-
1
-
-
0028786276
-
The Janus protein tyrosine kinase family and its role in cytokine signaling
-
Ihle, J. N. 1995. The Janus protein tyrosine kinase family and its role in cytokine signaling. Adv.Immunol. 60: 1-35.
-
(1995)
Adv.Immunol.
, vol.60
, pp. 1-35
-
-
Ihle, J.N.1
-
2
-
-
0027327484
-
JAK2 associates with the erythropoietin receptor and is tyrosine phosphorylated and activated following EPO stimulation
-
Witthuhn, B. et al. 1993. JAK2 associates with the erythropoietin receptor and is tyrosine phosphorylated and activated following EPO stimulation. Cell 74: 227-236.
-
(1993)
Cell
, vol.74
, pp. 227-236
-
-
Witthuhn, B.1
-
3
-
-
0030953469
-
1007 in the kinase activation loop
-
1007 in thekinase activation loop. Mol. Cell. Biol. 17: 2497-2501.
-
(1997)
Mol. Cell. Biol.
, vol.17
, pp. 2497-2501
-
-
Feng, J.1
-
4
-
-
0028582185
-
Crystal structure of the tyrosine kinase domain of the human insulin receptor
-
Hubbard, S. R. et al. 1994. Crystal structure of the tyrosine kinase domain of the human insulinreceptor. Nature 372: 746-754.
-
(1994)
Nature
, vol.372
, pp. 746-754
-
-
Hubbard, S.R.1
-
5
-
-
0030598848
-
Structure of the FGF receptor tyrosine kinase domain reveals a novel autoinhibitory mechanism
-
Mohammadi, M. et al. 1996. Structure of the FGF receptor tyrosine kinase domain reveals anovel autoinhibitory mechanism. Cell 86: 577-587.
-
(1996)
Cell
, vol.86
, pp. 577-587
-
-
Mohammadi, M.1
-
6
-
-
0027993022
-
Functional activation of Jal1 and Jak3 by selective association with IL-2 receptor subunits
-
Miyazaki, T. et al. 1994. Functional activation of Jal1 and Jak3 by selective association with IL-2 receptor subunits. Science 266: 1045-1047.
-
(1994)
Science
, vol.266
, pp. 1045-1047
-
-
Miyazaki, T.1
-
7
-
-
0028171065
-
c-JAK3 association in XSCID
-
c-JAK3 association in XSCID. Science 266: 1042-1045.
-
(1994)
Science
, vol.266
, pp. 1042-1045
-
-
Russell, S.M.1
-
8
-
-
0028840706
-
Defective lymphoid development in mice lacking Jak3
-
Nosaka, T. et al. 1995. Defective lymphoid development in mice lacking Jak3. Science 270:800-802.
-
(1995)
Science
, vol.270
, pp. 800-802
-
-
Nosaka, T.1
-
9
-
-
0029550822
-
Developmental defects of lymphoid cells in Jak3 kinase-deficient mice
-
Park, S. Y. et al. 1995. Developmental defects of lymphoid cells in Jak3 kinase-deficient mice.Immunity 3: 771-782.
-
(1995)
Immunity
, vol.3
, pp. 771-782
-
-
Park, S.Y.1
-
10
-
-
0028799457
-
Mice lacking Jak3 have defects in B lymphocyte maturation and Tlymphocyte activation
-
Thomis, D. C. et al. 1995. Mice lacking Jak3 have defects in B lymphocyte maturation and Tlymphocyte activation. Science 270: 794-797.
-
(1995)
Science
, vol.270
, pp. 794-797
-
-
Thomis, D.C.1
-
11
-
-
0031587848
-
Enforced expression of Bcl-2 in monocytes rescues macrophages and partially reverses osteopetrosis in op/op mice
-
Lagasse, E. et al. 1997. Enforced expression of Bcl-2 in monocytes rescues macrophages andpartially reverses osteopetrosis in op/op mice. Cell 89: 1021-1031.
-
(1997)
Cell
, vol.89
, pp. 1021-1031
-
-
Lagasse, E.1
-
13
-
-
0028880455
-
Generation of committed erythroid BFU-E and CFU-E progenitors does not require erythropoietin or the erythropoietin receptor
-
Wu, H. et al. 1995. Generation of committed erythroid BFU-E and CFU-E progenitors does notrequire erythropoietin or the erythropoietin receptor. Cell 83: 59-67.
-
(1995)
Cell
, vol.83
, pp. 59-67
-
-
Wu, H.1
-
14
-
-
0026063514
-
The cytoplasmic region of the erythropoietin receptor contains non overlapping positive and negative growth-regulatory domains
-
D'Andrea, A. D. et al. 1991. The cytoplasmic region of the erythropoietin receptor containsnonoverlapping positive and negative growth-regulatory domains. Mol. Cell Biol. 11:1980-1987.
-
(1991)
Mol. Cell Biol.
, vol.11
, pp. 1980-1987
-
-
D'Andrea, A.D.1
-
15
-
-
0028073675
-
Activation of the mitogen-activated protein kinase pathway by the erythropoietin receptor
-
Miura, Y. et al. 1994. Activation of the mitogen-activated protein kinase pathway by the erythropoietin receptor. J. Biol. Chem. 269: 29962-29969.
-
(1994)
J. Biol. Chem.
, vol.269
, pp. 29962-29969
-
-
Miura, Y.1
-
16
-
-
0028142585
-
Erythropoietin induces tyrosine phosphorylation and activation of phospholipase C-gamma 1 in a human erythropoietin-dependent cell line
-
Ren, H. Y. et al. 1994. Erythropoietin induces tyrosine phosphorylation and activation of phospholipase C-gamma 1 in a human erythropoietin-dependent cell line. J. Biol. Chem. 269:19633-19638.
-
(1994)
J. Biol. Chem.
, vol.269
, pp. 19633-19638
-
-
Ren, H.Y.1
-
17
-
-
0028032086
-
Erythropoietin-dependent association of phosphatidylinositol 3-kinasewith tyrosine-phosphorylated erythropoietin receptor
-
Miura, O. et al. 1994. Erythropoietin-dependent association of phosphatidylinositol 3-kinasewith tyrosine-phosphorylated erythropoietin receptor. J. Biol. Chem. 269: 614-620.
-
(1994)
J. Biol. Chem.
, vol.269
, pp. 614-620
-
-
Miura, O.1
-
18
-
-
0028852393
-
Hematopoietic cell phosphatase (HCP) associates with the erythropoietin receptor following Epo induced receptor tyrosine phosphorylation: Identification of potential binding sites
-
Yi, T. et al. 1995. Hematopoietic cell phosphatase (HCP) associates with the erythropoietinreceptor following Epo induced receptor tyrosine phosphorylation: Identification of potentialbinding sites. Blood 85: 87-95.
-
(1995)
Blood
, vol.85
, pp. 87-95
-
-
Yi, T.1
-
19
-
-
0027197067
-
Mutations at the murine motheaten locus are within the hematopoieticcell protein tyrosine phosphatase (Hcph) gene
-
Shultz, L. D. et al. 1993. Mutations at the murine motheaten locus are within the hematopoieticcell protein tyrosine phosphatase (Hcph) gene. Cell 73: 1445-1454.
-
(1993)
Cell
, vol.73
, pp. 1445-1454
-
-
Shultz, L.D.1
-
20
-
-
0028956353
-
Specific recruitment of the hematopoietic protein tyrosine phosphatase SH-PTP1 to the erythropoietin receptor causes inactivation of JAK2 and terminationof proliferative signals
-
Klingmuller, U. et al. 1995. Specific recruitment of the hematopoietic protein tyrosine phosphatase SH-PTP1 to the erythropoietin receptor causes inactivation of JAK2 and terminationof proliferative signals. Cell 80: 729-738.
-
(1995)
Cell
, vol.80
, pp. 729-738
-
-
Klingmuller, U.1
-
21
-
-
0028916417
-
Purification of interleukin-3 stimulated DNA binding factors demonstrates the involvement of multiple isoforms of Stat5 in signaling
-
Azam, M. et al. 1995. Purification of interleukin-3 stimulated DNA binding factors demonstrates the involvement of multiple isoforms of Stat5 in signaling. EMBO J. 14: 1402-1411.
-
(1995)
EMBO J.
, vol.14
, pp. 1402-1411
-
-
Azam, M.1
-
22
-
-
0029157421
-
Distribution of the mammalian Stat gene family in mouse chromosomes
-
Copeland, N. G. et al. 1995. Distribution of the mammalian Stat gene family in mouse chromosomes. Genomics 29: 225-228.
-
(1995)
Genomics
, vol.29
, pp. 225-228
-
-
Copeland, N.G.1
-
23
-
-
0013077966
-
Identification of tyrosine residues within the intracellular domain of theerythropoietin receptor crucial for STAT5 activation
-
Gobert, S. et al. 1996. Identification of tyrosine residues within the intracellular domain of theerythropoietin receptor crucial for STAT5 activation. EMBO J. 15: 2434-2441.
-
(1996)
EMBO J.
, vol.15
, pp. 2434-2441
-
-
Gobert, S.1
-
24
-
-
0029738317
-
Multiple tyrosine residues in the cytosolic domain of the erythropoietin receptor promote activation of STAT5
-
Klingmuller, U. et al. 1996. Multiple tyrosine residues in the cytosolic domain of the erythropoietin receptor promote activation of STAT5. Proc. Natl. Acad. Sci. USA 93: 8324-8328.
-
(1996)
Proc. Natl. Acad. Sci. USA
, vol.93
, pp. 8324-8328
-
-
Klingmuller, U.1
-
25
-
-
0029866781
-
Erythropoietin induces activation of Stat5 through association withspecific tyrosines on the receptor that are not required for a mitogenic response
-
Quelle, F. W. et al. 1996. Erythropoietin induces activation of Stat5 through association withspecific tyrosines on the receptor that are not required for a mitogenic response. Mol. Cell.Biol. 16: 1622-1631.
-
(1996)
Mol. Cell. Biol.
, vol.16
, pp. 1622-1631
-
-
Quelle, F.W.1
-
26
-
-
0028785893
-
Tyrosine 343 in the erythropoietin receptor positively regulates erythropoietin-induced cell proliferation and Stat5 activation
-
Damen, J. E. et al. 1995. Tyrosine 343 in the erythropoietin receptor positively regulates erythropoietin-induced cell proliferation and Stat5 activation. EMBO J. 14: 5557-5568.
-
(1995)
EMBO J.
, vol.14
, pp. 5557-5568
-
-
Damen, J.E.1
-
27
-
-
0029892399
-
Suppression of interleukin-3-induced gene expression by a C-terminaltruncated Stat5: Role of Stat5 in proliferation
-
Mui, A.-F. et al. 1996. Suppression of interleukin-3-induced gene expression by a C-terminaltruncated Stat5: role of Stat5 in proliferation. EMBO J. 15: 2425-2433.
-
(1996)
EMBO J.
, vol.15
, pp. 2425-2433
-
-
Mui, A.-F.1
-
28
-
-
0028234529
-
Jak-STAT pathways and transcriptional activation in response toIFNs and other extracellular signaling proteins
-
Darnell, J. E., Jr. et al. 1994. Jak-STAT pathways and transcriptional activation in response toIFNs and other extracellular signaling proteins. Science 264: 1415-1421.
-
(1994)
Science
, vol.264
, pp. 1415-1421
-
-
Darnell J.E., Jr.1
-
29
-
-
0029069145
-
Transcriptional responses to polypeptide ligands: The JAK-STATpathway
-
Schindler, C. et al. 1995. Transcriptional responses to polypeptide ligands: the JAK-STATpathway. Annu. Rev. Biochem. 64: 621-651.
-
(1995)
Annu. Rev. Biochem.
, vol.64
, pp. 621-651
-
-
Schindler, C.1
-
30
-
-
0030046753
-
STATs: Signal tranducers and activators of transcription
-
Ihle, J. N. 1996. STATs: signal tranducers and activators of transcription. Cell 84: 331-334.
-
(1996)
Cell
, vol.84
, pp. 331-334
-
-
Ihle, J.N.1
-
31
-
-
0030024563
-
Targeted disruption of the mouse Stat1 gene results in compromisedinnate immunity to viral disease
-
Durbin, J. E. et al. 1996. Targeted disruption of the mouse Stat1 gene results in compromisedinnate immunity to viral disease. Cell 84: 443-450.
-
(1996)
Cell
, vol.84
, pp. 443-450
-
-
Durbin, J.E.1
-
32
-
-
13344282731
-
Targeted disruption of the Stat1 gene in mice reveals unexpectedphysiologic specificity in the JAK-STAT signaling pathway
-
Meraz, M. A. et al. 1996. Targeted disruption of the Stat1 gene in mice reveals unexpectedphysiologic specificity in the JAK-STAT signaling pathway. Cell 84: 431-442.
-
(1996)
Cell
, vol.84
, pp. 431-442
-
-
Meraz, M.A.1
-
33
-
-
0030935260
-
Targeted disruption of the mouse Stat3 gene leads to early embryoniclethality
-
Takeda, K. et al. 1997. Targeted disruption of the mouse Stat3 gene leads to early embryoniclethality. Proc. Natl. Acad. Sci. USA 94: 3801-3804.
-
(1997)
Proc. Natl. Acad. Sci. USA
, vol.94
, pp. 3801-3804
-
-
Takeda, K.1
-
34
-
-
0027233526
-
Leukemia inhibitory factor is necessary for maintenance ofhaematopoietic stem cells and thymocyte stimulation
-
Escary, J. L. et al. 1993. Leukemia inhibitory factor is necessary for maintenance ofhaematopoietic stem cells and thymocyte stimulation. Nature 363: 361-364.
-
(1993)
Nature
, vol.363
, pp. 361-364
-
-
Escary, J.L.1
-
35
-
-
0028228543
-
Stat4: A novel GAS binding protein expressed in early myeloid differentiation
-
Yamamoto, K. et al. 1994. Stat4: A novel GAS binding protein expressed in early myeloid differentiation. Mol. Cell. Biol. 14: 4342-4349.
-
(1994)
Mol. Cell. Biol.
, vol.14
, pp. 4342-4349
-
-
Yamamoto, K.1
-
36
-
-
0028943484
-
Interleukin 12 activates Stat3 and Stat4 by tyrosine phosphorylation in T cells
-
Jacobson, N. G. et al. 1995. Interleukin 12 activates Stat3 and Stat4 by tyrosine phosphorylation in T cells. J. Exp. Med. 181: 1755-1762.
-
(1995)
J. Exp. Med.
, vol.181
, pp. 1755-1762
-
-
Jacobson, N.G.1
-
37
-
-
0028910222
-
Interleukin-12 induces tyrosine phosphorylation of JAK2 and TYK2: Differential use of Janus tyrosine kinases by interleukin-2 and interleukin-12
-
Bacon, C. M. et al. 1995. Interleukin-12 induces tyrosine phosphorylation of JAK2 and TYK2:differential use of Janus tyrosine kinases by interleukin-2 and interleukin-12. J. Exp. Med. 181:399-404.
-
(1995)
J. Exp. Med.
, vol.181
, pp. 399-404
-
-
Bacon, C.M.1
-
38
-
-
0029937270
-
Impaired IL-12 responses and enhanced development of Th2 cells inStat4-deficient mice
-
Kaplan, M. H. et al. 1996. Impaired IL-12 responses and enhanced development of Th2 cells inStat4-deficient mice. Nature 382: 174-177.
-
(1996)
Nature
, vol.382
, pp. 174-177
-
-
Kaplan, M.H.1
-
39
-
-
15844396183
-
Stat4 is required for IL-12 mediated responses of NK and T-cells
-
Thierfelder, W. E. et al. 1996. Stat4 is required for IL-12 mediated responses of NK and T-cells. Nature 382: 171-174.
-
(1996)
Nature
, vol.382
, pp. 171-174
-
-
Thierfelder, W.E.1
-
40
-
-
0028281585
-
Interleukin-12: A key modulator of immune function
-
Wolf, S. F. et al. 1994. Interleukin-12: a key modulator of immune function. Stem Cells 12:154-168.
-
(1994)
Stem Cells
, vol.12
, pp. 154-168
-
-
Wolf, S.F.1
-
41
-
-
0028964916
-
Identification and purification of human Stat proteins activated in responseto interleukin-2
-
Hou, J. et al. 1995. Identification and purification of human Stat proteins activated in responseto interleukin-2. Immunity 2: 321-329.
-
(1995)
Immunity
, vol.2
, pp. 321-329
-
-
Hou, J.1
-
42
-
-
0029057858
-
Cloning of murine Stat6 and human Stat6, stat proteins that are tyrosine phosphorylated in responses to IL-4 and IL-3 but are not required for mitogenesis
-
Quelle, F. W. et al. 1995. Cloning of murine Stat6 and human Stat6, stat proteins that are tyrosine phosphorylated in responses to IL-4 and IL-3 but are not required for mitogenesis. Mol.Cell. Biol. 15: 3336-3343.
-
(1995)
Mol. Cell. Biol.
, vol.15
, pp. 3336-3343
-
-
Quelle, F.W.1
-
43
-
-
15844374279
-
Lack of IL-4-induced Th2 response and IgE class switching in micewith disrupted Stat6 gene
-
Shimoda, K. et al. 1996. Lack of IL-4-induced Th2 response and IgE class switching in micewith disrupted Stat6 gene. Nature 380: 630-633.
-
(1996)
Nature
, vol.380
, pp. 630-633
-
-
Shimoda, K.1
-
44
-
-
0029876629
-
Stat6 is required for mediating responses to IL-4 and for the development of Th2 cells
-
Kaplan, M. H. et al. 1996. Stat6 is required for mediating responses to IL-4 and for the development of Th2 cells. Immunity 4: 313-319.
-
(1996)
Immunity
, vol.4
, pp. 313-319
-
-
Kaplan, M.H.1
-
45
-
-
0027452977
-
Disruption of the murine IL-4 gene blocks Th2 cytokine responses
-
Kopf, M. et al. 1993. Disruption of the murine IL-4 gene blocks Th2 cytokine responses. Nature362: 245-248.
-
(1993)
Nature
, vol.362
, pp. 245-248
-
-
Kopf, M.1
-
46
-
-
0031057929
-
Stat5a is mandatory for adult mammary gland development and lacto-genesis
-
1-15
-
Liu, X. et al. 1-15-1997. Stat5a is mandatory for adult mammary gland development and lacto-genesis. Genes Dev. 11: 179-186.
-
(1997)
Genes Dev.
, vol.11
, pp. 179-186
-
-
Liu, X.1
-
47
-
-
0030833570
-
Requirement of STAT5b for sexual dimorphism of body growth rates andliver gene expression
-
Udy, G. B. et al. 1997. Requirement of STAT5b for sexual dimorphism of body growth rates andliver gene expression. Proc. Natl. Acad. Sci. USA 94: 7239-7244.
-
(1997)
Proc. Natl. Acad. Sci. USA
, vol.94
, pp. 7239-7244
-
-
Udy, G.B.1
-
48
-
-
0029028363
-
Deregulated T cell activation and autoimmunity in mice lacking interleukin-2 receptor β
-
Suzuki, H. et al. 1995. Deregulated T cell activation and autoimmunity in mice lacking interleukin-2 receptor β. Science 268: 1472-1476.
-
(1995)
Science
, vol.268
, pp. 1472-1476
-
-
Suzuki, H.1
-
49
-
-
0025899598
-
Development and function of T cells in mice rendered interleukin-2deficient by gene targeting
-
Schorle, H. et al. 1991. Development and function of T cells in mice rendered interleukin-2deficient by gene targeting. Nature 352: 621-624.
-
(1991)
Nature
, vol.352
, pp. 621-624
-
-
Schorle, H.1
-
50
-
-
0027957316
-
Stripe-specific regulation of pair-rule genes by hopscotch, a putative Jakfamily tyrosine kinase in Drosophila
-
Binari, R. et al. 1994. Stripe-specific regulation of pair-rule genes by hopscotch, a putative Jakfamily tyrosine kinase in Drosophila. Genes & Dev. 8: 300-312.
-
(1994)
Genes & Dev.
, vol.8
, pp. 300-312
-
-
Binari, R.1
|