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Volumn 31, Issue 1-2, 1996, Pages 21-36

Identification and selective destruction of shared epitopes in human chorionic gonadotropin beta subunit

Author keywords

Epitope; Epitope specific vaccine; hCG; hLH; Mutagenesis; Protein engineering

Indexed keywords

ARGININE; CHORIONIC GONADOTROPIN BETA SUBUNIT; CONTRACEPTIVE VACCINE; EPITOPE; GLUTAMIC ACID; GLYCINE; HISTIDINE; LUTEINIZING HORMONE; MONOCLONAL ANTIBODY; SERINE; VALINE;

EID: 0030220279     PISSN: 01650378     EISSN: None     Source Type: Journal    
DOI: 10.1016/0165-0378(96)00978-3     Document Type: Article
Times cited : (35)

References (26)
  • 1
    • 0026488690 scopus 로고
    • Structural basis of antigenic specificity and design of new vaccines
    • Arnon, R. and Van-Regenmortel, M.H. (1992) Structural basis of antigenic specificity and design of new vaccines. FASEB J. 6, 3265-3274.
    • (1992) FASEB J. , vol.6 , pp. 3265-3274
    • Arnon, R.1    Van-Regenmortel, M.H.2
  • 2
    • 0025232722 scopus 로고
    • Monoclonal antibodes against the free subunits of human chorionic gonadotrophin
    • Berger, P., Klieber, R., Panmoung, W., Madersbacher, S., Wolf, H. and Wick, G. (1990) Monoclonal antibodes against the free subunits of human chorionic gonadotrophin. J. Endocrinol. 125, 301-309.
    • (1990) J. Endocrinol. , vol.125 , pp. 301-309
    • Berger, P.1    Klieber, R.2    Panmoung, W.3    Madersbacher, S.4    Wolf, H.5    Wick, G.6
  • 3
    • 0021948345 scopus 로고
    • Identification of epitopes associated with hCG and the βhCG carboxyl terminus by monoclonal antibodies produced against a synthetic peptide
    • Bidart, J.M., Ozturk, M., Bellet, D.H., Jolivet, M., Gras-Masse, H., Troalen, F., Bohuon, C.J. and Wands, J.R. (1985) Identification of epitopes associated with hCG and the βhCG carboxyl terminus by monoclonal antibodies produced against a synthetic peptide. J. Immunol. 134, 457-464.
    • (1985) J. Immunol. , vol.134 , pp. 457-464
    • Bidart, J.M.1    Ozturk, M.2    Bellet, D.H.3    Jolivet, M.4    Gras-Masse, H.5    Troalen, F.6    Bohuon, C.J.7    Wands, J.R.8
  • 4
    • 0029125838 scopus 로고
    • The groove between the α-and β-subunits of hormones with lutropin (LH) activity appears to contact the LH receptor, and its conformation is changed during hormone binding
    • Cosowsky, L., Venkateswara, R., Macdonald, G.J., Papkoff, H., Campbell, R.K. and Moyle, W.R. (1995) The groove between the α-and β-Subunits of hormones with lutropin (LH) activity appears to contact the LH receptor, and its conformation is changed during hormone binding. J. Biol. Chem. 270(34), 20011-20019.
    • (1995) J. Biol. Chem. , vol.270 , Issue.34 , pp. 20011-20019
    • Cosowsky, L.1    Venkateswara, R.2    Macdonald, G.J.3    Papkoff, H.4    Campbell, R.K.5    Moyle, W.R.6
  • 5
    • 0027449147 scopus 로고
    • Functional and immunological relevance of the COOH-terminal extension of human chorionic gonadotropin β: Implications for the WHO birth control vaccine
    • Dirnhofer, S., Klieber, R., De-Leeuw, R., Bidart, J.M., Merz, W.E., Wick, G. and Berger, P. (1993) Functional and immunological relevance of the COOH-terminal extension of human chorionic gonadotropin β: implications for the WHO birth control vaccine. FASEB. J. 7. 1381-1385.
    • (1993) FASEB. J. , vol.7 , pp. 1381-1385
    • Dirnhofer, S.1    Klieber, R.2    De-Leeuw, R.3    Bidart, J.M.4    Merz, W.E.5    Wick, G.6    Berger, P.7
  • 6
    • 0028205097 scopus 로고
    • The molecular basis for epitopes on the free β-subunit of human chorionic gonadotrophin its carboxyl-terminal peptide and the hCGβ-core fragment
    • Dirnhofer, S., Madersbacher, S., Bidart, J.M., Ten-Kortenaar, P.B., Spottl, G., Mann, K., Wick, G., Berger, P. et al. (1994) The molecular basis for epitopes on the free β-subunit of human chorionic gonadotrophin its carboxyl-terminal peptide and the hCGβ-core fragment. J. Endocrinol. 141, 153-162.
    • (1994) J. Endocrinol. , vol.141 , pp. 153-162
    • Dirnhofer, S.1    Madersbacher, S.2    Bidart, J.M.3    Ten-Kortenaar, P.B.4    Spottl, G.5    Mann, K.6    Wick, G.7    Berger, P.8
  • 7
    • 0027609916 scopus 로고
    • SETOR: Hardware-lighted three-dimensional solid model representations of macromolecules
    • Evans, S.V. (1993) SETOR: hardware-lighted three-dimensional solid model representations of macromolecules. J. Mol. Graphics 11, 134-138
    • (1993) J. Mol. Graphics , vol.11 , pp. 134-138
    • Evans, S.V.1
  • 8
    • 0002447044 scopus 로고
    • (McPherson, M.J., Ed.). IRL Press, Oxford, UK
    • Horton, R.M. and Pease, L.R. (1991) In: Directed Mutagenesis (McPherson, M.J., Ed.). p. 217. IRL Press, Oxford, UK.
    • (1991) Directed Mutagenesis , pp. 217
    • Horton, R.M.1    Pease, L.R.2
  • 9
    • 0026675750 scopus 로고
    • High resolution functional analysis of antibody-antigen interactions
    • Jin, L., Fendly, B.M. and Wells, J.A. (1992) High resolution functional analysis of antibody-antigen interactions. J. Mol. Biol. 226, 851-865.
    • (1992) J. Mol. Biol. , vol.226 , pp. 851-865
    • Jin, L.1    Fendly, B.M.2    Wells, J.A.3
  • 12
    • 0027524738 scopus 로고
    • Dominant determinants in hen eggwhite lysozyme correspond to the cryptic determinants within its self-homologue, mouse lysozyme: Implications in shaping of the T cell repertoire and autoimmunity
    • Moudgil, K.D. and Sercarz, E.E. (1993) Dominant determinants in hen eggwhite lysozyme correspond to the cryptic determinants within its self-homologue, mouse lysozyme: implications in shaping of the T cell repertoire and autoimmunity. J. Exp. Med. 178, 2131-2138.
    • (1993) J. Exp. Med. , vol.178 , pp. 2131-2138
    • Moudgil, K.D.1    Sercarz, E.E.2
  • 13
    • 0025309387 scopus 로고
    • Localization of residues that confer antibody binding specificity using human chorionic gonadotropin/luteinizing hormone β subunit chimeras and mutants
    • Moyle, W.R., Matzuk, M.M., Campbell, R.K., Coglian, E., Dean-Emig, D.M., Krichevsky, A., Barnett, R.W. and Boime, I. (1990) Localization of residues that confer antibody binding specificity using human chorionic gonadotropin/luteinizing hormone β subunit chimeras and mutants. J. Biol. Chem. 265, 8511-8518.
    • (1990) J. Biol. Chem. , vol.265 , pp. 8511-8518
    • Moyle, W.R.1    Matzuk, M.M.2    Campbell, R.K.3    Coglian, E.4    Dean-Emig, D.M.5    Krichevsky, A.6    Barnett, R.W.7    Boime, I.8
  • 14
    • 0024044173 scopus 로고
    • Genetic analysis of monoclonal antibody and HIV binding sites on the human lymphocyte antigen CD4
    • Peterson, A. and Seed, B. (1988) Genetic analysis of monoclonal antibody and HIV binding sites on the human lymphocyte antigen CD4. Cell 54, 65-72.
    • (1988) Cell , vol.54 , pp. 65-72
    • Peterson, A.1    Seed, B.2
  • 16
    • 0018664643 scopus 로고
    • Immunogenicity of three C-terminal synthetic peptides of the beta subunit of human chorionic gonadotropin and properties of the antibodies raised against 45-amino acid C-terminal peptide
    • Ramakrishnan, S., Das, C., Dubey, S.K., Salahuddin, M. and Talwar, G.P. (1979) Immunogenicity of three C-terminal synthetic peptides of the beta subunit of human chorionic gonadotropin and properties of the antibodies raised against 45-amino acid C-terminal peptide. J. Reprod. Immunol. 1, 249-261.
    • (1979) J. Reprod. Immunol. , vol.1 , pp. 249-261
    • Ramakrishnan, S.1    Das, C.2    Dubey, S.K.3    Salahuddin, M.4    Talwar, G.P.5
  • 17
    • 0028913014 scopus 로고
    • Structure of the brain-derived neurotrophic factor neurotrophin 3 heterodimer
    • Robinson, R.C., Radziejewski, C., Stuart, D.I. and Jones, E.Y. (1995) Structure of the brain-derived neurotrophic factor neurotrophin 3 heterodimer. Biochemistry 34, 4139-4146.
    • (1995) Biochemistry , vol.34 , pp. 4139-4146
    • Robinson, R.C.1    Radziejewski, C.2    Stuart, D.I.3    Jones, E.Y.4
  • 18
    • 0024604803 scopus 로고
    • Basic concepts and new aspects of vaccine development
    • Roitt, I.M. (1989) Basic concepts and new aspects of vaccine development. Parasitology 98, S7-S12.
    • (1989) Parasitology , vol.98
    • Roitt, I.M.1
  • 19
    • 0022636581 scopus 로고
    • The antigenic surface of human chorionic gonadotropin as mapped by murine monoclonal antibodies
    • Schwarz, S., Berger, P. and Wick, G. (1986) The antigenic surface of human chorionic gonadotropin as mapped by murine monoclonal antibodies. Endocrinology 118, 189-197.
    • (1986) Endocrinology , vol.118 , pp. 189-197
    • Schwarz, S.1    Berger, P.2    Wick, G.3
  • 20
    • 0000820364 scopus 로고
    • Molecular cloning of the human CD2 antigen by a rapid immunoselection procedure
    • Seed, B. and Aruffo, A. (1987) Molecular cloning of the human CD2 antigen by a rapid immunoselection procedure. Proc. Nat. Acad. Sci. USA 84, 3365-3369.
    • (1987) Proc. Nat. Acad. Sci. USA , vol.84 , pp. 3365-3369
    • Seed, B.1    Aruffo, A.2
  • 21
    • 0021265260 scopus 로고
    • Evolution of the genes for the beta subunits of human chorionic gonadotropin and luteinizing hormone
    • Talmadge, K., Vamvakopoulos, N.C. and Fiddes, J.C. (1984) Evolution of the genes for the beta subunits of human chorionic gonadotropin and luteinizing hormone. Nature 307, 37-40.
    • (1984) Nature , vol.307 , pp. 37-40
    • Talmadge, K.1    Vamvakopoulos, N.C.2    Fiddes, J.C.3
  • 23
    • 0027992834 scopus 로고
    • Immuno-contraception
    • Talwar, G.P. (1994). Immuno-contraception. Curr. Opin. Immunol. 6 (5), 698-704.
    • (1994) Curr. Opin. Immunol. , vol.6 , Issue.5 , pp. 698-704
    • Talwar, G.P.1
  • 24
    • 0022443638 scopus 로고
    • A surrogate hepatitis B virus antigenic epitope represented by a synthetic peptide and internal image anti-idiotype antibody
    • Thanavala, Y.M., Brown, S.E., Howard, C.R., Roitt, I.M. and Steward, M.W. (1986) A surrogate hepatitis B virus antigenic epitope represented by a synthetic peptide and internal image anti-idiotype antibody. J. Exp. Med. 164, 227-236.
    • (1986) J. Exp. Med. , vol.164 , pp. 227-236
    • Thanavala, Y.M.1    Brown, S.E.2    Howard, C.R.3    Roitt, I.M.4    Steward, M.W.5
  • 25
    • 0024520825 scopus 로고
    • A surface antigen of T. cruzi that mimics mammalian nerve tissue
    • Van Voorhis, W.C. and Eisen, H. (1989) A surface antigen of T. cruzi that mimics mammalian nerve tissue. J. Exp. Med. 169, 641-652.
    • (1989) J. Exp. Med. , vol.169 , pp. 641-652
    • Van Voorhis, W.C.1    Eisen, H.2
  • 26
    • 0028773646 scopus 로고
    • Structure of human chorionic gonadotropin at 2.6A resolution from MAD analysis of the selenomethionyl protein
    • Wu, H., Lustbader, J.W., Liu, Y., Canfield, R.E. and Hendrickson, W.A. (1994) Structure of human chorionic gonadotropin at 2.6A resolution from MAD analysis of the selenomethionyl protein. Structure 2, 545-558.
    • (1994) Structure , vol.2 , pp. 545-558
    • Wu, H.1    Lustbader, J.W.2    Liu, Y.3    Canfield, R.E.4    Hendrickson, W.A.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.