The role of p53 and pRB in apoptosis and cancer

Current Opinion in Genetics and Development

Volumn 12, Issue 1, 2002, Pages 60-66

  Hickman, Emma S ^a   Moroni, M Cristina ^a   Helin, Kristian ^a  

^a EUROPEAN INSTITUTE OF ONCOLOGY   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN DEPENDENT KINASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PROTEIN BAX; PROTEIN BCL 2; PROTEIN P53; RETINOBLASTOMA PROTEIN; TUMOR NECROSIS FACTOR RECEPTOR;

APOPTOSIS; CANCER; CANCER CELL; CARCINOGENESIS; CELL CYCLE; CELL PROLIFERATION; CELL SURVIVAL; HUMAN; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; REVIEW; SIGNAL TRANSDUCTION;

EID: 0036467582     PISSN: 0959437X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0959-437X(01)00265-9     Document Type: Review

References (54)

1. Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours
2. Tumor spectrum analysis in p53-mutant mice
3. p53, the cellular gatekeeper for growth and division
4. The complexity of p53 modulation: Emerging patterns from divergent signals
5. Regulation of p53 in response to DNA damage
6. Enhanced phosphorylation of p53 by ATM in response to DNA damage
7. Activation of the ATM kinase by ionising radiation and phosphorylation of p53
8. 1 by stabilizing p53
9. p53 transcriptional activity is essential for p53-dependent apoptosis following DNA damage
10. A transactivation-deficient mouse model provides insights into Trp53 regulation and function
11. Tumor suppressor p53 is a regulator of bcl-2 and bax gene expression in vitro and in vivo
12. Tumor suppressor p53 is a direct transcriptional activator of the human bax gene
13. Wild-type human p53 and a temperature-sensitive mutant induce Fas/APO-1 expression
14. A model for p53-induced apoptosis
15. PUMA, a novel proapoptotic gene, is induced by p53
16. PUMA induces the rapid apoptosis of colorectal cancer cells
17. Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis
18. Role of NF-κB in p53 mediated programmed cell death
19. p53AIP1, a potential mediator of p53-dependent apoptosis, and its regulation by Ser-46-phosphorylated p53
20. Pidd, a new death-domain-containing protein, is induced by p53 and promotes apoptosis
21. The biochemistry of apoptosis
22. APAF1 is a transcriptional target for E2F and p53
23. Inactivation of the apoptosis effector Apaf-1 in malignant melanoma
24. p53DINP1, a p53-inducible gene, regulates p53-dependent apoptosis
25. Stress signals utilize multiple pathways to stabilize p53
26. PERP, an apoptosis-associated target of p53, is a novel member of the PMP-22/gas3 family
27. Pw1/Peg3 is a potential cell death mediator and cooperates with Siah1a in p53-mediated apoptosis
28. The retinoblastoma protein and cell cycle control
29. The retinoblastoma gene family in differentiation and development
30. The hallmarks of cancer
31. Developmental basis of retinal-specific induction of cancer by RB mutation
32. Retinoblastoma gene promoter directs transgene expression exclusively to the nervous system
33. Cell-autonomous and non-cell autonomous functions of the Rb tumor suppressor in developing central nervous system
34. p53-dependent apoptosis produced by pRb-deficiency in the developing mouse lens
35. Loss of Rb activates both p53-dependent and independent cell death pathways in the developing mouse nervous system
36. The regulation of E2F by pRB-family proteins
37. Regulation of cell proliferation by the E2F transcription factors
38. CDC25A phosphatase is a target of E2F and is required for efficient E2F-1 induced S phase
39. Mutation of E2F1 supresses apoptosis and inappropriate S-phase entry and extends survival of Rb-deficient mouse embryos
40. E2F3 contributes both to the inappropriate proliferation and to the apoptosis arising in Rb mutant embryos
41. Distinct roles for E2F proteins in cell growth control an apoptosis
42. ARF links the tumour suppressors RB and p53
43. Tumor surveillance via ARF-p53 pathway
44. Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization
45. Role for the p53 homologue p73 in E2F-1-induced apoptosis
46. Role of the p53-homologue p73 in E2F1 induced apoptosis
47. E2Fs regulate the expression of genes involved in differentiation, development, proliferation and apoptosis
48. Apaf-1 and Caspase-9 in p53-dependent apoptosis and tumor inhibition
49. E2F-1 potentiates cell death by blocking antiapoptotic signaling pathways
50. Id2 is a retinoblastoma protein target and mediates signalling by Myc oncoproteins
51. Development of peripheral lymphoid organs and natural killer cells depends on the helix-loop-helix inhibitor Id2
52. Lactation defect in mice lacking the helix-loop-helix inhibitor Id2
53. Caspase 8 is deleted or silenced preferentially in childhood neuroblastomas with amplification of MYCN
54. KILLER/DR5 is a DNA damage-inducible p53-regulated death receptor gene