E-cadherin and adenomatous polyposis coli mutations are synergistic in intestinal tumor initiation in mice

Gastroenterology

Volumn 119, Issue 4, 2000, Pages 1045-1053

  Smits, Ron ^a   Ruiz, Patricia ^b   Diaz Cano, Salvador ^c   Luz, Arne ^c   Jagmohan Changur, Shantie ^a   Breukel, Cor ^a   Birchmeier, Carmen ^b   Birchmeier, Walter ^b   Fodde, Riccardo ^a  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^b MAX DELBRÜCK CENTER FOR MOLECULAR MEDICINE   (Germany)

^c INSTITUTE OF EPIDEMIOLOGY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BETA CATENIN; UVOMORULIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER GRADING; CANCER STAGING; CELL ADHESION; COLON CARCINOGENESIS; COLON POLYPOSIS; CONTROLLED STUDY; FEMALE; GENE INACTIVATION; GENE LOCUS; GENE LOSS; GENE MUTATION; HETEROZYGOSITY LOSS; INTESTINE TUMOR; KNOCKOUT GENE; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; SIGNAL TRANSDUCTION; STOMACH TUMOR; TUMOR GROWTH;

EID: 0033778728     PISSN: 00165085     EISSN: None     Source Type: Journal    
DOI: 10.1053/gast.2000.18162     Document Type: Article

References (65)

1. Identification and characterization of the familial adenomatous polyposis coli gene
2. Mutations of chromosome 5q21 genes in FAP and cotorectal cancer patients
3. Multiple intestinal neoplasia caused by a mutation in the murine homolog of the APC gene
4. A targeted chain-termination mutation in the mouse Apc gene results in multiple intestinal tumors
5. Loss of Apc heterozygosity and abnormal tissue building in nascent intestinal polyps in mice carrying a truncated Apc gene
6. Apc1638N: A mouse model for familial adenomatous polyposis-associated desmoid tumors and cutaneous cysts
7. Detailed analysis of genetic alterations in colorectal tumors from patients with and without familial adenomatous polyposis (FAP)
8. Inactivation of both APC alleles in human and mouse tumors
9. Loss of Apc+ in intestinal adenomas from Min mice
10. Loss of Apc and the entire chromosome 18 but absence of mutations at the Ras and Tp53 genes in intestinal tumors from Apc1638N, a mouse model for Apc-driven carcinogenesis
11. APC mutations occur early during colorectal tumorigenesis
12. The adenomatous polyposis coli (APC) tumor suppressor
13. Apc1638T: A mouse model delineating critical domains of the adenomatous polyposis coli protein involved in tumorigenesis and development
14. Beta-catenin: A key mediator of Writ signaling
15. Binding of GSK3beta to the APC-beta-catenin complex and regulation of complex assembly
16. Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC
17. Cell binding function of E-cadherin is regulated by the cytoplasmic domain
18. The cytoplasmic domain of the cell adhesion molecule uvomorulin associates with three independent proteins structurally related in different species
19. Uvomorulin-catenin complex formation is regulated by a specific domain in the cytoplasmic region of the cell adhesion molecule
20. Regulation of embryonic cell adhesion by the cadherin cytoplasmic domain
21. Cadherin expression in carcinomas: Role in the formation of cell junctions and the prevention of invasiveness
22. A causal role for E-cadherin in the transition from adenoma to carcinoma
23. The role of the cell-adhesion molecule E-cadherin as a tumour-suppressor gene
24. E-cadherin and APC compete for the interaction with beta-catenin and the cytoskeleton
25. The APC protein and E-cadherin form similar but independent complexes with alpha-catenin, beta-catenin and plakoglobin
26. Cell adhesion: The molecular basis of tissue atchitecture and morphogenesis
27. Cell adhesion: Old and new questions
28. The E-cadherin/epidermal growth factor receptor interaction: A hypothesis of reciprocal and reversible control of intercellular adhesion and cell proliferation
29. Cadherin adhesion in the intestinal crypt regulates morphogenesis, mitogenesis, motogenesis, and metaplasia formation
30. E-cadherin germline mutations in familial gastric cancer
31. Identification of germ-line E-cadherin mutations in gastric cancer families of European origin
32. Germline E-cadherin gene (CDH1) mutations predispose to familial gastric cancer and colorectal cancer
33. Single-cell mutation analysis of tumors from stained histologic slides
34. E-cadherin gene mutations in signet ring cell carcinoma of the stomach
35. E-cadherin inactivation in lobular carcinoma in situ of the breast: An early event in tumorigenesis
36. A targeted mutation in the mouse E-cadherin gene results in defective preimplantation development
37. Large bowel
38. Dysplasia in inflammatory bowel disease: Standardized classification with provisional clinical applications
39. Identification of a putative cell adhesion domain of uvomorulin
40. A possible new adhesive site in the cell-adhesion molecule uvomorulin
41. Intestinal and extra-intestinal tumor multiplicities in the Apc1638N mouse model after exposure to X-rays
42. The genetic background modifies the spontaneous and X-ray-induced tumor spectrum in the Apc1638N mouse model
43. E-cadherin is a tumour/invasion suppressor gene mutated in human lobular breast cancers
44. E-cadherin gene mutations provide clues to diffuse type gastric carcinomas
45. Mutations of the human E-cadherin (CDH1) gene
46. Somatic Apc mutations are selected upon their capacity to inactivate the beta-catenin downregulating activity
47. Binding to cadherins antagonizes the signaling activity of beta-catenin during axis formation in Xenopus
48. Uncoupling cadherin-based adhesion from wingless signalling in Drosophila
49. An in vivo structure-function study of armadillo, the beta-catenin homologue, reveals both separate and overlapping regions of the protein required for cell adhesion and for wingless signaling
50. Overexpression of cadherins and underexpression of beta-catenin inhibit dorsal mesoderm induction in early Xenopus embryos
51. Inhibition of beta-catenin-mediated transactivation by cadherin derivatives
52. E-cadherin binding prevents beta-catenin nuclear localization and beta-catenin/LEF-1-mediated transactivation
53. Armadillo is required for adherens junction assembly, cell polarity and morphogenesis during Drosophila embryogenesis
54. Inflammatory bowel disease and adenomas in mice expressing a dominant negative N-cadherin
55. Inactivation of the E-cadherin gene in primary gastric carcinomas and gastric carcinoma cell lines
56. E-cadherin gene mutations provide a genetic basis for the phenotypic divergence of mixed gastric carcinomas
57. Frequent somatic allelic inactivation of the E-cadherin gene in gastric carcinomas
58. Functional loss of E-cadherin and cadherin-11 alleles on chromosome 16q22 in colonic cancer
59. Loss of immunohistochemical E-cadherin expression in colon cancer is not due to structural gene alterations
60. The role of the cell-cell adhesion molecule E-cadherin in large bowel tumour cell invasion and metastasis
61. Loss of cell-cell and cell-matrix adhesion molecules in colorectal cancer
62. L-CAM expression in normal, premalignant, and malignant colon mucosa
63. The transcription factor snail is a repressor of E-cadherin gene expression in epithelial tumour cells
64. The transcription factor snail controls epithelial-mesenchymal transitions by repressing E-cadherin expression
65. Adhesion receptors in malignant transformation and dissemination of gastrointestinal tumors