The distribution of the anti-HIV drug, 2′3′-dideoxycytidine (ddC), across the blood-brain and blood-cerebrospinal fluid barriers and the influence of organic anion transport inhibitors

Journal of Neurochemistry

Volumn 80, Issue 3, 2002, Pages 392-404

  Gibbs, J E ^a   Thomas, S A ^a,b  

^a KING'S COLLEGE LONDON   (United Kingdom)

^b KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

2 3 dideoxycytidine; Blood brain barrier; Choroid plexuses; Efflux transporters; Organic anion inhibitors; Probenecid

Indexed keywords

2,4 DICHLOROPHENOXYACETIC ACID; 4 AMINOHIPPURIC ACID; DIGOXIN; PROBENECID; STAVUDINE; TAUROCHOLIC ACID; ZALCITABINE; ZIDOVUDINE;

ANIMAL EXPERIMENT; ANION TRANSPORT; ARTICLE; BLOOD BRAIN BARRIER; BLOOD CEREBROSPINAL FLUID BARRIER; CONTROLLED STUDY; DRUG BRAIN LEVEL; DRUG CEREBROSPINAL FLUID LEVEL; DRUG PENETRATION; GUINEA PIG; ISOTOPE LABELING; NONHUMAN; PRIORITY JOURNAL; TISSUE DISTRIBUTION; TRANSPORT KINETICS;

2,4-DICHLOROPHENOXYACETIC ACID; ANIMALS; ANTI-HIV AGENTS; BLOOD-BRAIN BARRIER; CAPILLARIES; CARBON RADIOISOTOPES; CHOROID PLEXUS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DIURETICS, OSMOTIC; GUINEA PIGS; HERBICIDES; MANNITOL; OCTANOLS; OLIGOPEPTIDES; ORGANIC ANION TRANSPORT PROTEIN 1; ORGANIC ANION TRANSPORTERS; ORGANIC ANION TRANSPORTERS, SODIUM-INDEPENDENT; P-AMINOHIPPURIC ACID; PERFUSION; PROBENECID; SODIUM CHLORIDE; TRITIUM; URICOSURIC AGENTS; ZALCITABINE; ZIDOVUDINE;

ANIMALIA; CAVIA PORCELLUS; SUS SCROFA;

EID: 0036488144     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.0022-3042.2001.00711.x     Document Type: Article

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