Transactivation of the IGFBP-2 promoter in human tumor cell lines

Molecular and Cellular Endocrinology

Volumn 175, Issue 1-2, 2001, Pages 211-218

  Elminger, Martin W ^a   Bell, Mathias ^b   Schüett, Burkhardt S ^a   Langkamp, Markus ^a   Kutoh, Eiji ^c   Ranke, Michael B ^a  

^a UNIVERSITY HOSPITAL TÜBINGEN   (Germany)

^b JUSTUS LIEBIG UNIVERSITY   (Germany)

^c JANSSEN RESEARCH FOUNDATION   (Belgium)

Author keywords

Choriocarcinoma; IGF analogues; IGFBP 2 promoter; IGFBP 3; Insulin like growth factor (IGF) II; Leukemia; Pro IGF

Indexed keywords

LUCIFERASE; MESSENGER RNA; SOMATOMEDIN B; SOMATOMEDIN BINDING PROTEIN 2; SOMATOMEDIN C; SOMATOMEDIN C DERIVATIVE;

ARTICLE; CHORIOCARCINOMA; CONTROLLED STUDY; HUMAN; HUMAN CELL; LEUKEMIA CELL; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TRANSACTIVATION; TRANSCRIPTION REGULATION; TUMOR CELL;

HUMANS; INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN 2; INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN 3; PROMOTER REGIONS (GENETICS); RNA, MESSENGER; SOMATOMEDINS; TRANS-ACTIVATION (GENETICS); TRANSFECTION; TUMOR CELLS, CULTURED;

EID: 0035946584     PISSN: 03037207     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0303-7207(00)00454-8     Document Type: Article

References (27)

1. Structure of the human insulin-like growth factor binding protein-2 gene
2. Three clustered Spl sites are required for efficient transcription of the TATA-less promoter of the gene for insulin-like growth factor binding protein 2 from the rat
3. Increased levels of insulin-like growth factor II (IGF-II) and IGF-binding protein-2 are associated with malignancy in sporadic adrenocortical tumors
4. Overexpression of insulin-like growth factor binding protein-2 in C6 glioma cells results in conditional alteration of cellular growth
5. Post-translational processing of the insulin-like growth factor-2 precursor
6. Elevated insulin-like growth factor binding protein (IGFBP)-2 and IGFBP-4 expression of leukemic T-cells is affected by autocrine/paracrine IGF-II action but not by IGF type-I receptor expression
7. Secretion of non-complexed 'big' (10-18 kD) forms of insulin-like growth factor-II by 12 soft tissue sarcoma cell lines
8. Elevated serum insulin-like growth factor binding protein 2 (IGFBP-2) and decreased IGFBP-3 in epithelial ovarian cancer: correlation with cancer antigen 125 and tumor-associated trypsin inhibitor
9. Insulin-like growth factor (IGF)-II binding to IGF-binding proteins and IGF receptors is modified by deletion of the N-terminal hexapeptide or substitution of arginine for glutamate-6 in IGF-II
10. Insulin-like growth factor-binding proteins-2 in patients with prostate carcinoma and benign prostatic hyperplasia
11. Overexpression of insulin-like growth factor binding protein-2 results in increased tumorigenic potential in Y-1 adrenocortical tumor cells
12. Insulin-like growth factors and their binding proteins: biological actions
13. Human neuroblastoma cells use either insulin-like growth factor-I or insulin-like growth factor-II in an autocrine pathway via the IGF-I receptor: variability of IGF, IGF-binding protein (IGFBP) and IGF receptor gene expression and IGF and IGFBP secretion in human neuroblastoma cells in relation to cellular proliferation
14. Identification and characterization of the putative retinoblastoma control element of the rat insulin-like growth factor binding protein-2 gene
15. Serum insulin-like growth factor (IGF)-I and IGF-binding proteins in lung cancer patients
16. The role of cell surface attachment and proteolysis in the insulin-like growth factor (IGF)-independent effects of IGF-binding protein-3 on apoptosis in breast epithelial cells
17. IGF-binding proteins as modulators of IGF action
18. IGFBP-2 expression in a human cell line is associated with increased IGFBP-3 proteolysis, decreased IGFBP-1 expression and increased tumorigenicity
19. Mutations in the B-domain of insulin-like growth factor-I influence the oxidative folding to yield products with modified biological properties
20. Serum levels of insulin-like growth factor-I, -II and insulin-like growth factor binding proteins-2 and -3 in children with acute lymphoblastic leukemia
21. Relaxation of insulin-like growth factor II gene imprinting implicated in Wilms' tumour
22. Effect of insulin-like growth factor binding protein-1 on integrin signaling and the induction of apoptosis in human breast cancer cells
23. Differential IGF-independent effects of insulin-like growth factor binding proteins (1-6) on apoptosis of breast epithelial cells
24. Inhibition of cellular proliferation by peptide analogues of insulin-like growth factors
25. Novel aspects of the insulin-like growth factor binding proteins
26. Elevated serum levels of IGFBP-2 found in children suffering from acute lymphoblastic leukemia is accompanied by the occurrence of IGFBP-2 RNA in the tumour clone
27. The expression and characterization of human recombinant proinsulin-like growth factor II and a mutant that is defective in the O-glycosylation of its E-domain