Platelet-derived growth factor (PDGF)-signaling mediates radiation- induced apoptosis in human prostate cancer cells with loss of p53 function

International Journal of Radiation Oncology Biology Physics

Volumn 39, Issue 3, 1997, Pages 731-736

  Kim, Harold E ^a   Han, Sue J ^b   Kasza, Thomas ^b   Han, Richard ^a   Choi, Hyeong Seon ^c   Palmer, Kenneth C ^a   Kim, Hyeong Reh C ^a,b  

^a WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

^c Ewha Womans University   (South Korea)

Author keywords

Human prostate cancer cells; Platelet derived growth factor; Radiation induced apoptosis

Indexed keywords

PLATELET DERIVED GROWTH FACTOR; PLATELET DERIVED GROWTH FACTOR RECEPTOR; PROTEIN P21; PROTEIN P53;

ARTICLE; CANCER CELL CULTURE; CANCER RADIOTHERAPY; CELL CYCLE G1 PHASE; CELL CYCLE S PHASE; CELL DEATH; CONTROLLED STUDY; EXPRESSION VECTOR; GENE FUNCTION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROSTATE CANCER; SIGNAL TRANSDUCTION; TUMOR SUPPRESSOR GENE;

APOPTOSIS; CELL NUCLEUS; CULTURE MEDIA, SERUM-FREE; CYCLIN-DEPENDENT KINASE INHIBITOR P21; CYCLINS; GENES, P53; GENETIC VECTORS; HUMANS; MALE; MICROSCOPY, ELECTRON; MUTATION; ONCOGENE PROTEINS V-SIS; PLATELET-DERIVED GROWTH FACTOR; PROSTATIC NEOPLASMS; RETROVIRIDAE PROTEINS, ONCOGENIC; SIGNAL TRANSDUCTION; TRANSFECTION; TUMOR CELLS, CULTURED; TUMOR SUPPRESSOR PROTEIN P53;

EID: 0030983798     PISSN: 03603016     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0360-3016(97)00358-1     Document Type: Article

References (32)

1. Bartek, J.; Iggo, R.; Gannon, J.; Lane, D. P. Genetic and immunochemical analysis of mutant p53 in human breast cancer cell lines. Oncogene 5:893-899; 1990.
2. Bejeck, B.; Li, D.; Deuel, T. F. Transformation by v-sis occurs by an internal autoactivation mechanism. Science 245:1496-1499; 1989.
3. Brugarolas, J.; Chandrasekaran, C.; Gordon, J. I.; Beach, D.; Jacks, T.; Gregory, J. Hannon. Radiation-induced cell cycle arrest compromised by p21 deficiency. Nature 377:552-577; 1995.
4. Chen, Y. Q.; Gao, X.; Grignon, D.; Sarkar, F. H.; Sark, W.; Cipriano, S.; Honn, K. V.; Borders, J. S.; Crissman, J. D. Multiple mechanisms of p53 inactivation in prostatic carcinomas. Cell. Mol. Biol. 1:330-337; 1994.
5. Claesson-Welsh, L.; Eriksson, A.; Westermark, B.; Heldin, C.-H. cDNA cloning and expression of the human A-type platelet-derived growth factor (PDGF) receptor establishe structural similarity to the B-type PDGF receptor. Proc. Natl. Acad. Sci. USA 86:4917-4921; 1989.
6. 1 checkpoint control. Cell 82:675-684; 1995.
7. Deuel, T. F. Polypeptide growth factors: Roles in normal anc abnormal cell growth. Annu. Rev. Cell Biol. 3:443-492 1987.
8. Deuel, T. F.; Huang, J. S.; Huang, S. S.; Stroobant, P.; Waterfield, M. D. Expression of a platelet-derived growth factor-like protein in simian sarcoma virus transformed cells. Science 221:1348-1350; 1983.
9. Doolittle, R. F.; Hunkapiller, M. W.; Hood, L. E.; Devare, S. G.; Robbins, K. C.; Aaronson, S. A.; Antoniades, H. N. Simian sarcoma virus one gene, v-sis, is derived from the gene (or genes) encoding a platelet-derived growth factor. Science 221:275-277; 1983.
10. El-Deiry, W. S.; Tokino, T.; Velculescu, V. E.; Levy, D. B.; Parsons, R.; Trent, J. M.; Lin, D.; Mercer, W. E.; Kinzler, K. W.; Vogelstein, B. WAF1, a potential mediator of p53 tumor suppression. Cell 75:817-825; 1993.
11. El-Deiry, W. S.; Harper, J. W.; O'Connor, P. M.; Velculescu, V. E.; Canman, C. E.; Jackman, J.; Pietenpol, J. A.; Burrell, M.; Hill, D. E.; Wang, Y. WAF1/CIP1 is induced in p53-mediated G1 arrest and apoptosis. Cancer Res. 54:1169-1174; 1994.
12. Greenberg, M. E.; Ziff, E. B. Stimulation of 3T3 cells induces transcription of the c-fos proto-oncogene. Nature 311:433-438; 1984.
13. Gujuluva, C. N.; Baek, J.-H.; Shin, K.-H.; Cherrick, H. M.; Park, N.-H. Effect of UV-irradiation on cell cycle, viability, and the expression of p53, gadd 153, and gadd 45 genes in normal and HPV-immortalized human oral keratinocytes. Oncogene 9:1819-1827; 1994.
14. Hallahan, D. E. Radiation-mediated gene expression in the pathogenesis of the clinical radiation response. Semin. Radiat. Oncol. 6:250-267; 1996.
15. Harper, J. W.; Adami, G. R.; Wei, N.; Keyomarsi, K.; Elledge, S. J. The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases. Cell 75:805-816; 1993.
16. Heldin, C.-H. Structural and functional studies on platelet-derived growth factor. EMBO J. 11:4251-4259; 1992.
17. Jung, M. And Dritschilo Signal transduction and cellular responses to ionizing radiation. Semin. Radiat. Oncol. 6:268-283; 1996.
18. Kelly, K.; Cochran, B. H.; Stiles, C. D.; Leder, P. Cell-specific regulation of the c-myc gene by lymphocyte mitogens and platelet-derived growth factor. Cell 35:603-610; 1983.
19. Kim, H.-R. C.; Upadhyay, S.; Li, G.; Palmer, K. C.; Deuel, T. F. Platelet-derived growth factor (PDGF) induces apoptosis in growth arrested murine fibroblasts. Proc. Natl. Acad. Sci. USA 92:9500-9504; 1995.
20. Kim, H.-R. C.; Upadhyay, S.; Korsemeyer, S.; Deuel, T. F. Platelet-derived growth factor (PDGF) B and A homodimers transform murine fibroblasts depending on the genetic background of the cell. J. Biol. Chem. 269:30604-30608; 1994.
21. Lau, L. F.; Nathan, D. Identification of a set of gene expressed during the G0/G1 transition of cultured mouse cells. EMBO J. 4:3145-3151; 1985.
22. Lowe, S. W. Cancer therapy and p53. Curr. Opin. Oncol. 7:547-753; 1995.
23. Lowe, S. W.; Bodis, S.; McClatchey, A.; Remington, L.; Ruley, H. E.; Fisher, D.; Housman, D. E.; Jacks, T. p53 status and the efficacy of cancer therapy in vivo. Science 266:807-810; 1994.
24. Martin, J. S.; Green, D. R.; Cotter, T. G. Dicing with death: Dissecting the components of the apoptosis machinery. Trends Biochem. Sci. 19:26-30; 1994.
25. Matsui, T.; Heidaran, M.; Miki, T.; Popescu, N.; LaRochelle, W.; Kraus, M.; Pierce, J.; Aaronson, S. Isolation of a novel receptor cDNA establishes the existence of two PDGF receptor genes. Science 243:800-804; 1989.
26. Michieli, P.; Chedid, M.; Lin, D.; Pierce, J. H.; Mercer, W. E.; Givol, D. Induction of WAF1/CIP1 by a p53-independent pathway. Cancer Res. 54:3391-3395; 1994.
27. Silvestrinii, R.; Veneroni, S.; Daidone, M. G.; Benini, E.; Boracchi, P.; Mezzetti, M.; Di Fronzo, G.; Rilke, F.; Veronesi, U. The bcl-2 protein: A prognostic indicator strongly related to p53 protein in lymph node-negative breast cancer patients. J. Natl. Cancer Inst. 86:499-504; 1994.
28. Strasser, A.; Harris, A. W.; Jacks, T.; Cory, S. DNA damage can induce apoptosis in proliferating lymphoid cells via p53-independent mechanisms inhibitable by bcl-2. Cell 79:329-339; 1994.
29. Stiles, C. D.; Capone, G. T.; Scher, C. D.; Antoniades, H. N.; Van Wyk, J. J.; Pledger, W. J. Dual control of cell growth by somatomedins and platelet-derived growth factor. Proc. Natl. Acad. Sci. USA 76:1279-1283; 1979.
30. Ware, J. L. Prostate tumor progression and metastasis. Biochem. Biophys. Acta 907:279-298; 1987.
31. Waldman, T.; Kinzler, K. W.; Vogelstein, B. p21 is necessary for the p53-mediated G1 arrest in human cancer cells. Cancer Res. 55:5187-5190; 1995.
32. Xiong, Y.; Hannon, G. J.; Zhang, H.; Casso, D.; Kobayashi, R.; Beach, D. p21 is a universal inhibitor of cyclin kinases. Nature 366:701-704; 1993.