p38 and Chk1 kinases: Different conductors for the G2/M checkpoint symphony

Current Opinion in Genetics and Development

Volumn 12, Issue 1, 2002, Pages 92-97

  Bulavin, Dmitry V ^a   Amundson, Sally A ^a   Fornace Jr, Albert J ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 (4 FLUOROPHENYL) 2 (4 HYDROXYPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; 7 HYDROXYSTAUROSPORINE; CAFFEINE; NOCODAZOLE; PROTEIN CHK1 KINASE; PROTEIN KINASE; PROTEIN TYROSINE PHOSPHATASE; SYNAPTOPHYSIN; UNCLASSIFIED DRUG;

CELL CYCLE G2 PHASE; DNA DAMAGE; GENOTOXICITY; HUMAN; MITOSIS; NONHUMAN; PHOSPHORYLATION; PRIORITY JOURNAL; REVIEW; STRESS;

EID: 0036467486     PISSN: 0959437X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0959-437X(01)00270-2     Document Type: Review

References (35)

1. Regulation of the G2/M transition by p53
2. The G2 DNA damage checkpoint delays expression of genes encoding mitotic regulators
3. Initiation of a G2/M checkpoint after ultraviolet radiation requires p38 kinase
4. The Chk1 protein kinase and the Cdc25C regulatory pathways are targets of the anticancer agent UCN-01
5. Cdc2 tyrosine phosphorylation is required for the DNA damage checkpoint in fission yeast
6. The G2/M DNA damage checkpoint inhibits mitosis through Tyr15 phosphorylation of p34cdc2 in Aspergillus nidulans
7. Role of inhibitory CDC2 phosphorylation in radiation-induced G2 arrest in human cells
8. Nuclear localization of cyclin B1 controls mitotic entry after DNA damage
9. Nuclear export of cyclin B1 and its possible role in the DNA damage-induced G2 checkpoint
10. Inhibition of ATM and ATR kinase activities by the radiosensitizing agent, caffeine
11. Caffeine inhibits the checkpoint kinase ATM
12. -/- mice
13. Chk1 is an essential kinase that is regulated by Atr and required for the G(2)/M DNA damage checkpoint
14. DNA damage-induced activation of p53 by the checkpoint kinase Chk2
15. Mitotic and G2 checkpoint control: Regulation of 14-3-3 protein binding by phosphorylation of Cdc25C on serine-216
16. Linkage of ATM to cell cycle regulation by the Chk2 protein kinase
17. The radiosensitizing agent 7-hydroxystaurosporine (UCN-01) inhibits the DNA damage checkpoint kinase hChk1
18. Cdc25 dependent activation of cyclin A/cdk2 is blocked in G2 phase
19. Involvement of the MKK6-p38γ cascade in γ-radiation-induced cell cycle arrest
20. Three distinct signalling responses by murine fibroblasts to genotoxic stress
21. Phosphorylation of human p53 by p38 kinase coordinates N-terminal phosphorylation and apoptosis in response to UV radiation
22. p53-inducible wip1 phosphatase mediates a negative feedback regulation of p38 MAPK-p53 signaling in response to UV radiation
23. Cdc25B and Cdc25C differ markedly in their properties as initiators of mitosis
24. Nuclear localization of Cdc25 is regulated by DNA damage and a 14-3-3 protein
25. Binding of 14-3-3 proteins and nuclear export control the intracellular localization of the mitotic inducer Cdc25
26. p55CDC25 is a nuclear protein required for the initiation of mitosis in human cells
27. Caffeine abolishes the mammalian G(2)/M DNA damage checkpoint by inhibiting ataxia-telangiectasia-mutated kinase activity
28. Nuclear exclusion of Cdc25 is not required for the DNA damage checkpoint in fission yeast
29. An essential phosphorylation-site domain of human CDC25C interacts with both 14-3-3 and cyclins
30. Cdc25B activity is regulated by 14-3-3
31. Absence of apparent phenotype in mice lacking cdc25c protein phosphatase
32. C-TAK1 protein kinase phosphorylates human Cdc25C on serine 216 and promotes 14-3-3 protein binding
33. Pyridinylimidazole compound SB 203580 inhibits the activity but not the activation of p38 mitogen-activated protein kinase
34. Inhibition of p38 MAP kinase as a therapeutic strategy
35. Association of Chk1 with 14-3-3 proteins is stimulated by DNA damage