Egr1 transcription factor: Multiple roles in prostate tumor cell growth and survival

Tumor Biology

Volumn 23, Issue 2, 2002, Pages 93-102

  Adamson, Eileen D ^a   Mercola, Dan ^b  

^a BURNHAM INSTITUTE   (United States)

^b SIDNEY KIMMEL CANCER CENTER   (United States)

Author keywords

Angiogenesis; Egr1 binding; Egr1 regulated; Gene promoters; Growth factors; Prostate cancer

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR; FIBROBLAST GROWTH FACTOR 1; FIBROBLAST GROWTH FACTOR 2; FIBRONECTIN; HEPARIN BINDING EPIDERMAL GROWTH FACTOR; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MESSENGER RNA; ORNITHINE DECARBOXYLASE; PLATELET DERIVED GROWTH FACTOR A; PLATELET DERIVED GROWTH FACTOR B; PROTEIN NAB1; PROTEIN NAB2; PROTEIN P300; PROTEIN P53; REGULATOR PROTEIN; SOMATOMEDIN B; SOMATOMEDIN BINDING PROTEIN 3; SOMATOMEDIN C; SOMATOMEDIN C RECEPTOR; TISSUE INHIBITOR OF METALLOPROTEINASE; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR EGR 1; TRANSCRIPTION FACTOR HIF 1ALPHA; TRANSCRIPTION FACTOR SP1; TRANSCRIPTION FACTOR SP3; TRANSFORMING GROWTH FACTOR ALPHA; TRANSFORMING GROWTH FACTOR BETA1; UNCLASSIFIED DRUG; UNINDEXED DRUG; UROKINASE; VASCULOTROPIN;

ANGIOGENESIS; APOPTOSIS; CELL DIFFERENTIATION; CELL STIMULATION; CELL SURVIVAL; CELL TYPE; GROWTH INHIBITION; HUMAN; NONHUMAN; PRIORITY JOURNAL; PROSTATE TUMOR; PROTEIN DNA BINDING; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN INDUCTION; PROTEIN INTERACTION; PROTEIN LOCALIZATION; REVIEW; STRESS; TUMOR GROWTH;

EID: 0036270508     PISSN: 10104283     EISSN: None     Source Type: Journal    
DOI: 10.1159/000059711     Document Type: Review

References (141)

1. A zinc finger-encoding gene coregulated with c-fos during growth and differentiation and after cellular depolarization
2. Nerve growth factor-induced gene encodes a possible transcriptional regulatory factor
3. A gene activated in mouse 3T3 cells by serum growth factors encodes a protein with 'zinc finger' sequence
4. Characterization of a mouse multiple family that encodes zinc finger structures
5. Cloning of tetradecanoyl phorbol ester-induced 'primary response' sequences and their expression in density-arrested Swiss 3T3 cells and a TPA non-proliferative variant
6. Decreased Egr-1 expression In human, mouse and rat mammary cells and tissues correlates with tumor formation
7. Expression patterns of immediate early transcription factors in human non-small cell lung cancer
8. The early growth response gene EGR-1 behaves as a suppressor gene that is down-regulated independent of ARF/Mdm2 but not p53 alterations in fresh human gliomas
9. Characterization of an early growth response gene, which encodes a zinc finger transcription factor, potentially involved in cell cycle regulation
10. TGFbeta-inducible early gene (TIEG) also codes for early growth response alpha (EGRalpha): Evidence of multiple transcripts from alternate promoters
11. Transcriptional activation of the zinc finger transcription factor BTEB2 gene by Egr-1 through mitogen-activated protein kinase pathways in vascular smooth muscle cells
12. NAB2, a corepressor of NGFI-A (Egr-1) and Krox20, is induced by proliferative and differentiative stimuli
13. Nab1, a corepressor of Ngfi-a (Egr-1), contains an active transcriptional repression domain
14. Modulation of early growth response (EGR) transcription factor-dependent gene expression by using recombinant adenovirus
15. The transcriptional corepressor NAB2 inhibits NGF-induced differentiation of PC12 cells
16. EGR2 mutations in inherited neuropathies dominant-negatively inhibit myelin gene expression
17. Early transcriptional events in cell growth: The Egr family
18. Effects of mechanical forces on signal transduction and gene expression in endothelial cells
19. Endothelial dysfunction, hemodynamic forces, and atherogenesis
20. Regulation of the tissue factor gene
21. Early growth response factor 1: A pleiotropic mediator of inducible gene expression
22. Tumor suppressor genes which encode transcriptional repressors: Studies on the EGR and Wilms' tumor (WT1) gene products
23. Early growth response protein 1 (Egr-1): Prototype of a zinc-finger family of transcription factors
24. Egr-1: Is it always immediate and early?
25. Identification of NAB1, a repressor of NGFI-A- and Krox20-mediated transcription
26. The transcriptional corepressor NAB2 blocks Egr-1-mediated growth factor activation and angiogenesis
27. Transcriptional regulation of PDGF-A and TGF-beta by +KTS WT1 deletion mutants and a mutant mimicking Denys-Drash syndrome
28. EGR-1 enhances tumor growth and modulates the effect of the Wilms' tumor 1 gene products on tumorigenicity
29. Transcriptional regulation of the tissue factor gene in human epithelial cells is mediated by Sp1 and EGR-1
30. The reciprocal role of Egr-1 and Sp family proteins in regulation of the PTP1B promoter in response to the p210 Bcr-Abl oncoprotein-tyrosine kinase
31. Pathways of Egr-1-mediated gene transcription in vascular biology
32. Growth and differentiation proceeds normally in cells deficient in the immediate early gene NGFI-A
33. Luteinizing hormone deficiency and female infertility in mice lacking the transcription factor NGFI-A (Egr-1)
34. Multiple pituitary and ovarian defects in Krox-24 (Ngfi-a, Egr-1)-targeted mice
35. Functional compensation by Egr4 in Egr1-dependent luteinizing hormone regulation and Leydig cell steroidogenesis
36. Tissue factor transcription driven by Egr-1 is a critical mechanism of murine pulmonary fibrin deposition in hypoxia
37. Egr-1, a master switch coordinating upregulation of divergent gene families underlying ischemic stress
38. Altered molecular response to adrenoreceptor-induced cardiac hypertrophy in Egr-1-deficient mice
39. Diminished molecular response to doxorubicin and loss of cardioprotective effect of dexrazoxane in Egr-1 deficient female mice
40. The full induction of human apoprotein A-I gene expression by the experimental nephrotic syndrome in transgenic mice depends on cis-acting elements in the proximal 256 base-pair promoter region and the trans-acting factor early growth response factor 1
41. Peptide growth factors and prostate cancer: New models, new opportunities
42. Longitudinal cohort analysis of lethal prostate cancer progression in transgenic mice
43. The insulin-like growth factor axis and prostate cancer: Lessons from the transgenic adenocarcinoma of mouse prostate (TRAMP) model
44. EGR1 target genes in prostate carcinoma cells identified by microarray analysis
45. Increased expression of early growth response-1 messenger ribonucleic acid in prostatic adenocarcinoma
46. Expression of early growth response genes in human prostate cancer
47. A transgenic mouse model of metastatic prostate cancer originating from neuroendocrine cells
48. Impaired prostate tumorigenesis in Egr1-deficient mice
49. Egr-1 mediates transcriptional activation of IGF-II gene in response to hypoxia
50. Transcriptional repression of human insulin-like growth factor-II P4 promoter by Wilms' tumor suppressor WT1
51. Repression of the insulin-like growth factor II gene by the Wilms tumor suppressor WT1
52. Transcriptional regulation of insulin-like growth factor-I receptor gene expression in prostate cancer cells
53. Epidermal growth factor modulates the expression of vascular endothelial growth factor in the human prostate
54. WT1 suppresses synthesis of the epidermal growth factor receptor and induces apoptosis
55. The Wilms' tumor gene product WT1 mediates the down-regulation of the rat epidermal growth factor receptor by nerve growth factor in PC12 cells
56. Early growth response-1 gene mediates up-regulation of epidermal growth factor receptor expression during hypoxia
57. The Wilms tumor suppressor WT1 encodes a transcriptional activator of amphiregulin
58. Preneoplastic mammary tumor markers: Cripto and amphiregulin are overexpressed in hyperplastic stages of tumor progression in transgenic mice
59. Complex post-transcriptional regulation of EGF-receptor expression by EGF and TGF-alpha in human prostate cancer cells
60. Correlation of TGF-alpha and EGF-receptor expression with proliferative activity in human astrocytic gliomas
61. Increased expression of heparin binding EGF (HB-EGF), amphiregulin, TGF alpha and epiregulin in androgen-independent prostate cancer cell lines
62. FGF-1-induced platelet-derived growth factor-A chain gene expression in endothelial cells involves transcriptional activation by early growth response factor-1
63. Inducible PDGF A-chain transcription in smooth muscle cells is mediated by Egr-1 displacement of Sp1 and Sp3
64. Regulation of PDGF-B in endothelial cells exposed to cyclic strain
65. Basic fibroblast growth factor transcriptional autoregulation requires EGR-1
66. Egr-1 activates basic fibroblast growth factor transcription. Mechanistic implications for astrocyte proliferation
67. Growth factor involvement in progression of prostate cancer
68. Molecular biology of prostate development and prostate cancer
69. Immunohistochemistry analysis of platelet-derived growth factor A and B chains and platelet-derived growth factor alpha and beta receptor expression in benign prostatic hyperplasias and Gleason-graded human prostate adenocarcinomas
70. Platelet-derived growth factor (PDGF)-signaling mediates radiation-induced apoptosis in human prostate cancer cells with loss of p53 function
71. Transforming growth factor-alpha enhances cyclin D1 transcription through the binding of early growth response protein to a cis-regulatory element in the cyclin D1 promoter
72. The immediate-early gene Egr-1 regulates the activity of the thymidine kinase promoter at the G0-to-G1 transition of the cell cycle
73. Cloning of the cyclin A1 genomic structure and characterization of the promoter region. GC boxes are essential for cell cycle-regulated transcription of the cyclin A1 gene
74. Ornithine decarboxylase is a transcriptional target of tumor suppressor WT1
75. Ornithine decarboxylase activity and its gene expression are increased in benign hyperplastic prostate
76. Inducible expression of Egr-1-dependent genes. A paradigm of transcriptional activation in vascular endothelium
77. Hypoxia in combination with FGF-2 induces tube formation by human microvascular endothelial cells in a fibrin matrix: Involvement of at least two signal transduction pathways
78. Differentially expressed genes in hormone refractory prostate cancer: Association with chromosomal regions involved with genetic aberrations
79. The transcription factor EGR-1 directly transactivates the fibronectin gene and enhances attachment of human glioblastoma cell line U251
80. Analysis of gene expression identifies candidate markers and pharmacological targets in prostate cancer
81. Expression profiling reveals hepsin overexpression in prostate cancer
82. Delineation of prognostic biomarkers in prostate cancer
83. The same sequence mediates activation of the human urokinase promoter by cAMP in mouse Sertoli cells and by SV40 large T antigen in COS cells
84. Inherited diseases of the vasculature
85. Tissue factor expression and angiogenesis in human prostate carcinoma
86. Tissue factor - A receptor involved in the control of cellular properties, including angiogenesis
87. Method for cloning in vivo targets of the Egr-1 transcription factor
88. Functional properties of WT1
89. Characterization of the human elk-1 promoter. Potential role of a downstream intronic sequence for elk-1 gene expression in monocytes
90. Growth of LLC-PK1 renal cells is mediated by EGR1 up-regulation of G protein alpha i-2 protooncogene transcription
91. LLC-PK1 cell growth is repressed by WT1 inhibition of G-protein alpha i-2 protooncogene transcription
92. Transcription of the dominant-negative helix-loop-helix protein Id1 is regulated by a protein complex containing the immediate-early response gene Egr1
93. Decreased expression of Wilms' tumor gene WT-1 and elevated expression of insulin growth factor-II (IGF-II) and type 1 IGF receptor genes in prostatic stromal cells from patients with benign prostatic hyperplasia
94. Involvement of Sp1 in the transcriptional regulation of the rat insulin-like growth factor-1 gene
95. Hepatitis C virus core protein transactivates insulin-like growth factor II gene transcription through acting concurrently on Egr1 and Sp1 sites
96. Transcriptional repression of the insulin-like growth factor I receptor (IGF-I-R) gene by the tumor suppressor WT1 involves binding to sequences both upstream and downstream of the IGF-I-R gene transcription start site
97. Control of insulin-like growth factor-II/mannose 6-phosphate receptor gene transcription by proximal promoter elements
98. Transactivation of the IGFBP-2 promoter in human tumor cell lines
99. Structure of the human insulin-like growth factor binding protein-2 gene
100. In vivo protein-DNA interactions at the c-jun promoter: Preformed complexes mediate the UV response
101. Regulation of ornithine decarboxylase gene expression by the Wilms' tumor suppressor WT1
102. WT1, the Wilms' tumor suppressor gene product, represses transcription through an interactive nuclear protein
103. The Wilms' tumor gene product, WT1, represses transcription of the platelet-derived growth factor A-chain gene
104. Egr-1-induced endothelial gene expression: A common theme in vascular injury
105. Mitogenic up-regulation of the PRL-1 protein-tyrosine phosphatase gene by Egr-1. Egr-1 activation is an early event in liver regeneration
106. Involvement of early growth response factor Egr-1 in apolipoprotein AI gene transcription
107. Cloning and characterization of the human BAG-1 gene promoter: Upregulation by tumor-derived p53 mutants
108. BAG-1 accelerates cell motility of human gastric cancer cells
109. Suppression of human fibrosarcoma cell growth by transcription factor, Egr-1, involves down-regulation of Bcl-2
110. WT1 modulates apoptosis by transcriptionally upregulating the bcl-2 protooncogene
111. E-cadherin is a WT1 target gene
112. Role of EGR1 in regulation of stimulus-dependent CD44 transcription in B lymphocytes
113. Transcriptional regulation of alpha 2(I) collagen gene expression by fibroblast growth factor-2 in MC3T3-E1 osteoblast-like cells
114. Transcriptional regulation of the Icam-1 gene in antigen receptor- and phorbol ester-stimulated B lymphocytes: Role for transcription factor EGR1
115. Comparison of ANG II with other growth factors on Egr-1 and matrix gene expression in cardiac fibroblasts
116. Involvement of Egr-1/RelA synergy in distinguishing T cell activation from tumor necrosis factor-alpha-induced NF-kappa B1 transcription
117. Sp1 and egr-1 have opposing effects on the regulation of the rat Pgp2/mdr1b gene
118. Early growth response-1-dependent apoptosis is mediated by p53
119. Ionizing radiation down-regulates p53 protein in primary Egr-1(-/-) mouse embryonic fibroblast cells causing enhanced resistance to apoptosis
120. Stress-induced transcription of the clusterin/apoJ gene
121. Clusterin/apoJ expression during the development of hemangioma
122. A nuclear factor other than Sp1 binds the GC-rich promoter of the gene encoding rat poly(ADP-ribose) polymerase in vitro
123. Characterization of an Krox-24/Egr-1-responsive element in the human tumor necrosis factor promoter
124. Lipopolysaccharide induction of the tumor necrosis factor-alpha promoter in human monocytic cells - Regulation by Egr-1, C-Jun, and Nf-kappa-B transcription factors
125. Egr-1 mediates extracellular matrix-driven transcription of membrane type 1 matrix metalloproteinase in endothelium
126. Zinc finger transcription factor Egr-1 activates Flt-1 gene expression in THP-1 cells on induction for macrophage differentiation
127. Up-regulation of vascular endothelial growth factor receptor Flt-1 after endothelial denudation: Role of transcription factor Egr-1
128. Transforming growth factor-beta - and tumor necrosis factor-alpha -mediated induction and proteolytic activation of MMP-9 in human skin
129. Transcriptional regulation of MMP-9 expression in stromal cells of human giant cell tumor of bone by tumor necrosis factor-alpha
130. Cloning and expression of novel mosaic serine proteases with and without a transmembrane domain from human lung
131. LPS induction of gene expression in human monocytes
132. Differential gene expression in migrating renal epithelial cells after wounding
133. Role and localization of urokinase receptor in the formation of new microvascular structures in fibrin matrices
134. Transcriptional induction of the urokinase receptor gene by a constitutively active Src. Requirement of an upstream motif (-152/-135) bound with Sp1
135. Analysis of the promoter region of the human VEGF-related factor gene
136. Vascular endothelial cell growth factor-induced tissue factor expression in endothelial cells is mediated by EGR-1
137. p53 and Egr-1 additively suppress transformed growth in HT1080 cells but Egr-1 counteracts p53-dependent apoptosis
138. Comparative reverse transcription-polymerase chain reaction and in situ hybridization analyses of human imprinted p57KIP2 and insulin-like growth factor 2 gene transcripts in fetal kidney and Wilms' tumors using archival tissue
139. Overlapping Egr-1 and Sp1 sites function in the regulation of transcription of the mouse thrombospondin 1 gene
140. Transcription factor EGR-1 suppresses the growth and transformation of human HT-1080 fibrosarcoma cells by induction of transforming growth factor b1
141. The Egr-1 transcription factor directly activates PTEN during irradiation-induced signalling