Synthesis, molecular modeling, and structure - Activity relationship of benzophenone-based CAAX-peptidomimetic farnesyltransferase inhibitors

Journal of Medicinal Chemistry

Volumn 44, Issue 18, 2001, Pages 2886-2899

  Sakowski, J ^a   Bohm M ^a   Sattler, I ^b   Dahse, H M ^b   Schlitzer, M ^a  

^a PHILIPPS UNIVERSITY MARBURG   (Germany)

^b HANS KNÖLL INSTITUTE   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BENZOPHENONE DERIVATIVE; N [3 BENZOYL 4 [2 (4 METHYLPHENYL)ACETYLAMINO]PHENYL]CYSTEINAMIDE; PROTEIN FARNESYLTRANSFERASE INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; BINDING SITE; CRYSTAL STRUCTURE; ENZYME CONFORMATION; MOLECULAR MODEL; PROTEIN STRUCTURE; PROTON NUCLEAR MAGNETIC RESONANCE; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

ALKYL AND ARYL TRANSFERASES; ANTINEOPLASTIC AGENTS; BENZOPHENONES; BINDING SITES; CYSTEINE; ENZYME INHIBITORS; HUMANS; MODELS, MOLECULAR; MOLECULAR MIMICRY; PEPTIDE FRAGMENTS; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR CELLS, CULTURED;

EID: 0035974644     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm010872r     Document Type: Article

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