Non-thiol farnesyltransferase inhibitors: Utilization of an aryl binding site by 5-arylacryloylaminobenzophenones

Bioorganic and Medicinal Chemistry

Volumn 10, Issue 8, 2002, Pages 2657-2662

  Mitsch, Andreas ^b   Böhm, Markus ^b   Wißner, Pia ^b   Sattler, Isabel ^c   Schlitzer, Martin ^a  

^a UNIVERSITY OF MUNICH   (Germany)

^b PHILIPPS UNIVERSITY MARBURG   (Germany)

^c HANS KNÖLL INSTITUTE   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

3 (1 ACETYL 1H INDOL 3 YL) N 3 BENZOYL 4 (4 TOLYLACETYLAMINO)PHENYLACRYLAMIDE; 3 BENZO[1,3]DIOXOL 5 YL N 5 BENZOYL 4 [2 (4 TOLYLACETYLAMINO)]PHENYLACRYLAMIDE; 3 BENZOTHIAZOL 2 YL N 3 BENZOYL 4 (4 TOLYLACETYLAMINO)PHENYLACRYLAMIDE; BENZOPHENONE DERIVATIVE; N 3 BENZOYL 4 (4 TOLYLACETYLAMINO)PHENYL 3 (9H FLUOREN 2 YL)ACRYLAMIDE; N 3 BENZOYL 4 (4 TOLYLACETYLAMINO)PHENYL 3 NAPHTHALEN 1 YLACRYLAMIDE; N 3 BENZOYL 4 (4 TOLYLACETYLAMINO)PHENYL 3 NAPHTHALEN 2 YLACRYLAMIDE; N 3 BENZOYL 4 (4 TOLYLACETYLAMINO)PHENYL 3 PHENYLACRYLAMIDE; N 3 BENZOYL 4 (4 TOLYLACETYLAMINO)PHENYL 3 QUINOLIN 2 YLACRYLAMIDE; PROTEIN FARNESYLTRANSFERASE INHIBITOR; UNCLASSIFIED DRUG; ENZYME INHIBITOR; FARNESYL TRANS TRANSFERASE; OLIGOPEPTIDE; TRANSFERASE;

ARTICLE; BINDING SITE; DRUG ACTIVITY; ENZYME BINDING; ENZYME INHIBITION; STRUCTURE ANALYSIS; CHEMICAL STRUCTURE; DRUG ANTAGONISM; ENZYMOLOGY; IC 50; KINETICS; MOLECULAR MIMICRY; PROTEIN BINDING; STRUCTURE ACTIVITY RELATION; SYNTHESIS; YEAST;

ALKYL AND ARYL TRANSFERASES; BENZOPHENONES; BINDING SITES; ENZYME INHIBITORS; FARNESYLTRANSTRANSFERASE; INHIBITORY CONCENTRATION 50; KINETICS; MODELS, MOLECULAR; MOLECULAR MIMICRY; OLIGOPEPTIDES; PROTEIN BINDING; STRUCTURE-ACTIVITY RELATIONSHIP; YEASTS;

EID: 0036280416     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0968-0896(02)00088-3     Document Type: Article

References (26)