메뉴 건너뛰기




Volumn 95, Issue 3, 2001, Pages 162-167

Determination of microsatellite instability, p53 and K-ras mutations in hepatic metastases from patients with colorectal cancer: Relationship with response to 5-fluorouracil and survival

Author keywords

Chemotherapy; Colorectal cancer; Hepatic metastasis; K ras; Microsatellite instability; p53; Prognosis

Indexed keywords

FLUOROURACIL; FOLINIC ACID; PROTEIN P53;

EID: 0035918589     PISSN: 00207136     EISSN: None     Source Type: Journal    
DOI: 10.1002/1097-0215(20010520)95:3<162::AID-IJC1028>3.0.CO;2-J     Document Type: Article
Times cited : (46)

References (58)
  • 2
    • 0029012118 scopus 로고
    • Phase II study of fluorouracil and its modulation in advanced colorectal cancer: A southwest oncology group study
    • Leichman CG, Fleming TR, Muggia FM, Tangen CM, Ardalan B, Doroshow JH, et al. Phase II study of fluorouracil and its modulation in advanced colorectal cancer: a Southwest Oncology Group study. J Clin Oncol 1995;13:1303-11.
    • (1995) J Clin Oncol , vol.13 , pp. 1303-1311
    • Leichman, C.G.1    Fleming, T.R.2    Muggia, F.M.3    Tangen, C.M.4    Ardalan, B.5    Doroshow, J.H.6
  • 3
    • 0024385167 scopus 로고
    • The modulation of fluorouracil with leucovorin in metastatic colorectal carcinoma: A prospective randomized phase III trial. Gastrointestinal tumor study group
    • Petrelli N, Douglass HO Jr, Herrera L, Russell D, Stablein DM, Bruckner HW, et al. The modulation of fluorouracil with leucovorin in metastatic colorectal carcinoma: a prospective randomized phase III trial. Gastrointestinal Tumor Study Group. J Clin Oncol 1989;7: 1419-26.
    • (1989) J Clin Oncol , vol.7 , pp. 1419-1426
    • Petrelli, N.1    Douglass, H.O.2    Herrera, L.3    Russell, D.4    Stablein, D.M.5    Bruckner, H.W.6
  • 5
    • 0028351657 scopus 로고
    • Chemotherapy for colorectal cancer
    • Moertel CG. Chemotherapy for colorectal cancer. N Engl J Med 1994;330:1136-42.
    • (1994) N Engl J Med , vol.330 , pp. 1136-1142
    • Moertel, C.G.1
  • 6
    • 0024539308 scopus 로고
    • A prospective randomized comparison of continuous infusion fluorouracil with a conventional bolus schedule in metastatic colorectal carcinoma: A mid-atlantic oncology program study
    • Lokich JJ, Ahlgren JD, Gullo JJ, Philips JA, Fryer JG. A prospective randomized comparison of continuous infusion fluorouracil with a conventional bolus schedule in metastatic colorectal carcinoma: a Mid-Atlantic Oncology Program Study. J Clin Oncol 1989;7:425-32.
    • (1989) J Clin Oncol , vol.7 , pp. 425-432
    • Lokich, J.J.1    Ahlgren, J.D.2    Gullo, J.J.3    Philips, J.A.4    Fryer, J.G.5
  • 7
    • 0024347268 scopus 로고
    • Biochemical modulation of fluorouracil: Evidence of significant improvement of survival and quality of life in patients with advanced colorectal carcinoma
    • Poon MA, O'Connell MJ, Moertel CG, Wieand HS, Cullinan SA, Everson LK, et al. Biochemical modulation of fluorouracil: evidence of significant improvement of survival and quality of life in patients with advanced colorectal carcinoma. J Clin Oncol 1989;7:1407-18.
    • (1989) J Clin Oncol , vol.7 , pp. 1407-1418
    • Poon, M.1    O'Connell, M.J.2    Moertel, C.G.3    Wieand, H.S.4    Cullinan, S.A.5    Everson, L.K.6
  • 8
    • 0028657658 scopus 로고
    • Enhanced cytotoxicity with interleukin-1 alpha and 5-fluorouracil in HCT116 colon cancer cells
    • Geoffroy FJ, Allegra CJ, Sinha B, Grem JL. Enhanced cytotoxicity with interleukin-1 alpha and 5-fluorouracil in HCT116 colon cancer cells. Oncol Res 1994;6:581-91.
    • (1994) Oncol Res , vol.6 , pp. 581-591
    • Geoffroy, F.J.1    Allegra, C.J.2    Sinha, B.3    Grem, J.L.4
  • 9
    • 0025611018 scopus 로고
    • Metabolism and mechanism of action of 5-fluorouracil
    • Parker WB, Cheng YC. Metabolism and mechanism of action of 5-fluorouracil. Pharmacol Ther 1990;48:381-95.
    • (1990) Pharmacol Ther , vol.48 , pp. 381-395
    • Parker, W.B.1    Cheng, Y.C.2
  • 10
    • 0025991626 scopus 로고
    • Biochemical pharmacology and analysis of fluoropyrimidines alone and in combination with modulators
    • Weckbecker G. Biochemical pharmacology and analysis of fluoropyrimidines alone and in combination with modulators. Pharmacol Ther 1991:50:367-424.
    • (1991) Pharmacol Ther , vol.50 , pp. 367-424
    • Weckbecker, G.1
  • 11
    • 0344783805 scopus 로고    scopus 로고
    • Phase II trial of oxaliplatin as first-line chemotherapy in metastatic colorectal cancer patients. Digestive group of French federation of cancer centers
    • Becouarn Y, Ychou M, Ducreux M, Borel C, Bertheault-Cvitkovic F, Seitz JF, et al. Phase II trial of oxaliplatin as first-line chemotherapy in metastatic colorectal cancer patients. Digestive Group of French Federation of Cancer Centers. J Clin Oncol 1998; 16:2739-44.
    • (1998) J Clin Oncol , vol.16 , pp. 2739-2744
    • Becouarn, Y.1    Ychou, M.2    Ducreux, M.3    Borel, C.4    Bertheault-Cvitkovic, F.5    Seitz, J.F.6
  • 12
    • 0031014627 scopus 로고    scopus 로고
    • Phase II study of irinotecan in the treatment of advanced colorectal cancer in chemotherapy-naive patients and patients pretreated with fluorouracil-based chemotherapy
    • Rougier P, Bugat R, Douillard JY, Culine S, Suc E, Brunet P, et al. Phase II study of irinotecan in the treatment of advanced colorectal cancer in chemotherapy-naive patients and patients pretreated with fluorouracil-based chemotherapy. J Clin Oncol 1997;15:251-60.
    • (1997) J Clin Oncol , vol.15 , pp. 251-260
    • Rougier, P.1    Bugat, R.2    Douillard, J.Y.3    Culine, S.4    Suc, E.5    Brunet, P.6
  • 13
    • 0028940399 scopus 로고
    • Thymidylate synthase gene and protein expression correlate and are associated with response to 5-fluorouracil in human colorectal and gastric tumors
    • Johnston PG, Lenz HJ, Leichman CG, Danenberg KD, Allegra CJ, Danenberg PV, et al. Thymidylate synthase gene and protein expression correlate and are associated with response to 5-fluorouracil in human colorectal and gastric tumors. Cancer Res 1995;55:1407-12.
    • (1995) Cancer Res , vol.55 , pp. 1407-1412
    • Johnston, P.G.1    Lenz, H.J.2    Leichman, C.G.3    Danenberg, K.D.4    Allegra, C.J.5    Danenberg, P.V.6
  • 15
    • 0027509209 scopus 로고
    • Prognostic value of p53 overexpression and c-Ki-ras gene mutations in colorectal cancer
    • Bell SM, Scott N, Cross D, Sagar P, Lewis FA, Blair GE, et al. Prognostic value of p53 overexpression and c-Ki-ras gene mutations in colorectal cancer. Gastroenterology 1993;104:57-64.
    • (1993) Gastroenterology , vol.104 , pp. 57-64
    • Bell, S.M.1    Scott, N.2    Cross, D.3    Sagar, P.4    Lewis, F.A.5    Blair, G.E.6
  • 16
    • 0025312728 scopus 로고
    • A genetic model for colorectal tumorigenesis
    • Fearon ER, Vogelstein B. A genetic model for colorectal tumorigenesis. Cell 1990;61:759-67.
    • (1990) Cell , vol.61 , pp. 759-767
    • Fearon, E.R.1    Vogelstein, B.2
  • 17
    • 0028879677 scopus 로고
    • P53 point mutation and survival in colorectal cancer patients
    • Goh HS, Yao J, Smith DR. p53 point mutation and survival in colorectal cancer patients. Cancer Res 1995;55:5217-21.
    • (1995) Cancer Res , vol.55 , pp. 5217-5221
    • Goh, H.S.1    Yao, J.2    Smith, D.R.3
  • 20
    • 0032948553 scopus 로고    scopus 로고
    • P53 and K-ras gene mutations correlate with tumor aggressiveness but are not of routine prognostic value in colorectal cancer
    • Tortola S, Marcuello E, Gonzalez I, Reyes G, Arribas R, Aiza G, et al. p53 and K-ras gene mutations correlate with tumor aggressiveness but are not of routine prognostic value in colorectal cancer. J Clin Oncol 1999;17:1375-81.
    • (1999) J Clin Oncol , vol.17 , pp. 1375-1381
    • Tortola, S.1    Marcuello, E.2    Gonzalez, I.3    Reyes, G.4    Arribas, R.5    Aiza, G.6
  • 21
    • 0028884525 scopus 로고
    • Cancer therapy and p53
    • Lowe SW. Cancer therapy and p53. Curr Opin Oncol 1995;7:547-53.
    • (1995) Curr Opin Oncol , vol.7 , pp. 547-553
    • Lowe, S.W.1
  • 22
    • 0032701521 scopus 로고    scopus 로고
    • Disruption of p53 in human cancer cells alters the responses to therapeutic agents
    • Bunz F, Hwang PM, Torrance C, Waldman T, Zhang Y, Dillehay L, et al. Disruption of p53 in human cancer cells alters the responses to therapeutic agents. J Clin Invest 1999;104:263-9.
    • (1999) J Clin Invest , vol.104 , pp. 263-269
    • Bunz, F.1    Hwang, P.M.2    Torrance, C.3    Waldman, T.4    Zhang, Y.5    Dillehay, L.6
  • 23
    • 0031869758 scopus 로고    scopus 로고
    • Predicting response to cancer chemotherapy: The role of p53
    • Weller M. Predicting response to cancer chemotherapy: the role of p53. Cell Tissue Res 1998;292:435-45.
    • (1998) Cell Tissue Res , vol.292 , pp. 435-445
    • Weller, M.1
  • 24
    • 0030592517 scopus 로고    scopus 로고
    • Lessons from hereditary colorectal cancer
    • Kinzler KW, Vogelstein B. Lessons from hereditary colorectal cancer. Cell 1996;87:159-70.
    • (1996) Cell , vol.87 , pp. 159-170
    • Kinzler, K.W.1    Vogelstein, B.2
  • 25
    • 0029904811 scopus 로고    scopus 로고
    • The role of DNA mismatch repair in platinum drug resistance
    • Fink D, Nebel S, Aebi S, Zheng H, Cenni B, Nehme A, et al. The role of DNA mismatch repair in platinum drug resistance. Cancer Res 1996;56:4881-6.
    • (1996) Cancer Res , vol.56 , pp. 4881-4886
    • Fink, D.1    Nebel, S.2    Aebi, S.3    Zheng, H.4    Cenni, B.5    Nehme, A.6
  • 27
    • 0027302046 scopus 로고
    • Efficient screening of p53 mutations by denaturing gradient gel electrophoresis in colorectal tumors
    • Hamelin R, Jego N, Laurent-Puig P, Vidaud M, Thomas G. Efficient screening of p53 mutations by denaturing gradient gel electrophoresis in colorectal tumors. Oncogene 1993;8:2213-2220.
    • (1993) Oncogene , vol.8 , pp. 2213-2220
    • Hamelin, R.1    Jego, N.2    Laurent-Puig, P.3    Vidaud, M.4    Thomas, G.5
  • 28
    • 0030903084 scopus 로고    scopus 로고
    • Single-step DGGE-based mutation scanning of the p53 gene: Application to genetic diagnosis of colorectal cancer
    • Guldberg P, Nedergaard T, Nielsen HJ, Olsen AC, Ahrenkiel V, Zeuthen J. Single-step DGGE-based mutation scanning of the p53 gene: application to genetic diagnosis of colorectal cancer. Hum Mutat 1997;9:348-55.
    • (1997) Hum Mutat , vol.9 , pp. 348-355
    • Guldberg, P.1    Nedergaard, T.2    Nielsen, H.J.3    Olsen, A.C.4    Ahrenkiel, V.5    Zeuthen, J.6
  • 29
    • 0033053670 scopus 로고    scopus 로고
    • Gastric carcinomas with microsatellite instability: Clinical features and mutations to the TGF-beta type II receptor, IGFII receptor, and bax genes
    • Iacopetta BJ, Soong R, House AK, Hamelin R. Gastric carcinomas with microsatellite instability: clinical features and mutations to the TGF-beta type II receptor, IGFII receptor, and BAX genes. J Pathol 1999;187:428-32.
    • (1999) J Pathol , vol.187 , pp. 428-432
    • Iacopetta, B.J.1    Soong, R.2    House, A.K.3    Hamelin, R.4
  • 30
    • 0031938045 scopus 로고    scopus 로고
    • Determination of the replication error phenotype in human tumors without the requirement for matching normal DNA by analysis of mononucleotide repeat microsatellites
    • Zhou XP, Hoang JM, Li YJ, Seruca R, Cameiro F, Sobrinho-Simoes M, et al. Determination of the replication error phenotype in human tumors without the requirement for matching normal DNA by analysis of mononucleotide repeat microsatellites. Genes Chromosomes Cancer 1998;21:101-7.
    • (1998) Genes Chromosomes Cancer , vol.21 , pp. 101-107
    • Zhou, X.P.1    Hoang, J.M.2    Li, Y.J.3    Seruca, R.4    Cameiro, F.5    Sobrinho-Simoes, M.6
  • 33
    • 0029125551 scopus 로고
    • Increased incidence of p53 mutations is associated with hepatic metastasis in colorectal neoplastic progression
    • Kastrinakis WV, Ramchurren N, Rieger KM, Hess DT, Loda M, Steele G, et al. Increased incidence of p53 mutations is associated with hepatic metastasis in colorectal neoplastic progression. Oncogene 1995;11:647-52.
    • (1995) Oncogene , vol.11 , pp. 647-652
    • Kastrinakis, W.V.1    Ramchurren, N.2    Rieger, K.M.3    Hess, D.T.4    Loda, M.5    Steele, G.6
  • 34
    • 0029778370 scopus 로고    scopus 로고
    • P53 mutations in primary colorectal adenocarcinomas and liver metastases
    • Yao J, Goh HS, Smith DR, p53 mutations in primary colorectal adenocarcinomas and liver metastases. Br J Surg 1996;83:1245-6.
    • (1996) Br J Surg , vol.83 , pp. 1245-1246
    • Yao, J.1    Goh, H.S.2    Smith, D.R.3
  • 36
    • 0032521205 scopus 로고    scopus 로고
    • Ki-ras mutation and p53 overexpression predict the clinical behavior of colorectal cancer: A southwest oncology group study
    • Ahnen DJ, Feigl P, Quan G, Fenoglio-Preiser C, Lovato LC, Bunn PA Jr, et al. Ki-ras mutation and p53 overexpression predict the clinical behavior of colorectal cancer: a Southwest Oncology Group study. Cancer Res 1998;58:1149-58.
    • (1998) Cancer Res , vol.58 , pp. 1149-1158
    • Ahnen, D.J.1    Feigl, P.2    Quan, G.3    Fenoglio-Preiser, C.4    Lovato, L.C.5    Bunn, P.A.6
  • 37
    • 14444285483 scopus 로고    scopus 로고
    • P53 point mutations and thymidylate synthase messenger RNA levels in disseminated colorectal cancer: An analysis of response and survival
    • Lenz HJ, Hayashi K, Salonga D, Danenberg KD, Danenberg PV, Metzger R, et al. p53 point mutations and thymidylate synthase messenger RNA levels in disseminated colorectal cancer: an analysis of response and survival. Clin Cancer Res 1998;4:1243-50.
    • (1998) Clin Cancer Res , vol.4 , pp. 1243-1250
    • Lenz, H.J.1    Hayashi, K.2    Salonga, D.3    Danenberg, K.D.4    Danenberg, P.V.5    Metzger, R.6
  • 38
    • 0030035584 scopus 로고    scopus 로고
    • P53 mutations as a possible predictor of response to chemotherapy in metastatic colorectal carcinomas
    • Benhattar J, Cerottini JP, Saraga E, Metthez G, Givel JC. p53 mutations as a possible predictor of response to chemotherapy in metastatic colorectal carcinomas, Int J Cancer 1996;69:190-2.
    • (1996) Int J Cancer , vol.69 , pp. 190-192
    • Benhattar, J.1    Cerottini, J.P.2    Saraga, E.3    Metthez, G.4    Givel, J.C.5
  • 39
    • 0031929626 scopus 로고    scopus 로고
    • TP53 and long-term prognosis in colorectal cancer: Mutations in the L3 zinc-binding domain predict poor survival
    • Borresen-Dale AL, Lothe RA, Meling GI, Hainaut P, Rognum TO, Skovlund E. TP53 and long-term prognosis in colorectal cancer: mutations in the L3 zinc-binding domain predict poor survival. Clin Cancer Res 1998;4:203-10.
    • (1998) Clin Cancer Res , vol.4 , pp. 203-210
    • Borresen-Dale, A.L.1    Lothe, R.A.2    Meling, G.I.3    Hainaut, P.4    Rognum, T.O.5    Skovlund, E.6
  • 40
    • 0029023358 scopus 로고
    • Evaluation of p53 protein expression as a marker for long-term prognosis in colorectal carcinoma
    • Mulder JW, Baas IO, Polak MM, Goodman SN, Offerhaus GJ. Evaluation of p53 protein expression as a marker for long-term prognosis in colorectal carcinoma. Br J Cancer 1995;71:1257-62.
    • (1995) Br J Cancer , vol.71 , pp. 1257-1262
    • Mulder, J.W.1    Baas, I.O.2    Polak, M.M.3    Goodman, S.N.4    Offerhaus, G.J.5
  • 41
    • 0026032511 scopus 로고
    • P53 in colorectal cancer: Clinicopathological correlation and prognostic significance
    • Scott N, Sagar P, Stewart J, Blair GE, Dixon MF, Quirke P. p53 in colorectal cancer: clinicopathological correlation and prognostic significance. Br J Cancer 1991;63:317-9.
    • (1991) Br J Cancer , vol.63 , pp. 317-319
    • Scott, N.1    Sagar, P.2    Stewart, J.3    Blair, G.E.4    Dixon, M.F.5    Quirke, P.6
  • 42
    • 0030037868 scopus 로고    scopus 로고
    • Clinical and pathological associations with p53 tumour-suppressor gene mutations and expression of p21WAF1/Cip1 in colorectal carcinoma
    • Slebos RJ, Baas IO, Clement M, Polak M, Mulder JW, Van Den Berg FM, et al. Clinical and pathological associations with p53 tumour-suppressor gene mutations and expression of p21WAF1/Cip1 in colorectal carcinoma. Br J Cancer 1996;74:165-71.
    • (1996) Br J Cancer , vol.74 , pp. 165-171
    • Slebos, R.J.1    Baas, I.O.2    Clement, M.3    Polak, M.4    Mulder, J.W.5    Van Den Berg, F.M.6
  • 43
    • 0344348993 scopus 로고    scopus 로고
    • Analysis of the p53/BAX pathway in colorectal cancer: Low BAX is a negative prognostic factor in patients with resected liver metastases
    • Sturm I, Kohne CH, Wolff G, Petrowsky H, Hillebrand T, Hauptmann S, et al. Analysis of the p53/BAX pathway in colorectal cancer: low BAX is a negative prognostic factor in patients with resected liver metastases. J Clin Oncol 1999;17:1364-74.
    • (1999) J Clin Oncol , vol.17 , pp. 1364-1374
    • Sturm, I.1    Kohne, C.H.2    Wolff, G.3    Petrowsky, H.4    Hillebrand, T.5    Hauptmann, S.6
  • 44
    • 0026453217 scopus 로고
    • Prognostic significance of cytoplasmic p53 oncoprotein in colorectal adenocarcinoma
    • Sun XF, Carstensen JM, Zhang H, Stal O, Wingren S, Hatschek T, et al. Prognostic significance of cytoplasmic p53 oncoprotein in colorectal adenocarcinoma. Lancet 1992;340:1369-73.
    • (1992) Lancet , vol.340 , pp. 1369-1373
    • Sun, X.F.1    Carstensen, J.M.2    Zhang, H.3    Stal, O.4    Wingren, S.5    Hatschek, T.6
  • 46
    • 0027451668 scopus 로고
    • P53-dependent apoptosis modulates the cytotoxicity of anticancer agents
    • Lowe SW, Ruley HE, Jacks T, Housman DE. p53-dependent apoptosis modulates the cytotoxicity of anticancer agents. Cell 1993;74:95-67.
    • (1993) Cell , vol.74 , pp. 95-167
    • Lowe, S.W.1    Ruley, H.E.2    Jacks, T.3    Housman, D.E.4
  • 47
    • 0033552948 scopus 로고    scopus 로고
    • Mutant p53 gain of function: Differential effects of different p53 mutants on resistance of cultured cells to chemotherapy
    • Blandino G, Levine AJ, Oren M. Mutant p53 gain of function: differential effects of different p53 mutants on resistance of cultured cells to chemotherapy. Oncogene 1999;18:477-85.
    • (1999) Oncogene , vol.18 , pp. 477-485
    • Blandino, G.1    Levine, A.J.2    Oren, M.3
  • 48
    • 0030865104 scopus 로고    scopus 로고
    • Characterization of the p53 tumor suppressor pathway in cell lines of the national cancer institute anticancer drug screen and correlations with the growth-inhibitory potency of 123 anticancer agents
    • O'Connor PM, Jackman J, Bae I, Myers TG, Fan S, Mutoh M, et al. Characterization of the p53 tumor suppressor pathway in cell lines of the National Cancer Institute anticancer drug screen and correlations with the growth-inhibitory potency of 123 anticancer agents. Cancer Res 1997;57:4285-300.
    • (1997) Cancer Res , vol.57 , pp. 4285-4300
    • O'Connor, P.M.1    Jackman, J.2    Bae, I.3    Myers, T.G.4    Fan, S.5    Mutoh, M.6
  • 49
    • 0033118475 scopus 로고    scopus 로고
    • Apoptosis, p53, and tumor cell sensitivity to anticancer agents
    • Brown JM, Wouters BG. Apoptosis, p53, and tumor cell sensitivity to anticancer agents. Cancer Res 1999;59:1391-9.
    • (1999) Cancer Res , vol.59 , pp. 1391-1399
    • Brown, J.M.1    Wouters, B.G.2
  • 50
    • 0030839388 scopus 로고    scopus 로고
    • Irinotecan hydrochloride (CPT-11) resistance identified by K-ras mutation in patients with progressive colon cancer after treatment with 5-fluorouracil (5-FU)
    • Nemunaitis J, Cox J, Meyer W, Courtney A, Mues G. Irinotecan hydrochloride (CPT-11) resistance identified by K-ras mutation in patients with progressive colon cancer after treatment with 5-fluorouracil (5-FU). Am J Clin Oncol 1997;20:527-9.
    • (1997) Am J Clin Oncol , vol.20 , pp. 527-529
    • Nemunaitis, J.1    Cox, J.2    Meyer, W.3    Courtney, A.4    Mues, G.5
  • 51
    • 0028957446 scopus 로고
    • Mutant K-ras oncogenes in colon cancers do not predict patient's chemotherapy response or survival
    • Markowitz S, Hines JD, Lutterbaugh J, Myeroff L, Mackay W, Gordon N, et al. Mutant K-ras oncogenes in colon cancers do not predict patient's chemotherapy response or survival. Clin Cancer Res 1995;1:441-5.
    • (1995) Clin Cancer Res , vol.1 , pp. 441-445
    • Markowitz, S.1    Hines, J.D.2    Lutterbaugh, J.3    Myeroff, L.4    Mackay, W.5    Gordon, N.6
  • 52
    • 0030846104 scopus 로고    scopus 로고
    • Prognostic implications of c-Ki-ras2 mutations in patients with advanced colorectal cancer treated with 5-fluorouracil and interferon: A study of the eastern cooperative oncology group (EST 2292)
    • Wadler S, Bajaj R, Neuberg D, Agarwal V, Haynes H, Benson AB III. Prognostic implications of c-Ki-ras2 mutations in patients with advanced colorectal cancer treated with 5-fluorouracil and interferon: a study of the Eastern Cooperative Oncology Group (EST 2292). Cancer J Sci Am 1997;3:284-8.
    • (1997) Cancer J Sci Am , vol.3 , pp. 284-288
    • Wadler, S.1    Bajaj, R.2    Neuberg, D.3    Agarwal, V.4    Haynes, H.5    Benson6
  • 53
    • 0032534069 scopus 로고    scopus 로고
    • A national cancer institute workshop on microsatellite instability for cancer detection and familial predisposition: Development of international criteria for the determination of microsatellite instability in colorectal cancer
    • Boland CR, Thibodeau SN, Hamilton SR, Sidransky D, Eshleman JR, Burt RW, et al. A National Cancer Institute Workshop on Microsatellite Instability for cancer detection and familial predisposition: development of international criteria for the determination of microsatellite instability in colorectal cancer. Cancer Res 1998; 58:5248-57.
    • (1998) Cancer Res , vol.58 , pp. 5248-5257
    • Boland, C.R.1    Thibodeau, S.N.2    Hamilton, S.R.3    Sidransky, D.4    Eshleman, J.R.5    Burt, R.W.6
  • 55
    • 0034642605 scopus 로고    scopus 로고
    • Tumor microsatellite instability and clinical outcome in young patients with colorectal cancer
    • Gryfe R, Kim H, Hsieh ET, Aronson MD, Holowaty EJ, Bull SB, et al. Tumor microsatellite instability and clinical outcome in young patients with colorectal cancer. N Engl J Med 2000;342:69-77.
    • (2000) N Engl J Med , vol.342 , pp. 69-77
    • Gryfe, R.1    Kim, H.2    Hsieh, E.T.3    Aronson, M.D.4    Holowaty, E.J.5    Bull, S.B.6
  • 56
    • 0033778049 scopus 로고    scopus 로고
    • Microsatellite instability is a favorable prognostic indicator in patients with colorectal cancer receiving chemotherapy
    • Hemminki A, Mecklin JP, Jarvinen H, Aaltonen LA, Joensuu H. Microsatellite instability is a favorable prognostic indicator in patients with colorectal cancer receiving chemotherapy. Gastroenterology 2000;119:921-8.
    • (2000) Gastroenterology , vol.119 , pp. 921-928
    • Hemminki, A.1    Mecklin, J.P.2    Jarvinen, H.3    Aaltonen, L.A.4    Joensuu, H.5
  • 57
    • 0030061148 scopus 로고    scopus 로고
    • Better survival rates in patients with MLH1-associated hereditary colorectal cancer
    • Sankila R, Aaltonen LA, Jarvinen HJ, Mecklin JP. Better survival rates in patients with MLH1-associated hereditary colorectal cancer. Gastroenterology 1996;110:682-7.
    • (1996) Gastroenterology , vol.110 , pp. 682-687
    • Sankila, R.1    Aaltonen, L.A.2    Jarvinen, H.J.3    Mecklin, J.P.4
  • 58
    • 0027136828 scopus 로고
    • Genomic instability in colorectal cancer: Relationship to clinicopathological variables and family history
    • Lothe RA, Peltomaki P, Meling GI, Aaltonen LA, Nystrom-Lahti M, Pylkkanen L, et al. Genomic instability in colorectal cancer: relationship to clinicopathological variables and family history. Cancer Res 1993;53:5849-52.
    • (1993) Cancer Res , vol.53 , pp. 5849-5852
    • Lothe, R.A.1    Peltomaki, P.2    Meling, G.I.3    Aaltonen, L.A.4    Nystrom-Lahti, M.5    Pylkkanen, L.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.