Vaccines and passive immunological approaches for the control of fertility and hormone-dependent cancers

Immunological Reviews

Volumn 171, Issue , 1999, Pages 173-192

  Talwar, G P ^a,b  

^a International Centre for Genetic Engineering and Biotechnlogy   (India)

^b Talwar Research Foundation   (India)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODY; CANCER VACCINE; CHORIONIC GONADOTROPIN; HORMONE ANTIBODY; LUTEINIZING HORMONE; SEX HORMONE;

CANCER IMMUNIZATION; CANCER IMMUNOTHERAPY; CONTROLLED STUDY; FERTILITY; HORMONE DEPENDENCE; HUMAN; MENSTRUAL CYCLE; NONHUMAN; OVULATION; PASSIVE IMMUNIZATION; PREGNANCY; PRIORITY JOURNAL; REVIEW; SEXUAL BEHAVIOR;

ANIMALS; AUTOIMMUNITY; CHORIONIC GONADOTROPIN; CONTRACEPTION, IMMUNOLOGIC; FAMILY PLANNING SERVICES; FEMALE; FERTILITY; GONADOTROPIN-RELEASING HORMONE; HUMANS; IMMUNIZATION, PASSIVE; MALE; PREGNANCY; PROSTATIC HYPERPLASIA; PROSTATIC NEOPLASMS; TESTOSTERONE; VACCINES;

EID: 0032697701     PISSN: 01052896     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1600-065X.1999.tb01348.x     Document Type: Review

References (76)

1. 1. Engelman R, LeRoy P. Sustaining water: population and the future of renewable water supplies. Washington DC: Population Action International; 1993.
2. 2. Behrman SJ. The immune response and infertility. In: Behrman SJ, Kistner RW, eds. Progress in infertility. Boston: Little Brown & Co; 1975. p. 793-815.
3. 3. Boettcher B, Hjort T, Rümke P, Schulman S, Vyazov OE. Auto and isoantibodies to antigens of the human reproduction systems. Acta Pathol Microbiol Scand 1977;30:173-180.
4. 4. Isojima S, Li TS, Ashitaka Y. Immunological analysis of sperm immobilizing factor found in sera of women with unexplained infertility. Am J Obstet Gynaecol 1968;101:677-683.
5. 5. Katsch S. Immunology, fertility and infertility: a historical survey. Am J Obstet Gynaecol 1959;77:946-956.
6. 6. Talwar GP. Immunology of contraception. London: Edward Arnold; 1980.
7. 7. Menge AC, et al. Sperm antibodies in serum and cervical mucus of infertile women. In: Bratanov K, et al. eds. Immunology of reproduction. Sofia: Bulgarian Academy of Science Press; 1979. p. 336-340.
8. 8. Rümke P. Sperm agglutinating auto-antibodies in relation to male infertility. Proc R Soc Med 1968;61:275-278.
9. 9. Shulman S. Agglutinating and immobilising antibodies to spermatozoa. In: Cohen J, Hendry WF, eds. Spermatozoa, antibodies and infertility. Oxford: Blackwell Scientific Publications; 1978. p. 81-99.
10. 10. Voisin GA, Toullet F, D'Almeida M. Characterization of spermatozoal auto, iso and alloantigens. In: Diczfalusy E, ed. Immunological approaches to fertility control. Stockholm: Karolinska Institute; 1974. p. 173-198.
11. 11. Liskin L, Pile JM, Quillan WF. Vasectomy safe and simple. Pop Rep 1983;4:61-100.
12. 12. Suri A, Chhabra S, Upadhyay S. Identification of human sperm antigen recognized by serum of an infertile women: a candidate for immuno-contraception. Am J Reprod Immunol 1996;36:317-326.
13. 13. Talwar GP. Immuno-contraception - past, present and future. In: Coutinho E, Spinola P, eds. Reproductive medicine: past, present and future. Chapter 59. Carnforth, Lancs: Parthenon Publishing; 1999. p. 1-13.
14. 14. O'Hern PA, Bambra CS, Isahakia M, Goldberg E. Reversible contraception in female baboons immunized with a synthetic epitope of sperm specific lactate dehydrogenase. Biol Reprod 1995;52:331-339.
15. 15. Lou Y-H, McElveen MF, Garza KM, Tung KSK. Rapid induction of auto antibodies by endogenous ovarian antigens and activated T cells: implication in autoimmune disease pathogenesis and B cell tolerance. J Immunol 1996;156:3535-3540.
16. 16. Moudgal NR, Suresh R. FSH and FSH derived vaccines. In: Talwar GP, Raghupathy R, eds. Birth control vaccines. Austin: RG Landes Company; 1995. p. 89-100.
17. 17. Fishel SB, Edwards RG, Evans CJ. Human chorionic gonadotropin secreted by preimplantation embryos cultured in vitro. Science 1984;223:816-818.
18. 18. Hearn JP, et al. Embryonic signals during the pre-implantation period in primates. J Reprod Fertil 1988;36 (Suppl):49-58.
19. 19. Talwar GP, et al. A vaccine that prevents pregnancy in women. Proc Natl Acad Sci USA 1994;91:8532-8536.
20. 20. Stevens VC, Cinader B, Powell JE, Lee AC, Koh SW. Preparation and formulation of a human chorionic gonadotropin antifertility vaccine: selection of a peptide immunogen. Am J Reprod Immunol 1981;1:307-314.
21. 21. Ramakrishnan S, Das C, Dubey SK, Salatuddin M, Talwar GP. Immunogenicity of three C-terminal synthetic peptides of hCG and properties of the antibodies raised agianst 45 amino acid c-terminal peptide. J Reprod Immunol 1979;1:249-261.
22. 22. Louvet JP, Ross GT, Birken S, Confield RE. Absence of neutralization effect of antiserum to the unique structural region of human chorionic gonadotropin. J Clin Endocrinol Metab 1975;39:1155-1158.
23. 23. Ohashi M, et al. Comparison of in vivo and in vitro neutralization of human chorionic gonadotropin activities by antisera to hCG and a carboxy terminal fragment of β subunit. Endocriology 1980;107:2034.
24. 24. Sahal D, Ramakrishnan S, Iyer KSN, Das C, Talwar GP. Immunological properties of a carboxy-terminal 53 amino acid peptide of the β subunit of hCG. J Reprod Immunol 1982;4:145-156.
25. 25. Jones WR, et al. Phase I clinical trial of a World Health Organization birth control vaccine. Lancet. 1988;1:1295-1298.
26. 26. Stevens VC, Fertility control through active immunization using placenta proteins. In: Diczfalusy E, ed. Karolinska Symposia -Immunological approaches to fertility control. Stockholm: Karolinska Institute; 1974. p. 357-375.
27. 27. Talwar GP, et al. Iso-immunization against human chorionic gonadotropin with conjugates of processed β-subunit of the hormone and tetanus toxoid. Proc Natl Acad Sci USA 1976;73:218-222.
28. 28. Nath I, Gupta PD, Bhuyan UN, Talwar GP. Autopsy report on rhesus monkeys immunized with Pr-β-hCG-TT vaccine. Contraception 1976;13:213-224.
29. 29. Nath I, Whittingham S, Lambert PH, Talwar GP. Screening for auto antibodies in human subjects immunized with Pr-β-hCG-TT. Contraception 1976;13:225-230.
30. 30. Rose NR, Burek CL, Smith JP. Safety evaluation of hCG vaccine in primates: auto antibody production. In: Talwar GP, ed. Contraception research for today and the nineties. New York: Springer Verlag; 1988. p. 231-240.
31. 31. Gupta PD, Nath I, Talwar GP. Immunofluorescence and electron microscopic studies on kidney, choroid and plexus and pituitary in rhesus monkeys immunized with the anti hCG vaccine Pr-β-hCG. Contraception 1978;18:91-104.
32. 32. Nath I, Dubey SK, Talwar GP. Hypersensitivity reactions in monkeys immunized with Pr-β-hCG-TT. Contraception 1976;13:231-236.
33. 33. Gaur A, Arunan K, Singh O, Talwar GP. Bypass by an alternate carrier of acquired unresponsiveness to hCG upon repeated immunization with tetanus conjugated vaccine. Int Immunol 1990;2:151-155.
34. 34. Talwar GP, et al. The HSD-hCG vaccine prevents pregnancy in women. Feasibility study of a reversible safe contraceptive vaccine. Am J Reprod Immunol 1997;37:153-160.
35. 35. Kumar S, Sharma NC, Bajaj JS, Talwar GP, Hingorani V. Clinical profile and toxicology studies on four women immunized with Pr-β hCG-TT. Contraception 1976;13:253-268.
36. 36. Nash H, et al. Observations on the antigenecity and clinical effects of a candidate anti pregnancy vaccine: β subunit of human chorionic gonadotropin linked to tetanus toxoid. Fertil Steril 1980;34:328-335.
37. 37. Talwar GP, et al. Phase I clinical trials with three formulations of anti-human chorionic gonadotropin vaccine. Contraception 1990;41:301-316.
38. 38. Kharat I, et al. Analysis of menstrual records of women immunized with anti-hCG vaccines inducing antibodies partially cross-reactive with hLH. Contraception 1990;41:293-299.
39. 39. Talwar GP, Singh O, Rao LV. An improved immunogen for anti-human chorionic gonadotropin vaccine eliciting antibodies reactive with a conformation native to the hormone without cross-reaction with human follicle stimulating hormone and human thyroid stimulating hormone. J Reprod Immunol 1988;14:203-212.
40. 40. Pal R, Singh O, Rao LV, Talwar GP. Bioneutralization capacity of the antibodies generated in women by the β subunit of hCG and β-hCG associated with the α subunit of ovine luteinizing hormone linked to carriers. Am J Reprod Immunol Microbiol 1990;22:124-126.
41. 41. Singh M, Das SK, Suri S, Singh O, Talwar GP. Regain of fertility and normality of progeny born at below protective threshold antibody titres in women immunized with the HSD-hCG vaccine. Am J Reprod Immunol 1998;39:395-398.
42. 42. Stoute JA, et al. A preliminary evaluation of a recombinant circumsporozoite protein vaccine against Plasmodium falciparum malaria. N Engl J Med 1997;336:86-91.
43. 43. Srinivan J, Singh O, Chakrabarti S, Talwar GP. Targeting vaccinia virus expressed β subunit of hCG to the cell surface induces antibodies. Infect Immun 1995;63:4907-4911.
44. 44. Gupta A, Chandrashekhar S, Pal Rahul, Talwar GP, Singh O. Indentification of novel transmembrane gene sequence and its use for cell surface targeting of β subunit of HCG. DNA Cell Biol 1998;17:573-581.
45. 45. Paoletti E. Recombinant avipox virus. Patent International 1989. W089/03-429, Health Research Inc.
46. 46. Stevens VC, Powell JE, Rickey M, Lee AC, Lewis DH. In: Alexander NJ, Griffin D, Spieler JM, Waites GMH, eds. Gamete interaction: prospects for immunocontraception. New York: Wiley-Liss; 1990. p. 549-563.
47. 47. Diwan M, Dawar H, Talwar GP. Induction of early and bioeffective response in rodents with the anti-LHRH vaccine given as single dose in biodegradable microspheres along with alum. Prostate 1998;35:279-284.
48. 48. Tandon A, Das C, Jailkhani BL, Talwar GP. Efficacy of antibodies generated by Pr-β-hCG-TT to terminate pregnancy in baboons: Its reversibility and rescue by medroxy progesterone acetate. Contraception 1981;24:83-95.
49. 49. Talwar GP, Das C, Tandon A, Sharma MG, Salahuddin M, Dubey SK. Immunization against hCG: efficacy and teratological studies. In: Anand Kumar TC, ed. Non-human primate models for study of human reproduction. Basel: S. Karger; 1980. p. 190-201.
50. 50. Deshmukh US, Pal R, Talwar GP, Gupta SK. Antibody response against epitopes on hCG mapped by monoclonal antibodies in women immunized with an anti-hCG vaccine and its implications for bioneutralization. J Reprod Immunol 1993;25:103-117.
51. 51. Gupta SK, Ramakrishnan S, Talwar GP. Properties and characteristics of an anti human chorionic gonadotropin monoclonal antibody. J Biosci 1982;4:105-114.
52. 52. Acevado HF, Tong JY, Hartsock RJ. Human chorionic gonadotropin, β subunit gene expression in cultured human fetal and cancer cells of different types and origins. Cancer 1995;76:1467-1475
53. 53. Kumar S, Talwar GP, Biswas DK. Necrosis and inhibition of growth of human lung tumour by anti-hCG antibodies. J Natl Cancer Inst 1991;84:42-47.
54. 54. Triozzi PL, et al. Clinical and immunologic effects of a synthetic β hCG vaccine. Int J Oncol 1995;5:1447-1453.
55. 55. Talwar GP, Chaudhuri MK, Jayshankar R. Inventors. Antigenic derivative of GnRH. UK Patent 2228262 1992.
56. 56. Gupta HM, Talwar GP, Salunke DM. A novel computer modelling approach to the structure of small bioactive peptides: the structure of the gonadotropin releasing hormone. Proteins 1993;16:48-56.
57. 57. Talwar GP, Gupta SK, Singh V, Sahal D, Iyer KSN, Singh O. Bioeffective monoclonal antibody against the decapeptide gonadotropin releasing hormone: reacting determinant and action on ovulation and estrus suppression. Proc Natl Acad Sci USA 1985;82:1228-1231.
58. 58. Fraser HM, Dewart PJ, Smith SK et al. Luteinizing hormone releasing hormone agonist in contraception in breast feeding women. J Clin Endocrinol Metab 1989;69:996-1002.
59. 59. Ladd A, Prabhu G, Tsong YY, Probst T, Chung W, Thau RB. Active immunization against gonadotropin-releasing hormone combined with androgen supplementation is a promising anti fertility vaccine for males. Am J Repord Immunol 1988;17:121-127.
60. 60. Rovan E, Fiebiger E, Kalla NR, Talwar GP, Aulitzky W, Frick J. Effect of active immunization to LHRH on the fertility and histoarchitecture of the reproductive organs of male rat. Urol Res 1992;20:323-334.
61. 61. Jayashankar R, Chaudhari MK, Singh O, Alam A, Talwar GP. Semisynthetic anti-LHRH vaccine causing atrophy of the prostate. Prostate 1989;14:3-11.
62. 62. Giri DK, Jayraman S, Neelaram GS, Jayashankar R, Talwar GP. Prostatic hypoplasia in bonnet monkeys following immunization with semisynthetic anti-LHRH vaccine. Exp Mol Pathol 1991;54:255-264.
63. 63. Fuerst J, et al. Effect of active immunization against LHRH on androgen sensitive Dunning R3327-PAP and indrogen independent Dunning R 3327-AT2.1 prostate cancer cell sublines. Prostate 1997;32:77-84.
64. 64. Talwar GP, Diwan M, Dawar H, Frick J, Sharma SK, Wadhwa SN. Counter GnRH vaccine. In: Rajalakshmi M, Griffin PD, eds. Male contraception present and future. New Delhi: New Age International; 1998. p. 309-318.
65. 65. Diwan M, Dawar H, Talwar GP. Induction of early and bioeffective antibody response in rodents with the anti LHRH vaccine given as a single dose in biodegradable microspheres along with alum. Prostate 1998;35:279-284.
66. 66. Sad S, Gupta HM, Talwar GP, Raghupathy R. Carrier induced suppression of the antibody response to "self" hapten. Immunol 1991;74:223-227.
67. 67. Gupta SK, Talwar GP. Paradoxical effect of antibodies against chorionic gonadotropin on Bewo carcinoma cells in vitro and in vivo: evidence for heterogeneity of cell types. In: Pattillo RA, Hussa RO, eds. Human trophoblast neoplasms. New York: Plenum Press; 1984. p. 271-288.
68. 68. Talwar GP, Naz RK, Das C, Das RP. A practicable immunological approach to block spermatogenesis without loss of androgens. Proc Natl Acad Sci USA 1979;76:5882-5885.
69. 69. Mustafa AS, Naz RK, Talwar GP. Relationship between becterial index and type of tubular damage in BCG induced aspermatogenesis. Ind J Exptl Biol 1981;19:1011-1014.
70. 70. Naz RK, Talwar GP. Reversibility of azoospermia induced by Bacillus Calmette Guérin. J Androl 1986;7:264-269.
71. 71. Das RP, Mustafa AS, Talwar GP. Atrophy of seminiferous tubules of mouse testes after intratesticular injection of BCG and their regeneration. Arch Androl 1982;9:245-250.
72. 72. Frick J, Kunit G, Joos H, Rovan E, Talwar GP. Effect of intratesticular administration of BCG on testicular function. Int Urol Nephrol 1983;15:71-81.
73. 73. Manik RS, Tomer OS, Raina VS, Talwar GP, Suri A. Blocking of spermatogenesis without loss of male sex hormones in buffalo bulls: trials with Talsur. In: Acharya RM, ed. Proceeding of the 2nd World Buffalo Congress. Volume III. Physiology and Reproduction; New Delhi: Indian Council of Agricultural Research; 1990. p. 12-16.
74. 74. Naz RK, Talwar GP. Ability of autoclaved BCG and extracts to induce aspermatogenesis. Ind J Med Res 1981;74:251-257.
75. 75. Singh O, Rao LV, Gaur A, Sharma NC, Alam A, Talwar GP. Antibody response and characteristics of antibodies in women immunized with three contraceptive vaccines inducing antibodies against human chorionic gonadotropin. Fertil Steril 1989;52:739-744.
76. 76. Thau R, et al. Advances in the development of an antifertility vaccine. In: Mettler L, Billington WD, eds. Reproductive immunology. Amsterdam: Elsevier; 1989. p. 237-244.