Immunoneutralisation of gonadotrophin releasing hormone: A potential treatment for oestrogen-dependent breast cancer

European Journal of Cancer Part A

Volumn 33, Issue 9, 1997, Pages 1468-1478

  Ferro, V A ^a   Stimson, W H ^a  

^a UNIVERSITY OF STRATHCLYDE   (United Kingdom)

Author keywords

Antibodies; Antineoplastic; Experimental mammary neoplasms; Gonad atrophy; Gonadotrophin releasing hormone analogue; Hormone dependent; Immunotherapy; Serum oestrogen

Indexed keywords

DIMETHYLBENZ[A]ANTHRACENE; ESTROGEN; GONADORELIN; NEUTRALIZING ANTIBODY;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY TITER; ANTINEOPLASTIC ACTIVITY; ARTICLE; BREAST CANCER; BREAST TUMOR; CANCER INHIBITION; FEMALE; IMMUNIZATION; IMMUNOTHERAPY; NONHUMAN; PRIORITY JOURNAL; RAT;

9,10-DIMETHYL-1,2-BENZANTHRACENE; ANIMALS; ATROPHY; DISEASE PROGRESSION; ESTRADIOL; FEMALE; GENITALIA, FEMALE; GONADOTROPIN-RELEASING HORMONE; IMMUNIZATION; IMMUNOGLOBULIN G; MAMMARY NEOPLASMS, EXPERIMENTAL; NEOPLASMS, HORMONE-DEPENDENT; PALPATION; RATS; RATS, SPRAGUE-DAWLEY;

EID: 0030783046     PISSN: 09598049     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0959-8049(97)00126-3     Document Type: Article

References (21)

1. Schally AV, Arimura A, Kastrin AJ. Hypothalmic regulatory hormones. Science 1973, 179, 341-350.
2. Conn PM, Huckle WR, Andrews WV, McArdle CA. The molecular mechanism of action of GnRH in the pituitary. In Clarke JH ed. Recent Progress in Hormone Research. Academic Press, New York, 1985, 43, 29-49.
3. Braden TD, Hawes BE, Conn PM. Synthesis of GnRH receptors by gonadotrope cell cultures. Endocrinology 1989, 125, 1623-1629.
4. Ferro VA, O'Grady JE, Notman J, Stimson WH. Development of a hormone neutralizing vaccine, using GnRH-glycys-PPD, for use in the treatment of oestrogen-dependent disorders. Ther Immun 1995, 2, 147-157.
5. Morrison CA, Fishleigh RV, Ward DJ, Robson B. Computer aided design and physiological testing of a LHRH analogue for "adjuvant-free" immunocastration. Febs Lett 1987, 214, 65-73.
6. Huggins C, Grand LG, Brillantes FP. Mammary cancer induced by a single feeding of polynuclear hydrocarbons and its suppression. Nature 1961, 189, 204-209.
7. Manni A, Trujillo JE, Pearson OH. Predominant role of prolactin in stimulating the growth of 7, 12-dimethylbenz(a)anthracene-induced mammary tumours. Cancer Res 1977, 37, 1216-1221.
8. Pearson OH, Molina A, Butler RP, Lerena L, Nasr H. Estrogens and prolactin in mammary cancer. In Dao TL ed. Estrogen Target Tissues and Neoplasia. University of Chicago Press, Chicago, IL, 1972, 287-305.
9. Jordan VC, Koerner S. Tamoxifen as an anti-tumour agent: role of oestradiol and prolactin. J Endocrinol 1976, 68, 305-311.
10. Ravdin PM, Jordan VC. Active immunisation to luteinising hormone releasing hormone to inhibit the induction of mammary tumours in the rat. Life Sci 1988, 43, 117-124.
11. Nicholson RI, Golder MP. The effect of synthetic anti-oestrogens on the growth and biochemistry of rat mammary tumours. Eur J Cancer 1975, 11, 571-579.
12. Ferro VA, O'Grady JE, Notman J, Stimson WH. Immunological castration of male rats using a GnRH analogue conjugated to PPD. Food Agric Immunol 1995, 7, 259-272.
13. Short DJ, Woodnott DP. In IAT Manual of Laboratory Animal Practice and Techniques. Crosby Lockwood, London, 1969, 342-346.
14. Ferro VA, O'Grady JE, Notman J, Stimson WH. A comparison of adjuvants used to investigate the immunogenicity of a GnRH analogue in male rats. Vaccine 1996, 14, 451-457.
15. Adams TE, Adams BM. Reproductive function and feedlot performance of beef heifers actively immunised against GnRH. J Anim Sci 1990, 68, 2793-2797.
16. Desmukh US, Talwar GP, Gupta SK. IgG subclass distribution of anti-hCG and anti-diptheria toxoid antibodies in women immunized with a hCG based immunocontraceptive vaccine. J Reprod Immunol 1994, 26, 65-72.
17. Ferro VA, Stimson WH. Effects of adjuvant, dose and carrier pre-sensitisation on the immunisation efficacy of a GnRH analogue. Drug Design Discovery 1996, 14, 179-195.
18. Miller WR. Aromatase inhibitors in the treatment of advanced breast cancer. Cancer Treatment Rev 1989, 16, 83-93.
19. Dowsett KF, Tshewang U, Knptt LM, Jackson AE, Trigg TE. Immunocastration of colts and immunospeying of fillies. Immunol Cell Biol 1993, 1, 501-508.
20. Nicholson RI, Walker KJ, Maynard PV. Anti-tumour potential of a new luteinizing hormone releasing hormone analogue, ICI 118630. Breast Cancer Exp Aspects 1980, 18, 295-299.
21. Furr BJA, Nicholson RI. Use of analogues of luteinising hormone-releasing hormone for the treatment of cancer. J Reprod Fert 1982, 64, 529-539.