Thymic Expression of Myelin Basic Protein (MBP): Activation of MBP-Specific T Cells by Thymic Cells in the Absence of Exogenous MBP

Journal of Immunology

Volumn 157, Issue 12, 1996, Pages 5249-5253

  Fritz, Robert B ^a   Zhao, Ming Lang ^a  

^a MEDICAL COLLEGE OF WISCONSIN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MYELIN BASIC PROTEIN; PEPTIDE;

ALLERGIC ENCEPHALOMYELITIS; AMINO ACID SEQUENCE; ANIMAL; ARTICLE; CHEMISTRY; CYTOLOGY; DENDRITIC CELL; IMMUNOLOGY; LYMPHOCYTE ACTIVATION; MOLECULAR GENETICS; MOUSE; MOUSE STRAIN; RAT; T LYMPHOCYTE; THYMUS;

AMINO ACID SEQUENCE; ANIMALS; DENDRITIC CELLS; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED STRAINS; MOLECULAR SEQUENCE DATA; MYELIN BASIC PROTEINS; PEPTIDES; RATS; T-LYMPHOCYTES; THYMUS GLAND;

EID: 0030589288     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (18)

1. Baker, D., O. A. Rosenwasser, J. K. O'Neill, and J. L. Turk. 1995. Genetic analysis of experimental allergic encephalomyelitis in mice J. Immunol. 155: 4046.
2. Chou, C. H., R. B. Fritz, F. C. Chou, and R. F. Kibler. 1979. The immune response of Lewis rats to peptide 68-88 of guinea pig myelin basic protein. I. T cell determinants. J. Immunol. 123:1540
3. Uitdehaag, B. M., C. J. De Groot, A. Kreike, P. H. van der Meide, C. H. Polman, and C. D. Dijkstra 1993. The significance of in-situ Ia antigen expression in the pathogenesis of autoimmune central nervous system disease. J. Autoimmun. 6:323.
4. Sobel, R. A., R. C. van der Veen, and M. B. Lees. 1986. The immunopathology of chronic experimental allergic encephalomyelitis induced in rabbits with bovine proteolipid protein. J. Immunol. 136:157.
5. Tuohy, V. K., Z J. Lu, R. A. Sobel, R. A. Laursen, and M. B. Lees. 1988. A synthetic peptide from myelin proteolipid protein induces experimental allergic encephalomyelitis. J. Immunol. 141:1126.
6. Kerlero de Rosbo, N., I. Mendel, and A. Ben-Nun. 1995. Chronic relapsing experimental autoimmune encephalomyelitis with a delayed onset and an atypical clinical course, induced in PL/J mice by myelin oligodendrocyte glycoprotein (MOG)-derived peptide: preliminary analysis of MOG T cell epitopes. Eur. J. Immunol. 25:985.
7. Fritz, R. B., C. H. Chou, and D. E. McFarlin. 1983. Relapsing murine experimental allergic encephalomyelitis induced by myelin basic protein. J. Immunol. 130:1024.
8. Fritz, R. B., M. J. Skeen, C. H. Chou, M. Garcia, and I. K. Egorov. 1985. Major histocompatibility complex-linked control of the murine immune response to myelin basic protein. J. Immunol. 134:2328.
9. Mathisen, P. M., S. Pease, J. Garvey, L. Hood, and C. Readhead. 1993. Identification of an embryonic isoform of myelin basic protein that is expressed widely in the mouse embryo. Proc. Natl. Acad. Sci. USA 90:10125.
10. Zelenika, D., B. Grima, and B. Pessac. 1993. A new family of transcripts of the myelin basic protein gene: expression in brain and in immune system. J. Neurochem. 60:1574.
11. Grima, B., D. Zelenika, and B. Pessac. 1993. A novel transcript overlapping the myelin basic protein gene. J. Neurochem. 59:2318.
12. Fritz, R. B., and I. Kalvakolanu. 1995. Thymic expression of the golli-myelin basic protein gene in the SJL/J mouse. J. Neuroimmunol. 57:93.
13. Campagnoni, A. T., T. M. Pribyl, C. W. Campagnoni, K. Kampf, S. Amur-Umarjee, C. F. Landry, V. W. Handley, S. L. Newman, B. Garbay, and K. Kitamura. 1993. Structure and developmental regulation of golli-mbp, a 105-kilobase gene that encompasses the myelin basic protein gene and is expressed in cells in the oligodendrocyte lineage in the brain. J. Biol. Chem. 268:4930.
14. Campagnoni, A. T. 1988. Molecular biology of myelin proteins from the central nervous system. J. Neurochem. 51:1.
15. Diebler, G. E., R. E. Martenson, and M. W. Kies. 1972. Large scale preparation of myelin basic protein from central nervous system tissue of several species Prep. Biochem. 2:139.
16. + T lymphocytes in the priming of T lymphocytes to peptide antigen in vivo. J. Immunol. 151:6742.
17. Crowley, M. T., K. Inaba, M. D. Witmer-Pack, S. Gezelter, and R. M. Steinman. 1990. Use of the fluorescence activated cell sorter to enrich dendritic cells from mouse spleen. J. Immunol. Methods 133:55.
18. Wekerle, H., M. Bradl, C. Linnington, G. Kaab, and K. Kojima. 1996. The shaping of the brain-specific T lymphocyte repertoire in the thymus. Immunol. Rev. 149:231.