The inability of the nonobese diabetic class II molecule to form stable peptide complexes does not reflect a failure to interact productively with DM

Journal of Immunology

Volumn 161, Issue 6, 1998, Pages 2961-2967

  Peterson, Mary ^a   Sant, Andrea J ^a  

^a UNIVERSITY OF CHICAGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLYCOPROTEIN; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; PEPTIDE;

ANIMAL CELL; ANTIGEN PRESENTATION; ARTICLE; COMPLEX FORMATION; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; DISEASE PREDISPOSITION; DNA POLYMORPHISM; GENE TRANSFER; MOUSE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ANIMALS; ANTIGEN-PRESENTING CELLS; CELL LINE; DIABETES MELLITUS, TYPE 1; DIMERIZATION; ELECTROPHORESIS, POLYACRYLAMIDE GEL; HISTOCOMPATIBILITY ANTIGENS CLASS II; HLA-D ANTIGENS; MACROMOLECULAR SUBSTANCES; MICE; MICE, INBRED NOD; PEPTIDES; PROTEIN CONFORMATION; SODIUM DODECYL SULFATE;

EID: 0032530276     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (56)

1. Todd, J. A. 1990. Genetic control of autoimmunity in type 1 diabetes. Immunol. Today 11:122.
2. Castano, L., and S. Eisenbarth. 1990. Type-I diabetes: a chronic autoimmune disease of human, mouse, and rat. Annu. Rev. Immunol. 8:647.
3. + T-cell clones derived from lymphocytes infiltrating the islets of NOD mice. Diabetes 41:998.
4. Wang, Y. I., L. Hao, R. G. Gill, and K. J. Lafferty. 1987. Autoimmune diabetes in NOD mouse is L3T4 T-lymphocyte-dependent. Diabetes 36:535.
5. Bendelac, A., C. Carnaud, C. Boitard, and J. Bach. 1987. Syngeneic transfer of autoimmune diabetes from diabetic NOD mice to healthy neonates. J. Exp. Med. 166:823.
6. + islet-specific T cell clone. Science 249:1433.
7. Yagi, H., M. Matsumoto, K. Kunimoto, J. Kawaguchi, S. Makino, and M. Harada. 1992. Analysis of the roles of CD4 and CD8 T cells in autoimmune diabetes of NOD mice using transfer to NOD athymic nude mice. Eur. J. Immunol. 22:2387.
8. Cisse, A., M. Chauffert, D. Chevenne, B. Parfait, C. Julier, Z. Assouline, S. Michel, and F. Trivin. 1996. Distribution of HLA-DQA1 and -DQB1 alleles and DQA1-DQB1 genotypes among Senegalese patients with insulin-dependent diabetes mellitus. Tissue Antigens 47:333.
9. Kockum, I., C. B. Sanjeevi, S. Eastman, M. Landin-Olsson, G. Dahlquist, and A. Lernmark. 1995. Population analysis of protection by HLA-DR and DQ genes from insulin-dependent diabetes mellitus in Swedish children with insulin-dependent diabetes and controls. Eur. J. Immunogenet. 22:443.
10. Routsias, J., and G. K. Papadopoulos. 1995. Polymorphic structural features of modeled HLA-DQ molecules segregate according to susceptibility or resistance to IDDM. Diabetologia 38:1251.
11. Sanjeevi, C. B., T. P. Lybrand, C. DeWeese, M. Landin-Olsson, I. Kockum, G. Dahlquist, G. Sundkvist, D. Stenger, and A. Lernmark. 1995. Polymorphic amino acid variations in HLA-DQ are associated with systematic physical property changes and occurrence of IDDM: Members of the Swedish Childhood Diabetes Study. Diabetes 44:125.
12. Thorsby, E., and K. S. Ronningen. 1992. Role of HLA genes in predisposition to develop insulin-dependent diabetes mellitus. Ann. Med. 24:523.
13. Hattori, M., J. Buse, R. Jackson, L. Glimcher, M. Dorf, M. Minami, S. Makino, K. Moriwaki, H. Kuzuya, H. Imura, W. Strauss, J. Seidman, and G. Eisenbarth. 1986. The NOD mouse: recessive diabetogenic gene in the major histocompatibility complex. Science 321:733.
14. Leiter, E. H., D. V. Serreze, and M. Prochazaka. 1990. The genetics and epidemiology of diabetes in NOD mice. Immunol. Today 11:147.
15. Tochino, Y. 1987. The NOD mouse as a model of type 1 diabetes. Crit. Rev. Immunol. 8:49.
16. Wicker, L. S., J. A. Todd, and L. B. Peterson. 1995. Genetic control of autoimmune diabetes in the NOD mouse. Annu. Rev. Immunol. 13:179.
17. Acha-Orbea, H., and H. O. McDevitt. 1987. The first external domain of the nonobese diabetic mice class III-A β-chain is unique. Proc. Natl. Acad. Sci. USA 84:2435.
18. McDevitt, H., S. Singer, and R. Tisch. 1996. The role of MHC class II genes in susceptibility and resistance to type I diabetes in the NOD mouse. Horm. Metab. Res. 28:287.
19. Brown, J., T. Jardetzky, J. Gorga, L. Stern, R. Urban, J. Strominger, and D. Wiley. 1993. Three-dimensional structure of the human class II histocompatibility antigen HLA-DR1. Nature 364:33.
20. Stern, L., J. Brown, T. Jardetzky, J. Gorga, R. Urban, J. Strominger, and D. Wiley. 1994. Crystal structure of the human class II MHC protein HLA-DRI complexed with an influenza virus peptide. Nature 368:215.
21. Nalefski, E. A., K. T. Y. Shaw, and A. Rao. 1995. An ion pair in class II major histocompatibility complex heterodimers critical for surface expression and peptide presentation. J. Biol. Chem. 270:22351.
22. Busch, R., and E. Mellins. 1996. Developing and shedding inhibitions: how MHC class II molecules reach maturity. Curr. Opin. Immunol. 8:51.
23. Vogt, A. B., H. Kropshofer, and G. J. Hammerling. 1997. How HLA-DM affects the peptide repertoire bound to HLA-DR molecules. Hum. Immunol. 54:170.
24. Katz, J. F., C. Stebbins, E. Appella, and A. J. Sant. 1996. Invariant chain and DM edit self-peptide presentation by major histocompatibility complex (MHC) class II molecules. J. Exp. Med. 184:1747.
25. Weber, S. A., B. D. Evavold, and P. E. Jensen. 1996. Enhanced dissociation of HLA-DR-bound peptides in the presence of HLA-DM. Science 274:618.
26. van Ham, S. M., U. Gruneberg, G. Malcherek, I. Broker, A. Melms, and J. Trowsdale. 1996. Human histocompatibility leukocyte antigen (HLA)-DM edits peptides presented by HLA-DR according to their ligand-binding motifs. J. Exp. Med. 184:2019.
27. Kropshofer, H., A. B. Vogt, G. Moldenhauer, J. Hammer, J. S. Blum, and G. J. Hammerling. 1996. Editing of the HLA-DR-peptide repertoire by HLA-DM. EMBO J. 15:6144.
28. g7 molecules from nonobese diabetic mice are poor peptide binders. J. Immunol. 156:450.
29. Loss, G. E., C. E. Elias, P. E. Fields, R. K. Ribaudo, M. McKisic, and A. J. Sant. 1993. MHC class II-restricted presentation of an internally synthesized antigen displays cell-type variability and segregates from the exogenous class II and endogenous class I antigen presentation pathways. J. Exp. Med. 178:73.
30. Stebbins, C. C., M. E. Peterson, W. M. Suh, and A. J. Sant. 1996. DM-mediated release of a naturally occurring invariant chain degradation intermediate from MHC class II molecules. J. Immunol. 157:4892.
31. Landis, D., B. Beck, J. Buerstedde, S. Degraw, D. Klein, N. Koch, D. Murphy, M. Pierres, T. Tada, K. Yamamoto, C. Benoist, and D. Mathis. 1986. The assignment of chain specificities for anti-Ia monoclonal antibodies using L cell transfectants. J. Immunol. 137:3002.
32. Koch, N., G. Hammerling, N. Tada, S. Kimura, and U. Hammerling. 1982. Cross-blocking studies with monoclonal antibodies against I-A molecules of haplotypes b, d, and k. Eur. J. Immunol. 12:909.
33. Koch, N., S. Koch, and G. J. Hammerling. 1982. Ia invariant chain detected on lymphocyte surfaces by monoclonal antibody. Nature 299:644.
34. Stebbins, C. C., G. E. Loss, C. G. Elias, A. Chervonsky, and A. J. Sant. 1995. The requirement for DM in class II-restricted antigen presentation and SDS-stable dimer formation is allele-and species-dependent. J. Exp. Med. 181:223.
35. Schagger, H., and G. von Jagow. 1987. Tricine-sodium dodecyl sulfate-polyacrylamide gel electrophoresis for the separation of proteins in the range of 1 to 100 kDa. Anal. Biochem. 166:368.
36. Sadegh-Nasseri, S., and R. N. Germain. 1991. A role for peptide in determining MHC class II structure. Nature 353:167.
37. Dornmair, K., B. Rothenhausler, and H. M. McConnell. 1989. Structural intermediates in the reactions of antigenic peptides with MHC molecules. Cold Spring Harb. Symp. Quant. Biol. 54:409.
38. g7. Int. Immunol. 9:43.
39. Karlsson, L., A. Peletraux, R. Lindstedt, M. Lijedahl, and P. A. Peterson. 1994. Reconstitution of an operational MHC class II compartment in nonantigen-presenting cells. Science 266:1569.
40. k class II molecules in human APC containing deleted or mutated HLA DM genes. J. Immunol. 153: 5382.
41. Morris, P., J. Shaman, M. Attaya, M. Amaya, S. Goodman, C. Bergman, J. J. Monaco, and E. Mellins. 1994. An essential role for HLA-DM in antigen presentation by class II major histocompatability molecules. Nature 368:551.
42. Fling, S. P., B. Arp, and D. Pious. 1994. HLA-DMA and -DMB genes are both required for MHC class II/peptide complex formation in antigen-presenting cells. Nature 368:554.
43. Sanderson, F., C. Thomas, J. Neefjes, and J. Trowsdale. 1996. Association between HLA-DM and HLA-DR in vivo. Immunity 4:87.
44. Denzin, L. K., and P. Cresswell. 1995. HLA-DM induces CLIP dissociation from MHC class II αβ dimers and facilitates peptide loading. Cell 82:155.
45. Morris, P., J. Shaman, M. Attaya, M. Amaya, S. Goodman, C. Bergman, J. J. Monaco, and E. Mellins. 1994. An essential role for HLA-DM in antigen presentation by class II major histocompatibility molecules. Nature 368:551.
46. Cotner, T., E. Mellins, A. Johnson, and D. Pious. 1993. Mutations affecting antigen processing impair class II-restricted allorecognition. J. Immunol. 146:414.
47. Mellins, E., L. Smith, B. Arp, T. Corner, E. Celis, and D. Pious. 1990. Defective processing and presentation of exogenous antigens in mutants with normal HLA class II genes. Nature 343:71.
48. Sloan, V. S., P. Cameron, G. Porter, M. Gammon, M. Amaya, E. Mellins, and D. Zaller. 1995. Mediation by HLA-DM of dissociation of peptides from HLA-DR. Nature 375:802.
49. Peterson, M., and J. Miller. 1992. Antigen presentation enhanced by the alternatively spliced invariant chain gene product p41. Nature 357:596.
50. Momburg, F., S. Fuchs, J. Drexler, R. Busch, M. Post, G. J. Hammerling, and L. Adorini. 1993. Epitope-specific enhancement of antigen presentation by invariant chain. J. Exp. Med. 178:1453.
51. Pinet, V., M. Malnati, and E. Long. 1994. Two processing pathways for the MHC class II-restricted presentation of exogenous influenza virus antigen. J. Immunol. 152:4852.
52. Cresswell, P. 1996. Invariant chain structure and MHC class II function. Cell 84:505.
53. Ceman, S., and A. J. Sant. 1995. The function of invariant chain in class II-restricted antigen presentation. Semin. Immunol. 7:373.
54. Ghosh, P., M. Amaya, E. Mellins, and D. C. Wiley. 1995. The structure of an intermediate in class II MHC maturation: CLIP bound to HLA-DR3. Nature 378:457.
55. Reich, E. P., H. von-Grafenstein, A. Barlow, K. E. Swenson, K. Williams, and C. A. Janeway. 1994. Self peptides isolated from MHC glycoproteins of nonobese diabetic mice. J. Immunol. 152:2279.
56. g7, the class II major histocompatibility complex (MHC) molecule of NOD and Biozzi AB/H mice. J. Exp. Med. 185:1013.