Antifertility vaccines

Trends in Immunology

Volumn 23, Issue 4, 2002, Pages 213-219

  Delves, Peter J ^a   Lund, Torben ^a   Roitt, Ivan M ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGEN; CHORIONIC GONADOTROPIN ANTIBODY; CHORIONIC GONADOTROPIN BETA SUBUNIT; CONTRACEPTIVE VACCINE; FERTILIZATION ANTIGEN 1; FOLLITROPIN; GONADORELIN; HYALURONIDASE; INHIBIN; INTERLEUKIN 4; INTERLEUKIN 5; INTERLEUKIN 6; LACTATE DEHYDROGENASE ISOENZYME; LUTEINIZING HORMONE; PIG ZONA PELLUCIDA ANTIGEN; RIBOFLAVIN BINDING PROTEIN; SECRETORY IMMUNOGLOBULIN; SPERM AGGLUTINATION ANTIGEN 1; SPERM ANTIBODY; SPERM ANTIGEN; SPERM PROTEIN 17; UNCLASSIFIED DRUG; ZONA PELLUCIDA GLYCOPROTEIN B;

ANTIBODY PRODUCTION; ANTIBODY RESPONSE; ANTIBODY SPECIFICITY; AUTOIMMUNITY; BIRTH CONTROL; CLINICAL TRIAL; DRUG EFFECT; DRUG EFFICACY; FERTILITY; HUMAN; IMMUNIZATION; IMMUNOCONTRACEPTION; IMMUNOGENICITY; NONHUMAN; REVIEW; SPERMATOZOON; VACCINATION;

ANIMALS; AUTOANTIBODIES; CHORIONIC GONADOTROPIN; CONTRACEPTION, IMMUNOLOGIC; FAMILY PLANNING SERVICES; FEMALE; HUMANS; IMMUNOGLOBULIN A; MALE; MICE; MODELS, ANIMAL; MODELS, BIOLOGICAL; OOCYTES; RATS; SPERMATOZOA; VACCINES, CONTRACEPTIVE;

EID: 0036533595     PISSN: 14714906     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1471-4906(02)02182-8     Document Type: Review

References (61)

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4. Vaccine for contraceptive targeting sperm
5. Transcutaneous immunization induces mucosal and systemic immunity: A potent method for targeting immunity to the female reproductive tract
6. Intranasal immunization with CpG oligodeoxynucleotides as an adjuvant dramatically increases IgA and protection against herpes simplex virus 2 in the genital tract
7. Autoimmune diseases
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12. 4 as a contraceptive vaccine
13. A chimeric sperm peptide induces antibodies and strain-specific reversible infertility in mice
14. Mechanism of infertility in male guinea pigs immunized with sperm PH-20
15. Effect of immunization with synthetic peptide corresponding to region 1-17 of human seminal plasma inhibin on fertility of male rats
16. Cytokine enhancement of immune responses important for immunocontraception
17. RASA, a recombinant single-chain variable fragment (scFv) antibody directed against the human sperm surface: Implications for novel contraceptives
18. A combinatorial phage-display library for the generation of specific Fab fragments recognizing human spermatozoa and inhibiting fertilizing capacity in vitro
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20. Therapy of mucosal candidiasis by expression of an anti-idiotype in human commensal bacteria
21. Immunocontraception in feral horses: One inoculation provides one year of infertility
22. Immunocontraception of African elephants
23. Immunization of monkeys with recombinant complementary deoxyribonucleic acid expressed zona pellucida proteins
24. Failure of female baboons (Papio anubis) to conceive following immunization with recombinant nonhuman primate zona pellucida glycoprotein B expressed in Escherichia coli
25. The contraceptive potential of ZP3 and ZP3 peptides in a primate model
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27. Primate response to immunization with a homologous zona pellucida peptide
28. Effectiveness of zona pellucida protein ZPB as an immunocontraceptive antigen
29. A zona pellucida peptide vaccine induces antibodies and reversible infertility without ovarian pathology
30. A contraceptive peptide vaccine targeting sulfated glycoprotein ZP2 of the mouse zona pellucida
31. Delineation of a conserved B-cell epitope on Bonnet monkey (Macaca radiata) and human zona pellucida glycoprotein B by monoclonal antibodies demonstrating inhibition of sperm-egg binding
32. Analysis of B-cell epitopes of a glycoprotein porcine zona pellucida (pZP1)
33. Selection of peptides targeting the human sperm surface using random peptide phage display identify ligands homologous to ZP3
34. Conversion of poorly immunogenic malaria repeat sequences into a highly immunogenic vaccine candidate
35. Engineering vaccines with heterologous B- and T-cell epitopes using immunoglobulin genes
36. Antibodies to human ZP3 induce reversible contraception in transgenic mice with 'humanized' zonae pellucidae
37. 2 Prospects of riboflavin carrier protein (RCP) as an antifertility vaccine in male and female mammals
38. Immunocontraceptive potential of major antigenic determinants of chicken riboflavin carrier protein in the female rat
39. Immunoneutralisation of gonadotrophin-releasing hormone: A potential treatment for oestrogen-dependent breast cancer
40. New GnRH-like peptide construct to optimize efficient immunocastration of male pigs by immunoneutralization of GnRH
41. Immunocontraception of white-tailed deer with GnRH vaccine
42. Is FSH-based contraceptive vaccine a feasible proposition for the human male?
43. The suitability of human chorionic gonadotropin (hCG)-based birth-control vaccines
44. Human chorionic gonadotropin β-subunit gene expression in cultured human fetal and cancer cells of different types and origins
45. In vitro development of in-vivo-produced rhesus monkey morulae and blastocysts to hatched, attached and post-attached blastocyst stages: Morphology and early secretion of chorionic gonadotrophin
46. Embryonic signals during the peri-implantation period in primates
47. Antifertility vaccines
48. Immunological hazards associated with vaccination of humans
49. Assays of antibodies to a C-terminal peptide or the entire β-subunit of human chorionic gonadotropin
50. Immunogenicity of a fusion protein linking the β-subunit carboxyl terminal peptide (CTP) of human chorionic gonadotropin to the B-subunit of Escherichia coli heat-labile enterotoxin (LTB)
51. Enhanced immunogenicity of a contraceptive vaccine using diverse synthetic carriers with permissible adjuvant
52. Immune-stimulating activity of two new chitosan-containing adjuvant formulations
53. High expression of human chorionic gonadotrophin β-subunit using a synthetic vaccinia virus promoter
54. Reversible protection of disulfide bonds followed by oxidative folding render recombinant hCGβ highly immunogenic
55. Absence of corpus luteum rescue by chorionic gonadotropin in women immunized with a contraceptive vaccine
56. Can epitope-focused vaccines select advantageous immune responses?
57. Epitope-specific focusing of the immune response to a minimized human chorionic gonadotropin analog
58. Identification and selective destruction of shared epitopes in human chorionic gonadotropin β-subunit
59. Refocusing of B-cell responses following a single amino acid substitution in an antigen
60. Elimination of luteinizing hormone cross-reactive epitopes from human chorionic gonadotropin