Cathepsin B immunohistochemical staining in tumor and endothelial cells is a new prognostic factor for survival in patients with brain tumors

Clinical Cancer Research

Volumn 5, Issue 3, 1999, Pages 559-567

  Strojnik, Tadej ^a   Kos, Janko ^b,c   Židanik, Boris ^a   Golouh, Rastko ^d   Lah, Tamara ^e  

^a UNIVERSITY MEDICAL CENTRE MARIBOR   (Slovenia)

^b JO EF STEFAN INSTITUTE   (Slovenia)

^c KRKA   (Slovenia)

^d INSTITUTE OF ONCOLOGY   (Slovenia)

^e NATIONAL INSTITUTE OF BIOLOGY   (Slovenia)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MARKER; CATHEPSIN B; CYSTEINE PROTEINASE; STEFIN A;

ADOLESCENT; ADULT; AGED; ARTICLE; BRAIN TUMOR; CANCER MORTALITY; CANCER SURVIVAL; CELLULAR DISTRIBUTION; CHILD; CLINICAL FEATURE; FEMALE; GLIOMA; HUMAN; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROGNOSIS; PROTEIN LOCALIZATION; RADIOLOGY; SCORING SYSTEM; TUMOR GROWTH;

ADOLESCENT; ADULT; AGED; BRAIN NEOPLASMS; CATHEPSIN B; CHILD; CHILD, PRESCHOOL; CYSTATINS; ENDOTHELIUM; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MIDDLE AGED; PROGNOSIS; SURVIVAL RATE; TUMOR MARKERS, BIOLOGICAL;

EID: 0032999141     PISSN: 10780432     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (56)

1. Youmans, J. R. Neurological Surgery, pp. 3040-3136. New York: W. B. Saunders Company, 1990.
2. Gately, S., Tsanaclis, A. M. C., Takano, S., Klagsbrun, and M., Brem, S. Cells transfected with the basic tibroblast growth factor gene fused to a signal sequence are invasive in vitro and in situ in the brain. Neurosurgery (Baltimore), 36: 780-788, 1995.
3. Giese, A., and Westphal, M. Glioma invasion in the central nervous system. Neurosurgery (Baltimore), 39: 235-252, 1996.
4. Giese, A., Loo, M. A., Rief, M. D., Tran, N., and Berens, M. E. Substrates for astrocytoma invasion. Neurosurgery (Baltimore), 37: 294-302, 1995.
5. Giese, A., Kluwe, L., Laube, B., Meissner, H., Berens, M. E., and Westphal, M. Migration of human glioma cells on myelin. Neurosurgery (Baltimore), 38: 755-764, 1996.
6. Merzak, A., Koochekpour, S., Dkhissi, F., Raynal, S., Lawrence, D., and Pilkington, G. J. Synergism between growth factors in the control of glioma cell proliferation, migration and invasion in vitro. Int. J. Oncol., 6: 1079-1085, 1995.
7. Maidment, S. L., Merzak, A., Koochekpour, S., Rooprai, H. K., Rucklidge, G. J., and Pilkington, G. J. The effect of exogenous gangliosides on matrix metalloproteinase secretion by human glioma cells in vitro. Eur. J. Cancer, 32A: 868-871, 1996.
8. Silbergeld, D. L., and Chicoine, M. R. Isolation and characterization of human malignant glioma cells from histologically normal brain. J. Neurosurg., 86: 525-531, 1997.
9. Pilkington, G. J. The paradox of neoplastic glial cell invasion of the brain and apparent metastatic failure. Anticancer Res., 17: 4103-4109, 1997.
10. Pilkington, G. J. Tumor cell migration in the central nervous system. Brain Pathol., 4: 157-166, 1994.
11. Mikkelsen, T., Yan, P. S., Ho, K. L., Sameni, M., Sloane, B. F., and Rosenblum, M. L. Immunolocalization of Cat B in human glioma: implications for tumor invasion and angiogenesis. J. Neurosurg., 83: 285-290, 1995.
12. Kos, J., Šmid, A., Krašovec, M., Svetic, B., Lenarčič, B., Vrhovec, I., Škrk, J., and Turk, V. Lysosomal proteases Cats D, B, H, L and their inhibitors stefins A and B in head and neck Cancer. Biol. Chem. Hoppe-Seyler, 378: 401-405, 1995.
13. Ledakis, P., Tester, W. T., Rosenberg, N., Romero-Fischmann, D., Daskal, I., and Lah, T. T. Cats D, B, and L in malignant human lung tissue. Clin. Cancer Res., 2: 561-568, 1996.
14. McCormick, D. Secretion of Cat B by human gliomas in vitro. Neuropathol. Appl. Neurobiol., 19: 146-151, 1993.
15. Kos, J., and Lah, T. Cysteine proteinases and their endogenous inhibitors: target proteins for prognosis, diagnosis and therapy in cancer (Review). Oncol. Rep., 5: 1349-1361, 1998.
16. Castiglioni, T., Merino, M. J., Elsner, B., Lah, T. T., Sloane, B. F., and Emmert-Buck, M. R. Immunohistochemical analysis of Cats D, B and L in human breast cancer. Hum. Pathol., 25: 857-862, 1994.
17. Paku, S. Current concepts in tumor-induced angiogenesis. Pathol. Oncol. Res., 4: 62-76, 1998.
18. Graeff, H., Harbeck, N., Pache, L., Wilhem, O., Janicke, F., and Schmitt, M. Prognostic impact and clinical relevance of tumor-associated proteases in breast cancer. Fibrinolysis, 6: 45-53, 1992.
19. Schmitt, M., Janicke, F., and Graeff, F. Tumor-associated proteases. Fibrinolysis, 6 (Suppl. 4): 3-26, 1992.
20. Hsu, D. W., Efird, J. T., and Hedley-Whyte, E. T. Prognostic role of urokinase-type plasminogen activator in human gliomas. Am. J. Pathol., 147: 114-123, 1995.
21. Paganetti, P. A., Caroni, P., and Schwab, M. Glioblastoma infiltration into central nervous system tissue in vitro: involvement of a metalloproteinase. J. Cell Biol., 107: 2281-2291, 1988.
22. Lund-Johansen, M., Rucklidge, G. J., Milne, G., Bjerkvig, R. A metalloproteinase, capable of destroying cultured brain tissue isolated from rat glioma cells. Anticancer Res., 11: 1001-1006, 1991.
23. Apodaca, G., Rutka, J. T., Bouhana, K., Berens, M. E., Giblin, J. R., Rosenblum, M. L., McKerrow, J. H., and Banda, M. J. Expression of metalloproteinases and metalloproteinase inhibitors by fetal astrocytes and glioma cells. Cancer Res., 50: 2322-2329, 1990.
24. Nakano, A., Tani, E., Miyazaki, K., Yamamoto, Y., and Furuyama, J. Matrix metalloproteinases and tissue inhibitors of metalloproteinases in human gliomas. J. Neurosurg., 83: 298-307, 1995.
25. Sitrin, R. G., Gyetko, M. R., Kole, K. L., McKeever, P., and Varani, J. Possession of heterogeneous profiles of plasminogen activators and plasminogen activator inhibitors by human glioma cell lines. Cancer Res., 50: 4957-4961, 1990.
26. Garcia, M., Platet, N., Liaudet, E., Laurent, V., Derocq, D., Brouillet, J. P., and Rochefort, H. Biological and clinical significance of cathepsin D in breast cancer metastasis. Stem Cells, 14: 642-650, 1996.
27. Ren, W. P., and Sloane, B. F. Cathepsins D, and B in breast cancer. In: R. Dickson and M. Lippman (eds.), Mammary Tumor Cell Cycle, Differentiation and Metastasis, pp. 325-352. Kluwer Academic Publishers, 1996.
28. Sloane, B. F., Moin, K., and Lah, T. T. Regulation of lysosomal endopeptidases in malignant neoplasia. . In: T. G. Pretlow and T. P. Pretlow (eds.), Biochemical and Molecular Aspects of Selected Cancers, Vol. 2, pp. 411-466. Academic Press, 1994.
29. Lah, T. T., and Kos, J. Cysteine proteinases in cancer progression and their clinical relevance for prognosis. Biol. Chem., 379: 125-130, 1998.
30. Duffy, M. J. Proteases as prognostic markers in cancer (Minireview). Clin. Cancer Res., 2: 613-618, 1996.
31. Lah, T. T., Kos, J., Blejec, A., Frkovič-Grazio, S., Golouh, R, Vrhovec, I., and Turk, V. The expression of lysosomal proteinases and their inhibitors in breast cancer: possible relationship to prognosis of the disease. Pathol. Oncol. Res., 3: 89-99, 1997.
32. Thomssen, C., Schmitt, M., Goretzki, L., Oppelt, P., Pache, L., Dettmar, P., Janicke, F., and Graeff, H. Prognostic value of the cysteine proteases cathepsins B and cathepsins L in human breast cancer. Clin. Cancer Res., 1: 741-746, 1995.
33. Foekens, J., Kos, J., Peters, H. A., Krašovec, M., Look, M. P., Cimerman, N., Meijer-van-Gelder, M., Henzen Logmans, S. C., Putten, W. L. J, and Klijn, J. G. M. Prognostic significance of cathepsin B and L in primary human breast cancer. J. Clin. Oncol., 16: 1013-1021, 1998.
34. Budihna, M., Strojan, P., Šmid, L., Škrk, J., Vrhovec, I., Rudolf, Z., Zargi, M., Krašovec, M., Svetic, B., Kopitar-Jerala, N., and Kos, J. Prognostic value of cathepsins B, H, L, D and their endogenous inhibitors stefins A and B in head and neck carcinoma. Biol. Chem., 377: 385-390, 1996.
35. Kos, J., Nielsen, H-J., Krašovec, M., Christensen, O. J., Cimerman, N., Stephen, R. W., and Brunner, N. Prognostic values of cathepsin B and carcioembrionic antigen in sera of patients with colorectal carcinoma. Clin. Cancer Res., 4: 1511-1516, 1998.
36. Kos, J., Štabuc, B., Schweiger, A., Krašovec, M., Cimerman, N., Kopitar-Jerala, N., and Vrhovec, I. Cathepsins B, H, and L, and their inhibitors stefin A, and cystatin C in sera of melanoma patients. Clin. Cancer Res., 3: 1815-1822, 1997.
37. Sivaparvathi, M., Sawaya, R., Wang, S. W., Rayford, A., Yamamoto, M., Liotta, L. A., Nicolson, G. L., and Rao, J. S. Overexpression and localization of Cat B during the progression of human gliomas. Clin. Exp. Metastasis, 13: 49-56, 1995.
38. Rempel, S. A., Rosenblum, M. L., Mikkelsen, T., Yan, P-S., Ellis, K. D., Golembieski, W. A., Sameni, M., Rozhin, J., Ziegler, G., and Sloane, B. F. Cat B expression and localization in glioma progression and invasion. Cancer Res., 54: 6027-6031, 1994.
39. Turk, V., and Bode, W. Human cysteine proteinases and their inhibitors, stefins and cystatins. In: F. X. Aviles (ed.), Innovations in Proteases and their Inhibitors, pp. 47-59. Berlin: W. de Gruyter, 1993.
40. Kominami, E., Bando, Y., Wakamatsu, N., and Katunuma, N. Different tissue distribution of two types of thiol proteinase inhibitors from rat liver epidermis. J. Biochem., 96: 1437-1442.
41. Alavaikoo, M., Aine, R., Rinne, A., Jarvinen, M., Blanco, G., Apaja-Sarkkinen, M., and Hopsu-Havu, V. K. Behavior of dendritic reticulum cells possessing immunoreactive acid cysteine-proteinase inhibitor in human lymphoid secondary follicles and in follicular center cell lymphomas. Int. J. Cancer, 35: 319-325, 1985.
42. Lah, T. T., Kokalj-Kunovar, M., Štrukelj, B., Pungerčar, J., Magajna, D., Drobnič-Košorok, M., Kastelic, L., Babnik, J., Golouh, R., and Turk, V. Stefins and lysosomal cathepsins B, 1 and D in human breast carcinoma. Int. J. Cancer, 50: 36-44, 1992.
43. Sivaparvathi, M., McCutcheon, I., Sawaya, R., Nicolson, G. L., and Rao, J. S. Expression of cysteine protease inhibitors in human gliomas and meningiomas. Clin. Exp. Metastasis, 14: 344-350, 1996.
44. Kleihues, P., Burger, P. C., and Scheithauer, B. W. The new WHO classification of brain tumors. Brain Pathol., 3: 255-268, 1993.
45. Kaplan, E. L., and Meier, P. Nonparametric estimation from incomplete observation. J. Am. Stat. Assoc., 53: 457-481, 1958.
46. Koblinski, J. B., and Sloane, B. F. Is altered localization of cathepsin B causally related to malignant progression? In: N. Katunuma et al. (eds. ), Medical Aspects of Proteases and Protease Inhibitors, pp. 185-194. CIS Press, 1997.
47. Sukoh, N., Abe, S., Nakajima, I., Ogura, S., Isobe, H., Inoue, K., and Kawakami, Y. Immunohistochemical distribution of cathepsin B and basement membrane antigens in human lung adenocarcinoma: association with invasion and metastasis. Virchows Arch., 424: 33-38. 1994.
48. Weiss, R. E., Liu, B. C. S., Ahlering, T. E., Dubeau, L., and Droller, M. J. Mechanism of human bladder tumor invasion: role of protease cathepsin. Br. J. Urol., 144: 798-804, 1990.
49. Campo, E., Munoz, J., Miquel, R., Palacin, A., Cardesa, A., Sloane, B. F., and Emmert-Buck, M. R. Cathepsin B expression in colorectal carcinomas correlates with tumor progression and shortened patient survival. Am. J. Pathol., 145: 301-309, 1994.
50. Mantovani, A. Tumor-associated macrophages. Curr. Opin. Immunol., 2: 689-692, 1990.
51. Fidler, I. J. Inhibition of pulmonary metastasis by intravenous injection of specifically activated macrophages. Cancer Res., 34: 1074-1078, 1974.
52. Lah, T. T., Hawlley, M., Rock, K. L., and Goldberg, A. L. γ-Interferon causes selective induction of lysosomal proteases cathepsins B and L, in macrophages. FEBS Lett., 262: 85-89, 1995.
53. Sinha, A. A., Gleason, D. F., Staley, N. A., Wilson, M. J., Sameni, M., and Sloane, B. F. Cathepsin B in angiogenesis of human prostate: an immunohistochemical and immunoelectron microscopic analysis. Anat. Rec., 241: 353-362, 1995.
54. Buck, M. R., Karustis, D. G., Day, A. N., Honn, K. V., and Sloane, B. F. Degradation of extracellular matrix proteins by human cathepsin B from normal and tumor tissues. Biochem. J., 282: 273-278, 1992.
55. Liotta, L. A., Steeg, P. S., and Stetler-Stevenson, W. G. Cancer metastasis and angiogenesis: an imbalance of positive and negative regulation. Cell, 64: 327-336, 1991.
56. Kuopio, T., Kankaanranta, A., Jalava, P., Kronqvist, P., Kotkansalo, T., Weber, E., and Collan, Y. Cysteine proteinase inhibitor cystatin A in breast cancer. Cancer Res., 58: 432-436, 1998.