메뉴 건너뛰기




Volumn 15, Issue 9, 1997, Pages 882-886

Engineering vaccines with heterologous B and T cell epitopes using immunoglobulin genes

Author keywords

Antibody engineering; Rational protein design; Vaccine design

Indexed keywords

B LYMPHOCYTE ANTIBODY; EPITOPE; PROTOZOON ANTIBODY; T LYMPHOCYTE ANTIBODY;

EID: 0030828486     PISSN: 10870156     EISSN: 15461696     Source Type: Journal    
DOI: 10.1038/nbt0997-882     Document Type: Article
Times cited : (45)

References (43)
  • 1
    • 0027129063 scopus 로고
    • Antigenized antibodies
    • Zanetti, M. 1992. Antigenized antibodies. Nature 355:466-477.
    • (1992) Nature , vol.355 , pp. 466-477
    • Zanetti, M.1
  • 3
    • 0025635730 scopus 로고
    • Expression of an exogenous peptide epitope genetically engineered in the variable domain of an immunoglobulin: Implications for antibody and peptide folding
    • Sollazzo, M., Billetta, R., and Zanetti, M. 1990. Expression of an exogenous peptide epitope genetically engineered in the variable domain of an immunoglobulin: Implications for antibody and peptide folding. Prot. Engineer. 4:215-220.
    • (1990) Prot. Engineer , vol.4 , pp. 215-220
    • Sollazzo, M.1    Billetta, R.2    Zanetti, M.3
  • 5
    • 0027136185 scopus 로고
    • Active immunity against the CD4 receptor using an antibody antigenized with residues 41-55 of the first extracellular domain
    • Lanza, P., Billetta, R., Antonenko, S., and Zanetti, M. 1993. Active immunity against the CD4 receptor using an antibody antigenized with residues 41-55 of the first extracellular domain. Proc. Natl. Acad. Sci. USA 90:11683-11687.
    • (1993) Proc. Natl. Acad. Sci. USA , vol.90 , pp. 11683-11687
    • Lanza, P.1    Billetta, R.2    Antonenko, S.3    Zanetti, M.4
  • 6
    • 0028795304 scopus 로고
    • Induction of antibodies to the human immunodeficiency virus type 1 by immunization of baboons with immunoglobulin molecules carrying the principal neutralizing determinant of the envelope protein
    • Zaghouani, H., Anderson, S.A., Sperber, K.E., Daian, C., Kennedy, R.C., Mayer, L., and Bona C.A. 1995. Induction of antibodies to the human immunodeficiency virus type 1 by immunization of baboons with immunoglobulin molecules carrying the principal neutralizing determinant of the envelope protein. Proc. Natl. Acad. Sci. USA 92:31-635.
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 31-635
    • Zaghouani, H.1    Erson, S.A.2    Sperber, K.E.3    Daian, C.4    Kennedy, R.C.5    Mayer, L.6    Bona, C.A.7
  • 7
    • 0027398099 scopus 로고
    • Presentation of a viral T cell epitope expressed In the CDR3 region of a self immunoglobulin molecule
    • Zaghouani, H., Steinman, R., Nonacs, R., Shah, H., Gerhard, W., and Bona, C. 1993. Presentation of a viral T cell epitope expressed In the CDR3 region of a self immunoglobulin molecule. Science 259:224-227.
    • (1993) Science , vol.259 , pp. 224-227
    • Zaghouani, H.1    Steinman, R.2    Nonacs, R.3    Shah, H.4    Gerhard, W.5    Bona, C.6
  • 8
    • 0028947160 scopus 로고
    • Major histocompatibility complex class I-restricted presentation of influenza virus nucleoprotein peptide by B lymphoma cells harboring an antibody gene antigenized with the virus peptide
    • Billetta, R., Filaci, G., and Zanetti, M. 1995. Major histocompatibility complex class I-restricted presentation of influenza virus nucleoprotein peptide by B lymphoma cells harboring an antibody gene antigenized with the virus peptide. Eur. J. Immunol. 25:776-783.
    • (1995) Eur. J. Immunol , vol.25 , pp. 776-783
    • Billetta, R.1    Filaci, G.2    Zanetti, M.3
  • 9
    • 0031010866 scopus 로고    scopus 로고
    • In vivo role of B lymphocytes in somatic transgene Immunization
    • Xiong, S., Gerloni, M., and Zanetti, M. 1997. In vivo role of B lymphocytes in somatic transgene Immunization. Proc. Natl. Acad. Sci. USA 94:6352-6357.
    • (1997) Proc. Natl. Acad. Sci. USA , vol.94 , pp. 6352-6357
    • Xiong, S.1    Gerloni, M.2    Zanetti, M.3
  • 10
    • 0030967275 scopus 로고    scopus 로고
    • Somatic transgene Immunization with DNA encoding an immunoglobulin heavy chain
    • Gerloni, M., Billetta, R., Xiong, S., and Zanetti, M. 1997. Somatic transgene Immunization with DNA encoding an immunoglobulin heavy chain. DNA Cell. Biol. 16:611-625.
    • (1997) DNA Cell. Biol , vol.16 , pp. 611-625
    • Gerloni, M.1    Billetta, R.2    Xiong, S.3    Zanetti, M.4
  • 11
    • 0030865220 scopus 로고    scopus 로고
    • Immunity to Plasmodium falciparum sporozoites by somatic transgene immunization
    • Gerloni, M., Ballou, W.R., Billetta, R., and Zanetti, M. 1997. Immunity to Plasmodium falciparum sporozoites by somatic transgene immunization. Nature Biotechnology 15:876-881.
    • (1997) Nature Biotechnology , vol.15 , pp. 876-881
    • Gerloni, M.1    Ballou, W.R.2    Billetta, R.3    Zanetti, M.4
  • 12
    • 0027411456 scopus 로고
    • Heterologous protection against influenza by injection of DNA encoding a viral protein
    • Ulmer, J.B., Donnelly, J.J., Parker, S.E., Rhodes, G.H., Felgner, P.L., Dwarki, V.J., et al. 1993. Heterologous protection against influenza by injection of DNA encoding a viral protein. Science 259:1745-1749.
    • (1993) Science , vol.259 , pp. 1745-1749
    • Ulmer, J.B.1    Donnelly, J.J.2    Parker, S.E.3    Rhodes, G.H.4    Felgner, P.L.5    Dwarki, V.J.6
  • 13
    • 0027284896 scopus 로고
    • Gene inoculation generates immune responses against human immunodeficiency virus type 1
    • Wang, B., Ugen, K., Srikantan, V., Agadjanyan, M., Dang, K., Refaeli, Y., et al. 1993. Gene inoculation generates immune responses against human immunodeficiency virus type 1. Proc. Natl. Acad. Sci. USA 90:4156-4160.
    • (1993) Proc. Natl. Acad. Sci. USA , vol.90 , pp. 4156-4160
    • Wang, B.1    Ugen, K.2    Srikantan, V.3    Agadjanyan, M.4    Dang, K.5    Refaeli, Y.6
  • 14
    • 0028060149 scopus 로고
    • Intradermal gene Immunization: The possible role of DNA uptake in the induction of cellular immunity to viruses
    • Raz, E., Carson, D.A., Parker, S.E., Parr, T.B., Abal, A.M., Aichinger, G., et al. 1994. Intradermal gene Immunization: the possible role of DNA uptake in the induction of cellular immunity to viruses. Proc. Natl. Acad. Sci. USA 91:9519-9523.
    • (1994) Proc. Natl. Acad. Sci. USA , vol.91 , pp. 9519-9523
    • Raz, E.1    Carson, D.A.2    Parker, S.E.3    Parr, T.B.4    Abal, A.M.5    Aichinger, G.6
  • 15
    • 0028077102 scopus 로고
    • Protection against malaria by Immunization with Plasmid DNA encoding circumsporozoite protein
    • Sedegah, M., Hedstrom, R., Hobart, P., and Hoffman, S.L. 1994. Protection against malaria by Immunization with Plasmid DNA encoding circumsporozoite protein. Proc. Natl. Acad. Sci. USA 91:9866-9870.
    • (1994) Proc. Natl. Acad. Sci. USA , vol.91 , pp. 9866-9870
    • Sedegah, M.1    Hedstrom, R.2    Hobart, P.3    Hoffman, S.L.4
  • 16
    • 0028081659 scopus 로고
    • Direct gene transfer in skeletal muscle: Plasmid DNA-based immunization against the hepatitis B virus surface antigen
    • Davis, H.L., Michel, M.L., Mancini, M., Schleef, M., and Whalen, R.G. 1994. Direct gene transfer in skeletal muscle: plasmid DNA-based immunization against the hepatitis B virus surface antigen. Vaccine 12:1503-1509.
    • (1994) Vaccine , vol.12 , pp. 1503-1509
    • Davis, H.L.1    Michel, M.L.2    Mancini, M.3    Schleef, M.4    Whalen, R.G.5
  • 19
    • 0027727904 scopus 로고
    • Examination of parameters affecting the elicitation of humoral immune responses by particle bombardment-mediated genetic immunization
    • Eisenbraun, M.D., Fuller, D.H., and Haynes, J.R. 1993. Examination of parameters affecting the elicitation of humoral immune responses by particle bombardment-mediated genetic immunization. DNA Cell Biol. 12:791-797.
    • (1993) DNA Cell Biol , vol.12 , pp. 791-797
    • Eisenbraun, M.D.1    Fuller, D.H.2    Haynes, J.R.3
  • 20
    • 0001967883 scopus 로고
    • The carrier effect in the secondary response to hapten-protein conjugates. II. Cellular cooperation
    • Mitchison, N.A. 1971. The carrier effect in the secondary response to hapten-protein conjugates. II. Cellular cooperation. Eur. J. Immunol. 1:18-27.
    • (1971) Eur. J. Immunol , vol.1 , pp. 18-27
    • Mitchison, N.A.1
  • 21
    • 0023182064 scopus 로고
    • Safety and Immunogenicity in man of a synthetic peptide malaria vaccine against Plasmodium falciparum sporozoites
    • Herrington, D.A., Clyde, D.F., Losonsky, G., Cortesia, M., Murphy, J.R., Davis, J., et al. 1987. Safety and Immunogenicity in man of a synthetic peptide malaria vaccine against Plasmodium falciparum sporozoites. Nature 328:257-259.
    • (1987) Nature , vol.328 , pp. 257-259
    • Herrington, D.A.1    Clyde, D.F.2    Losonsky, G.3    Cortesia, M.4    Murphy, J.R.5    Davis, J.6
  • 22
    • 0024310231 scopus 로고
    • Vaccine engineering: Enhancement of immunogenicity of synthetic peptide vaccines related to hepatitis in chemically defined models consisting of T- and B-cell epitopes
    • Tam, J.P. and Lu, Y.A. 1989. Vaccine engineering: enhancement of immunogenicity of synthetic peptide vaccines related to hepatitis in chemically defined models consisting of T- and B-cell epitopes. Proc. Natl. Acad. Sci. USA 88:9084-9088.
    • (1989) Proc. Natl. Acad. Sci. USA , vol.88 , pp. 9084-9088
    • Tam, J.P.1    Lu, Y.A.2
  • 23
    • 0025099759 scopus 로고
    • Incorporation of T and B epitopes of the circumsporozoite protein in a chemically defined synthetic vaccine against malaria
    • Tam, J.P., Clavijo, P., Lu, Y.A., Nussenzweig, V., Nussenzweig, R.S., and Zavala, F. 1990. Incorporation of T and B epitopes of the circumsporozoite protein in a chemically defined synthetic vaccine against malaria. J. Exp. Med. 171:299-306.
    • (1990) J. Exp. Med , vol.171 , pp. 299-306
    • Tam, J.P.1    Clavijo, P.2    Lu, Y.A.3    Nussenzweig, V.4    Nussenzweig, R.S.5    Zavala, F.6
  • 24
    • 0026003043 scopus 로고
    • Immunogenicity of multiple antigen peptides (MAP) containing T and B cell epitopes of the repeat region of the P. falciparum circumsporozoite protein
    • Munesinghe, D.Y, Clavijo, P., Calle, M.C., Nussenzweig, R.S., and Nardin, E. 1991. Immunogenicity of multiple antigen peptides (MAP) containing T and B cell epitopes of the repeat region of the P. falciparum circumsporozoite protein. Eur. J. Immunol. 21:3015-3020.
    • (1991) Eur. J. Immunol , vol.21 , pp. 3015-3020
    • Munesinghe, D.Y.1    Clavijo, P.2    Calle, M.C.3    Nussenzweig, R.S.4    Nardin, E.5
  • 26
    • 0026629667 scopus 로고
    • Safety and Immunogenicity in volunteers of a recombinant Plasmodium falciparum circumsporozoite protein malaria vaccine produced in Lepidopteran cells
    • Herrington, D.A., Losonsky, G.A., Smith, G., Volvovitz, F., Cochran, M., Jackson, K., et al. 1992. Safety and Immunogenicity in volunteers of a recombinant Plasmodium falciparum circumsporozoite protein malaria vaccine produced in Lepidopteran cells. Vaccine 10:841-846.
    • (1992) Vaccine , vol.10 , pp. 841-846
    • Herrington, D.A.1    Losonsky, G.A.2    Smith, G.3    Volvovitz, F.4    Cochran, M.5    Jackson, K.6
  • 28
    • 0024819071 scopus 로고
    • Conserved repetitive epitope recognized by CD4+ clones from a malaria-immunized volunteer
    • Nardin, E.H., Herrington, D.A., Davis, J., Levine, M., Stuber, D., Takacs, B., et al. 1989. Conserved repetitive epitope recognized by CD4+ clones from a malaria-immunized volunteer. Science 246:1603-1606.
    • (1989) Science , vol.246 , pp. 1603-1606
    • Nardin, E.H.1    Herrington, D.A.2    Davis, J.3    Levine, M.4    Stuber, D.5    Takacs, B.6
  • 30
    • 0028048489 scopus 로고
    • Antibodies specific for the neuronal form of the scr protein elicited by an antigenized antibody
    • Rigaudy, P., Simon, S., Hunter, T., Sollazzo, M., Billetta, R., Zanetti, M., et al. 1994. Antibodies specific for the neuronal form of the scr protein elicited by an antigenized antibody. DNA Cell Biol. 13:585-591.
    • (1994) DNA Cell Biol , vol.13 , pp. 585-591
    • Rigaudy, P.1    Simon, S.2    Hunter, T.3    Sollazzo, M.4    Billetta, R.5    Zanetti, M.6
  • 31
    • 0021802935 scopus 로고
    • Transfeotomas provide novel chimeric antibodies
    • Morrison, S. 1985. Transfeotomas provide novel chimeric antibodies. Science 229:1202-1207.
    • (1985) Science , vol.229 , pp. 1202-1207
    • Morrison, S.1
  • 32
    • 0002014464 scopus 로고
    • Ligand expression using antigenization of antibody: Principle and methods
    • Billetta, R. and Zanetti, M. 1992. Ligand expression using antigenization of antibody: Principle and methods. ImmunoMethods 1:41-51.
    • (1992) Immunomethods , vol.1 , pp. 41-51
    • Billetta, R.1    Zanetti, M.2
  • 33
    • 0023033248 scopus 로고
    • Synthetic Plasmodium falciparum circumsporozoite peptides elicit heterogenous L3T4+ T cell proliferative responses in H-2b mice
    • Togna, A.R., Del, G.G., Verdini, A.S., Bonelli, F., Pessi, A., Engers, H.D., and Corradin, G. 1986. Synthetic Plasmodium falciparum circumsporozoite peptides elicit heterogenous L3T4+ T cell proliferative responses in H-2b mice. J. Immunol. 137:2956-2960.
    • (1986) J. Immunol , vol.137 , pp. 2956-2960
    • Togna, A.R.1    Del, G.G.2    Verdini, A.S.3    Bonelli, F.4    Pessi, A.5    Engers, H.D.6    Corradin, G.7
  • 37
    • 0023278330 scopus 로고
    • Canonical structures for the hypervariable regions of immunoglobulins
    • Chothia, C. and Lesk, A.M. 1987. Canonical structures for the hypervariable regions of immunoglobulins. J. Mol. Biol. 196:901-917.
    • (1987) J. Mol. Biol , vol.196 , pp. 901-917
    • Chothia, C.1    Lesk, A.M.2
  • 38
    • 0015733869 scopus 로고
    • Three-dimensional structure of the Fab’ fragment of a human immunoglobulin at 2.8 A resolution
    • Poljak, R.J., Amzel, L.M., Avey, H.P., Chen, B.L., Phizackerly, R.P., and Saul, F 1973. Three-dimensional structure of the Fab’ fragment of a human immunoglobulin at 2.8 A resolution. Proc. Natl. Acad. Sci. USA 70:3305-3310 (1973).
    • (1973) Proc. Natl. Acad. Sci. USA , vol.70 , pp. 3305-3310
    • Poljak, R.J.1    Amzel, L.M.2    Avey, H.P.3    Chen, B.L.4    Phizackerly, R.P.5    Saul, F.6
  • 39
    • 0024478211 scopus 로고
    • Molecular characterization of the VH region of murine autoantibodies from neonatal and adult BALB/c mice
    • Sollazzo, M., Hasemann, C.A., Meek, K.D., Glotz, D., Capra, J.D., and Zanetti, M. 1989. Molecular characterization of the VH region of murine autoantibodies from neonatal and adult BALB/c mice. Eur. J. Immunol. 19:453-457.
    • (1989) Eur. J. Immunol , vol.19 , pp. 453-457
    • Sollazzo Hasemann, M.C.A.1    Meek, K.D.2    Glotz, D.3    Capra, J.D.4    Zanetti, M.5
  • 40
    • 0009482260 scopus 로고
    • Electrophoretic transfer of proteins from Polyacrylamide gels to nitrocellulose sheets: Procedure and some applications
    • Towbin, H., Staehelin, T., and Gordon, J. 1979. Electrophoretic transfer of proteins from Polyacrylamide gels to nitrocellulose sheets: Procedure and some applications. Proc. Natl. Acad. Sci. USA 76:4350-4354.
    • (1979) Proc. Natl. Acad. Sci. USA , vol.76 , pp. 4350-4354
    • Towbin, H.1    Staehelin, T.2    Gordon, J.3
  • 42
    • 0028817155 scopus 로고
    • Validity of nucleic acid purities monitored by 260nm/280nm absorbance ratios
    • Glasel, J.A. 1995. Validity of nucleic acid purities monitored by 260nm/280nm absorbance ratios. Bio Techniques 18:62-63.
    • (1995) Bio Techniques , vol.18 , pp. 62-63
    • Glasel, J.A.1
  • 43
    • 0027174660 scopus 로고
    • Memory effectors: A potent, IL-4-secretlng helper T cell population that develops in vivo after restimulation with antigen
    • Bradley, L.M., Duncan, D.D., Yoshlmoto, K., and Swain, S.L. 1993. Memory effectors: a potent, IL-4-secretlng helper T cell population that develops in vivo after restimulation with antigen. J. Immunol. 150:3119-3130.
    • (1993) J. Immunol , vol.150 , pp. 3119-3130
    • Bradley, L.M.1    Duncan, D.D.2    Yoshlmoto, K.3    Swain, S.L.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.