17. ENDRES, M., NAMURA, S., SHIMIZU-SASAMATA, M., WAEBER, C., ZHANG, L., GOMEZ-ISLA, T., HYMAN, B. & MOSKOWITZ, M.A. (1998). Attenuation of delayed neuronal death after mild focal ischemia by inhibitors of the caspase family. J. Cerebr. Blood Flow Metab., 18, 238-247
18. FIX, A.S., HORN, J.W., WIGHTMAN, K.A., JOHNSON, C.A., LONG, G.G., STORTS, R.W., FARBER, N., WOZNIAK, D.F. & OLNEY, J.W. (1993). Neuronal vacuolization and necrosis induced by the noncompetitive N-methyl-D-aspartate (NMDA) antagonist MK(+)801 (Dizocilpine Maleate): A light and electron microscope evaluation of the rat retrosplenial cortex. Exp. Neurol., 123, 204-215.
19. FRIEDLANDER, R.M., GAGLIARDINI, V., HARA, H., FINK, K.B., LI, W., MACDONALD, G., FISHMAN, M.C., GREENBERNG, A.H., MOSKOWITZ, M.A. & YUAN, J. (1997). Expression of a dominant negative mutant of ICE in transgenic mice prevents neuronal cell death induced by trophic factor withdrawal and ischemic brain injury. J. Exp. Med., 185, 933-940.
20. GILL. R. & WOODRUFF, G.N. (1990). The neuroprotective actions of kynurenic acid and MK-801 in gerbils are synergistic and not related to hypothermia. Eur. J. Pharmacol., 176, 143-149.
21. GOTTI, B., BENAVIDES, J., MACKENZIE, E.T. & SCATTON, B. (1990). The pharmacotherapy of focal cerebral ischemia in the mouse. Brain Res., 522, 290-307.
22. HAKA, H., FINK, K., ENDRES, M., FRIEDLANDER, R.M., GAGLIARDINI, V., YUAN, J. & MOSKOWITZ, M.A. (1997a). Attenuation of transient focal cerebral ischemic injury in transgenic mice expressing a mulant ICE inhibitory protein. J. Cereb. Blood Flow Metab., 17, 370-375.
23. HARA, H., FRIEDLANDER, R.M., GAGLIARDIDI, V., AYATA, C., FINK, K., HUANG, Z., SASAMATA, M.S., YUAN, J. & MOSKOWITZ, M.A. (1997b). Inhibition of interleukin 1β converting enzyme family proteases reduces ischemic and excitotoxic neuronal damage. Proc. Natl. Acad. Sci. U.S.A., 94, 2007-2012.
24. HARA, H., HUANG, P.L., PANAHIAN, N., FISHMAN, M.C. & MOSKOWITZ, M.A. (1996). Reduced brain edema and infarction volume in mice lacking the neuronal isoform of nitric oxide synthase after transient MCA occlusion. J. Cereb. Blood Flow Metab., 16, 605-611.
25. HATFIELD, R.H., GILL, R. & BRAZELL, C. (1992). The dose response relationship and therapeutic window for dizocilpine (MK-801) in a rat focal ischemia model. Eur. J. Pharmacol., 216, 1-7.
26. HAWKINSON, J.E., HUBER, K.R., SAHOTA, P.S., HSU, H.H., WEBER, E. & WHITEHOUSE, M.J. (1997). The N-methyl-D-aspartate (NMDA) receptor glycine site antagonist ACEA 1021 does not produce pathological changes in the rat brain. Brain Res., 744, 227-234.
27. HUANG, Z., HUANG, P.L., PANAHIAN, N., DALKARA, T., FISHMAN, M.C. & MOSKOWITZ, M.A. (1994). Effects of cerebral ischemia in mice deficient in neuronal nitric oxide synthase. Science. 265, 1883-1885.
28. LI, Y., CHOPP, M., JIANG, N. & ZALOGA, C. (1995a). In situ detection of DNA fragmentation after focal ischemia in mice. Mol. Brain Res., 28, 164-168.
29. LI, Y., CHOPP, M., JIANG, N., ZHANG, Z.G. & ZALOGA, C. (1995b). Induction of DNA fragmentation after 10-120 minutes of focal cerebral ischemia in rats. Stroke. 26, 1252-1257.
30. LI, Y., CHOPP, M., JIANG, N., ZHANG, Z.G., & ZALOGA, C. (1995c). Temporal profile of in situ DNA fragmentation after transient middle cerebral artery occlusion in the rat. J. Cereb. Blood Flow Metab., 15, 389-397.
31. LINNIK, M.D., MILLER, C.A., CAVALLO, J.S., MASON, P.J., THOMPSON, F.Y., MONTGOMERY, L.R. & SCHROEDER, K.K. (1995). Apoptotic DNA fragmentation in the rat cerebral cortex induced by permanent middle cerebral artery occlusion. Mol. Brain. Res., 32, 116-124.
32. MACDERMOTT, A.B., MAYER, M.L., WESTBROOK, G.L., SMITH, S.J. & BARKER, J.L (1986). NMDA-receptor activation increases cytoplasmic calcium concentration in cultured spinal cord neurons. Nature, 321, 519-522.
33. MACMANUS, J.P., HILL, L.E., HUANG, Z.G., RANSQUINHA, I., XUE, D. & BUCHAN, A.M. (1995a). DNA damage consistent with apoptosis in transient focal ischaemic neocortex. Mol. Neurosci., 5, 93-496.
34. MACMANUS, J.P., HILL, L.E., PRESTON, E., RASQUINHA, I., WALKER, T. & BUCHAN, A.M. (1995b). Differences in DNA fragmentation following transient cerebral or decapitation ischemia in rats. J. Cereb. Blood Flow Metab., 15, 728-737.
35. MARGAILL, I., PARMENTIER, S., CALLEBERT, J. ALLIX, M., BOULU, R.G. & PLOTKIN, M. (1996). Short therapeutic window for MK-801 in transient focal cerebral ischemia in normotensive rats. J. Cereb. Blood Flow Metab., 16, 107-113.
36. NAMURA, S., ZHU, J., FINK, K., ENDRES, M., TOMASELLI, K.J., SRINIVASAN, A., YUAN, J. & MOSKOWITZ, M.A. (1997). CPP32 activation in neuronal apoplosis after transient focal cerebral ischemia in mice. Soc. Neurosci. Abstr., 23, 336-339.
37. NAMURA, S., ZHU, J., LINK, K., ENDRES, M., SRINIVASAN, A., TOMASELLI, K.J., YUAN, J. & MOSKOWITZ, M.A. (1998). Activation and cleavage of caspase-3 in apoptosis induced by experimental cerebral ischemia. J Neurosci. In press.
38. ÖNAL, M.Z., FUHAL, I., TALISUMAK, T., LOCKE, K.W., SANDAGE, B.W. & FISHER, M. (1997). Synergistic effects of citicoline and MK-801 in temporary experimental focal ischemia in rats. Stroke. 28, 1060-1065.
39. OLIFE, H.S., MAREK, P., MIYAZAKI, B. & WEBER, E. (1996). The neuroprotective efficacy of MK-801 in focal cerebral ischemia varies with rat strain and vendor. Brain Res., 731, 208-212.
40. OLNEY, J.W., LABRUYERE, J. & PRICE, M.T. (1989). Pathological changes induced in cerebrocortical neurons by phencyclidine and related drugs. Science. 244, 1360-1362.
41. PARK, C.K., NEHLS, D.G., GRAHAM, D.I., TESDALE, G.M. & MCCILLOCH, J. (1988a). The glutamate antagonist MK-801 reduces focal ischemic brain damage in the rat. Ann. Neurol., 24, 43-51.
42. PARK, C.K., NEHLS, D.G., GRAHAM, D.I., TESDALE, G.M. & MCCULLOCH, J. (1988b). Focal cerebral ischemia in the cat: treatment with the glutamate antagonist MK-801 after induction of ischemia. J. Cereb. Blood Flow Metab., 8, 757-762.
43. SCHULZ, J.B., MATTHEWS, R.T., WÜLLNER, U., BREMEN, D., LOMMARTZSCH, J., WELLER, M., BEAL, M.F., DICHGANS, J. & KLOCKGETHER, T. (1997). Synergistic neuroprotective effects of MK-801 and delayed administration of ZVAD.FMK, a caspase inhibitor, for treatment of cerebral histotoxic hypoxia in vivo. Soc. Neurosci. Abstr. 23, 1390.
44. STEINBERG, G.K., KUNIS, D., SALEH, J. & DELAPAZ, R. (1991). Protection after transient focal ischemia by the N-methyl-D-aspartate antagonist dextrorphan is dependent upon plasma and brain levels. J. Cereb. Blood Flow Metab., 11, 1015-1024.
45. WYLLIE, A.H., KERR, J.E.R. & CURRIE, A.R. (1980). Cell death; the significance of apoptosis. Int. Rev. Cytol., 68, 251-306.
46. YAO, H., GINSBERG, M.D., WATSON, B.D., PRADO, R., DIETRICH, W.D., KRAYDIEH, S. & BUSTO, R. (1993). Failure of MK-801 to reduce infarct volume in thrombotic middle cerebral artery occlusion in rats. Stroke. 24, 864-870.
47. YUAN, J. & HORVITZ, H.R. (1990). The Caenorhabditis elegans genes ced-3 and ced-4 act cell autonomously to cause programmed cell death. Develop. Biol., 138, 33-41.
48. YUAN, J., SHAHAM, S., LEDOUX, S., ELLIS, H.M. & HORVITZ, H.R. (1993). The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1β-converting enzyme. Cell. 75, 641-652.