Probing the specificity of cysteine proteinases at subsites remote from the active site: Analysis of P4, P3, P2' and P3' variations in extended substrates

Biochemical Journal

Volumn 347, Issue 1, 2000, Pages 123-129

  Portaro, Fernada C Vieira ^a   Santos, Ana Beatriz F ^a   Cezari, Maria Helena S ^b   Juliano, Maria Aparecida ^a   Juliano, Luiz ^b   Carmona, Euridice ^a  

^a INSTITUTO BUTANTAN   (Brazil)

^b FEDERAL UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Cathepsins B and L; Fluorogenic peptide; Limited proteolysis; Papain; Protease substrate

Indexed keywords

AMINO ACID; ASPARAGINE; CATHEPSIN B; CATHEPSIN L; CYSTEINE PROTEINASE; PAPAIN; TRYPTOPHAN;

ARTICLE; BINDING SITE; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME KINETICS; ENZYME SUBSTRATE; HUMAN; NONHUMAN; PRIORITY JOURNAL; RAT;

AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; CATHEPSIN B; CATHEPSINS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CYSTEINE ENDOPEPTIDASES; ENDOPEPTIDASES; FLUORESCENT DYES; HUMANS; KINETICS; OLIGOPEPTIDES; PAPAIN; RATS; RECOMBINANT PROTEINS; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; SUBSTRATE SPECIFICITY;

FELIS CATUS;

EID: 0034176273     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/0264-6021:3470123     Document Type: Article

References (51)

1. 1 Berti, P. J. and Storer, A. C. (1995) J. Mol. Biol. 246, 273-283
2. 2 Kirschke, H., Barrett, A. J. and Rawlings, N. D. (1995) Protein Profile 2, 1587-1644
3. 3 Authier, F., Posner, B. I. and Bergeron, J. J. (1996) FEBS Lett. 389, 55-60
4. 4 Kakegawa, H., Nikawa, T., Tagami, K., Kamioka, H., Sumitani, K., Kawata, T., Drobnic-Kosorok, M., Lenarcic, B., Turk, V. and Katunuma, N. (1993) FEBS Lett. 321, 247-250
5. 5 Esser, R. E., Angelo, R. A., Murphey, M. D., Watt, L. M., Thornburg, L. P., Palmer, J. T., Talhouk, J. W. and Smith, R. E. (1994) Arthritis Rheum. 37, 236-247
6. 6 Duffy, M. J. (1992) Biotherapy 4, 46-52
7. 7 Katumuna, N., Kominomi, E. and Li, K. (1987) Am. J. Pathol. 127, 681-688
8. 8 Wurtz, A. and Bouchut, E. (1879) Compt. Rend. 89, 425-430
9. 9 Brocklehurst, K., Willenbrock, F. and Salih, E. (1987) in Hydrolytic Enzymes (Neuberger, A. and Brocklehurst, K., eds.), pp. 39-158, Elsevier Biomedical Press, Amsterdam
10. 10 Storer, A. C. and Ménard, R. (1994) Methods Enzymol. 244, 486-500
11. 11 Ménard, R. and Storer, A. C. (1998) in Handbook of Proteolytic Enzymes (Barrett, A. J., Rawling, N. D. and Woesner, J. F., eds.), pp. 555-557, Academic Press, New York
12. 12 Berger, A. and Schechter, I. (1970) Phil. Trans. R. Soc. Lond. B 257, 249-264
13. 13 Kärgel, H. J., Dettmer, R., Etzold, G., Kirschke, H., Bohley, P. and Langner, J. (1980) FEBS Lett. 114, 257-260
14. 14 Hasnain, S., Hirama, T., Huber, C. P., Mason, P. and Mort, J. S. (1993) J. Biol. Chem. 268, 235-240
15. 15 Jia, Z., Hasnain, S., Hirama, T., Lee, X., Mort, J. S., To, R. and Huber, C. P. (1995) J. Biol. Chem. 270, 5527-5533
16. 16 Shaw, E. (1990) Adv. Enzymol. Relat. Areas Mol. Biol. 63, 271-347
17. 17 Krantz, A., Copp, L. J., Coles, J., Smith, R. A. and Heard, S. B. (1991) Biochemistry 30, 4678-4687
18. 18 Pliura, D. H., Bonaventura, B. J., Smith, R. A., Coles, P. J. and Krantz, A. (1992) Biochem. J. 288, 759-762
19. 19 Taralp, A., Kaplan, H., Sytwu, I.-I., Vlattas, I., Bohacek, R., Knap, A. K., Hirama, T., Huber, C. P. and Hasnain, S. (1995) J. Biol. Chem. 270, 18036-18043
20. 20 Garcia-Echeverria, C. and Rich, D. H. (1992) FEBS Lett. 297, 100-102
21. 21 Garcia-Echeverria, C. and Rich, D. H. (1992) Biochem. Biophys. Res. Commun. 187, 615-619
22. 22 Ménard, R., Carmona, E., Plouffe, C., Brömme, D., Konishi, Y., Lefebvre, J. and Storer, A. C. (1993) FEBS Lett. 328, 107-110
23. 23 Turk, D., Guncar, G., Podobnik, M. and Turk, B. (1998) Biol. Chem. 379, 137-147
24. 24 Nägler, D. K., Storer, A. C., Portaro, F. C. V., Carmona, E., Juliano, L. and Ménard, R. (1997) Biochemistry 36, 12608-12615
25. 25 Musil, D., Zucic, D., Turk, D., Engh, R. A., Mayr, I., Huber, R., Popovic, T., Turk, V., Towatari, T., Katunuma, N. and Bode, W. (1991) EMBO J. 10, 2321-2330
26. 26 Illy, C., Quraishi, O., Wang, J., Purisima, E., Vernet, T. and Mort, J. (1997) J. Biol. Chem. 272, 1197-1202
27. 27 Turk, D., Podibnik, M., Popovic, T., Katsunuma, N., Bode, W., Huber, R. and Turk, V. (1995) Biochemistry 34, 4791-4797
28. 28 Yamamoto, A., Hara, T., Tomoo, K., Ishida, T., Fujii, T., Hata, Y., Murata, M. and Kitamura, K. (1997) J. Biochem. (Tokyo) 121, 974-977
29. 29. Nägler, D. K., Tam, W., Storer, A. C., Krupa, J. C., Mort, J. S. and Ménard, R. (1999) Biochemistry 38, 4868-4874
30. 30 Rowan, A. D., Mason, P., Mach, L. and Mort, J. S. (1992) J. Biol. Chem. 267, 15993-15999
31. 31 Carmona, E., Dufour, É., Plouffe, C., Takebe, S., Manson, P., Mort, S. M. and Ménard, R. (1996) Biochemistry 35, 8149-8157
32. 32 Ménard, R., Khouri, H. E., Plouffe, C., Dupras, R., Rippoli, D., Vernet, T., Tessier, D. C., Laliberté, F., Thomas, D. Y. and Storer, A. C. (1990) Biochemistry 29, 6706-6713
33. 33 Barrett, A. J. and Kirshke, H. (1981) Methods Enzymol. 80, 771-778
34. 34 Hirata, Y., Cezari, M. H. S, Nakaie, C. R., Boschcov, P., Ito, A. S., Juliano, M. A. and Juliano, L. (1994) Lett. Peptide Sci. 1, 299-308
35. 35 Chagas, J. R., Juliano, L. and Prado, E. S. (1990) Anal. Biochem. 192, 419-425
36. 36 Wilkinson, G. N. (1961) Biochem. J. 80, 324-332
37. 37 Heinrikson, R. L. and Meredith, S. C. (1984) Anal. Biochem. 436, 65-74
38. 38 Drenth, J., Jansonius, J. N., Koekoek, R., Swen, H. M. and Wolthers, B. G. (1968) Nature (London) 218, 929-932
39. 39 Lecaille, F., Serveau, C., Gauthier, F. and Lalmanach, G. (1999) FEBS Lett. 445, 311-314
40. 40 Hilaire, P. M., Willert, M., Juliano, M. A., Juliano, L. and Morten, M. J. (1999) J. Combin. Chem. 1, 509-523
41. 41 Turk, D., Podobnik, M., Kuhelj, R., Dolinar, M. and Turk, V. (1996) FEBS Lett. 384, 211-214
42. 42 Cygler, M., Sivaraman, J., Grochulski, P., Coulombe, R., Storer, A. C. and Mort, J. S. (1996) Structure 4, 405-416
43. 43 Drenth, J., Kalk, K. H. and Swen, H. M. (1976) Biochemistry 15, 3731-3738
44. 44 Varughese, K. I., Ahmed, F. R., Carey, P. R., Hasnain, S., Huber, C. P. and Storer, A. C. (1989) Biochemistry 28, 1330-1332
45. 45 Kim, M., Yamamoto, D., Matsumoto, K., Inoue, M., Ishida, T., Mizuno, H., Sumiya, S. and Kitamura, K. (1992) Biochem. J. 287, 797-803
46. 46 Schröder, E., Phillips, C., Garman, E., Marlos, K. and Grawford, C. (1993) FEBS Lett. 315, 38-42
47. 47 Fujishima, A., Imai, Y., Toshiyuki, N., Fujisawa, Y., Yamamoto, Y. and Sugawara, T. (1997) FEBS Lett. 407, 47-50
48. 48 O'Hara, B. P., Hemmings, A. M., Buttle, D. J. and Pearl, L. H. (1995) Biochemistry 34. 13190-13195
49. 49 Gauthier, F., Moreau, T., Lalmanach, G., Brillard-Bourdet, M., Ferrer, D., Martino, M. and Juliano, L. (1993) Arch. Biochem. Biophys. 306, 304-308
50. 50 Coulombe, R., Grochulski, P., Sivaraman, J., Ménard, R., Mort, J. S. and Cygler, M. (1996) EMBO J. 15, 5492-5503
51. 51 Servau, C., Lalmanach, G., Juliano, M. A., Scharfstein, J., Juliano, L. and Gauthier, F. (1996) Biochem. J. 313, 951-956