Wired for reproduction: Organization and development of sexually dimorphic circuits in the mammalian forebrain

Annual Review of Neuroscience

Volumn 25, Issue , 2002, Pages 507-536

  Simerly, Richard B ^a  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

Amygdala; Hippocampus; Hypothalamus; Limbic; Sexual differentiation

Indexed keywords

CELL NUCLEUS RECEPTOR; ESTROGEN; HORMONE RECEPTOR; NEUROTRANSMITTER; NEUROTROPHIN; SEX HORMONE; TESTOSTERONE; TRANSCRIPTION FACTOR;

AMYGDALOID NUCLEUS; BRAIN DEVELOPMENT; CELL DEATH; CELL MIGRATION; FOREBRAIN; GENE OVEREXPRESSION; HIPPOCAMPUS; HYPOTHALAMUS; NERVE CELL; NERVE CELL PLASTICITY; NERVE FIBER TRANSPORT; NERVOUS SYSTEM DEVELOPMENT; NEUROANATOMY; NEUROBIOLOGY; PREOPTIC NUCLEUS; PRIORITY JOURNAL; REPRODUCTION; REVIEW; SEX DIFFERENCE; SEX DIFFERENTIATION; SEXUAL BEHAVIOR; SIGNAL TRANSDUCTION; SYNAPTOGENESIS; TRANSCRIPTION REGULATION;

ANIMALS; CELL DIFFERENTIATION; GENES, REGULATOR; GONADAL STEROID HORMONES; HUMANS; NERVE GROWTH FACTORS; NEURAL PATHWAYS; NEURONAL PLASTICITY; PROSENCEPHALON; REPRODUCTION; SEX CHARACTERISTICS; SIGNAL TRANSDUCTION;

EID: 0036308456     PISSN: 0147006X     EISSN: None     Source Type: Book Series    
DOI: 10.1146/annurev.neuro.25.112701.142745     Document Type: Review

References (173)

1. Estrogen and Bcl-2: Gene induction and effect of transgene in experimental stroke
2. Androgen enhances neuronal degeneration in the developing preoptic area: Apoptosis in the anteroventral periventricular nucleus (AVPvN-POA)
3. Estrogen and apoptosis in the developing sexually dimorphic preoptic area in female rats
4. Nuclear hormone receptors and gene expression
5. Sexual differentiation of the zebra finch song system: Positive evidence, negative evidence, null hypotheses, and a paradigm shift
6. Sex difference in the phosphorylation of cAMP response element binding protein (CREB) in neonatal rat brain
7. Excitatory versus inhibitory GABA as a divergence point in steroid-mediated sexual differentiation of the brain
8. Ventral premammillary nuclei mediate pheromonal-induced LH release stimuli in the rat
9. Estrogen receptors in dendrites and axon terminals in the guinea pig hypothalamus
10. Cytoarchitectonic sexual dimorphisms of the medial preoptic and anterior hypothalamic areas in guinea pig, rat, hamster, and mouse
11. Sexual dimorphism in the vertebrate nervous system
12. Slit proteins: Key regulators of axon guidance, axonal branching, and cell migration
13. Estrogen promotes neuron addition to an avian song-control nucleus by regulating post-mitotic events
14. Programmed cell death in the developing nervous system
15. Connections of the posterior nucleus of the amygdala
16. Projections of the ventral premamillary nucleus
17. Organization of projections from the medial nucleus of the amygdala: A PHAL study in the rat
18. Projections of the ventral subiculum to the amygdala, septum, and hypothalamus: A PHAL anterograde tract-tracing study in the rat
19. Estrogen receptors and insulin-like growth factor-I receptors mediate estrogen-dependent synaptic plasticity
20. The C. elegans protein EGL-1 is required for programmed cell death and interacts with the Bcl-2-like protein CED-9
21. The neonatal testosterone surge: A comparative study
22. Regressive events in neurogenesis
23. Mossy fiber growth and synaptogenesis in rat hippocampal slices in vitro
24. Cellular survival: A play in three Akts
25. Structural sexual dimorphisms in the anteroventral periventricular nucleus of the rat hypothalamus are sensitive to gonadal steroids perinatally, but develop peripubertally
26. Sex differences in neurotransmitter systems
27. Anatomy and function of extrahypothalamic vasopressin systems in the brain
28. Testosterone propionate administration prevents the loss of neurons within the central part of the medial preoptic nucleus
29. Hormonal modification of the number of total and late-arising neurons in the central part of the medial preoptic nucleus of the rat
30. Genetic control of programmed cell death in the nematode C. elegans
31. Estrogen-induced remodeling of hypothalamic neural circuitry
32. Motoneuronal death during human fetal development
33. Regulation of motoneuron death in the spinal nucleus of the bulbocavernosus
34. Neuroprotection by estradiol
35. Endocrine glia: Roles of glial cells in the brain actions of steroid and thyroid hormones and in the regulation of hormone secretion
36. Interaction of the signalling pathways of insulin-like growth factor-I and sex steroids in the neuroendocrine hypothalamus
37. Early androgen and age-related modifications in female rat reproduction
38. The thyroid hormone receptor binds with opposite transcriptional effects to a common sequence motif in thyroid hormone and estrogen response elements
39. Estrogen and NGF synergistically protect terminally differentiated, ERalpha-transfected PC12 cells from apoptosis
40. Stable transfection of PC12 cells with estrogen receptor (ERalpha): Protective effects of estrogen on cell survival after serum deprivation
41. Mechanisms and molecules that control growth cone guidance
42. Developmental mechanisms that generate precise patterns of neuronal connectivity
43. The 13th J.A.F. Stevenson Memorial Lecture. Sexual differentiation of the brain: Possible mechanisms and implications
44. Gonadal hormones and the organization of brain structure and function
45. Evidence for a morphological sex difference within the medial preoptic area of the rat brain
46. Sexual differentiation of the brain
47. The hippocampal formation: Morphological changes induced by thyroid, gonadal and adrenal hormones
48. Coexpression of ERβ with ERα and progestin receptor proteins in the female rat forebrain: Effects of estradiol treatment
49. The posterior nucleus of the amygdala: A unique component of sexually dimorphic forebrain circuits
50. Target specific hormonal regulation of sexually dimorphic projections from the principal nucleus of the bed nuclei of the stria terminalis
51. Hormonal regulation of CREB phosphorylation in the anteroventral periventricular nucleus
52. Projections of the sexually dimorphic anteroventral periventricular nucleus in the female rat
53. Sexual dimorphism in the CNS and the role of steroids
54. Sex differences in cell migration in the preoptic area/anterior hypothalamus of mice
55. New evidence for estrogen receptors in gonadotropin-releasing hormone neurons
56. Estrogen receptor-beta immunoreactivity in luteinizing hormone-releasing hormone neurons of the rat brain
57. Development of a sexually dimorphic projection from the bed nuclei of the stria terminalis to the anteroventral periventricular nucleus in the rat
58. Influence of sex steroids on expression of estrogen receptor mRNA in explant cultures of the principal nucleus of the bed nuclei of the stria terminalis
59. Developmental critical period for sexual differentiation of dopaminergic neurons in the anteroventral periventricular nucleus (AVPV)
60. Target dependent sexual differentiation of a limbic-hypothalamic pathway
61. Regional induction of c-fos-like protein in rat brain after estradiol administration
62. Formation of the sexually dimorphic nucleus of the preoptic area: Neuronal growth, migration and changes in cell number
63. Hormonal enhancement of neurogenesis and its relationship to the duration of olfactory memory
64. Trophic effects of androgen: Development and hormonal regulation of neuron number in a sexually dimorphic vocal motor nucleus
65. Rapid actions of plasma membrane estrogen receptors
66. Apoptosis: A basic biological phenomenon with wide-ranging implications in tissue kinetics
67. Co-expression of estrogen and thyroid hormone receptors in individual hypothalamic neurons
68. Bcl-2 and Bax function independently to regulate cell death
69. Ethology and pharmacology of hypothalamic aggression in the rat
70. Features of the neuroendocrine regulation of masculine sexual behavior
71. Arcuate nucleus of the hypothalamus: Effects of age and sex
72. The nerve growth factor 35 years later
73. Sex differences in the distribution and projections of testosterone target neurons in the medial preoptic area and the bed nucleus of the stria terminalis of rats
74. Influence of sex and estrus cycle on the sexual dimorphisms of the hypothalamic ventromedial nucleus: Stereological evaluation and Golgi study
75. Stereological evaluation and Golgi study of the sexual dimorphisms in the volume, cell numbers, and cell size in the medial preoptic nucleus of the rat
76. Sexual dimorphism in the mammalian limbic system
77. Overexpression of BCL-2 in transgenic mice protects neurons from naturally occurring cell death and experimental ischemia
78. Sexual differentiation of neuronal circuitry in the hypothalamus
79. Excitatory neurotransmission and sexual differentiation of the brain
80. Tracking the estrogen receptor in neurons: Implications for estrogen-induced synapse formation
81. Invited review. Estrogens effects on the brain: Multiple sites and molecular mechanisms
82. Nuclear receptor coregulators: Cellular and molecular biology
83. Estrogen modulates spontaneous alternation and the cholinergic phenotype in the basal forebrain
84. Ultrastructural evidence that hippocampal alpha estrogen receptors are located at extranuclear sites
85. Gonadal steroids promote glial differentiation and alter neuronal morphology in the developing hypothalamus in a regionally specific manner
86. Gonadal steroids reduce the density of axospinous synapses in the developing rat arcuate nucleus: An electron microscopy analysis
87. Brain-derived neurotrophic factor mediates estradiol-induced dendritic spine formation in hippocampal neurons
88. Apoptosis in neural development and disease
89. Formation of neurons in the sexually dimorphic anteroventral periventricular nucleus of the preoptic area of the rat: Effects of prenatal treatment with testosterone propionate
90. Cell death in the development of the posterior cortex in male and female rats
91. Eph receptors and ephrins in neural development
92. Development of connectional diversity and specificity in the mammalian brain by the pruning of collateral projections
93. Diverse migratory pathways in the developing cerebral cortex
94. Programmed cell death of developing mammalian neurons after genetic deletion of caspases
95. Neurogenesis and cell migration into the sexually dimorphic preoptic area/anterior hypothalamus of the fetal ferret
96. Bcl-xL is an antiapoptotic regulator for postnatal CNS neurons
97. Estrogens, brain and behavior: Studies in fundamental neurobiology and observations related to women's health
98. Sexual dimorphism in the preoptic area of the rat
99. Mouse models of cell death
100. Semaphorins and their receptors in vertebrates and invertebrates
101. Chemoarchitecture of the rat lateral septal nucleus
102. Connections of the rat lateral septal complex
103. Estradiol is concentrated in tyrosine hydroxylase-containing neurons of the hypothalamus
104. Circuits and mechanisms governing hypothalamic responses to stress: A tale of two paradigms
105. Estradiol induces formation of dendritic spines in hippocampal neurons: Functional correlates
106. CREB: A stimulus-induced transcription factor activated by a diverse array of extracellular signals
107. Role of co-activators and co-repressors in the mechanism of steroid/thyroid receptor action
108. Absence of oestradiol concentration in cell nuclei of LHRH-immunoreactive neurones
109. Estrogen modulates the growth-associated protein GAP-43 mRNA in the rat preoptic area and basal hypothalamus
110. The ontogeny of GAP-43 (neuromodulin) mRNA in postnatal rat brain: Evidence for a sex dimorphism
111. Comparative distribution of estrogen receptor-α and -β mRNA in the rat central nervous system
112. Hormonal control of the development and regulation of tyrosine hydroxylase expression within a sexually dimorphic population of dopaminergic cells in the hypothalamus
113. Hormonal control of neuropeptide gene expression in sexually dimorphic olfactory pathways
114. Prodynorphin and proenkephalin gene expression in the anteroventral periventricular nucleus of the rat: Sexual differentiation and hormonal regulation
115. Distribution and regulation of steroid hormone receptor gene expression in the central nervous system
116. Anatomical substrates of hypothalamic integration
117. Organization and regulation of sexually dimorphic neuroendocrine pathways
118. Development of sexually dimorphic forebrain pathways
119. Distribution of androgen and estrogen receptor mRNA-containing cells in the rat brain: An in sim hybridization study
120. Projections of the medial preoptic nucleus: A Phaseolus vulgaris leucoagglutinin anterograde tract-tracing study in the rat
121. The distribution of monoaminergic cells and fibers in a periventricular nucleus involved in the control of gonadotropin release: Immunohistochemical evidence for a dopaminergic sexual dimorphism
122. Estrogen receptor-dependent sexual differentiation of dopaminergic neurons in the preoptic region of the mouse
123. Aromatase cytochrome P450, the enzyme responsible for estrogen biosynthesis
124. The mitogen-activated protein kinase pathway mediates estrogen neuroprotection after glutamate toxicity in primary cortical neurons
125. Ovarian hormones elicit phosphorylation of Akt and extracellular-signal regulated kinase in explants of the cerebral cortex
126. Estrogen-induced activation of mitogen-activated protein kinase in cerebral cortical explants: Convergence of estrogen and neurotrophin signaling pathways
127. Axonal growth-associated proteins
128. Identification of a potential estrogen response element in the gene coding for brain derived neurotrophic factor (BDNF)
129. Signal transduction underlying growth cone guidance by diffusible factors
130. Cerebral hemisphere regulation of motivated behavior(1)
131. What is the amygdala?
132. Estrogen stimulates a transient increase in the number of new neurons in the dentate gyrus of the adult female rat
133. A role for medial preoptic nucleus on afternoon of proestrus in female rats
134. The molecular biology of axon guidance
135. Caspases: Enemies within
136. Sex steroids and the development of the newborn mouse hypothalamus and prepoptic area in vitro: Implications for sexual differentiation
137. Estrogen and insulin synergism in neurite growth enhancement in vitro: Mediation of steroid effects by interactions with growth factors?
138. Autoradiographic localization of [3H] estradiol related to steroid responsiveness in cultures of the newborn mouse hypothalamus and preoptic area
139. Novel mechanisms of estrogen action in the brain: New players in an old story
140. Programmed neuronal death in insect development
141. Cell death in development
142. CREB-binding protein and p300 in transcriptional regulation
143. Estrogen causes sexual differentiation of dopaminergic neurons in the AVPV of the rat hypothalamus by inducing caspase mediated cell death
144. Rapid membrane effects of steroids in neuroblastoma cells: Effects of estrogen on mitogen activated protein kinase signaling cascade and c-fos immediate early gene transcription
145. Neuropeptides and the integration of motor responses to dehydration
146. Plasma testosterone and progesterone titers of pregnant rats, their male and female fetuses and neonatal offspring
147. Thyroid hormone causes sexually distinct neurochemical and morphological alterations in rat septal-diagonal band neurons
148. Widespread elimination of naturally occurring neuronal death in Bax-deficient mice
149. Estrogens: Trophic and protective factors in the adult brain
150. Electrophysiological and cellular effects of estrogen on neuronal function
151. Estradiol mediates fluctuation in hippocampal synapse density during the estrous cycle in the adult rat
152. Estradiol increases the sensitivity of hippocampal CA1 pyramidal cells to NMDA receptor-mediated synaptic input: Correlation with dendritic spine density
153. The distributions of apoptotic cells in the medial preoptic areas of male and female neonatal rats
154. Apoptosis in the nervous system
155. Developmental change in the steroid hormone signal for cell-autonomous, segment-specific programmed cell death of a motoneuron
156. Assembling the presynaptic active zone: A characterization of an active zone precursor vesicle
157. The mechanism of action of thyroid hormones
158. Resistance to DNA fragmentation and chromatin condensation in mice licking the DNA fragmentation factor 45
159. 17-beta-estradiol induces an inhibitor of active caspases
160. Estrogen rapidly induces the phosphorylation of the cAMP response element binding protein in rat brain
161. Evidence for a role of dendritic filopodia in synaptogenesis and spine formation
162. BCL-2 overexpression rescues motoneurons in the spinal nucleus of the bulbocavernosus of female mice