Transcription elongation factor P-TEFb mediates Tat activation of HIV-1 transcription at multiple stages

EMBO Journal

Volumn 17, Issue 13, 1998, Pages 3681-3691

  Zhou, Qiang ^a   Chen, Dan ^a   Pierstorff, Erik ^a   Luo, Kunxin ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

HIV 1 Tat; P TEFb; Tat SF1; Transcription elongation factor; Transcriptional activation

Indexed keywords

CYCLINE; ELONGATION FACTOR; ELONGATION FACTOR P; PHOSPHOTRANSFERASE; RNA POLYMERASE II; UNCLASSIFIED DRUG;

ARTICLE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; HELA CELL; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; TRANSACTIVATION; TRANSCRIPTION REGULATION;

BASE SEQUENCE; CELL LINE, TRANSFORMED; CYCLINS; GENE PRODUCTS, TAT; HELA CELLS; HIV LONG TERMINAL REPEAT; HIV-1; HUMANS; MOLECULAR SEQUENCE DATA; NUCLEIC ACID CONFORMATION; PEPTIDE CHAIN ELONGATION, TRANSLATIONAL; PHOSPHORYLATION; POSITIVE TRANSCRIPTIONAL ELONGATION FACTOR B; PROTEIN KINASES; PROTEIN-SERINE-THREONINE KINASES; RNA, DOUBLE-STRANDED; RNA, VIRAL; TRANS-ACTIVATION (GENETICS); TRANS-ACTIVATORS;

EID: 0032127436     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/17.13.3681     Document Type: Article

References (36)

1. Chun, R. and Jeang, K. (1996) Requirements for RNA polymerase II carboxyl-terminal domain for activated transcription of human retroviruses, human T-cell lymphotrophic virus I and HIV-1. J. Biol. Chem., 271, 27888-27894.
2. Cujec, T., Okamoto, H., Fujinaga, K., Meyer, J., Chamberlin, H., Morgan, D. and Peterlin, B.M. (1997) The HIV transactivator TAT binds to the CDK-activating kinase and activates the phosphorylation of the carboxy-terminal domain of RNA polymerase II. Genes Dev., 11, 2645-2657.
3. Dahmus, M. (1996) Reversible phosphorylation of the C-terminal domain of RNA polymerase II. J. Biol. Chem., 271, 19009-19012.
4. Feng, S. and Holland, E.C. (1988) HIV-1 tat trans-activation requires the loop sequence within tar. Nature, 334, 165-167.
5. Garcia, J.A., Harrich, D., Soultanakis, E., Wu, F., Mitsuyasu, R. and Gaynor, R.B. (1989) Human immunodeficiency virus type 1 LTR TATA and TAR region sequences required for transcriptional regulation. EMBO J., 8, 765-778.
6. Garcia-Martinez, L., Mavankal, G., Neveu, J., Lane, W., Ivanov, D. and Gaynor, R.B. (1997) Purification of a Tat-associated kinase reveals a TFIIH complex that modulates HIV-1 transcription. EMBO J., 16, 2836-2850.
7. Garriga, J., Mayol, X. and Grana, X. (1996) The CDC2-related kinase PITALRE is the catalytic subunit of active multimeric protein complexes. Biochem. J., 319, 293-298.
8. Grana, X., De Luca, A., Sang, N., Fu, Y., Claudio, P., Rosenblatt, J., Morgan, D. and Giordano, A. (1994) PITALRE, a nuclear CDC2-related protein kinase that phosphorylates the retinoblastoma protein in vitro. Proc. Natl Acad. Sci. USA, 91, 3834-3838.
9. Harlow, E. and Lane, D. (1988) Antibodies: A Laboratory Manual. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
10. Herrmann, C. and Rice, A. (1993) Specific interaction of the human immunodeficiency virus Tat proteins with a cellular protein kinase. Virology, 197, 601-608.
11. Herrmann, C.H. and Rice, A. (1995) Lentivirus Tat proteins specifically associate with a cellular protein kinase. TAK, that hyperphosphorylates the carboxyl-terminal domain of the large subunit of RNA polymerase II: candidate for a Tat cofactor. J. Virol., 69, 1612-1620.
12. Jones, K.A. (1997) Taking a new TAK on Tat transactivation. Genes Dev., 11, 2593-2599.
13. Jones, K.A. and Peterlin, B.M. (1994) Control of RNA initiation and elongation at the HIV-1 promoter. Annu. Rev. Biochem., 63, 717-743.
14. Keen, N.J., Churcher, M.J. and Karn, J. (1997) Transfer of Tat and release of TAR RNA during the activation of the human immunodeficiency virus type-1 transcription elongation complex. EMBO J., 16, 7260-5272.
15. Mancebo, H. et al. (1997) P-TEFb kinase is required for HIV Tat transcriptional activation in vivo and in vitro. Genes Dev., 11, 2633-2644.
16. Marciniak, R.A. and Sharp, P.A. (1991) HIV-1 Tat protein promotes formation of more-processive elongation complexes. EMBO J., 10, 4189-4196.
17. Marciniak, R.A., Garcia-Blanco, M.A. and Sharp, P.A. (1990) Identification and characterization of a HeLa nuclear protein that specifically binds to the trans-activation-response (TAR) element of human immunodeficiency virus. Proc. Natl Acad. Sci. USA, 87, 3624-3628.
18. Marshall, N. and Price, D. (1995) Purification of P-TEFb, a transcription factor required for the transition into productive elongation. J. Biol. Chem., 270, 12335-12338.
19. Marshall, N., Peng, J., Xie, Z. and Price, D. (1996) Control of RNA polymerase II elongation potential by a novel carboxyl-terminal domain kinase. J. Biol. Chem., 271, 27176-27183.
20. Okamoto, H., Sheline, C., Corden, J., Jones, K. and Peterlin, B.M. (1996) Trans-activation by human immunodeficiency virus Tat protein requires the C-terminal domain of RNA polymerase II. Proc. Natl Acad. Sci. USA, 93, 11575-11579.
21. Parada, C. and Roeder, R. (1996) Enhanced processivity of RNA polymerase II triggered by Tat-induced phosphorylation of its carboxyl-terminal domain. Nature, 384, 375-378.
22. Parvin, J.D. and Sharp, P.A. (1993) DNA topology and a minimal set of basal factors for transcription by RNA polymerase II. Cell, 73, 533-540.
23. Peng, J., Zhu, Y., Milton, J.T. and Price, D.H. (1998) Identification of multiple cyclin subunits of human P-TEFb. Genes Dev., 12, 755-762.
24. Reeder, T.C. and Hawley, D.K. (1996) Promoter proximal sequences modulate RNA polymerase II elongation by a novel mechanism. Cell, 87, 767-777.
25. Reines, D., Conaway, J.W. and Conaway, R.C. (1996) The RNA polymerase II general elongation factors. Trends Biochem. Sci., 21, 351-355.
26. Roy, S., Delling, U., Chen, C.H., Rosen, C.A. and Sonenberg, N. (1990) A bulge structure in HIV-1 TAR RNA is required for Tat binding and Tat-mediated trans-activation. Genes Dev., 4, 1365-1373.
27. Selby, M.J., Bain, E.S., Luciw, P.A. and Peterlin, B.M. (1989) Structure, sequence, and position of the stem-loop in tar determine transcriptional elongation by tat through the HIV-1 long terminal repeat. Genes Dev., 3, 547-558.
28. Wei, P, Garber, M.E., Fang, S., Fischer, W.H. and Jones, K.A. (1998) A novel CDK9-associated C-type cyclin interacts directly with HIV-1 Tat and mediates its high-affinity, loop-specific binding to TAR RNA. Cell. 92, 451-462.
29. Wu, F., Garcia, J., Sigman, D. and Gaynor, R.B. (1991) Tat regulates binding of the human immunodeficiency virus trans-activating region RNA loop-binding protein TRP-185. Genes Dev., 5, 2128-2140.
30. Wu-Baer, F., Lane, W.S. and Gaynor, R.B. (1995a) The cellular factor TRP-185 regulates RNA polymerase II binding to HIV-1 TAR RNA. EMBO J., 14, 5995-6009.
31. Wu-Baer, F., Sigman, D. and Gaynor, R.B. (1995b) Specific binding of RNA polymerase II to the human immunodeficiency virus transactivating region RNA is regulated by cellular cofactors and Tat. Proc. Natl Acad. Sci. USA, 92, 7153-7157.
32. Yang, X., Herrmann, C. and Rice, A.P. (1996) The human immunodeficiency virus Tat proteins specifically associate with TAK in vivo and require the carboxyl-terminal domain of RNA polymerase II for function. J. Virol., 70, 4576-4584.
33. Zhou, Q. and Sharp, P.A. (1995) Novel mechanism and factor for regulation by HIV-1 Tat. EMBO J., 14, 321-328.
34. Zhou, Q. and Sharp, P.A. (1996) Tat-SF1: cofactor for stimulation of transcriptional elongation by HIV-1 Tat. Science, 274, 605-610.
35. Zhou, Q., Lieberman, P.M, Boyer, T.G. and Berk, A.J. (1992) Holo-TFIID supports transcriptional stimulation by diverse activators and from a TATA-less promoter. Genes Dev., 6, 1964-1974.
36. Zhu, Y., Pe'ery, T., Peng, J., Ramanathan, Y., Marshall, N., Marshall, T., Amendt, B., Mathews, M. and Price, D. (1997) Transcription elongation factor P-TEFb is required for HIV-1 Tat transactivation in vitro. Genes Dev., 11, 2622-2632.