Prospects of riboflavin carrier protein (RCP) as an antifertility vaccine in male and female mammals

Human Reproduction Update

Volumn 3, Issue 4, 1997, Pages 325-334

  Adiga, P R ^a   Subramanian, S ^a   Rao, Jayasimha ^a   Kumar, Mukesh ^a  

^a INDIAN INSTITUTE OF SCIENCE   (India)

Author keywords

Antifertility vaccine; Female contraception; Male contraception; Riboflavin carrier protein

Indexed keywords

CONTRACEPTIVE VACCINE; DIPHTHERIA TOXOID; EPITOPE; ESTROGEN; NEUTRALIZING ANTIBODY; RIBOFLAVIN; RIBOFLAVIN BINDING PROTEIN; VITAMIN;

ACROSOME; ACTIVE IMMUNIZATION; AMINO TERMINAL SEQUENCE; ANIMAL CELL; ANIMAL EXPERIMENT; CARBOXY TERMINAL SEQUENCE; CONTRACEPTION; CONTROLLED STUDY; EMBRYO DEVELOPMENT; FEMALE; FEMALE FERTILITY; HUMAN CELL; IMMUNOCONTRACEPTION; IMMUNOHISTOCHEMISTRY; MALE; MALE FERTILITY; NIDATION; NONHUMAN; OOCYTE DEVELOPMENT; OVARY CYCLE; PASSIVE IMMUNIZATION; PREGNANCY TERMINATION; PRIORITY JOURNAL; PROTEIN LOCALIZATION; REVIEW; SPERMATOZOON;

EID: 0030665827     PISSN: 13554786     EISSN: None     Source Type: Journal    
DOI: 10.1093/humupd/3.4.325     Document Type: Review

References (43)

1. Adiga, P.R. (1994) Riboflavin carrier protein in reproduction. In Dakshinamurty, K. (ed.), Vitamin Receptors. Cambridge University Press, Cambridge, UK, pp. 137-176.
2. Adiga, P.R. and Murty, C.V.R. (1983) Vitamin carrier protein during embryonic development in birds and mammals. In Porter, R. and Whelan, J. (eds), Ciba Foundation Symposium 98. Pitman, London, pp. 111-136.
3. Adiga, P.R., Seshagiri, P.B. and Visweswariah, S.S. (1986) Reproduction-specific vitamin carrier protein involved in transplacental vitamin transport in mammals including primates. In Hau, J. (ed.), Pregnancy Proteins in Animals. de Gruyter, Berlin, pp. 317-329.
4. Adiga, P.R., Karande, A.A. and Beena T.K. (1993) A synthetic oligopeptide as a vaccine against riboflavin carrier protein. In Talwar, G.P., Rao, K.V.S. and Chauhan, V.S. (eds), Recombinant and Synthetic Vaccines. Narosa Publishing House, New Delhi, pp. 226-232.
5. Adiga, P.R., Karande, A.A., Visweswariah, S.S. and Seshagiri, P.B. (1988) Estrogen-induced riboflavin carrier protein and its role in fetal development. In Imura, H., Shizume, K. and Yoshida, S. (eds), Progress in Endocrinology. Vol. 2. Excerpta Medica, Amsterdam, pp. 343-348.
6. Adiga, P.R., Karande, A.A., Visweswariah, S.S. and Seshagiri, P.B. (1991) Carrier protein mediated transplacental riboflavin transport in the primates. In Moudgal, N.R., Yoshinaga, K., Rao, A.J. and Adiga, P.R. (eds), Perspectives in Primate Reproductive Biology. Wiley Eastern, New Delhi, pp. 129-140.
7. Bardin, C.W., Cheng, C.Z., Musto, N.A. and Gunsalus, G. (1988) The Sertoli cell. In Knobil, E. and Neil, J. (eds), Physiology of Reproduction. Raven Press, New York, USA, pp. 933-973.
8. Beena, T.K. (1994) Antigenic Determinants of Chicken Riboflavin Carrier Protein: Structural and Functional Aspects. Ph.D. Thesis, Indian Institute of Science, Bangalore.
9. Best, C.L. and Hill, J. (1995) Natural infertility due to immunological factors. In Talwar, G.P. and Raghupathy, R. (eds), Birth Control Vaccines. R.G.Landes Co, Austin, USA, pp. 5-28.
10. Bhat, K.G., Malhotra, P., Karande, A.A. and Adiga, P.R. (1995) Immunohistochemical localization of riboflavin carrier protein in testicular cells of mammals. Ind. J. Exp. Biol., 33, 12-16.
11. Blum, J.-C. (1966) Modalities du transfert de la riboflavine¿l'oeuf chez la poule. In Proceedings of the 7th International Congress on Nutrition, Braumschweig, Germany. Vieweg, Germany, pp. 550-553.
12. Bronson, R.A. (1993) Secretory IgA and antisperm antibodies in the male and female reproductive tract. In Griffin P.D. and Johnson, P.M. (eds), Local Immunity in Reproductive Tract Tissues. Oxford University Press, Delhi, India, pp. 307-320.
13. Clagett, C.O. (1971) Genetic control of the riboflavin bindingprotein. Fed. Proc., 30, 127-129.
14. Dufau, M.L. (1985) Endocrine regulation and communicating functions of the Leydig cell. Ann. Rev. Physiol., 50, 483-508.
15. Griswold, M.D. (1988) Protein secretions of Sertoli cells. Int. Rev. Cytol., 110, 133-155.
16. Hamazume, Y., Mega, T. and Ikenaka, T. (1984) Characterization of hen's egg white- and yolk-riboflavin binding proteins and amino acid sequence of egg white riboflavin binding protein. J. Biochem. (Japan), 95, 1633-1644.
17. Karande, A.A. and Adiga, P.R. (1991) Early pregnancy termination in rats immunized with denatured chicken riboflavin carrier protein. Ind. J. Biochem. Biophys., 28, 476-480.
18. Karande, A.A., Velu, N.K. and Adiga, P.R. (1991) A monoclonal antibody recognizing the C-terminal region of chicken egg white riboflavin carrier protein terminates early pregnancy in mice. Mol. Immunol., 28, 471-480.
19. Koshy, B.T., Karande, A.A. and Adiga, P.R. (1996) Antigenic determinants at the carboxy terminus of chicken egg white riboflavin carrier protein (RCP): epitope mapping and antibody-mediated pregnancy curtailment in rodents. Vaccine, 14, 307-312.
20. MacLachlan, I., Nimpf, J., White, H.B.III and Schneider, W.J. (1993) Riboflavinuria in the rd chicken. 5'-splice site mutation in the gene for riboflavin binding protein. J. Biol. Chem., 268, 232221-232226.
21. Miller, R.L., Koszalk, T.R. and Brent, R.L. (1976) Transport of molecules across placental membrane. Cell Surface Rev., 1, 145-207.
22. Miller, M.S., Buss, E.G. and Clagett, C.O. (1981a) The role ofoligosaccharide in the transport of egg yolk riboflavin binding protein. Biochim. Biophys. Acta, 677, 225-233.
23. Miller, M.S., Buss, E.G. and Clagett, C.O. (1981b) Effect of carbohydrate modification on transport of chicken egg white riboflavin binding protein. Comp. Biochem. Physiol., 69B, 681-686.
24. Miller, M.S., Benore-Parsons, M. and White, H.B. (1982) Dephosphorylation of chicken riboflavin binding protein and phosvitin decreases their uptake by oocyte. J. Biol. Chem., 257, 688-694.
25. Muniyappa, K. and Adiga, P.R. (1980) Occurrence and functional importance of a riboflavin carrier protein in the pregnant rat. FEBS Lett., 110, 209-212.
26. Murthy, U.S. and Adiga, P.R. (1978) Estrogen induced synthesis of riboflavin binding protein in immature chicks: kinetics and hormonal specificity. Biochim. Biophys. Acta, 538, 364-375.
27. Murty, C.V.R. and Adiga, P.R. (1982) Pregnancy suppression by active immunization against gestation-specific riboflavin carrier protein. Science, 216, 191-193.
28. Naz, R.K., Sacco, A., Singh, O. et al. (1995) Development of contraceptive vaccines for humans using antigens derived from gametes (spermatozoa and zona pellucida) and hormones (human chorionic gonadotropin): current Status. Hum. Reprod. Update, 1, 1-18.
29. Psychoyos, A. (1973) Section 7. In Creep, R.O., Astwood, E.D. and Geiger, S.R. (eds), Handbook of Physiology. Vol. II, Part 2. American Physiological Society, Washington DC, USA.
30. Rao, J., Seshagiri, P.B., Rupasri, A. and Adiga, P.R. (1995) Mucosal immunization of riboflavin carrier protein prevents implantation in female rats. In International Symposium on Prospects of Zona Pellucida Glycoproteins for Immunocontraception and 7th Annual Conference of Indian Society for the Study of Reproduction and Fertility. [Programme and Abstracts]. National Institute of Immunology, New Delhi, India, p.52.
31. Sarkar, S., Sooryanarayana, Adiga, P.R. and Visweswariah, S.S. (1996) Chicken riboflavin carrier protein is a ligand for the low density lipoprotein receptor family. In Discussion Meeting on Perspectives in Biochemistry and Molecular Biology. [Abstracts] Indian Institute of Science, Bangalore, India, p. 307.
32. Schneider, W.J., Slaughter, C.J., Goldstein, J.L. et al. (1983) J. Cell Biol., 97, 1635-1640.
33. Seshagiri, P.B. and Adiga, P.R. (1987) Pregnancy suppression in the bonnet monkey by active immunization with the chicken riboflavin carrier protein. J. Reprod. Immunol., 12, 93-107.
34. Skinner, M.K. (1991) Cell-cell interactions in the testis. Endocr. Rev., 12, 45-77.
35. Sooryanarayana, Adiga, P.R. and Visweswariah, S.S. (1996) Hyperexpression of chicken riboflavin carrier protein: antibodies to the recombinant protein curtail pregnancy in rodents. Protein Expr. Purific., 7, 147-154.
36. Sridhar, L., Kumar, M. and Adiga, P.R. (1996) Active immunization with riboflavin carrier protein suppresses fertility in male rodents and monkeys. In Discussion Meeting on Perspectives in Biochemistry and Molecular Biology. [Abstracts] Indian Institute of Science, Bangalore, India. p. 334.
37. Subramanian, S. and Adiga, P.R. (1996a) Hormonal modulation of riboflavin carrier protein secretion by immature rat Sertoli cells in culture. Mol. Cell. Endocrinol., 120, 41-50.
38. Subramanian, S. and Adiga, P.R. (1996b) Hormonal modulation of secretion of immunoreactive riboflavin carrier protein by adult rat Leydig cells in vitro. Ind. J. Biochem. Biophys., 33, 274-280.
39. Visweswariah, S.S. and Adiga, P.R. (1987) Purification of a circulatory riboflavin carrier protein from pregnant bonnet monkey (M.radiata). Comparison with chicken egg vitamin carrier. Biochem. Biophys. Acta, 915, 141-148.
40. Visweswariah, S.S. and Adiga, P.R. (1988) Estrogen modulation of riboflavin carrier protein in the bonnet monkey (M.radiata) J. Steroid. Biochem., 31, 91-96.
41. White, H.B.III and Merrill, A.H. (1988) Ann. Rev. Nutr., 8, 278-299.
42. White, H.B.III, Nuwaysir, E.F., Komara, S.P. et al. (1992) Effect of riboflavin binding protein deficiency on riboflavin metabolism in the laying hen. Arch. Biochem. Biophys., 295, 29-34.
43. Yanagimachi, R., Yanagimachi, H. and Rogers, B.J. (1976) The use of zona-free animal ova as test system for assessment of fertilizing capacity of human spermatozoa. Biol. Reprod., 15, 471-476.