Transcription elongation factor P-TEFb is required for HIV-1 Tat transactivation in vitro

Genes and Development

Volumn 11, Issue 20, 1997, Pages 2622-2632

  Zhu, Yuerong ^a   Pe'ery, Tsafrira ^b   Peng, Junmin ^a   Ramanathan, Yegnanarayana ^b   Marshall, Nick ^a   Marshall, Tricia ^a   Amendt, Brad ^a   Mathews, Michael B ^b   Price, David H ^a  

^a UNIVERSITY OF IOWA   (United States)

^b RUTGERS NEW JERSEY MEDICAL SCHOOL   (United States)

Author keywords

HIV 1 Tat; P TEFb; RNA polymerase II; Transactivation; Transcription elongation factor

Indexed keywords

CYCLIN DEPENDENT KINASE; ELONGATION FACTOR; PROTEIN KINASE; RNA POLYMERASE II; TRANSACTIVATOR PROTEIN;

ARTICLE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; DROSOPHILA; HELA CELL; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; LONG TERMINAL REPEAT; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN PHOSPHORYLATION; RNA TRANSLATION; SEQUENCE HOMOLOGY; TRANSACTIVATION;

HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 15144348173     PISSN: 08909369     EISSN: None     Source Type: Journal    
DOI: 10.1101/gad.11.20.2622     Document Type: Article

References (58)

1. Aso, T., W.S. Lane, J.W. Conaway, and R.C. Conaway. 1995. Elongin (SIII): A multisubunit regulator of elongation by RNA polymerase II. Science 269: 1439-1443.
2. Ausubel, F.M., R. Brent, R.E. Kingston, D.D. Moore, J.G. Seidman, J.A. Smith, and K. Struhl. 1989. Current protocols in molecular biology Greene Publishing Associates/Wiley-Intersience, New York, NY.
3. Bentley, D.L. 1995. Regulation of transcriptional elongation by RNA polymerase II. Curr. Opin. Genet. Dev. 5: 210-216.
4. Blau, J., H. Xiao, S. McCracken, P. O'Hare, J. Greenblatt, and D. Bentley. 1996. Three functional classes of transcriptional activation domains. Mol. Cell. Biol. 16: 2044-2055.
5. Braddock, M., A.M. Thorburn, A.J. Kingsman, and S.M. Kingsman. 1991. Blocking of Tat-dependent HIV-1 RNA modification by an inhibitor of RNA polymerase II processivity. Nature 350:439-441.
6. Carroll, R., B.M. Peterlin, and D. Derse. 1992. Inhibition of human immunodeficiency virus type 1 Tat activity by coexpression of heterologous trans activators. J. Virol. 66: 2000-2007.
7. Chun, R.F. and K.T. Jeang. 1996. Requirements for RNA polymerase II carboxyl-terminal domain for transcription of human retroviruses, human T-cell lymphotrophic virus, and HIV-1. J. Biol. Chem. 271:27888-27894.
8. Cujec, T.P., H. Cho, E. Maldonado, J. Meyer, D. Reinberg, and B.M. Peterlin. 1997. The human immunodeficiency virus transactivator Tat interacts with the RNA polymerase II holoenzyme. Mol. Cell. Biol. 17: 1817-1823.
9. Cullen, B.R. 1993. Does HIV-1 Tat induce a change in viral initiation rights? Cell 73: 417-420.
10. Dahmus, M.E. 1996. Reversible phosphorylation of the c-terminal domain of RNA polymerase II. J. Biol. Chem. 271: 19009-19012.
11. Egyhazi, E., A. Ossoinak, A. Pigon, C. Holmgren, J.M. Lee, and A.L. Greenleaf. 1996. Phosphorylation dependence of the initiation of productive transcription of Balbiani ring 2 genes in living cells. Chromosoma 104: 422-433.
12. Feinberg, M.B., D. Baltimore, and A.D. Frankel. 1991. The role of Tat in the human immunodeficiency virus life cycle indicates a primary effect on transcriptional elongation. Proc. Natl. Acad. Sci. 88: 4045-4049.
13. Garcia-Martinez, L.F., D. Ivanov, and R.B. Gaynor. 1997a. Association of Tat with purified HIV-1 and HIV-2 transcription preinitiation complexes. J. Biol. Chem. 272: 6951-6958.
14. Garcia-Martinez, L.F., G. Mavankal, J.M. Neveu, W.S. Lane, D. Ivanov, and R.B. Gaynor. 1997b. Purification of a Tat-associated kinase reveals a TFIIH complex that modulates HIV-1 transcription. EMBO J. 16: 2836-2850.
15. Garriga, J., X. Mayol, and X. Grana. 1996a. The CDC2-related kinase PITALRE is the catalytic subunit of active multimeric protein complexes. Biochem. J. 319: 293-298.
16. Garriga, J., E. Segura, X. Mayol, C. Grubmeyer, and X. Grana. 1996b. Phosphorylation site specificity of the CDC2-related kinase PITALRE. Biochem. J. 320: 983-989.
17. Goodrich, J.A. and R. Tjian. 1994. Transcription factors IIE and IIH and ATP hydrolysis direct promoter clearance by RNA polymerase II. Cell 77: 145-156.
18. Grana, X., A. De Luca, N. Sang, Y. Fu, P.P. Claudio, J. Rosenblatt, D.O. Morgan, and A. Giordano. 1994. PITALRE, a nuclear CDC2-related protein kinase that phosphorylates the retinoblastoma protein in vitro. Proc. Natl. Acad. Sci. 91: 3834-3838.
19. Guo, H. and D.H. Price. 1993. Mechanism of DmS-II-mediated pause suppression by Drosophila RNA polymerase II. J. Biol. Chem. 268: 18762-18770.
20. Herrmann, C.H. and A.P. Rice. 1993. Specific interaction of the human immunodeficiency virus Tat proteins with a cellular protein kinase. Virology 197: 601-608.
21. _. 1995. Lentivirus Tat proteins specifically associate with a cellular protein kinase, TAK, that hyperphosphorylates the carboxyl-terminal domain of the large subunit of RNA polymerase II: Candidate for a Tat cofactor. J. Virol. 69: 1612-1620.
22. Irie, K., S. Nomoto, I. Miyajima, and K. Matsumoto. 1991. SGV1 encodes a CDC28/cdc2-related kinase required for a G alpha subunit-mediated adaptive response to pheromone in S. cerevisiae. Cell 65: 785-795.
23. Jeang, K.-T., R. Chun, N.H. Lin, A. Gatignol, C.G. Glabe, and H. Fan. 1993. In vitro and in vivo binding of human immunodeficiency virus type 1 Tat protein and Sp1 transcription factor. J. Virol. 67: 6224-6233.
24. Jones, K.A. and B.M. Peterlin. 1994. Control of RNA initiation and elongation at the HIV-1 promoter. Annu. Rev. Biochem. 63: 717-743.
25. Kao, S.-Y., A.F. Calman, P.A. Luciw, and E.M. Peterlin. 1987. Antitermination of transcription within the long terminal repeat of HIV by the tat gene product. Nature 330: 489-493.
26. Kashanchi, F., G. Piras, M.F. Radonovich, J.F. Duvall, A. Fattaey, C.M. Chiang, R.G. Roeder, and J.N. Brady. 1994. Direct interaction of human TFIID with the HIV-1 transactivator tat. Nature 367: 295-299.
27. Keen, N.J., M.J. Gait, and J. Karn. 1996. Human immunodeficiency virus type-1 Tat is an integral component of the activated transcription-elongation complex. Proc. Natl. Acad. Sci. 93:2505-2510.
28. Kephart, D.D., B.Q. Wang, Z.F. Burton, and D.H. Price. 1994. Functional analysis of Drosophila factor 5 (TFIIF), a general transcription factor. J. Biol. Chem. 269: 13536-13543.
29. Kerppola, T.K. and C.M. Kane. 1991. RNA polymerase: Regulation of transcript elongation and termination. FASEB J. 5: 2833-2842.
30. Laspia, M.F., A.P. Rice, and M.B. Mathews. 1989. HIV-1 Tat protein increases transcriptional initiation and stabilizes elongation. Cell 59: 283-292.
31. Laspia, M.F., A.P. Rice, and M.B. Mathews. 1990. Synergy between HIV-1 Tat and adenovirus E1A is principally due to stabilization of transcriptional elongation. Genes & Dev. 4: 2397-2408.
32. Laspia, M.F., P. Wendel, and M.B. Mathews. 1993. HIV-1 Tat overcomes inefficient transcriptional elongation in vitro. J. Mol. Biol. 232: 732-746.
33. Lee, J.M. and A.L. Greenleaf. 1997. Modulation of RNA polymerase II elongation efficiency by c-terminal heptapeptide repeat domain kinase I. J Biol. Chem. 272: 10990-10993.
34. Madore, S.J. and B.R. Cullen. 1993. Genetic analysis of the cofactor requirement for human immunodeficiency virus type 1 Tat function. J. Virol. 67: 3703-3711.
35. Marciniak, R.A. and P.A. Sharp. 1991. HIV-1 Tat protein promotes formation of more-processive elongation complexes. EMBO J. 10:4189-4196.
36. Marshall, N.F. and D.H. Price. 1992. Control of formation of two distinct classes of RNA polymerase II elongation complexes. Mol. Cell. Biol. 12: 2078-2090.
37. _. 1995. Purification of P-TEFb, a transcription factor required for the transition into productive elongation. J. Biol. Chem. 270: 12335-12338.
38. Marshall, N.F., J.M. Peng, Z. Xie, and D.H. Price. 1996. Control of RNA polymerase II elongation potential by a novel carboxyl-terminal domain kinase. J. Biol. Chem. 271:27176-27183.
39. Mavankal, G., S.H.I. Ou, H. Oliver, D. Sigman, and R.B. Gaynor. 1996. Transcription factors, and gene expression. Human immunodeficiency virus type 1 and 2 Tat proteins specifically interact with RNA polymerase II. Proc. Natl. Acad. Sci. 93: 2089-2094.
40. O'Brien, T., S. Hardin, A. Greenleaf, and J.T. Lis. 1994. Phosphorylation of RNA polymerase II C-terminal domain and transcriptional elongation. Nature 370: 75-77.
41. Parada, C.A. and R.G. Roeder. 1996. Enhanced processivity of RNA polymerase II triggered by Tat-induced phosphorylation of its carboxy-terminal domain. Nature 384: 375-378.
42. Pendergrast, P.S. and N. Hernandez. 1997. RNA-targeted activators, but not DNA-targeted activators, repress the synthesis of short transcripts at the human immunodeficiency virus type 1 long terminal repeat. J. Virol. 71: 910-917.
43. c cell nuclear extracts. J. Biol. Chem. 262: 3244-3255.
44. Reines, D., J.W. Conaway, and R.C. Conaway. 1996. The RNA polymerase II general elongation factors. Trends Biochem. Sci. 21:351-355.
45. Rice, A.P. and F. Carlotti. 1990. Structural analysis of wild-type and mutant human immunodeficiency virus type 1 Tat proteins. J. Virol. 64: 6018-6026.
46. Sheldon, M., R. Ratnasabapathy, and N. Hernandez. 1993. Characterization of the inducer of short transcripts, a human immunodeficiency virus type 1 transcriptional element that activates the synthesis of short RNAs. Mol. Cell. Biol. 13: 1251-1263.
47. Shilatifard, A., W.S. Lane, K.W. Jackson, R.C. Conaway, and J.W. Conaway. 1996. An RNA polymerase II elongation factor encoded by the human ELL gene. Science 271: 1873-1876.
48. Spencer, C.A. and M. Groudine. 1990. Transcription elongation and eukaryotic gene regulation. Oncogene 5: 777-786.
49. Sterner, D.E., J.M. Lee, S.E. Hardin, and A.L. Greenleaf. 1995. The yeast carboxyl-terminal repeat domain kinase CTDK-I is a divergent cyclin-cyclin-dependent kinase complex. Mol. Cell. Biol. 15:5716-5724.
50. Tamm, I. and T. Kikuchi. 1979. Early termination of heterogeneous nuclear RNA transcripts in mammalian cells: accentuation by 5,6-dichloro 1-beta-D-ribofuranosylbenzimidazole. Proc. Natl. Acad. Sci. 76: 5750-5754.
51. Tsuchiya, H., T. Iseda, and O. Hino. 1996. Identification of a novel protein (VBP-1) binding to the vonHippel-Lindau (VHL) tumor suppressor gene product. Cancer Res. 56: 2881-2885.
52. Veschambre, P., P. Simard, and P. Jalinot. 1995. Evidence for functional interaction between the HIV-1 Tat transactivator and the TATA box binding protein in vivo. J. Mol. Biol. 250: 169-180.
53. Wright, S. 1993. Regulation of eukaryotic gene expression by transcriptional attenuation. Mol. Biol. Cell 4: 661-668.
54. Xie, Z. and D.H. Price. 1996. Purification of an RNA polymerase II transcript release factor from Drosophila. J. Biol. Chem. 271: 11043-11046.
55. Yang, X.Z., C.H. Herrmann, and A.P. Rice. 1996. The human immunodeficiency virus tat proteins specifically associate with TAK in vivo and require the carboxy-terminal domain of RNA polymerase II for function. J. Virol. 70: 4576-4584.
56. Yankulov, K., K. Yamashita, R. Roy, J.M. Egly, and D.L. Bentley. 1995. The transcriptional elongation inhibitor 5,6-dichloro1-β-D-ribofuranosylbenzimidazole inhibits transcription factor IIH-associated protein kinase. J. Biol. Chem. 270: 23922-23925.
57. Yankulov, K.Y., M. Pandes, S. McCracken, D. Bouchard, and D.L. Bentley. 1996. TFIIH functions in regulating transcriptional elongation by RNA polymerase II in Xenopus oocytes. Mol. Cell. Biol. 16:3291-3299.
58. Zhou, Q.A. and P.A. Sharp. 1996. TAT-SF1 - cofactor for stimulation of transcriptional elongation by HIV-1 Tat. Science 274:605-610.