Lysosomal cathepsins: Structure, role in antigen processing and presentation, and cancer

Advances in Enzyme Regulation

Volumn 42, Issue , 2002, Pages 285-303

  Turk, Vito ^a   Turk, Boris ^a   Gunčar, Gregor ^a   Turk, Dušan ^a   Kos, Janko ^a,b  

^a JO EF STEFAN INSTITUTE   (Slovenia)

^b KRKA D D   (Slovenia)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGEN; ANTINEOPLASTIC AGENT; CATHEPSIN; CATHEPSIN B; CATHEPSIN H; CATHEPSIN L; CATHEPSIN X; CYSTATIN; CYSTATIN C; CYSTEINE PROTEINASE; DIPEPTIDYL PEPTIDASE I; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; MONOCLONAL ANTIBODY; POLYCLONAL ANTIBODY; PROTEIN INHIBITOR; STEFIN A; THYROPIN; TUMOR ANTIGEN; UNCLASSIFIED DRUG;

ANGIOGENESIS; ANIMAL CELL; ANTIGEN PRESENTATION; CANCER; CANCER INVASION; CHEMICAL ANALYSIS; CHEMICAL STRUCTURE; CHEMISTRY; CONFERENCE PAPER; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME SPECIFICITY; ENZYME SUBSTRATE; ENZYME SUBSTRATE COMPLEX; ENZYMOLOGY; HUMAN; HUMAN TISSUE; IMMUNE RESPONSE; IMMUNOLOGY; LYSOSOME; MAJOR HISTOCOMPATIBILITY COMPLEX; METABOLISM; NEOPLASM; NEOVASCULARIZATION (PATHOLOGY); NONHUMAN; PROTEIN CONFORMATION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; TIME; TUMOR GROWTH; TUMOR IMMUNITY;

ANTIGEN PRESENTATION; ANTIGENS; ANTINEOPLASTIC AGENTS; CATHEPSINS; CYSTATINS; CYSTEINE ENDOPEPTIDASES; HUMANS; LYSOSOMES; MAJOR HISTOCOMPATIBILITY COMPLEX; MODELS, MOLECULAR; NEOPLASM INVASIVENESS; NEOPLASMS; NEOVASCULARIZATION, PATHOLOGIC; PROTEIN CONFORMATION; SUBSTRATE SPECIFICITY; TIME FACTORS;

ANIMALIA;

EID: 0036374209     PISSN: 00652571     EISSN: None     Source Type: Book Series    
DOI: 10.1016/S0065-2571(01)00034-6     Document Type: Conference Paper

References (103)

1. Cystatins
2. Introduction: Cysteine peptidases and their clans
3. A fragment of the major histocompatibility complex class II-associated p41 invariant chain inhibits cruzipain, the major cysteine proteinase from Trypanosoma cruzi
4. Major histocompatibility complex class II-associated p41 invariant chain fragment is a strong inhibitor of lysosomal cathepsin L
5. The 2.0 Å X-ray crystal structure of chicken egg white cystatin and its possible model of interaction with cysteine proteinases
6. Intracellular proteases
7. Deficient major histocompatibility complex class II antigen presentation in a subset of Hodgkin's disease tumor cells
8. Friends and relations of the cystatin superfamily - New members and their evolution
9. Ribbons 2.0
10. Endosomal proteolysis and MHC class II function
11. The residual pro-part of cathepsin C fulfills the criteria required for an intramolecular chaperone in folding and stabilizing the human proenzyme
12. Interaction of cystatin C variants with papain and human cathepsins B, H and L
13. Structure of human procathepsin L reveals the molecular basis of inhibition by the prosegment
14. Human recombinant prodipeptidyl peptidase I (cathepsin C) can be activated by cathepsin L and S but not by autocatalytic processing
15. Cathepsin B and D are dispensable for major histocompatibility complex class II-mediated antigen presentation
16. Oligomeric structure and substrate inhibition of human cathepsin C
17. Cathepsin S controls the trafficing and maturation of MHC class II molecules in dendritic cells
18. Thyroidal processing by thyroidal proteases
19. Proteases - Invasion and more
20. Expression of cathepsins B and S in the progression of prostate carcinoma
21. Cathepsin B acts as a dominant execution protease in tumor cell apoptosis induced by tumor necrosis factor
22. Potent slow binding inhibition of cathepsin B by its propeptide
23. Human cystatin D
24. Potency, selectivity of inhibition of cathepsin K, L and S by their respective propeptides
25. Crystal structure of cathepsin X: A flip-flop of the ring of his23 allows carboxy-mono-peptidase and carboxy-dipeptidase activity of the protease
26. Crystal structure of porcine cathepsin H at 2.1 A resolution: Location of the mini-chain c-terminal carboxyl group defines cathepsin h aminopeptidase function
27. Crystal structure of MHC class II-associated p41 Ii fragment bound to cathepsin L reveals the structural basis for differentiation between cathepsin L and S
28. Studies on thiol protease inhibitors. Part I. Isolation and characterization of E-64, a new thiol proteinase inhibitor
29. Urokinase-type plasminogen activation in three human breast cancer cell lines correlates with their in vitro invasiveness
30. Cathepsin S regulates the expression of cathepsin L and the turnover of γ-interferon-inducible lysosomal thiol reductase in B lymphocytes
31. Lymphoid monoclonal antibodies reactive with lung tumors
32. Participation of cathepsin L on bone resorption
33. Structure based development of novel specific inhibitors for cathepsin L and S in vitro and in vivo
34. Proteinases I: Lysosomal cysteine proteinases
35. Cathepsin S from bovine spleen. Purification distribution, intracellular localization Action on proteins
36. Biochemical characterization of human cathepsin X revealed that the enzyme is an exopeptidase, acting as carboxymonopeptidase or carboxydipeptidase
37. Unraveling the role of proteases in cancer
38. Lysosomal proteases cathepsins D, B, H, L and their inhibitors stefins A and B in head and neck cancer
39. Cysteine proteinases and their endogenous inhibitors: Target proteins for prognosis diagnosis and therapy in cancer
40. Cathepsin S in tumors, regional lymph nodes and sera of patients with lung cancer: Relation to prognosis and immune response
41. Cysteine proteinases and their inhibitors in extracellular fluids: Markers for diagnosis and prognosis in cancer
42. Thyropins - New structurally related proteinase inhibitors
43. Saxiphilin, a saxitoxin-binding protein with two thyroglobulin type-1 domains, is an inhibitor of papain-like cysteine proteinases
44. Thyroglobulin type-1 domains in equistatin inhibit both papain-like cysteine proteinases and cathepsin D
45. The p41 isoform of invariant chain is a chaperone for cathepsin L
46. Cathepsin L: Critical role in ii degradation and CD4t cell selection in the thymus
47. Crystal structure of human cathepsin K complexed with a potent inhibitor
48. Crystal structure of human cathepsin S
49. The refined 2.15 Å X-ray structure of human liver cathepsin B: The structural basis for its specificity
50. Human cathepsin X: A cysteine protease with unique carboxypeptidase activity
51. Impaired invariant chain degradation and antigen presentation and diminished collagen-induced arthritis in cathepsin S null mice
52. Inhibition of carcinoma cell invasion and liver metastases formation by the cysteine proteinase inhibitor E-64
53. Cystatin E is a novel human cysteine proteinase inhibitor with structural resemblance to family 2 cystatins
54. Cystatin F is a glycosylated human low molecular weight cysteine proteinase inhibitor
55. Purification of the complex of cathepsin L and the MHC class II-associated invariant chain fragment from human kidney
56. Developmental regulation of invariant chain proteolysis controls MHC class II trafficing in mouse dendritic cells
57. MHC class II restricted antigen presentation
58. Characterization by spectroscopic, kinetic and equilibrium methods of the interaction between recombinant human cystatin A (stefin A) and cysteine proteinases
59. A new purification procedure of human kidney cathepsin H, its properties and kinetic data
60. Probing the specificity of cysteine proteinases at subsites remote from the active site: Analysis of P4, P3, P′2 and P′3 variations in extended substrates
61. Invasion of ras-transformed breast epithelial cells depends on the proteolytic activity of cysteine and aspartic proteinases
62. Cathepsin S activity regulates antigen presentation and immunity
63. Cathepsin D in breast cancer: Mechanisms and clinical applications, a 1999 overview
64. On the size of the active site in proteases. I. Papain
65. Tumor-associated proteases
66. Antigen-processing machinery breakdown and tumor growth
67. Cysteinyl proteinases and their selective inactivation
68. Peptidyl diazomethanes as inhibitors of cysteine and serine proteinases
69. Cathepsin S required for normal MHC class 11 peptide loading and germinal center development
70. Lysosomal enzymes and their endogenous inhibitors in neoplasia
71. Lysosomal protease pathways to apoptosis
72. Cathepsin B immunostaining in tumor and endothelial cells is a new prognostic factor for survival in patients with brain tumors
73. The refined 2.4 Å X-ray crystal structure of recombinant human stefin B in complex with the cysteine proteinase papain: A novel type of proteinase inhibitor interaction
74. Inhibition mechanism of cathepsin L - Specific inhibitors based on the crystal structure of papain-CLIK-148 complex
75. The cystatins: Protein inhibitors of cysteine proteinases
76. Lysosomal cysteine proteinases and their inhibitors cystatins
77. Human cathepsin B is a metastable enzyme stabilized by specific ionic interactions associated with the active site
78. Acidic pH as a physiological regulator of human cathepsin L activity
79. Kinetics of the pH-induced inactivation of human cathepsin L
80. Revised definition of substrate binding sites of papain-like cysteine proteases
81. Dipeptidyl-peptidase I
82. The p41 fragment story
83. Lysosomal cysteine proteinases: Structure and regulation
84. Crystal structure of cathepsin B inhibited with CA030 at 2.0 Å resolution: A basis for the design of specific epoxysuccinyl inhibitors
85. Structural, functional aspects of papain-like cysteine proteinases and their protein inhibitors
86. Lysosomal cysteine proteases: Facts and opportunities
87. Lysosomal cysteine proteases: More than scavengers
88. Structure of human dipeptidyl peptidase I (cathepsin C): Exclusion domain added to an endopeptidase framework creates the machine for activation of granular serine proteases
89. Anti-human procathepsin D activation peptide antibodies inhibit breast cancer development
90. Cathepsin B in infiltrated lymph nodes is of prognostic significance for patients with nonsmall cell lung carcinoma
91. Fluorometric microassays for the determination of cathepsin L and cathepsin S activities in tissue extracts
92. Intracellular transport and peptide loading of MHC class II molecules: Regulation by chaperones and motors
93. Lack of class II transactivator causes severe deficiency of HLA-DR expression in small cell lung cancer
94. Immunochemical localisation of cathepsin S, cathepsin L and MHC class II-associated p41 isoform of invariant chain in human lymph node tissue
95. Crystal structure of human osteoclast cathepsin K complex with E-64
96. Cathepsin B/cystatin C complex levels in sera from patients with lung and colorectal cancer
97. Isolation of cathepsin B and α-N-benzoylarginine-β-napthylamide hydrolase on activated thiol sepharose