Amino acid substitutions that convert the protein substrate specificity of farnesyltransferase to that of geranylgeranyltransferase type I

Journal of Biological Chemistry

Volumn 272, Issue 1, 1997, Pages 680-687

  Villar, Keith Del ^a   Mitsuzawa, Hiroshi ^a,b   Yang, Wenli ^a   Sattler, Isabel ^a,c   Tamanoi, Fuyuhiko ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b NATIONAL INSTITUTE OF GENETICS   (Japan)

^c HANS KNÖLL INSTITUTE   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

FARNESYL TRANS TRANSFERASE; GERANYLTRANSFERASE; MUTANT PROTEIN;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ARTICLE; ENZYME KINETICS; ENZYME SPECIFICITY; ENZYME SUBSTRATE; ESCHERICHIA COLI; NONHUMAN; PRIORITY JOURNAL; SACCHAROMYCES CEREVISIAE; SITE DIRECTED MUTAGENESIS;

ALKYL AND ARYL TRANSFERASES; AMINO ACID SEQUENCE; BINDING SITES; FARNESYLTRANSTRANSFERASE; FUNGAL PROTEINS; GERANYLTRANSTRANSFERASE; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; SEQUENCE ALIGNMENT; SERINE; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY; TRANSFERASES; TYROSINE;

ESCHERICHIA COLI; FELIS CATUS; SACCHAROMYCES CEREVISIAE;

EID: 0039948032     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.272.1.680     Document Type: Article

References (50)

1. Reiss, Y., Goldstein, J. L., Seabra, M. C., Casey, P. J., and Brown, M. S. (1990) Cell 62, 81-88
2. Kohl, N. E., Diehl, R. E., Schaber, M. D., Rands, E., Soderman, D. D., He, B., Moores, S. L., Pompliano, D. L., Ferro-Novick, S., Powers, S., Thomas, K. A., and Gibbs, J. B. (1991) J. Biol. Chem. 266, 18884-18888
3. Zhang, F. L., and Casey, P. J. (1996) Annu. Rev. Biochem. 65, 241-270
4. Glomset, J. A., and Farnsworth, C. C. (1994) Annu. Reu. Cell Biol. 10, 181-205
5. Clarke, S. (1992) Annu. Reu. Biochem. 61, 355-386
6. Schafer, W. R., and Rine, J. (1992) Annu. Rev. Genet. 26, 209-237
7. Moomaw, J. F., and Casey, P. J. (1992) J. Biol. Chem. 267, 17438-17443
8. Yokoyama, K., and Gelb, M. H. (1993) J. Biol. Chem. 268, 4055-4060
9. Yokoyama, K., Goodwin, G. W., Ghomashchi, F., Glomset, J. A., and Gelb, M. H. (1991) Proc. Natl. Acad. Sci. U. S. A. 88, 5302-5306
10. Yokoyama, K., McGeady, P., and Gelb, M. H. (1995) Biochemistry 34, 1344-1354
11. Moores, S. L., Schaber, M. D., Mosser, S. D., Rands, E., O'Hara, M. B., Garsky, V. M., Marshall, M. S., Pompliano, D. L., and Gibbs, J. B. (1991) J. Biol. Chem. 266, 14603-14610
12. Gomez, R., Goodman, L. E., Tripathy, S. K., O'Rourke, E., Manne, V., and Tamanoi, F. (1993) Biochem. J. 289, 25-31
13. Trueblood, C. E., Ohya, Y., and Rine, J. (1993) Mol. Cell Biol. 13, 4260-4275
14. Ohya, Y., Goebl, M., Goodman, L. E., Petersen-Bjørn, S., Friesen, J. D., Tamanoi, F., and Anraku, Y. (1991) J. Biol. Chem. 266, 12356-12360
15. Gibbs, J. B., Oliff, A., and Kohl, N. E. (1994) Cell 77, 175-178
16. Tamanoi, F (1993) Trends Biochem. Sci. 18, 349-353
17. James, G. L., Goldstein, J. L., Brown, M. S., Rawson, T. E., Somers, T. C., McDowell, R. S., Crowley, C. W., Lucas, B. K., Levinson, A. D., and Masters, J. C. (19930 Science 260, 1937-1942
18. Kohl, N. E., Mosser, S. D., deSolms, S. J., Giuliani, E. A., Pompliano, D. L., Graham, S. L., Smith, R. L., Scolnick, E. M., Oliff, A., and Gibbs, J. B. (1993) Science 260, 1934-1937
19. Buss, J., and Masters, J. C., Jr. (1996) Chem. Biol. 2, 787-791
20. Seabra, M. C., Reiss, Y., Casey, P. J., Brown, M. S., and Goldstein, J. L. (1991) Cell 65, 429-434
21. Reiss, Y., Seabra, M. C., Armstrong, S. A., Slaughter, C. A., Goldstein, J. L., and Brown, M. S. (1991) J. Biol. Chem. 266, 10672-10677
22. Ying, W., Sepp-Lorenzino, L., Cai, K., Aloise, P., and Coleman, P. S. (1994) J. Biol. Chem. 269, 470-477
23. Goodman, L. E., Judd, S. R., Farnsworth, C. C., Powers, S., Gelb, M. H., Glomset, J. A., and Tamanoi, F. (1990) Proc. Natl. Acad. Sci. U. S. A. 87, 9665-9669
24. He, B., Chen, P., Chen, S.-Y., Vancura, K. L., Michaelis, S., and Powers, S. (1991) Proc. Natl. Acad. Sci. U. S. A. 88, 11373-11377
25. Mayer, M. P., Prestwich, G. D., Dolence, J. M., Bond, P. D., Wu, H., and Poulter, C. D. (1993) Gene (Amst.) 132, 41-47
26. Finegold, A. A., Johnson, D. I., Farnsworth, C. C., Gelb, M. H., Judd, S. R., Glomset, J. A., and Tamanoi, F. (1991) Proc. Natl. Acad. Sci. U. S. A. 88, 4448-4452
27. Mayer, M. L., Caplin, B. E., and Marshall, M. S. (1992) J. Biol. Chem. 267, 20589-20593
28. Chen, W. J., Andres, D. A., Goldstein, J. L., Russell, D. W., and Brown, M. S. (1991) Cell 66, 327-334
29. Caplin, B. E., Hettich, L. A., and Marshall, M. S. (1994) Biochim. Biophys. Acta 1205, 39-48
30. Mitsuzawa, H., Esson, K., and Tamanoi, F. (1995) Proc. Natl. Acad. Sci. U. S. A. 92, 1704-1708
31. Nakayama, N., Arai, K., and Matsumoto, K. (1988) Mol. Cell. Biol. 8, 5410-5416
32. Sikorski, R. S., and Hieter, P. (1989) Genetics 122, 19-27
33. Sherman, F. (1991) Methods Enzymol. 194, 3-21
34. Gietz, D., St. Jean, A., Woods, R. A., and Schiestl, R. H. (1992) Nucleic Acids Res. 20, 1425
35. Qadota, H., Ishii, I., Fujiyama, A., Ohya, Y., and Anraku, Y. (1992) Yeast 8, 735-741
36. Smith, D. B., and Johnson, K. S. (1988) Gene (Amst.) 67, 31-40
37. Finegold, A. A. (1992) Yeast Geranylgeranyltransferase: A Member of the Protein Prenyltransferase Family. Ph.D. thesis, University of Chicago
38. Ho, S. N., Hunt, H. D., Horton, R. M., Pullen, J. K., and Pease, L. R. (1989) Gene (Amst.) 77, 51-59
39. Higuchi, R. (1990) PCR Protocols: A Guide to Methods and Applications (Innis, M. A., Gelfand, D. H., Sninsky, J. J., and White, T. J., eds) pp. 177-183, Academic Press, San Diego
40. Reiss, Y., Brown, M. S., and Goldstein, J. L. (1992) J. Biol. Chem. 267, 6403-6408
41. Chen, W.-J., Moomaw, J. F., Overton, L., Kost, T. A., and Casey, P. J. (1993) J. Biol. Chem. 268, 9675-9680
42. Zhang, F. L., Diehl, R. E., Kohl, N. E., Gibbs, J. B., Giros, B., Casey, P. J., and Omer, C. A. (1994) J. Biol. Chem. 269, 3175-3180
43. Zhang, F. L. Fu, H. W., Casey, P. J., and Bishop, W. R. (1996) Biochemistry 35, 8166-8171
44. Goodman, L. E., Perou, C. M., Fujiyama, A., and Tamanoi, F. (1988) Yeast 4, 271-281
45. Omer, C. A., Kral, A. M., Diehl, R. E., Prendergast, G. C., Powers, S., Allen, C. M., Gibbs, J. B., and Kohl, N. E. (1993) Biochemistry 32, 5167-5176
46. Yang, Z., Cramer, C. L., and Watson, J. C. (1993) Plant Physiol. 101, 667-674
47. Zhang, F. L., Moomaw, J. F., and Casey, P. J. (1994) J. Biol. Chem. 269, 23465-23470
48. Therrien, M., Chang, H. C., Solomon, N. M., Karim, F. D., Wassarman, D. A., and Rubin, G. M. (1995) Cell 83, 879-888
49. Diaz, M., Sanches, Y., Bennett, T., Sun, C. R., Godoy, C., Tamanoi, F., Duran, A., and Perez, P. (1993) EMBO J. 12, 5245-5254
50. Creighton, T. E. (1993) Proteins: Structures and Molecular Properties, 2nd Ed., p. 4, Freeman, New York