MPP + induced SH-SY5Y apoptosis is potentiated by cyclosporin A and inhibited by aristolochic acid

Brain Research

Volumn 811, Issue 1-2, 1998, Pages 143-146

  Fall, Christopher P ^a   Bennett Jr , James P ^a  

^a UNIVERSITY OF VIRGINIA HEALTH SYSTEM   (United States)

Author keywords

Apoptosis; Aristolochic acid; Cyclosporin; Mitochondrial transition pore

Indexed keywords

1 METHYL 4 PHENYLPYRIDINIUM; ARISTOLOCHIC ACID; CYCLOSPORIN A; N METHYLPYRIDINIUM; NEUROTOXIN; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CONTROLLED STUDY; HUMAN; HUMAN CELL; MITOCHONDRIAL MEMBRANE; NEUROBLASTOMA CELL; PARKINSONISM; PRIORITY JOURNAL;

1-METHYL-4-PHENYLPYRIDINIUM; APOPTOSIS; ARISTOLOCHIC ACIDS; CYCLOSPORINE; DRUG SYNERGISM; ENZYME INHIBITORS; MITOCHONDRIA; NEURONS; PHENANTHRENES; PHOSPHOLIPASES A; TUMOR CELLS, CULTURED;

EID: 0032539085     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(98)00879-8     Document Type: Article

References (8)

1. Broekemeier K.M., Pfeiffer D.R. Inhibition of the mitochondrial permeability transition by cyclosporin A during long time frame experiments: relationship between pore opening and the activity of mitochondrial phospholipases. Biochemistry. 34:1995;16440-16449.
2. Darzynkiewicz Z., Juan G., Li X., Gorczyca W., Murakami T., Traganos F. Cytometry in cell necrobiology: analysis of apoptosis and accidental cell death (necrosis). Cytometry. 27:1997;1-20.
3. Moreno J.J. Effect of aristolochic acid on arachidonic acid cascade and in vivo models of inflammation. Immunopharmacology. 26:1993;1-9.
4. Pastorino J.G., Simbula G., Yamamoto K., Glascott P.A. Jr., Rothman R.J., Farber J.L. The cytotoxicity of tumor necrosis factor depends on induction of the mitochondrial permeability transition. Journal of Biological Chemistry. 271:1996;29792-29798.
5. Snyder J.W., Pastorino J.G., Attie A.M., Farber J.L. Protection by cyclosporin A of cultured hepatocytes from the toxic consequences of the loss of mitochondrial energization produced by 1-methyl-4-phenylpyridinium. Biochemical Pharmacology. 44:1992;833-835.
6. Zamzami N., Marchetti P., Castedo M., Hirsch T., Susin S.A., Masse B., Kroemer G. Inhibitors of permeability transition interfere with the disruption of the mitochondrial transmembrane potential during apoptosis. FEBS Letters. 384:1996;53-57.
7. Zamzami N., Susin S.A., Marchetti P., Hirsch T., Gomez-Monterrey I., Castedo M., Guido K. Mitochondrial control of nuclear apoptosis. Journal of Experimental Medicine. 183:1996;1533-1544. see comments.
8. Zoratti M., Szabo I. The mitochondrial permeability transition. Biochimica et Biophysica Acta. 1241:1995;139-176.