Antibodies to human ZP3 induce reversible contraception in transgenic mice with 'humanized' zonae pellucidae

Human Reproduction

Volumn 14, Issue 3, 1999, Pages 593-600

  Greenhouse, Stephen ^a   Castle, Philip E ^b   Dean, Jurrien ^b  

^a NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

^b GEORGE WASHINGTON UNIVERSITY SCHOOL OF MEDICINE AND HEALTH SCIENCES   (United States)

Author keywords

Contraception; Human ZP3; Knockout mice; Monoclonal antibodies; Spermatozoon ovum interactions

Indexed keywords

ANTIBODY; GLYCOPROTEIN; MONOCLONAL ANTIBODY;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTRACEPTION; CONTROLLED STUDY; EXTRACELLULAR MATRIX; FEMALE; FERTILITY; FETUS DEVELOPMENT; GENETIC ENGINEERING; HISTOLOGY; MATING; MOUSE; NONHUMAN; OOCYTE; OVARY; SPERM; STEREOSPECIFICITY; TRANSGENIC MOUSE; ZONA PELLUCIDA;

ANIMALIA; MAMMALIA; MUS MUSCULUS;

EID: 0032998999     PISSN: 02681161     EISSN: None     Source Type: Journal    
DOI: 10.1093/humrep/14.3.593     Document Type: Article

References (37)

1. Afzalpurkar, A., Shibahara, H., Hasegawa, A. et al. (1997) Immunoreactivity and in-vitro effect on human sperm-egg binding of antibodies against peptides corresponding to bonnet monkey zona pellucida-3 glycoprotein. Hum. Reprod., 12, 2664-2670.
2. Bagavant, H., Fusi, RM., Baisch, J. et al. (1997) Immunogenicity and contraceptive potential of a human zona pellucida 3 peptide vaccine. Biol. Reprod., 56, 764-770.
3. Barriere, P., Bercegeay, S., Mirallie, S. et al. (1998) Human zona pellucida glycoproteins and sperm binding: an urge for accurate nosology and nomenclature. Mol. Hum. Reprod., 4, 524-525.
4. Bleil, J.D. and Wassarman, P.M. (1980a) Mammalian sperm-egg interaction: identification of a glycoprotein in mouse egg zonae pellucidae possessing receptor activity for sperm. Cell, 20, 873-882.
5. Bleil, J.D. and Wassarman, P.M. (1980b) Structure and function of the zona pellucida: identification and characterization of the proteins of the mouse oocyte's zona pellucida. Dev. Biol., 76, 185-202.
6. Burnette, W.N. (1981) 'Western blotting': electrophoretic transfer of proteins from sodium dodecyl sulfate-polyacrylamide gels to unmodified nitrocellulose and radiographie detection with antibody and radioiodinated protein A. Anal. Biochem., 112, 195-203.
7. Chamberlin, M.E. and Dean, J. (1990) Human homolog of the mouse sperm receptor. Proc. Natl Acad. Sei. USA, 87, 6014-6018.
8. East, I.J. and Dean, J. (1984) Monoclonal antibodies as probes of the distribution of ZP-2, the major sulfated glycoprotein of the murine zona pellucida. J. Cell Biol., 98, 795-800.
9. East, I.J., Mattison, D.R. and Dean, J. (1984) Monoclonal antibodies to the major protein of the murine zona pellucida: effects on fertilization and early development. Dev. Biol., 104, 49-56.
10. East, I.J., Gulyas, BJ. and Dean, J. (1985) Monoclonal antibodies to the murine zona pellucida protein with sperm receptor activity: effects on fertilization and early development. Dev. Biol., 109, 268-273.
11. Epifano, O., Liang, L., Familari, M. et al. (1995) Coordinate expression of the three zona pellucida genes during mouse oogenesis. Development, 121, 1947-1956.
12. Green, D.P. (1997) Three-dimensional structure of the zona pellucida. Rev. Reprod., 2, 147-156.
13. Harris, J.D., Hibler, D.W., Fontenot, O.K. et al. (1994) Cloning and characterization of zona pellucida genes and cDNAs from a variety of mammalian species: ZPA, ZPB, and ZPC gene families. DNA Seq., 4, 361-393.
14. Harrison, P.F. and Rosenfield, A. (eds) (1996) Contraceptive Research and Development. Looking into the Future. Institute of Medicine, National Academy Press, Washington, DC, p. 10.
15. Henshaw, S.K. (1998) Unintended pregnancy in the United States. Fain. Plann. Perspect., 30, 24-29, 46.
16. Laemmli, U.K. (1970) Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature, 227, 680-685.
17. Liang, L. and Dean, J. (1993) Conservation of the mammalian secondary sperm receptor genes results in promoter function of the human homologue in heterologous mouse oocytes. Dev. Biol., 156, 399-408.
18. Liang, L., Chamow, S.M. and Dean, J. (1990) Oocyte-specific expression of mouse Zp-2: developmental regulation of the zona pellucida genes. Mol. Cell Biol, 10, 1507-1515.
19. Liu, C, Litscher, E.S., Mortillo, S. et ai. (1996) Targeted disruption of the mZP3 gene results in production of eggs lacking a zona pellucida and infertility in female mice. Proc. Natl Acad. Sei. USA, 93, 5431-5436.
20. Lou, Y., Ang, J., Thai, H. et al. (1995) A zona pellucida 3 peptide vaccine induces antibodies and reversible infertility without ovarian pathology. J. Immunol., 155, 2715-2720.
21. Mahi-Brown, C.A. (1996) Primate response to immunization with a homologous zona pellucida peptide. J. Reprod. Fertil., 50 (Suppl.), 165-174.
22. Millar, S.E., Chamow, S.M., Baur, A.W. et al. (1989) Vaccination with a synthetic zona pellucida peptide produces long-term contraception in female mice. Science, 246, 935-938.
23. Moller, C.C. and Wassarman, P.M. (1989) Characterization of a proteinase that cleaves zona pellucida glycoprotein ZP2 following activation of mouse eggs. Dev. Biol., 132, 103-112.
24. Paterson, M., Wilson, M.R., van Duin, M. and Aitken, R.J. (1996) Evaluation of zona pellucida antigens as potential candidates for immunocontraception. J. Reprod. Fertil. Suppl., 50 (Suppl.), 175-182.
25. Primakoff, P., Lathrop, \V., Woolman, L. et al. (1988) Fully effective contraception in male and female guinea pigs immunized with the sperm protein PH-20. Nature, 335, 543-546.
26. Rankin, T., Familari, M., Lee, E. ei al. (1996) Mice homozygous for an insertional mutation in the Zp3 gene lack a zona pellucida and are infertile. Development, 122, 2903-2910.
27. Rankin, T., Tong, Z., Castle, P.E. et al. (1998) Human ZP3 restores fertility in Zp3 null mice without affecting order-specific sperm binding. Development, 125, 2415-2424.
28. Rhim, S.U., Millar, S.E., Robey, F. et al. (1992) Autoimmune disease of the ovary induced by an 8 amino acid zona pellucida peptide. J. Clin. Invest., 89, 28-35.
29. Ringuette, M.J., Chamberlin, M.E., Baur, A.W. et al. (1988) Molecular analysis of cDNA coding for ZP3, a sperm binding protein of the mouse zona pellucida. Dev. Biol., 127, 287-295.
30. Sacco, A.G., Yurewicz, E.C., Subramanian, M.G. and DeMayo, F. (1981) Zona pellucida composition: species cross reactivity and contraceptive potential of amiserum to a purified pig zona pellucida antigen (PPZA). Biol. Reprod., 25, 997-1008.
31. Shabanowitz, R.B. and O'Rand, M.G. (1988) Characterization of the human zona pellucida from fertilized and unfertilized eggs. J. Reprod. Fertil., 82, 151-161.
32. Shimizu, S., Tsuji, M. and Dean, J. (1983) In vitro biosynthesis of three sulfated glycoproteins of murine zonae pellucidae by oocytes grown in follicle culture. J. Biol. Cliem., 258, 5858-5863.
33. Shivers, C.A., Dudkiewicz, A.B., Franklin, L.E. and Fussell, E.N. (1972) Inhibition of sperm-egg interaction by specific antibody. Science, 178, 1211-1213.
34. Snell, W.J. and White, J.M. (1996) The molecules of mammalian fertilization. Cell, 85, 629-637.
35. Tung, K.S., Lou, Y.H., Garza, K.M. and Teuscher, C. (1997) Autoimmune ovarian disease: mechanism of disease induction and prevention. Curr. Opin. Immunol., 9, 839-845.
36. VandeVoort, C.A., Schwoebel, E.D. and Dunbar, B.S. (1995) Immunization of monkeys with recombinant complimentary deoxyribonucleic acid expressed zona pellucida proteins. Fertil. Steril., 64, 838-847.
37. Yanagimachi, R. (1994) Mammalian fertilization. In Knobil, E. and Neil, J. (eds), The Physiology of Reproduction. Raven Press, New York, pp. 189-317.