The early growth response gene EGR-1 behaves as a suppressor gene that is down-regulated independent of ARF/Mdm2 but not p53 alterations in fresh human gliomas

Clinical Cancer Research

Volumn 7, Issue 9, 2001, Pages 2788-2796

  Calogero, Antonella ^a   Arcella, Antonietta ^a,b   De Gregorio, Giorgia ^a   Porcellini, Antonio ^a,b   Lombari, Vincenza ^a,b   Gagliardi, Franco Maria ^a,c   Caruso, Riccardo ^a,c   Frati, Luigi ^a,b   Ragona, Giuseppe ^a,b   Zani, Massimo ^b   Giannini, Giuseppe ^b   Gulino, Alberto ^b   Mercola, Dan ^d,e   Liu, Chaoting ^d  

^a IRCCS NEUROMED   (Italy)

^b SAPIENZA UNIVERSITY OF ROME   (Italy)

^c SAPIENZA UNIVERSITY OF ROME   (Italy)

^d SIDNEY KIMMEL CANCER CENTER   (United States)

^e UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EARLY GROWTH RESPONSE FACTOR 1; PROTEIN; PROTEIN MDM2; PROTEIN P53; UNCLASSIFIED DRUG;

ARTICLE; ASTROCYTOMA; CANCER GROWTH; CARCINOGENESIS; CLINICAL ARTICLE; CONTROLLED STUDY; GENE DELETION; GENE EXPRESSION; GENE FREQUENCY; GENE MUTATION; GENETIC ANALYSIS; GLIOBLASTOMA; GLIOMA; GROWTH REGULATION; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; PRIORITY JOURNAL; SUPPRESSOR GENE;

BLOTTING, NORTHERN; BRAIN NEOPLASMS; CYCLIN-DEPENDENT KINASE INHIBITOR P16; DNA MUTATIONAL ANALYSIS; DNA, NEOPLASM; DNA-BINDING PROTEINS; DOWN-REGULATION; EARLY GROWTH RESPONSE PROTEIN 1; GENE DELETION; GENE EXPRESSION REGULATION, NEOPLASTIC; GLIOMA; HUMANS; IMMEDIATE-EARLY PROTEINS; IMMUNOHISTOCHEMISTRY; MUTATION, MISSENSE; NUCLEAR PROTEINS; PROTEINS; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-MDM2; RNA, MESSENGER; RNA, NEOPLASM; TRANSCRIPTION FACTORS; TUMOR SUPPRESSOR PROTEIN P14ARF; TUMOR SUPPRESSOR PROTEIN P53;

EID: 0034802945     PISSN: 10780432     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (44)

1. Tumor suppressor gene in human nervous system neoplasia
2. Molecular biology of central nervous system tumors
3. Toward gene therapy for central nervous system
4. A zinc finger-encoding gene coregulated with c-fos during growth and differentiation and after cellular depolarization
5. A nerve growth factor-induced gene encodes a possible transcriptional regulatory factor
6. Suppression of growth and transformation and induction of apoptosis by EGR-1
7. UV activates growth factor receptors via reactive oxygen intermediates
8. Role of EGR-1 in thapsigargin-inducible apoptosis in the melanoma cell line A375-C6
9. Early growth response-1-dependent apoptosis is mediated by p53
10. Ionizing radiation-inducible apoptosis in the absence of p53 linked to transcription factor EGR-1
11. EGR-1 negatively regulates human tumor cell growth via the DNA-binding domain
12. The WT1 Wilms' tumor gene product: A developmentally regulated transcription factor in the kidney that functions as a tumor suppressor
13. Decreased EGR-1 expression in human, mouse and rat mammary cells and tissues correlates with tumor formation
14. Expression patterns of immediate early transcription factors in human non-small cell lung cancer
15. Expression of EGR-1 correlates with the transformed phenotype and the type of viral latency in EBV genome positive lymphoid cell lines
16. The transcription factor EGR-1 directly transactivates the fibronectin gene and enhances attachment of human glioblastoma cell line U251
17. Cytogenetic and molecular delineation of the smallest commonly deleted region of chromosome 5 in malignant myeloid diseases
18. Transcription factor EGR-1 suppresses the growth and transformation of human HT-1080 fibrosarcoma cells by induction of transforming growth factor-β1
19. The role of transforming growth factor β in glioma progression
20. Suppression of v-sis-dependent transformation by the transcription factor, EGR-1
21. Ionizing radiation down-regulates p53 protein in primary EGR-1-/- mouse embryonic fibroblast cells causing enhanced resistance to apoptosis
22. p53 and EGR-1 additively suppress transformed growth in HT1080 cells but EGR-1 counteracts p53-dependent apoptosis
23. Cooperative signals governing ARF-mdm2 interaction and nucleolar localization of the complex
24. The Pezcoller lecture: Cancer cell cycles revisited
25. Disruption of the ARF-Mdm2-p53 tumor suppressor pathway in Myc-induced lymphomagenesis
26. 1-S transition control gene abnormalities
27. p53 gene mutation and INK4A-ARF deletion appear to be two mutually exclusive events in human glioblastoma
28. Frequent co-alterations of TP53, p16/CDKN2A, p14ARF, PTEN tumor suppressor genes in human glioma cell lines
29. Egr transcription factors in the nervous system
30. Induction of nitric oxide in glial cells
31. Various rat adult tissues express only one major mRNA species from the glyceraldehyde-3-phosphate-dehydrogenase multigenic family
32. Suppression of v-sis-dependent transformation by the transcription factor, EGR-1
33. Amplification and overexpression of the Mdm2 gene in a subset of human malignant gliomas without p53 mutations
34. CDKN2(p16/MTS1) gene deletion or CDK4 amplification occurs in the majority of glioblastomas
35. Mutations of thyrotropin receptor isolated from thyroid autonomous adenomas confer TSH-independent growth to thyroid cells
36. Molecular diagnosis of p53 mutations in gastric carcinoma by touch preparation
37. Molecular abnormalities of Mdm2 and p53 genes in adult soft tissue sarcomas
38. Comparative study of p53 gene mutations, protein accumulation, and response to cisplatin-based chemotherapy in advanced ovarian carcinoma
39. INK4a/ARF locus alteration in human non-Hodgkin's lymphomas mainly occur in tumors with wild-type p 53 gene
40. The p16(1NK4α)/p19(ARF) gene mutations are infrequent and are mutually exclusive to p53 mutations in Indian oral squamous cell carcinomas
41. Incidence of p14ARF gene deletion in high-grade adult and pediatric astrocytomas
42. The transcription factor EGR-1 suppresses transformation of human fibrosarcoma HT1080 cells by coordinated induction of TGF β-1, fibronectin and plasminogen activator inhibitor-1
43. Functional analysis of the transforming growth factor β responsive elements in the WAF1/Cip1/p21 promoter
44. Transforming growth factor β induces the cyclin-dependent kinase inhibitor p21 through a p53-independent mechanism