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Volumn 281, Issue 5377, 1998, Pages 692-695

Regulation of a transcription factor network required for differentiation and metabolism

Author keywords

[No Author keywords available]

Indexed keywords

INSULIN; NUCLEAR FACTOR; TRANSCRIPTION FACTOR;

EID: 0032584567     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.281.5377.692     Document Type: Article
Times cited : (305)

References (43)
  • 2
    • 0027270989 scopus 로고
    • K. L. Clark, E. D. Halay, E. Lai, S. K. Burley, Nature 364, 412 (1993); C. E. McPherson, E.-Y. Shim, D. S. Friedman, K. S. Zaret, Cell 75, 387 (1993); L. A. Cirillo et al., EMBO J. 17, 244 (1998).
    • (1993) Nature , vol.364 , pp. 412
    • Clark, K.L.1    Halay, E.D.2    Lai, E.3    Burley, S.K.4
  • 3
    • 0027507894 scopus 로고
    • K. L. Clark, E. D. Halay, E. Lai, S. K. Burley, Nature 364, 412 (1993); C. E. McPherson, E.-Y. Shim, D. S. Friedman, K. S. Zaret, Cell 75, 387 (1993); L. A. Cirillo et al., EMBO J. 17, 244 (1998).
    • (1993) Cell , vol.75 , pp. 387
    • McPherson, C.E.1    Shim, E.-Y.2    Friedman, D.S.3    Zaret, K.S.4
  • 4
    • 0032472365 scopus 로고    scopus 로고
    • K. L. Clark, E. D. Halay, E. Lai, S. K. Burley, Nature 364, 412 (1993); C. E. McPherson, E.-Y. Shim, D. S. Friedman, K. S. Zaret, Cell 75, 387 (1993); L. A. Cirillo et al., EMBO J. 17, 244 (1998).
    • (1998) EMBO J. , vol.17 , pp. 244
    • Cirillo, L.A.1
  • 6
    • 0029962261 scopus 로고    scopus 로고
    • F. P. Lemaigre and G. G. Rousseau, Biochem. J. 303, 1 (1994); S. Cereghini, FASEB J. 10, 267 (1996).
    • (1996) FASEB J. , vol.10 , pp. 267
    • Cereghini, S.1
  • 7
    • 0031054568 scopus 로고    scopus 로고
    • S. A. Duncan, A. Nagy, W. Chan, Development 124, 279 (1997); M. Stoffel and S. A. Duncan, Proc. Natl. Acad. Sci. U.S.A. 94, 13209 (1997); S. A. Duncan et al., unpublished data.
    • (1997) Development , vol.124 , pp. 279
    • Duncan, S.A.1    Nagy, A.2    Chan, W.3
  • 8
    • 0030695445 scopus 로고    scopus 로고
    • S. A. Duncan, A. Nagy, W. Chan, Development 124, 279 (1997); M. Stoffel and S. A. Duncan, Proc. Natl. Acad. Sci. U.S.A. 94, 13209 (1997); S. A. Duncan et al., unpublished data.
    • (1997) Proc. Natl. Acad. Sci. U.S.A. , vol.94 , pp. 13209
    • Stoffel, M.1    Duncan, S.A.2
  • 9
    • 0031054568 scopus 로고    scopus 로고
    • unpublished data
    • S. A. Duncan, A. Nagy, W. Chan, Development 124, 279 (1997); M. Stoffel and S. A. Duncan, Proc. Natl. Acad. Sci. U.S.A. 94, 13209 (1997); S. A. Duncan et al., unpublished data.
    • Duncan, S.A.1
  • 10
    • 0025718822 scopus 로고
    • J. M. Tian and U. Schibler, Genes Dev. 5, 2225 (1991); C. J. Kuo et al., Nature 355, 458 (1992).
    • (1991) Genes Dev. , vol.5 , pp. 2225
    • Tian, J.M.1    Schibler, U.2
  • 11
    • 0025718822 scopus 로고
    • J. M. Tian and U. Schibler, Genes Dev. 5, 2225 (1991); C. J. Kuo et al., Nature 355, 458 (1992).
    • (1992) Nature , vol.355 , pp. 458
    • Kuo, C.J.1
  • 12
    • 10544236911 scopus 로고    scopus 로고
    • K. Yamagata et al., Nature 384, 458 (1996); ibid., p. 455.
    • (1996) Nature , vol.384 , pp. 458
    • Yamagata, K.1
  • 13
    • 10544236911 scopus 로고    scopus 로고
    • K. Yamagata et al., Nature 384, 458 (1996); ibid., p. 455.
    • Nature , pp. 455
  • 16
    • 0028169992 scopus 로고    scopus 로고
    • S. L. Ang and J. Rossant, Cell 78, 561 (1994); D. C. Weinstein et al., ibid., p. 575; W. S. Chen et al., Genes Dev. 8, 2466 (1994).
    • (1994) Cell , vol.78 , pp. 561
    • Ang, S.L.1    Rossant, J.2
  • 17
    • 0028169992 scopus 로고    scopus 로고
    • S. L. Ang and J. Rossant, Cell 78, 561 (1994); D. C. Weinstein et al., ibid., p. 575; W. S. Chen et al., Genes Dev. 8, 2466 (1994).
    • Cell , pp. 575
    • Weinstein, D.C.1
  • 18
    • 0028148776 scopus 로고
    • S. L. Ang and J. Rossant, Cell 78, 561 (1994); D. C. Weinstein et al., ibid., p. 575; W. S. Chen et al., Genes Dev. 8, 2466 (1994).
    • (1994) Genes Dev. , vol.8 , pp. 2466
    • Chen, W.S.1
  • 19
    • 0030750728 scopus 로고    scopus 로고
    • C. Vaisse et al. Diabetes 46, 1364 (1997); L. Miquerol et al., J. Biol. Chem. 269, 8944 (1994); F. Rausa et al., Dev. Biol. 192, 228 (1997).
    • (1997) Diabetes , vol.46 , pp. 1364
    • Vaisse, C.1
  • 20
    • 0028246642 scopus 로고
    • C. Vaisse et al. Diabetes 46, 1364 (1997); L. Miquerol et al., J. Biol. Chem. 269, 8944 (1994); F. Rausa et al., Dev. Biol. 192, 228 (1997).
    • (1994) J. Biol. Chem. , vol.269 , pp. 8944
    • Miquerol, L.1
  • 21
    • 0031573810 scopus 로고    scopus 로고
    • C. Vaisse et al. Diabetes 46, 1364 (1997); L. Miquerol et al., J. Biol. Chem. 269, 8944 (1994); F. Rausa et al., Dev. Biol. 192, 228 (1997).
    • (1997) Dev. Biol. , vol.192 , pp. 228
    • Rausa, F.1
  • 22
    • 3542995212 scopus 로고    scopus 로고
    • note
    • The HNF-3α targeting vector was constructed by deleting the DNA binding and transactivation domains between the Afl III and Nhe I sites in exon 2. The E. coli lacZ gene was fused in frame to exon 2 of HNF-3α, which placed it under the control of HNF-3α transcriptional regulatory sequences. Recombinant ES cell clones were genotyped by Southern blotting. DNAs were digested with Hind III-Eco RV and blots were probed with HNF-3α genomic DNA, which lay 5′ to sequences present in the targeting vector. The wild-type allele produced a 7.5-kb restriction fragment, whereas the targeted allele produced a 4.5-kb fragment. HNF-3α -/-ES cells were selected by growing HNF-3α in medium containing G418 (2.0 mg/ml). Three independent HNF-3α -/-(A8, A10, A11) lines were cloned and further analyzed.
  • 24
    • 3543006676 scopus 로고    scopus 로고
    • note
    • Steady-state vHNF-1 (HNF-1β) mRNA levels in the VE were measured by RT-PCR to control for equal amounts of VE in embryoid bodies (data not shown).
  • 25
    • 3543012092 scopus 로고    scopus 로고
    • note
    • LacZ-specific primers were used to compare steady-state mRNA concentrations of β-galactosidase in HNF-3α +/-and HNF-3α -/-EBs.
  • 26
    • 0025162339 scopus 로고
    • E. Lai et al., Genes Dev. 4, 1427 (1990); E. Lai, V. R. Prezioso, W. Tao, W. S. Chen, J. E. Darnell Jr., ibid. 5, 416 (1991); K. L. Clark, E. D. Halay, E. Lai, S. K. Burley, Nature 364, 412 (1993).
    • (1990) Genes Dev. , vol.4 , pp. 1427
    • Lai, E.1
  • 28
    • 0027270989 scopus 로고
    • E. Lai et al., Genes Dev. 4, 1427 (1990); E. Lai, V. R. Prezioso, W. Tao, W. S. Chen, J. E. Darnell Jr., ibid. 5, 416 (1991); K. L. Clark, E. D. Halay, E. Lai, S. K. Burley, Nature 364, 412 (1993).
    • (1993) Nature , vol.364 , pp. 412
    • Clark, K.L.1    Halay, E.D.2    Lai, E.3    Burley, S.K.4
  • 29
    • 0027318791 scopus 로고    scopus 로고
    • H. Sasaki and B. L. M. Hogan, Development 118, 47 (1993); A. P. Monaghan, K. H. Kaestner, E. Grau, G. Schutz, ibid. 119, 567 (1993); S.-L. Ang et al., ibid., p. 1301; A. R. I. Altaba, V. R. Prezioso, J. E. Darnell Jr., T. M. Jessell, Mech. Dev. 44, 91 (1993).
    • (1993) Development , vol.118 , pp. 47
    • Sasaki, H.1    Hogan, B.L.M.2
  • 30
    • 0027425313 scopus 로고
    • H. Sasaki and B. L. M. Hogan, Development 118, 47 (1993); A. P. Monaghan, K. H. Kaestner, E. Grau, G. Schutz, ibid. 119, 567 (1993); S.-L. Ang et al., ibid., p. 1301; A. R. I. Altaba, V. R. Prezioso, J. E. Darnell Jr., T. M. Jessell, Mech. Dev. 44, 91 (1993).
    • (1993) Development , vol.119 , pp. 567
    • Monaghan, A.P.1    Kaestner, K.H.2    Grau, E.3    Schutz, G.4
  • 31
    • 0027318791 scopus 로고    scopus 로고
    • H. Sasaki and B. L. M. Hogan, Development 118, 47 (1993); A. P. Monaghan, K. H. Kaestner, E. Grau, G. Schutz, ibid. 119, 567 (1993); S.-L. Ang et al., ibid., p. 1301; A. R. I. Altaba, V. R. Prezioso, J. E. Darnell Jr., T. M. Jessell, Mech. Dev. 44, 91 (1993).
    • Development , pp. 1301
    • Ang, S.-L.1
  • 32
    • 0027318791 scopus 로고    scopus 로고
    • H. Sasaki and B. L. M. Hogan, Development 118, 47 (1993); A. P. Monaghan, K. H. Kaestner, E. Grau, G. Schutz, ibid. 119, 567 (1993); S.-L. Ang et al., ibid., p. 1301; A. R. I. Altaba, V. R. Prezioso, J. E. Darnell Jr., T. M. Jessell, Mech. Dev. 44, 91 (1993).
    • (1993) Mech. Dev. , vol.44 , pp. 91
    • Altaba, A.R.I.1    Prezioso, V.R.2    Darnell Jr., J.E.3    Jessell, T.M.4
  • 34
    • 3543028743 scopus 로고    scopus 로고
    • note
    • HNF-3β -/-embryos were generated by crossing HNF-3β +/-mice. Embryos were dissected from the uterus at day E8.5 and stained with 5-bromo-4-chloro-3-indolyl β-D-galactopyranoside. Results obtained (data not shown) were as described in (8).
  • 35
    • 3543015080 scopus 로고    scopus 로고
    • note
    • The production of HNF-3β +/-ES cell lines, B13 and 4B1, has been described (8). Genotypes of HNF-3β mutant ES cell lines were analyzed by Southern blotting (8). HNF-3β -/-line B14 was derived from HNF-3β +/-line B13, and HNF-β -/-lines 5.2 and 5.1 are from 4B1 as described in (8).
  • 36
    • 0026602720 scopus 로고
    • M. O. Bergot, M. J. M. Diaz-Guerra, N. Puzenat, M. Raymondjean, A. Kahn, Nucleic Acids Res. 20, 1871 (1992); D. Granner, T. Andreone, K. Sasaki, E. Beale, Nature 305, 549 (1993); R. M. O'Brian et al., Mol. Cell. Biol. 15, 1747 (1995); T. G. Unterman et al., Biochem. Biophys. Res. Commun. 203, 1835 (1994).
    • (1992) Nucleic Acids Res. , vol.20 , pp. 1871
    • Bergot, M.O.1    Diaz-Guerra, M.J.M.2    Puzenat, N.3    Raymondjean, M.4    Kahn, A.5
  • 37
    • 0020613008 scopus 로고
    • M. O. Bergot, M. J. M. Diaz-Guerra, N. Puzenat, M. Raymondjean, A. Kahn, Nucleic Acids Res. 20, 1871 (1992); D. Granner, T. Andreone, K. Sasaki, E. Beale, Nature 305, 549 (1993); R. M. O'Brian et al., Mol. Cell. Biol. 15, 1747 (1995); T. G. Unterman et al., Biochem. Biophys. Res. Commun. 203, 1835 (1994).
    • (1993) Nature , vol.305 , pp. 549
    • Granner, D.1    Andreone, T.2    Sasaki, K.3    Beale, E.4
  • 38
    • 0028860340 scopus 로고
    • M. O. Bergot, M. J. M. Diaz-Guerra, N. Puzenat, M. Raymondjean, A. Kahn, Nucleic Acids Res. 20, 1871 (1992); D. Granner, T. Andreone, K. Sasaki, E. Beale, Nature 305, 549 (1993); R. M. O'Brian et al., Mol. Cell. Biol. 15, 1747 (1995); T. G. Unterman et al., Biochem. Biophys. Res. Commun. 203, 1835 (1994).
    • (1995) Mol. Cell. Biol. , vol.15 , pp. 1747
    • O'Brian, R.M.1
  • 39
    • 0027967521 scopus 로고
    • M. O. Bergot, M. J. M. Diaz-Guerra, N. Puzenat, M. Raymondjean, A. Kahn, Nucleic Acids Res. 20, 1871 (1992); D. Granner, T. Andreone, K. Sasaki, E. Beale, Nature 305, 549 (1993); R. M. O'Brian et al., Mol. Cell. Biol. 15, 1747 (1995); T. G. Unterman et al., Biochem. Biophys. Res. Commun. 203, 1835 (1994).
    • (1994) Biochem. Biophys. Res. Commun. , vol.203 , pp. 1835
    • Unterman, T.G.1
  • 41
    • 0030659557 scopus 로고    scopus 로고
    • S. Ogg et al. Nature 389, 994 (1997); K. Lin, J. B. Dorman, A. Rodan, C. Kenyon, Science 278, 1319 (1997).
    • (1997) Nature , vol.389 , pp. 994
    • Ogg, S.1
  • 43
    • 3543024619 scopus 로고    scopus 로고
    • note
    • We thank J. E. Darnell Jr. for comments and guidance and for sharing the environment to initiate this work and P. Hoodless for providing a genomic HNF-3α clone. M.S. and S.A.D. also thank J. Smith and T. Minsa for giving us enthusiasm for science. M.S. is an Irma Hirschl Scholar, Pew Scholar, and Robert and Harriet Heilbrunn Professor. S.A.D. is a Naomi Judd American Liver and an Alexandrine and Alexander Sinsheimer Scholar. M.A.N. was supported by a postdoctoral fellowship of the Spanish Ministry of Education and Culture. D.D. was supported by the Fons de la Recherche en Sante du Quebec and the National Cancer Institute of Canada (NCIC). J.R. is a NCIC Terry Fox Research Scientist, a Medical Research Council Distinguished Scientist, and a Howard Hughes Medical Institute International Research Scholar. Supported in part by the American Diabetes Association and by the March of Dimes.


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