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Volumn 760, Issue 1-2, 1997, Pages 59-67

Saturation kinetics, specificity and NBMPR sensitivity of thymidine entry into the central nervous system

Author keywords

Blood brain barrier; Carrier mediated; Choroid plexus; NBMPR; Nucleoside; Specificity; Thymidine; Transport

Indexed keywords

AMINO ACID; CARBOXYLIC ACID; DEOXYCYTIDINE; DEOXYRIBONUCLEOTIDE; GUANOSINE DERIVATIVE; HEXOSE; NITROBENZYLTHIOINOSINE; NUCLEOSIDE; PYRIMIDINE DERIVATIVE; THYMIDINE; URIDINE;

EID: 0030831293     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(97)00276-X     Document Type: Article
Times cited : (32)

References (58)
  • 3
    • 0021081489 scopus 로고
    • Heterogenity of nucleoside transport in mammalian cells: Two types of transport activity in L1210 and other cultured neoplastic cells
    • Belt J.A. Heterogenity of nucleoside transport in mammalian cells: two types of transport activity in L1210 and other cultured neoplastic cells. Mol. Pharmacol. 24:1983;479-484.
    • (1983) Mol. Pharmacol. , vol.24 , pp. 479-484
    • Belt, J.A.1
  • 5
    • 0016836221 scopus 로고
    • Independent blood-brain barrier transport systems for nucleic acid precursors
    • Cornford E.M., Oldendorf W.H. Independent blood-brain barrier transport systems for nucleic acid precursors. Biochim. Biophys. Acta. 394:1975;211-219.
    • (1975) Biochim. Biophys. Acta , vol.394 , pp. 211-219
    • Cornford, E.M.1    Oldendorf, W.H.2
  • 6
    • 0025359970 scopus 로고
    • Nucleoside transport in L1210 murine leukemia cells: Evidence for three transporters
    • Crawford C.R., Ng C.Y.C., Noel L.D., Belt J.A. Nucleoside transport in L1210 murine leukemia cells: evidence for three transporters. J. Biol. Chem. 265:1990;9732-9736.
    • (1990) J. Biol. Chem. , vol.265 , pp. 9732-9736
    • Crawford, C.R.1    Ng, C.Y.C.2    Noel, L.D.3    Belt, J.A.4
  • 7
    • 0021047121 scopus 로고
    • Determination of ribonucleosides, deoxyribonucleosides, and purine and pyrimidine bases in adult rabbit cerebrospinal fluid and plasma
    • Eells J.T., Spector R. Determination of ribonucleosides, deoxyribonucleosides, and purine and pyrimidine bases in adult rabbit cerebrospinal fluid and plasma. Neurochem. Res. 8:1983;1307-1320.
    • (1983) Neurochem. Res. , vol.8 , pp. 1307-1320
    • Eells, J.T.1    Spector, R.2
  • 8
    • 0021050911 scopus 로고
    • Purine and pyrimidine base and nucleoside concentrations in human cerebrospinal fluid and plasma
    • Eells J.T., Spector R. Purine and pyrimidine base and nucleoside concentrations in human cerebrospinal fluid and plasma. Neurochem. Res. 8:1983;1451-1457.
    • (1983) Neurochem. Res. , vol.8 , pp. 1451-1457
    • Eells, J.T.1    Spector, R.2
  • 9
    • 0017035257 scopus 로고
    • The mechanism of interaction between high-affinity probes and the uridine transport system of mammalian cells
    • Eilam Y., Cabantchik I. The mechanism of interaction between high-affinity probes and the uridine transport system of mammalian cells. J. Cell. Physiol. 89:1977;831-838.
    • (1977) J. Cell. Physiol. , vol.89 , pp. 831-838
    • Eilam, Y.1    Cabantchik, I.2
  • 10
    • 0001892390 scopus 로고
    • Exchange diffusion of large neutral amino acids between blood and brain
    • in: L. Rakic, D.J. Begley, H. Davson and B.V. Zlokovic (Eds.) Macmillan Press, London
    • A. Gjedde, Exchange diffusion of large neutral amino acids between blood and brain, in: L. Rakic, D.J. Begley, H. Davson and B.V. Zlokovic (Eds.), Peptide and Amino Acids Transport Mechanisms in the Central Nervous System, Macmillan Press, London, 1988, pp. 209-217.
    • (1988) Peptide and Amino Acids Transport Mechanisms in the Central Nervous System , pp. 209-217
    • Gjedde, A.1
  • 12
    • 0027299916 scopus 로고
    • +-nucleoside transport in brush-border membrane vesicles from human kidney
    • +-nucleoside transport in brush-border membrane vesicles from human kidney. Biochim. Biophys. Acta. 1149:1993;202-208.
    • (1993) Biochim. Biophys. Acta , vol.1149 , pp. 202-208
    • Gutierrez, M.M.1    Giacomini, K.M.2
  • 13
    • 0021996006 scopus 로고
    • 3H]nitrobenzylthioinosine to the nucleoside transport system in mammalian central nervous system membranes: Evidence for interconvertible conformations of the binding site/transporter complex
    • 3H]nitrobenzylthioinosine to the nucleoside transport system in mammalian central nervous system membranes: evidence for interconvertible conformations of the binding site/transporter complex. J. Neurochem. 45:1985;527-535.
    • (1985) J. Neurochem. , vol.45 , pp. 527-535
    • Hammond, J.R.1    Clanachan, A.S.2
  • 14
    • 0027422902 scopus 로고
    • Comparison of uptake characteristics of thymidine and zidovudine in a human intestinal epithelial model system
    • Hu M. Comparison of uptake characteristics of thymidine and zidovudine in a human intestinal epithelial model system. J. Pharm. Sci. 82:1993;829-833.
    • (1993) J. Pharm. Sci. , vol.82 , pp. 829-833
    • Hu, M.1
  • 15
    • 0027305423 scopus 로고
    • +-dependent nucleoside transport systems of rat intestine in isolated oocytes of Xenopus laevis: Demonstration that rat jejunum expresses the purine-selective system N1 (cif) and a second, novel system N3 having broad substrate specificity for purine and pyrimidine nucleosides
    • +-dependent nucleoside transport systems of rat intestine in isolated oocytes of Xenopus laevis: demonstration that rat jejunum expresses the purine-selective system N1 (cif) and a second, novel system N3 having broad substrate specificity for purine and pyrimidine nucleosides. J. Biol. Chem. 268:1993;20613-20619.
    • (1993) J. Biol. Chem. , vol.268 , pp. 20613-20619
    • Huang, Q.Q.1    Harvey, C.M.2    Paterson, A.R.P.3    Cass, C.E.4    Young, J.D.5
  • 16
    • 0024494386 scopus 로고
    • Characterization of sodium-dependent nucleoside transport in rabbit intestinal brush-border membrane vesicles
    • Jarvis S.M. Characterization of sodium-dependent nucleoside transport in rabbit intestinal brush-border membrane vesicles. Biochim. Biophys. Acta. 979:1989;132-138.
    • (1989) Biochim. Biophys. Acta , vol.979 , pp. 132-138
    • Jarvis, S.M.1
  • 17
    • 0022968142 scopus 로고
    • Nucleoside transporter of cerebral microvessels and choroid plexus
    • Kalaria R.J., Harik S.J. Nucleoside transporter of cerebral microvessels and choroid plexus. J. Neurochem. 47:1986;1849-1856.
    • (1986) J. Neurochem. , vol.47 , pp. 1849-1856
    • Kalaria, R.J.1    Harik, S.J.2
  • 18
    • 0023872576 scopus 로고
    • Adenosine receptors and the nucleoside transporter in human brain vasculature
    • Kalaria R.J., Harik S.J. Adenosine receptors and the nucleoside transporter in human brain vasculature. J. Cereb. Blood Flow Metab. 8:1988;32-39.
    • (1988) J. Cereb. Blood Flow Metab. , vol.8 , pp. 32-39
    • Kalaria, R.J.1    Harik, S.J.2
  • 20
    • 0023521093 scopus 로고
    • Phenylalanine transport across the blood-brain barrier as studied with the in situ brain perfusion technique
    • Momma S., Aoyagi M., Rapoport S.I., Smith Q.R. Phenylalanine transport across the blood-brain barrier as studied with the in situ brain perfusion technique. J. Neurochem. 48:1987;1291-1300.
    • (1987) J. Neurochem. , vol.48 , pp. 1291-1300
    • Momma, S.1    Aoyagi, M.2    Rapoport, S.I.3    Smith, Q.R.4
  • 21
    • 84985200587 scopus 로고
    • The uptake of purines by rat brain in vivo and in vitro
    • Nakagawa S., Guroff G. The uptake of purines by rat brain in vivo and in vitro. J. Neurochem. 20:1973;1143-1149.
    • (1973) J. Neurochem. , vol.20 , pp. 1143-1149
    • Nakagawa, S.1    Guroff, G.2
  • 23
    • 0018237164 scopus 로고
    • Lower limits of cerebrovascular permeability to nonelectrolytes in the conscious rat
    • Ohno K., Pettigrew K.D., Rapoport S.I. Lower limits of cerebrovascular permeability to nonelectrolytes in the conscious rat. Am. J. Physiol. 235:1978;H299-H307.
    • (1978) Am. J. Physiol. , vol.235
    • Ohno, K.1    Pettigrew, K.D.2    Rapoport, S.I.3
  • 25
    • 0025302443 scopus 로고
    • +-dependent, active nucleoside transport in mouse spleen lymphocytes, leukemia cells, fibroblasts and macrophages, but not in equivalent human or pig cells; Dipyridamole enhances nucleoside salvage by cells with both active and facilitated transport
    • +-dependent, active nucleoside transport in mouse spleen lymphocytes, leukemia cells, fibroblasts and macrophages, but not in equivalent human or pig cells; dipyridamole enhances nucleoside salvage by cells with both active and facilitated transport. Biochim. Biophys. Acta. 1025:1990;32-42.
    • (1990) Biochim. Biophys. Acta , vol.1025 , pp. 32-42
    • Plagemann, P.G.W.1    Aran, J.M.2
  • 26
    • 0025118705 scopus 로고
    • +-dependent, active nucleoside transport in rat and mouse peritoneal macrophages, a mouse macrophage cell line and normal rat kidney cells
    • +-dependent, active nucleoside transport in rat and mouse peritoneal macrophages, a mouse macrophage cell line and normal rat kidney cells. Biochim. Biophys. Acta. 1028:1990;289-298.
    • (1990) Biochim. Biophys. Acta , vol.1028 , pp. 289-298
    • Plagemann, P.G.W.1    Aran, J.M.2
  • 28
    • 0015577523 scopus 로고
    • Nucleic acid pools of Novikoff rat hepatoma cells growing in suspension culture. : IV. Nucleoside transport in cells depleted of nucleotides by treatment with KCN
    • Plagemann P.G.W., Erbe J. Nucleic acid pools of Novikoff rat hepatoma cells growing in suspension culture. IV. Nucleoside transport in cells depleted of nucleotides by treatment with KCN J. Cell Physiol. 81:1973;101-111.
    • (1973) J. Cell Physiol. , vol.81 , pp. 101-111
    • Plagemann, P.G.W.1    Erbe, J.2
  • 29
    • 0021276095 scopus 로고
    • Nucleoside transport in cultured mammalian cells: Multiple forms with different sensitivity to inhibition by nitrobenzylthioinosine or hypoxanthine
    • Plagemann P.G.W., Wohlhueter R.M. Nucleoside transport in cultured mammalian cells: multiple forms with different sensitivity to inhibition by nitrobenzylthioinosine or hypoxanthine. Biochim. Biophys. Acta. 773:1984;39-52.
    • (1984) Biochim. Biophys. Acta , vol.773 , pp. 39-52
    • Plagemann, P.G.W.1    Wohlhueter, R.M.2
  • 31
    • 0024963083 scopus 로고
    • +-dependent and -independent transport of uridine and its phosphorylation in mouse spleen cells
    • +-dependent and -independent transport of uridine and its phosphorylation in mouse spleen cells. Biochim. Biophys. Acta. 981:1989;315-325.
    • (1989) Biochim. Biophys. Acta , vol.981 , pp. 315-325
    • Plagemann, P.G.W.1    Woffendin, C.2
  • 33
    • 85063241786 scopus 로고    scopus 로고
    • The characteristics of basolateral nucleoside transport in the perfused sheep choroid plexus and the effect of NO inhibition on these processes
    • in press
    • Z.B. Redzic, M.B. Segal, H. Al-Sarraf, K.A. Smart, I.D. Markovic, J.M. Gasic, L.M. Rakic, The characteristics of basolateral nucleoside transport in the perfused sheep choroid plexus and the effect of NO inhibition on these processes, Brain Res., (1997) in press.
    • (1997) Brain Res.
    • Redzic, Z.B.1    Segal, M.B.2    Al-Sarraf, H.3    Smart, K.A.4    Markovic, I.D.5    Gasic, J.M.6    Rakic, L.M.7
  • 34
    • 0021148137 scopus 로고
    • Kinetic analysis of L-leucine transport across the blood-brain barrier
    • Smith Q.R., Takasato Y., Rapoport S.I. Kinetic analysis of L-leucine transport across the blood-brain barrier. Brain Res. 311:1984;167-170.
    • (1984) Brain Res. , vol.311 , pp. 167-170
    • Smith, Q.R.1    Takasato, Y.2    Rapoport, S.I.3
  • 35
    • 0019126174 scopus 로고
    • Thymidine transport in the central nervous system
    • Spector R. Thymidine transport in the central nervous system. J. Neurochem. 35:1980;1092-1098.
    • (1980) J. Neurochem. , vol.35 , pp. 1092-1098
    • Spector, R.1
  • 36
    • 0019277090 scopus 로고
    • Thymidine accumulation by choroid plexus in vitro
    • Spector R. Thymidine accumulation by choroid plexus in vitro. Arch. Biochem. Biophys. 205:1980;85-93.
    • (1980) Arch. Biochem. Biophys. , vol.205 , pp. 85-93
    • Spector, R.1
  • 37
    • 0020362616 scopus 로고
    • Nucleoside transport in choroid plexus: Mechanism and specificity
    • Spector R. Nucleoside transport in choroid plexus: mechanism and specificity. Arch. Biochem. Biophys. 216:1982;693-703.
    • (1982) Arch. Biochem. Biophys. , vol.216 , pp. 693-703
    • Spector, R.1
  • 38
    • 0022235662 scopus 로고
    • Uridine transport and metabolism in the central nervous system
    • Spector R. Uridine transport and metabolism in the central nervous system. J. Neurochem. 45:1985;1411-1418.
    • (1985) J. Neurochem. , vol.45 , pp. 1411-1418
    • Spector, R.1
  • 39
    • 0020327924 scopus 로고
    • Localization and mechanism of thymidine transport in the central nervous system
    • Spector R., Berlinger W.G. Localization and mechanism of thymidine transport in the central nervous system. J. Neurochem. 39:1982;837-841.
    • (1982) J. Neurochem. , vol.39 , pp. 837-841
    • Spector, R.1    Berlinger, W.G.2
  • 40
    • 0020570254 scopus 로고
    • Deoxycytidine transport and metabolism in choroid plexus
    • Spector R., Huntoon S. Deoxycytidine transport and metabolism in choroid plexus. J. Neurochem. 40:1983;1474-1480.
    • (1983) J. Neurochem. , vol.40 , pp. 1474-1480
    • Spector, R.1    Huntoon, S.2
  • 41
    • 0020506932 scopus 로고
    • Deoxycytidine transport and metabolism in the central nervous system
    • Spector R., Huntoon S. Deoxycytidine transport and metabolism in the central nervous system. J. Neurochem. 41:1983;1131-1136.
    • (1983) J. Neurochem. , vol.41 , pp. 1131-1136
    • Spector, R.1    Huntoon, S.2
  • 42
    • 0021364179 scopus 로고
    • Specificity and sodium dependence of the active nucleoside transport system in choroid plexus
    • Spector R., Huntoon S. Specificity and sodium dependence of the active nucleoside transport system in choroid plexus. J. Neurochem. 42:1984;1048-1052.
    • (1984) J. Neurochem. , vol.42 , pp. 1048-1052
    • Spector, R.1    Huntoon, S.2
  • 43
    • 0021017676 scopus 로고
    • Uptake of adenosine by isolated bovine cortex microvessels
    • Stefanovich V. Uptake of adenosine by isolated bovine cortex microvessels. Neurochem. Res. 8:1983;1459-1469.
    • (1983) Neurochem. Res. , vol.8 , pp. 1459-1469
    • Stefanovich, V.1
  • 44
    • 0022250241 scopus 로고
    • Kinetic analysis of cerebrovascular isoleucine transport from saline and plasma
    • Takasato Y., Momma S., Smith Q.R. Kinetic analysis of cerebrovascular isoleucine transport from saline and plasma. J. Neurochem. 45:1985;1013-1020.
    • (1985) J. Neurochem. , vol.45 , pp. 1013-1020
    • Takasato, Y.1    Momma, S.2    Smith, Q.R.3
  • 45
    • 0030602035 scopus 로고    scopus 로고
    • Identification of a saturable uptake system for deoxyribonucleosides at the blood-brain and blood-cerebrospinal fluid barriers
    • Thomas S.A., Segal M.B. Identification of a saturable uptake system for deoxyribonucleosides at the blood-brain and blood-cerebrospinal fluid barriers. Brain Res. 741:1996;230-239.
    • (1996) Brain Res. , vol.741 , pp. 230-239
    • Thomas, S.A.1    Segal, M.B.2
  • 46
    • 0018162402 scopus 로고
    • Uptake of thymidine into isolated rat hepatocytes: Evidence for two transport systems
    • Ungemach F.R., Hegner D. Uptake of thymidine into isolated rat hepatocytes: evidence for two transport systems. Hoppe-Seyler's Z. Physiol. Chem. 359:1978;845-856.
    • (1978) Hoppe-Seyler's Z. Physiol. Chem. , vol.359 , pp. 845-856
    • Ungemach, F.R.1    Hegner, D.2
  • 47
    • 0024263350 scopus 로고
    • Sodium-dependent nucleoside transport in mouse intestinal epithelial cells: Two transport systems with differing substrate specificities
    • Vijayalakshmi D., Belt J.A. Sodium-dependent nucleoside transport in mouse intestinal epithelial cells: two transport systems with differing substrate specificities. J. Biol. Chem. 263:1988;19419-19423.
    • (1988) J. Biol. Chem. , vol.263 , pp. 19419-19423
    • Vijayalakshmi, D.1    Belt, J.A.2
  • 49
    • 0025981264 scopus 로고
    • Multiple sodium-dependent nucleoside transport systems in bovine renal brush-border membrane vesicles
    • Williams T.C., Jarvis S.M. Multiple sodium-dependent nucleoside transport systems in bovine renal brush-border membrane vesicles. Biochem. J. 274:1991;27-33.
    • (1991) Biochem. J. , vol.274 , pp. 27-33
    • Williams, T.C.1    Jarvis, S.M.2
  • 50
    • 0000981770 scopus 로고
    • The roles of transport and phosphorylation in nutrient uptake in cultured animal cells
    • Wohlhueter R.M., Plagemann P.G.W. The roles of transport and phosphorylation in nutrient uptake in cultured animal cells. Int. Rev. Cytol. 64:1980;171-240.
    • (1980) Int. Rev. Cytol. , vol.64 , pp. 171-240
    • Wohlhueter, R.M.1    Plagemann, P.G.W.2
  • 51
    • 0020065520 scopus 로고
    • Uptake of adenosine by isolated rat brain capillaries
    • Wu P.H., Phillis J.W. Uptake of adenosine by isolated rat brain capillaries. J. Neurochem. 38:1982;687-690.
    • (1982) J. Neurochem. , vol.38 , pp. 687-690
    • Wu, P.H.1    Phillis, J.W.2
  • 52
    • 0021146238 scopus 로고
    • Uptake by central nervous tissues as a mechanism for the regulation of extracellular adenosine concentrations
    • Wu P.H., Phillis J.W. Uptake by central nervous tissues as a mechanism for the regulation of extracellular adenosine concentrations. Neurochem. Int. 6:1984;613-632.
    • (1984) Neurochem. Int. , vol.6 , pp. 613-632
    • Wu, P.H.1    Phillis, J.W.2
  • 53
    • 0027467824 scopus 로고
    • Formycin B elimination from the cerebrospinal fluid of the rat
    • Wu X., Hui A.C., Giacomini K.M. Formycin B elimination from the cerebrospinal fluid of the rat. Pharm. Res. 10:1993;611-615.
    • (1993) Pharm. Res. , vol.10 , pp. 611-615
    • Wu, X.1    Hui, A.C.2    Giacomini, K.M.3
  • 54
    • 0028293655 scopus 로고
    • Further characterization of the sodium-dependent nucleoside transporter (N3) in choroid plexus from rabbit
    • Wu X., Gutierrez M.M., Giacomini K.M. Further characterization of the sodium-dependent nucleoside transporter (N3) in choroid plexus from rabbit. Biochim. Biophys. Acta. 1191:1994;190-196.
    • (1994) Biochim. Biophys. Acta , vol.1191 , pp. 190-196
    • Wu, X.1    Gutierrez, M.M.2    Giacomini, K.M.3
  • 55
    • 0026794356 scopus 로고
    • Sodium-dependent nucleoside transport in choroid plexus from rabbit
    • Wu X., Yuan G., Brett C.M., Hui A.C., Giacomini K.M. Sodium-dependent nucleoside transport in choroid plexus from rabbit. J. Biol. Chem. 267:1992;8813-8818.
    • (1992) J. Biol. Chem. , vol.267 , pp. 8813-8818
    • Wu, X.1    Yuan, G.2    Brett, C.M.3    Hui, A.C.4    Giacomini, K.M.5
  • 56
    • 0020502155 scopus 로고
    • Nucleoside transport in animal cells
    • Young J.D., Jarvis S.M. Nucleoside transport in animal cells. Biosci. Rep. 3:1983;309-322.
    • (1983) Biosci. Rep. , vol.3 , pp. 309-322
    • Young, J.D.1    Jarvis, S.M.2
  • 57
    • 0022527283 scopus 로고
    • Measurement of solute transport across the blood-brain barrier in the perfused guinea-pig brain: Method and application to N-methyl-α-aminoisobutyric acid
    • Zlokovic B.V., Begley D.J., Djuricic B.M., Mitrovic D.M. Measurement of solute transport across the blood-brain barrier in the perfused guinea-pig brain: method and application to N-methyl-α-aminoisobutyric acid. J. Neurochem. 46:1986;1444-1451.
    • (1986) J. Neurochem. , vol.46 , pp. 1444-1451
    • Zlokovic, B.V.1    Begley, D.J.2    Djuricic, B.M.3    Mitrovic, D.M.4
  • 58
    • 0024435745 scopus 로고
    • Kinetic analysis of leucine-enkephalin cellular uptake at the luminal side of the blood-brain barrier of an in situ perfused guinea-pig brain
    • Zlokovic B.V., Mackic J.B., Djuricic B., Davson H. Kinetic analysis of leucine-enkephalin cellular uptake at the luminal side of the blood-brain barrier of an in situ perfused guinea-pig brain. J. Neurochem. 53:1989;1333-1340.
    • (1989) J. Neurochem. , vol.53 , pp. 1333-1340
    • Zlokovic, B.V.1    Mackic, J.B.2    Djuricic, B.3    Davson, H.4


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