FGF-1-induced platelet-derived growth factor-A chain gene expression in endothelial cells involves transcriptional activation by early growth response factor-1

Circulation Research

Volumn 81, Issue 2, 1997, Pages 282-288

  Delbridge, Gabrielle J ^a   Khachigian, Levon M ^a  

^a UNIVERSITY OF NEW SOUTH WALES   (Australia)

Author keywords

Early growth response factor; Fibroblast growth factor; platelet derived growth factor; Transcription

Indexed keywords

FIBROBLAST GROWTH FACTOR 1; PLATELET DERIVED GROWTH FACTOR A; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR SP1;

ANIMAL CELL; ARTICLE; ATHEROSCLEROSIS; CATTLE; ENDOTHELIUM CELL; GENE EXPRESSION; GENETIC TRANSCRIPTION; NONHUMAN; PRIORITY JOURNAL; VASCULAR ENDOTHELIUM;

EID: 0030873077     PISSN: 00097330     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.RES.81.2.282     Document Type: Article

References (50)

1. Brogi E, Winkles JA, Underwood R, Clinton SK, Alberts GF, Libby P. Distinct patterns of expression of fibroblast growth factors and their receptors in human atheroma and nonatherosclerotic arteries. J Clin Invest. 1993;92:2408-2418.
2. Hughes SE, Crossman D, Hall PA. Expression of basic and acidic fibroblast growth factors and their receptor in normal and atherosclerotic human arteries. Cardiovasc Res. 1943;27:1214-1219.
3. Flugelman MY. Inhibition of intravascular thrombosis and vascular smooth muscle proliferation by gene therapy. Thromb Haemost. 1995;74:406-410.
4. Barrett TB, Benditt EW. Platelet-derived growth factor gene expression in human atherosclerotic plaques and normal artery wall. Proc Natl Acad Sci U S A. 1988;85:2810-2814.
5. Murry CE, Bartosek T, Giachelli CM, Alpers CE, Schwartz SM. Platelet-derived growth factor-A mRNA expression in fetal, normal adult, and atherosclerotic human aortas; analysis by competitive polymerase chain reaction. Circulation. 1996;93:1095-1106.
6. Rekhter M, Gordon D. Does platelet-derived growth factor-A chain stimulate proliferation of arterial mesenchymal cells in human atherosclerostic plaques? Circ Res. 1994;75:410-417.
7. Ross R. The pathogenesis of atherosclerosis: a perspective for the 1990s. Nature. 1993;362:801-809.
8. Heldin C-H Backstrom G, Ostman A, Hammacher A, Ronnstrand L, Ruhin K, Nister M, Westermark B. Binding of different dimeric forms of PDGF to human fibroblasts: evidence for two separate receptor types. EMBO J. 1988;7:1387-1393.
9. Claesson-Welsh L, Eriksson A, Westermark B, Heldin C-H. cDNA cloning and expression of the human A-type platelet-derived growth factor (PDGF) receptor establishes structural similarity to the B-type receptor.Proc Natl Acad Sci U S A. 1989;86:4917-4921.
10. Claesson-Welsh L, Eriksson A, Moren A, Severinsson L, Ek B, Ostman A, Betsholtz C, Heldin C-H. cDNA cloning and expression of a human platelet-derived growth factor (PDGF) receptor specific for a B-chain-containing PDGF molecule. Mol Cell Biol. 1988;8:3476-3486.
11. Escobedo JA, Navanakasatussas S, Coussens LS, Coughlin SR, Bell GI, Williams LT. A common PDGF receptor is activated by homodimeric A and B forms of PDGF. Science. 1988;240:1532-1535.
12. Gronwald RGK, Grant EJ, Haldeman BA, Hart CE, O'Hara PJ, Hagen FS, Ross R, Bowen-Pope DF, Murray MJ. Cloning and expression of a cDNA coding for the human platelet-derived growth factor receptor: evidence for more than one receptor class. Proc Natl Acad Sci U S A. 1988;85:3435-3439.
13. Yoyote K, Mori S. Siegbahn A, Ronnstrand L, Wernstedt C, Heldin C-H, Claesson-Welsh L, Structural determinants in the platelet-derived growth factor alpha-receptor implicated in modulation of chemotaxis. J Biol Chem. 1996;271:5101-5111.
14. Burgess WH, Maciag T. The heparin-binding (fibroblast) growth factor family of proteins. Annu Rev Biochem. 1989;58:575-606.
15. van der Geer P, Hunter T, Lindberg RA. Receptor protein-tyrosine kinases and their signal transduction pathways. Annu Rev Cell Biol. 1994;10:251-337.
16. Weiner HL, Swain JL. Acidic fibroblast growth factor mRNA is expressed by cardiac myocytes in culture and the protein is localized to the extracellular matrix. Proc Natl Acad Sci U S A. 1989;86:2683-2687.
17. Bonthron DT, Morton CC, Orkin SH, Collins T. Platelet-derived growth factor A chain: gene structure, chromosomal location, and basis for alternative mRNA splicing, Proc Natl Acad Sci U S A. 1988;85:1492-1496.
18. Rorsman F, Bywater M, Knott TJ, Scott J, Betsholtz C. Structural characterization of the human platelet-derived growth factor A-chain cDNA and gene: alternative exon usage predicts two different precursor proteins. Mol Cell Biol. 1988;8:571-577.
19. Takimoto Y, Wang ZY, Kobler K, Deuel TF. Promoter region of the human platelet-derived growth factor A-chain gene. Proc Natl Acad Sci U S A. 1991;88:1686-1690.
20. Lin X, Wang Z, Gu L, Deuel TF. Functional analysis of the human platelet-derived growth factor A-chain promoter region. J Biol Chem. 1992;267:25614-25619.
21. Bhandari B, Wenzel UO, Marra F, Abboud HE. A nuclear protein in mesangial cells that binds to the promoter of the platelet-derived growth factor A-chain gene. J Biol Chem. 1995;270:5541-5548.
22. Silverman ES, Khachigian LM, Lindner V, Williams AJ, Collins T. Inducible PDGF A-chain transcription in vascular smooth muscle cells is mediated by Egr-1 displacement of Sp1 and Sp3. Am J Physiol. In press.
23. Khachigian LM, Williams AJ, Collins T. Interplay of Sp1 and Egr-1 in the proximal PDGF-A promoter in cultured vascular endothelial cells. J Biol Chem. 1995;270:27679-27686.
24. Kaetzel DM, Maul RS, Liu B, Bonthron D, Fenstermaker RA, Coyne DW. Platelet-derived growth factor A-chain transcription is mediated by positive and negative regulatory regions in the promoter. Biochem J. 1994;301:321-327.
25. Wang Z, Lin X-H, Qiu Q-Q, Deuel TF. Modulation of transcription of the platelet-derived growth factor A-chain gene by a promoter region sensitive to S1 nuclease. J Biol Chem. 1992;267:17022-17031
26. Dynan WS, Tjian R. The promoter-specific transcription factor Sp1 binds to upstream sequences in the SV40 early promoter. Cell. 1983:35:79-87.
27. Kadonaga JT, Camer KR, Masiarz FR, Tjian R. Isolation of cDNA encoding transcription factor Sp1 and functional analysis of the DNA binding domain. Cell. 1987:51:1079-1090.
28. Sukhattne VP, Cao X, Chang LL, Tsai-Morris C-H, Stamenkovich D, Ferreira PCP, Cohen DR, Edwards SA, Shows TB, Curran T, Le Beau MM, Adamson ED. A zinc-finger encoding gene coregulated with c-Fos during growth and differentiation and after depolarization. Cell. 1988;53:37-43.
29. Rauschet FJ III, Morris JF, Tournay OE, Cook DM, Curran T. Binding of the Wilms' tumor locus zinc finger protein to the EGR-1 consensus sequence. Science. 1990;250:1259-1262.
30. Wang ZY. Madden SL, Deuel TF, Rauscher FJ III. The Wilms' tumor gene product, WT-1, represses transcription of the platelet-derived growth factor A-chain gene. J Biol Chem. 1992;267:21999-22002.
31. Gay CG, Winkles JA. Heparin-binding growth factor-1 stimulation of human endothelial cells induces platelet-derived growth factor A-chain gene expression. J Biol Chem. 1990;265:3284-3292.
32. Sambrook J, Fritsch EF, Maniatis T. Molecular Cloning: A Laboratory Manual. 2nd ed. Plainview, NY: Cold Spring Harbor Laboratory Press; 1989.
33. Khachigian LM, Fries JWU, Benz MW, Bonthron DT, Collins T. Novel cis-acting elements in the human platelet-derived growth factor B-chain core promoter that mediate gene expression in cultured vascular endothelial cells. J Biol Chem. 1994;269:22647-22656.
34. Khachigian LM, Lindner V, Williams AJ, Collins T. Egr-1-induced endothelial gene expression: a common theme in vascular injury. Science. 1996;271:1427-1431.
35. Starksen NF, Harsh GR, Gibbs VC, Williams LT. Regulated expression of the platelet-derived growth factor A chain gene in microvascular endothelial cells. J Biol Chem. 1987;262:14381-14384.
36. Kavanaugh WM, Harsh GR IV, Starksen NF, Rocco CM, Williams LT. Transcriptional regulation of the A and B chain genes of platelet-derived growth factor in microvascular endothelial cells. J Biol Chem. 1988;263:8470-8472.
37. Jaye M, Howk R, Burgess W, Ricca GA, Chiu IM, Ravera MW, O'Brien SJ, Modi WS, Maciag T, Drohan WN. Human endothelial cell growth factor: cloning, nudeotide sequence, and chromosomal localization. Science. 1986;233:541-545.
38. Vlodavsky I, Korner G, Ishai-Michaeli R, Bar-Shavit R, Fuks Z. Extracellular matrix-resident growth factors and enzymes: possible involvement in tumor metastasis and angiogenesis. Cancer Metastasis Rev. 1990;9:203-226.
39. Thanos D, Maniatis T. The high mobility group protein HMGI(Y) is required for NF-kappaB-dependent virus induction of the human IFN-beta gene. Cell. 1992;71:777-789.
40. Perkins ND, Edward NL, Duckett CS, Agranoff AB. A cooperative interaction between NF-kappaB and Sp1 is required for HIV-1 enhancer activation. EMBO J. 1993;12:3551-3558.
41. Du W, Thanos D, Maniatis T. Mechanisms of transcriptional synergism between distinct virus-inducible enhancer elements. Cell. 1993;74:887-898.
42. Stein B, Baldwin AS. Distinct mechanisms for regulation of the interleukin-8 gene involve synergism and cooperativity between C/EBP and NF-kappaB. Mol Cell Biol. 1993;13:7191-7198.
43. Stein B, Baldwin AS Jr, Ballard DW, Greene WC, Angel P, Herrlich P. Cross-coupling of the NF-kappaB p65 and Fos/Jun transcription factors produce potentiated biological function. EMBO J. 1993;12:3879-3891.
44. Neish AS, Read MA, Thanos D, Pine R, Maniatis T, Collins T. Endothelial Interferon regulatory factor 1 cooperates with NF-kappaB as a transcriptional activator of vascular cell adhesion molecule 1. Mol Cell Biol. 1995;15:2558-2569.
45. Gerritsen ME, Williams AJ, Neish AS, Moore S, Shi Y, Collins T. CBP/p300 are transcriptional coactivators of p65. Proc Natl Acad Sci U S A. In press.
46. Myers RL, Payson RA, Chotani MA, Deavan LL, Chiu I-M. Gene structure and differential expression of acidic fibroblast growth factor mRNA: identification and distribution of four different transcripts. Oncogenc. 1993;8:341-349.
47. Chotani MA, Payson RA, Winkles JA, Chiu I-M. Human fibroblast growth factor 1 gene expression in vascular smooth muscle cells is modulated via an alternate promoter in response to serum and phorbol ester. Nucleic Acids Res. 1995;23:434-441.
48. Hall JA, Harris MA, Intres R, Harris SE. Acidic fibroblast growth factor gene 5′ non-coding exon and flanking region from hamster DDT1 cells: identification of the promoter region and transcriptional regulation by testosterone and aFGF protein. J Cell Biochem. 1943;51:116-127.
49. Alberts GF, Hsu DKW, Peifley KA, Winkles JA. Differential regulation of acidic and basic fibroblast growth factor gene expression in fibroblast growth factor-treated rat aortic smooth muscle cells. Circ Res, 1994;75:261-267.
50. Winkles JA, Gay CG, Serum, phorbol ester, and polypeptide mitogens increase class 1 and 2 heparin-binding (acidic and basic fibroblast) growth factor gene expression in human vascular smooth muscle cells. Cell Growth Differ. 1991;2:531-540.