Regulation of macrophage gene expression by pro- and anti-inflammatory cytokines

Pathobiology

Volumn 67, Issue 5-6, 1999, Pages 241-244

  Hamilton, T A ^a   Ohmori, Y ^a   Tebo, J M ^a   Kishore, R ^a  

^a LERNER RESEARCH INSTITUTE   (United States)

Author keywords

IFN ; IL 10; IL 4; LPS; MRNA stability; STAT6

Indexed keywords

CYTOKINE; GAMMA INTERFERON; GROWTH FACTOR; INTERLEUKIN 10; INTERLEUKIN 4; MESSENGER RNA; NUCLEOTIDE; STAT1 PROTEIN; STAT6 PROTEIN;

CONFERENCE PAPER; GENE CONTROL; GENE DELETION; GENE EXPRESSION REGULATION; GENE MAPPING; HUMAN; HUMAN CELL; IMMUNE RESPONSE; INFLAMMATION; MACROPHAGE; MOLECULAR MODEL; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DNA BINDING; RNA DEGRADATION; SIGNAL TRANSDUCTION; SITE DIRECTED MUTAGENESIS; TRANSCRIPTION REGULATION;

FELIS CATUS;

EID: 0342470975     PISSN: 10152008     EISSN: None     Source Type: Journal    
DOI: 10.1159/000028101     Document Type: Conference Paper

References (5)

1. Darnell JE Jr: STATs and gene regulation. Science 1997;277:1630.
2. Ohmori Y, Hamilton TA: STAT6 is required for the anti-inflammatory activity of interleukin-4 in mouse peritoneal macrophages. J Biol Chem 1998;273:29202.
3. Kim HS, Armstrong D, Hamilton TA, Tebo JM: IL-10 suppresses LPS-induced KC mRNA expression via a translation-dependent decrease in mRNA stability. J Leukoc Biol 1998; 64:33.
4. Ross J: mRNA stability in mammalian cells. Microbiol Rev 1995;59:423-450.
5. Kishore R, Tebo JM, Kolosov M, Hamilton TA: Cutting edge: Clustered AU-rich elements are the target of IL-10-mediated mRNA destabilization in mouse macrophages. J Immunol 1999;162:2457.