Mutations of the STK11 gene in sporadic gastric carcinoma

International Journal of Oncology

Volumn 13, Issue 3, 1998, Pages 601-604

  Park, Won Sang ^a   Moon, Young Wan ^a   Yang, Young Mok ^b   Kim, Young Sil ^c   Kim, Young Dae ^d   Fuller, Brian G ^a   Vortmeyer, Alexander O ^a   Fogt, Franz ^e   Lubensky, Irina A ^a   Zhuang, Zhengping ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b Konkuk University   (South Korea)

^c The Catholic University of Korea College of Medicine   (South Korea)

^d Seoul Medical Science Institute   (South Korea)

^e PENN PRESBYTERIAN MEDICAL CENTER   (United States)

Author keywords

Gastric carcinoma; Peutz Jeghers syndrome; STK11 gene

Indexed keywords

CYTOSINE; DNA; LEUCINE; PROLINE; THYMINE;

AMINO ACID SUBSTITUTION; ARTICLE; CHROMOSOME 19P; CONTROLLED STUDY; DNA SEQUENCE; GENE MUTATION; HUMAN; HUMAN TISSUE; MISSENSE MUTATION; PEUTZ JEGHERS SYNDROME; PRIORITY JOURNAL; STOMACH CARCINOMA;

EID: 13144251118     PISSN: 10196439     EISSN: None     Source Type: Journal    
DOI: 10.3892/ijo.13.3.601     Document Type: Article

References (31)

1. Ministry of Health and Social Affairs: Five year's report for cancer registry program in the Republic of Korea. J Korean Cancer Res Assoc 21: 151-216, 1989.
2. Strickler JG, Zheng J, Shu Q, Burgart LJ, Albert SR and Shibata D: p53 mutations and microsatellite instability in sporadic gastric cancer: when guardians fail. Cancer Res 54: 4750-4755, 1994.
3. Powell SM, Cummings OW, Mullen JA, Asghar A, Fuga G, Piva P, Minacci C, Megha T, Tosi P and Jackson CE: Characterization of the APC gene in sporadic gastric adenocarcinomas. Oncogene 12: 1953-1959, 1996.
4. Tahara E: Genetic alterations in human gastrointestinal cancers: the application to molecular diagnosis. Cancer 75: 1410-1417, 1995.
5. Peutz JLA: Very remarkable case of familial polyposis of mucous membrane of intestinal tract and nasopharynx accompanied by peculiar pigmentations of skin and mucous menbrane. Ned Maandschr Geneesk 10: 134-146, 1921.
6. Jeghers SK. Mckusick VA and Katz KH: Generalized intestinal polyposis and melanin spots of the oral moucosa, lips and digits. N Engl J Med 241: 993-1005, 1949.
7. Perzin KH and Bridge MF: Adenomatous and carcinomatous changes in hamartomatous polyps of the small intestine Peutz-Jeghers syndrome. Cancer 49: 971-983, 1982.
8. Giardiello FM, Welsh LH, Hamilton SR, Offerhaus GJA, Gittelsohn AM, Booker SV, Krush AJ, Yardley LH and Luk GD: Increased risk of cancer in the Peutz-Jeghers syndrome. N Engl J Med 316: 1511-1514, 1987.
9. Dodds WJ, Schulte WJ, Hensley GT and Hogan WJ: Peutz-Jeghers syndrome and gastrointestinal malignancy. Am J Roentgenol 115: 374-377, 1972.
10. Hazawa K, Iida M, Matsumoto T, Kohrogi N, Kinoshita H, Yao T and Fujishima M: Cancer in Peutz-Jeghers syndrome. Cancer 72: 2777-2781, 1993.
11. Utsunomiya J, Gocho H, Miyanaga T, Hamaguchi E and Kashimure A: Peutz-Jeghers syndrome: its natural course and management. Johns Hopkins Med J 136: 71-82, 1975.
12. Savvina TV, Pomelov VS and Budaev KD: Cysts of the body of gastric mucosa glands in a female patient with Peutz-Jeghers syndrome and stomach cancer. Arkh Patol 45: 65-68, 1983.
13. Hemminki A, Tomlinson I, Markie D, Jarvinen H, Sistonen P, Bjorkqvist A-M, Knuutila S, Salovaara R, Bodmer W, Shibata D, De la Chappelle A and Aaltonen LA: Localization of a susceptibility locus for Peutz-Jeghers syndrome to 19p using comparative genomic hybridization and targeted linkage analysis. Nat Genet 15: 87-90, 1997.
14. Amos CI, Bali D, Thiel TJ, Anderson JP, Gourley I, Frazier ML, Lynch PM, Luchtefeld MA, Young A, McGarrity TJ and Seldin MF: Fine mapping of a genetic locus for Peutz-Jeghers syndrome on chromosome 19p. Cancer Res 57: 3653-3656, 1997.
15. Jenne EE, Reimann H, Nezu J, Friedel W, Loff S, Jeschke R, Muller O, Back W and Zimmer M: Peutzer-Jeghers syndrome is caused by mutations in a novel serine threonine kinase. Nat Genet 18: 38-43, 1998.
16. Knudson AG: Hereditary cancer, oncogenes, and antioncogenes. Cancer Res 45: 1437-1443, 1985.
17. Friend SH, Bernards R, Rogelj S, Weinberg RA, Rapaport JM, Albert DM and Dryja TP: A human DNA segment with properties of the gene that predisposes to retinoblastoma and osteosarcoma. Nature 323: 643-646, 1986.
18. Malkin D, Li FP, Strong LC, Fraumeni JF Jr, Nelson CE, Kim DH, Kassel J, Gryka MA, Bischoff FZ, Tainsky MA and Friend SH: Germ line p53 mutations in a familial syndrome of breast cancer, sarcomas, and other neoplasms. Science 250: 1233-1238, 1990.
19. Chandrasekharappa SC, Guru SC, Manickam P, Olufemi SE, Collins FS, Emmert-Buck MR, Debelenko LV, Zhuang Z, Lubensky IA, Liotta LA, Crabtree JS, Wang Y, Roe BA, Weisemann J, Boguski MS, Agarwal SK, Kester MB, Kim YS, . Heppner C, Dong Q, Spiegel AM, Burns AL and Marx SJ: Positional cloning of the gene for multiple endocrine neoplasia-type 1. Science 276: 404-407, 1997.
20. Iavarone A, Matthay KK, Steinkirchner TM and Israel MA: Germ-line and somatic p53 mutations in multifocal osteogenic sarcoma. Proc Natl Acad Sci USA 89: 4207-4209, 1992.
21. Heppner C, Kester MB, Agarwal SK, Debelenko LV, Emmert-Buck MR, Guru SC, Manickam P, Olufemi SE, Skarulis MC, Koppman JL, Alexander RH, Kim YS, Sagger SK, Lubensky IA, Zhuang Z, Liotta LA, Chandrasekharappa SC, Collins FS, Spiegel AM, Burns AL and Marx SJ: Somatic mutation of the MEN1 gene in parathyroid tumors. Nat Genet 16: 375-378, 1997.
22. Lauren P: The two histplogical main types of gastric carcinoma. Diffuse and so-called intestinal type carcinoma: an attempt at histoclinical classification. Acta Pathol Microbiol Scand 64: 31-49, 1965.
23. Zhuang Z, Bertheau P, Emmert-Buck MR, Liotta LA; Gnarra J, Linehan W and Lubensky IA: A microdissection technique for archival DNA analysis of specific cell populations in lesions 1 mm in size. Am J Pathol 146: 620-625, 1995.
24. Spigelman AD, Murday V and Phillips RK: Cancer and the Peutz-Jeghers syndrome. Gut 30: 1588-1590, 1989.
25. Nishisho I, Nakamura Y, Miyoshi Y, Miki Y, Ando H, Horii A, Kayama K, Utsunomiya J, Baba S, Hedge P, Markham A, Krush AJ, Petersen G, Hamilton SR, Nilbert MC, Levy DB, Bryan TM, Presinger AC, Smith KJ, Su L-K, Kinzler KW and Vogelstein B: Mutations of chromosome 5q21 genes in FAP and colorectal cancer patients. Science 253: 665-669, 1991.
26. Su JY, Erikson E and Mailer JL: Cloning and characterization of a novel serine/threonine protein kinase expressed in early Xenopus embryos. J Biol Chem 271: 14430-14437, 1996.
27. Isacchi A, Sarmientos P, Lorenzetti R and Soria M: Mature apolipoprotein AI and its precursor proApoAI: influence of the sequence at the 5' end of the gene on the efficiency of expression in Escherichia coli. Gene 81: 129-137, 1989.
28. Milland J, Christiansen D, Thorley BR, McKenzie IF and Loveland BE: Translation is enhanced after silent nucleotide substitutions in A+T- rich sequences of the coding region of CD46 cDNA. Eur J Biochem 238: 221-230, 1996.
29. Sheffield VC, Beck JS, Kwitek AE, Sandstrom DW and Stone EM: The sensitivity of single-strand conformation polymorphism analysis for the detection of single base substitutions. Genomics 16: 325-332, 1993.
30. Zhuang Z, Vortmeyer AO, Pack S, Huang S, Pham TA, Wang C, Park WS, Agarwal SK, Debelenko LV, Kester M, Guru SC, Manickam P, Olufemi SE, Yu F, Heppner C, Crabtree JS, Skarulis MC, Venxon DJ, Emmert-Buck MR, Spiegel AM, Chandrasekharappa SC, Collins FS, Burns AL, Marx SJ and Lubensky IA: Somatic mutations of the MEN1 tumor suppressor gene in sporadic gastrinomas and insulinomas. Cancer Res 57: 4682-4686, 1997.
31. Lee YY, Kang SH, Seo JY, Jung CW, Lee KU, Choe KJ, Kim BK, Kim NK, Koeffler HP and Bang YJ: Alterations of 16INK4A and p15INK4B genes in gastric carcinomas. Cancer 80: 1889-1896, 1997.